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1. Junior doctors in England agree to talks with government

   Wed, 15 May 2024 23:50:21 -0000

   Members of the British Medical Association union have been staging walkouts for more than a year.

2. More hospitals leaving patients in corridors to free up ambulances

   Wed, 15 May 2024 01:24:22 -0000

   A new policy sees people treated in NHS hospital corridors as admissions outstrip beds.

3. Millions more middle-aged are obese, study suggests

   Wed, 15 May 2024 00:29:58 -0000

   Using a lower cut-off for obesity would give a truer picture of who is affected, researchers say.

4. People with HIV can be sperm and egg donors

   Wed, 15 May 2024 01:33:42 -0000

   UK laws have changed to keep up with the science that shows it can be safe.

5. Brazilian butt lift firms banned after woman in hospital

   Tue, 14 May 2024 16:39:58 -0000

   The woman required emergency hospital treatment following the procedure in a hotel function room.

6. Teenager used pills for illegal abortion, court hears

   Tue, 14 May 2024 15:05:11 -0000

   Sophie Harvey, of St Mary’s Road, Cirencester, is accused of taking the drug to end her pregnancy.

7. Family of weight-loss op victim call for sales ban

   Tue, 14 May 2024 14:12:42 -0000

   Shannon Bowe's family want UK hotel chains to stop hosting Turkish surgery "clinics" and sales days.

8. Top doctor cancer-free a year after world-first therapy

   Tue, 14 May 2024 05:50:59 -0000

   Richard Scolyer has undergone a new treatment for glioblastoma, based on his own melanoma research.

9. 'Horrendous birth experience left me in therapy'

   Mon, 13 May 2024 17:33:31 -0000

   Hundreds of women have contacted BBC News with their traumatic experiences of giving birth.

10. I lost my mum, dad and baby sister to HIV in infected blood scandal

    Mon, 13 May 2024 04:45:05 -0000

    Families torn apart by the infected blood scandal break their silence to BBC Panorama.

11. Assisted dying debate terrifying for disabled, says Liz Carr

    Tue, 07 May 2024 05:01:33 -0000

    As legal assisted dying receives more support, the actress expresses deep concern for disability rights.

12. AstraZeneca to withdraw Covid vaccine

    Wed, 08 May 2024 11:27:55 -0000

    The firm said the decision was taken because of a decline in demand for the vaccine.

13. We need to normalise death and dying, says carer

    Mon, 06 May 2024 09:35:56 -0000

    Abi Vance, who cared for a friend with terminal cancer, said "normalising" death might help people.

14. NHS problems leave new doctors without jobs

    Sun, 05 May 2024 01:32:46 -0000

    The NHS needs more doctors so why have some medical students been left in limbo waiting for a job?

15. Victims infected with Hep C after blood screening began

    Thu, 09 May 2024 21:05:02 -0000

    Lawyers tell the BBC people infected after September 1991 should be allowed to claim compensation.

16. How is the King's cancer treatment going?

    Fri, 26 Apr 2024 17:00:04 -0000

    The King's medical team are "sufficiently pleased" with his progress after he was diagnosed with cancer in February.

17. Chat room helps Destiny-Rae, 5, find a new kidney

    Tue, 23 Apr 2024 01:00:57 -0000

    An online friendship between two mums led to a new kidney for five-year-old Destiny-Rae.

18. Five surprisingly simple ways to optimise your diet

    Fri, 03 May 2024 12:53:30 -0000

    Here's five tips for better eating from BBC Ideas

19. Are weight-loss injections the answer to obesity?

    Sun, 19 Mar 2023 00:52:45 -0000

    The appeal is clear - but should we be turning to appetite-suppressing injections?

20. What is the law on assisted suicide and euthanasia?

    Tue, 14 May 2024 11:53:35 -0000

    Many countries have legalised assisted dying, assisted suicide or euthanasia, which are different.

21. What is pregabalin and why can it be dangerous?

    Thu, 21 Mar 2024 14:09:52 -0000

    The prescription drug has been linked to a number of deaths in the UK and around the world.

22. What is the new vaping tax and when will it start?

    Wed, 06 Mar 2024 15:25:45 -0000

    The government will introduce a new vaping tax on top of measures to stop children vaping.

23. Why are we so ill? The working-age health crisis

    Mon, 22 Apr 2024 08:52:38 -0000

    The number of under 65s struggling with poor health is rising - and it's a threat to the economy.

24. How much do junior doctors really get paid?

    Fri, 11 Aug 2023 12:51:17 -0000

    The BBC asked two junior doctors in England to show us their payslips and reveal their salaries.

25. What is the infected blood scandal and how many people died?

    Mon, 13 May 2024 09:26:36 -0000

    Thousands were infected with HIV and hepatitis C, in the worst treatment disaster in NHS history.

26. Children used as 'guinea pigs' in clinical trials

    Thu, 18 Apr 2024 21:00:43 -0000

    They were given infected blood products in trials without their knowledge, the BBC has found.

27. Infected blood inquiry: Five things we have learned

    Fri, 03 Feb 2023 15:34:45 -0000

    An inquiry into the "worst treatment disaster in NHS history" hears its final evidence.

28. How 175 British children were infected with HIV

    Thu, 06 Oct 2022 00:23:44 -0000

    Families of some of those affected are giving evidence at a public inquiry into the treatment disaster.

29. 'I'll keep fighting until everyone is compensated'

    Wed, 17 Aug 2022 11:02:43 -0000

    A woman who lost both parents in the infected blood scandal says many victims still need justice.

30. Can health secretary name NHS trusts performing well?

    Thu, 11 Apr 2024 09:09:11 -0000

    Victoria Atkins is challenged to name some health trusts meeting their targets to cut waiting lists.

31. 'I embrace my alopecia, but I’d love my old hair back’

    Sun, 03 Mar 2024 23:36:30 -0000

    People living with alopecia could have access to treatment on the NHS in Scotland for the first time.

32. Sunak reveals he fasts at beginning of the week

    Mon, 29 Jan 2024 12:37:18 -0000

    The PM says he tries to fast at the start of the week so he can indulge in his “weakness for sugary things” on other days.

33. 'There are loads of people that vape at school'

    Mon, 29 Jan 2024 14:54:43 -0000

    A group of teenagers in Fife have been making a documentary about the impact of disposable vapes.

34. UK Covid inquiry comes to Scotland… in 90 seconds

    Tue, 16 Jan 2024 11:51:26 -0000

    The BBC's Kirsten Campbell outlines what can be expected during three weeks of evidence held in Edinburgh.

35. A cancer patient's second chance at motherhood, plus a pastor's journey through depression

    Wed, 15 May 2024 22:44:58 -0000

    The Fox News Health Newsletter brings you trending and important stories about health warnings, drug shortages, mental health issues and more in this weekly recap.

36. Health care costs up to 300% higher for privately insured patients than those with Medicare, report reveals

    Wed, 15 May 2024 17:28:56 -0000

    Patients who have private insurance may end up paying significantly more for medical care compared to those who have public health insurance, such as Medicare, according to a report.

37. Pet medication for deadly cat illness soon to be available in US: 'Huge triumph'

    Wed, 15 May 2024 09:00:44 -0000

    A drug used to treat feline infectious peritonitis will be available in the United States as of June 1, in a move cat advocates and cat lovers say is a "cause for celebration."

38. Pastor based in Dallas shares depression journey, urges others to seek help: ‘Don’t hesitate’

    Tue, 14 May 2024 08:00:00 -0000

    Pastors and other clergy members often serve as pillars of support in times of crisis — but what happens when they are the ones who need lifted up? A pastor and mental health professionals chime in.

39. 8 of the most important health stories this week, in case you missed them

    Sun, 12 May 2024 19:22:59 -0000

    With a new week beckoning, check out some of the top recent stories in Health that you may have missed, or have been meaning to check out — here are 8 key developments.

40. Experimental cancer treatment gives New Jersey mom a chance for a second baby: ‘I decided to go for it’

    Sun, 12 May 2024 08:00:13 -0000

    A New Jersey mom had just given birth when she received a life-changing diagnosis — and she feared she wouldn’t be able to have more children. Here's how she got a second chance at motherhood.

41. Artificial intelligence not always helpful for reducing doctor burnout, studies suggest

    Sat, 11 May 2024 21:58:50 -0000

    Incorporating generative AI in electronic health record systems might not ease burnout as much as anticipated, according to studies from medical sites across the country.

42. Common cooking ingredient could reduce dementia mortality risk, study suggests

    Sat, 11 May 2024 21:30:17 -0000

    Infusing more olive oil into your diet could pay big dividends in cognitive health, a new study from the Harvard T.H. Chan School of Public Health suggests. Experts offered insights.

43. Nurses call for change as many reveal they're ‘extremely likely’ to leave profession: ‘Emotional, stressful'

    Fri, 10 May 2024 08:30:08 -0000

    Nurses aren’t optimistic that this year will be any better than last year — and more than one-third of them are “extremely likely" to change jobs, according to a new survey.

44. Orangutan in Indonesian rainforest treats own facial wound, say researchers: ‘Appeared intentional’

    Thu, 09 May 2024 09:30:33 -0000

    An orangutan in Indonesia that sustained a facial wound treated it himself, according to a study published in the journal Scientific Reports this month. Researchers and a veterinarian weighed in.

45. As Ozzy Osbourne announces stem cell therapy, experts urge caution, highlight risks

    Thu, 09 May 2024 09:00:56 -0000

    As rock legend Ozzy Osbourne has turned to stem cell therapy, some experts caution that the treatment is not for everyone. A doctor weighed in on the potential risks.

46. Handling grief on Mother's Day, plus disease-fighting foods and heart health risks

    Wed, 08 May 2024 20:51:34 -0000

    The Fox News Health Newsletter brings you trending and important stories about health warnings, drug shortages, mental health issues and more in this weekly recap.

47. Sleep experts sound alarm on late night screen time: How your phone could be sabotaging your rest

    Wed, 08 May 2024 17:58:34 -0000

    Despite knowing the negative effects, many still use smartphones in bed, disrupting their sleep patterns. This is caused by artificial light that suppresses melatonin.

48. Struggling to fall asleep? Try this simple trick to drift off quickly

    Wed, 08 May 2024 09:30:42 -0000

    For those who are struggling to get enough sleep, the ABCs may be the key to getting more Zs. Experts weigh in on the effectiveness of a simple sleep hack.

49. Grieving during Mother’s Day: 5 tips for navigating the first holiday after losing a mom

    Wed, 08 May 2024 08:00:38 -0000

    Mother’s Day is a celebration for most — but for those who have lost their moms, it can be a difficult day marked by grief and isolation. A mental health professional offers guidance.

50. Americans breathe in carcinogenic chemicals found in cars: study

    Wed, 08 May 2024 02:33:14 -0000

    An article in Environmental Science and Technology argues that the cancer-causing chemicals found inside Americans' cars could be impacted by temperature and air flow.

51. Eating yogurt could help prevent one common disease, according to the FDA

    Wed, 08 May 2024 00:54:09 -0000

    Some say that including yogurt in our diets could help keep diabetes at bay, a claim that gets no objection from the FDA. A nutritionist weighs in on the benefits.

52. Ask a doc: 'Is it dangerous to crack my neck or back?'

    Tue, 07 May 2024 17:56:11 -0000

    Cracking your back or neck might provide quick relief and a satisfying popping noise — but is it a safe practice? Medical professionals share the risks of the habit.

53. Seniors and breast cancer: Why aren’t older women told to get mammograms?

    Tue, 07 May 2024 09:30:33 -0000

    The U.S. Preventive Services Task Force recommends that women between the ages of 40 and 74 should get mammograms every other year, but some experts object to the older cut-off age.

54. As cholera cases rise worldwide, health officials sound 'concerning' alarm about vaccine shortages

    Mon, 06 May 2024 21:24:29 -0000

    As cholera continues to surge — and as vaccines remain in short supply — experts are warning about the global risk. Here's what to know about the bacterial disease.

55. 6 things very few people know about spirituality

    Wed, 15 May 2024 08:30:00 -0000

    Spirituality is a beautiful journey and way of life. It brings inner peace and fosters acceptance of others. Through spirituality, people learn many valuable lessons. However, there are some key truths and insights that are helpful to know from the start.

56. 10 benefits of walking for 10 mins after meals

    Wed, 15 May 2024 06:30:00 -0000

    ​Walking for just 10 minutes after each meal can significantly impact your overall health and well-being. This simple habit can enhance digestion, regulate blood sugar levels, and improve your mood. Here are ten specific benefits:​

57. Human Library offers unique literary experience

    Wed, 15 May 2024 12:30:00 -0000

    The Human Library, or ‘Menneskebiblioteket’, was founded in Copenhagen in the year 2000. It was created as a project for the Roskilde Festival by Ronni Abergel, Dany Abergel, Asma Mouna and Christoffer Erichsen.

58. Most stunning saris showcased at Cannes

    Wed, 15 May 2024 11:09:08 -0000

    Let's take a look at some of the iconic sari looks from Cannes.

59. Boldest makeup looks of Indian celebs at Cannes

    Wed, 15 May 2024 07:30:00 -0000

    Let's take a look at some of the boldest makeup looks of Indian celebrities at Cannes over the years.

60. Madhavi Raje, the Rajmata of Gwalior Royal family

    Wed, 15 May 2024 08:38:18 -0000

    Union Minister Jyotiraditya Scindia's mother, 'Rajmata' Madhavi Raje, passed away at AIIMS in New Delhi. Formerly from the royal Rana dynasty of Nepal, she married Maharaja Madhavrao Scindia in 1966, becoming a key figure in Gwalior's social and cultural activities. Involved in philanthropic works, she also established Maharaja Madhavrao Scindia II gallery in Gwalior Palace museum.

61. Eating this much sugar daily is safe as per ICMR

    Wed, 15 May 2024 02:55:04 -0000

    ICMR and NIN recommend reducing sugar intake, highlighting risks from processed foods. Excess sugar can harm muscles, immune system, and increase cancer risks. FSSAI warns of sugar adulteration with health risks like nausea.

62. Indian starlet Deepti Sadhwani stuns at Festival de Cannes

    Wed, 15 May 2024 07:38:34 -0000

    Farhana Bodi, Deepti Sadhwani, Meryl Streep, Miss North India, Femina Miss India, Taarak Mehta Ka Ooltah Chashmah, Haryanvi songs, Nazar Hati Durghatana Ghati, Rock Band Party, Baadshah, Meet Brothers, and LaLa Lala Lori shine at the 2024 Cannes Film Festival.

63. Brand Aishwarya at Cannes over the years

    Wed, 15 May 2024 06:23:07 -0000

    Aishwarya Rai Bachchan, a Bollywood star, debuted at the Cannes Film Festival in 2002, showcasing Indian attire and building her global brand value. Her presence symbolizes elegance, beauty, and her Indian heritage, making her a cultural ambassador on the international stage.

64. Can consuming oil actually make you fat?

    Tue, 14 May 2024 18:30:00 -0000

    The Dietary Guidelines for Indians-2024 highlight the importance of fats and oils for nutritional needs, emphasizing diverse sources and proper intake. Led by the ICMR-NIN Expert Committee and Dr. Neelanjana Singh, the guidelines provide insights on managing different types of fats and essential fatty acids.

65. 10 habits that can change your child's life

    Tue, 14 May 2024 23:30:00 -0000

    By integrating these habits into your child's daily life over a period of three months, you'll witness positive changes in their behavior.

66. IPL 2024: Top 10 items banned from IPL matches

    Tue, 14 May 2024 08:32:19 -0000

    To prioritize the safety and security of all attendees, IPL stadiums enforce stringent regulations prohibiting certain items from entry....

67. How to create strong bonds with your family

    Wed, 15 May 2024 03:37:40 -0000

    The International Day of Families, established by the UN General Assembly in 1993 and celebrated on May 15th, marks its 30th anniversary in 2024 with the theme 'Families and Climate Change'. The day aims to highlight the impact of climate change on families and the role of family traditions in fostering climate action.

68. Kiara Advani set to make her Cannes debut

    Tue, 14 May 2024 17:30:00 -0000

    The Cannes Film Festival took off on May 14 this year, and will see an active run till May 25. Like every year, many Bollywood stars will mark their presence including Aishwarya Rai Bachchan, and Aditi Rao Hydari, whereas Kiara Advani is also set to make her debut on the international red carpet.

69. Turmeric water vs turmeric milk: Which is healthier?

    Tue, 14 May 2024 13:30:00 -0000

    Turmeric, rich in curcumin and antioxidants, boosts immunity, fights inflammation, aids digestion, and promotes skin health. Haldi milk aids inflammation, immunity, and sleep quality, while Haldi water supports liver health, metabolism, weight management, skin health, and digestive system health.

70. TOI Health News Morning Briefing

    Wed, 15 May 2024 01:42:26 -0000

    Read TOI Health News Morning Briefing here. A 42-year-old woman alleges AstraZeneca's COVID vaccine left her disabled; FLiRT variants' transmissibility examined; Actor Shamita Shetty undergoes endometriosis surgery; KP.2 variant more transmissible; Vitamin D deficiency impacts all ages; Hypertension risks discussed; Healthy wheat alternatives for diabetics; Tips to manage consistent bowel pain; Dehydration signs in kids during heatwave.

71. Best Cannes makeup looks from 2023

    Tue, 14 May 2024 07:30:00 -0000

    Let's take a look at some of the best Cannes makeup looks from 2023.

72. Ghostly "God's Hand" caught on Dark Energy Camera

    Tue, 14 May 2024 07:30:00 -0000

    A new telescope in Chile captures an awe-inspiring image dubbed "God's Hand," revealing CG 4, a cometary globule 1,300 light-years away. Dense clouds of gas and dust form its hand-like structure, with an eight-light-year tail. The DECam's image, cutting through cosmic dust, showcases the region's star-forming activity within the Gum Nebula. This significant discovery aids astronomers in unraveling the mysteries of star formation and nebular dynamics.

73. Are FLiRT- new COVID variants, more infectious?

    Tue, 14 May 2024 09:30:00 -0000

    ​KP.2, which is part of the FLiRT variants, is said to be highly transmissible in nature. However, doctors have said that it is not virulent. "There is no reason to believe that the FLiRT group of variants being reported are more virulent than the existing variants," Dr Lancelot Pinto, Consultant Pulmonologist and Epidemiologist, P. D. Hinduja Hospital and MRC, Mahim, told IANS. "KP.2 appears to be more transmissible," he added.​

74. 5 powerful shlokas from Bhagavad Gita

    Tue, 14 May 2024 09:23:34 -0000

    The Bhagavad Gita is a part of the Indian epic Mahabharata and contains many insightful lessons, teachings, and rules and morals of conduct for people. The Bhagavad Gita is the conversation between Shri Krishna and the prince Arjuna, for whom Shri Krishna himself became the charioteer and the recipient of Gandhari’s curse. Here we list the 5 most famous and powerful shlokas from Bhagavad Gita and what they mean.

75. Nemolizumab and topical steroid combination effective against prurigo nodularis: Study

    Wed, 15 May 2024 16:30:55 -0000

    <img src='https://medicaldialogues.in/h-upload/2021/05/07/152466-topical-corticosteroid.webp' /><p style="text-align: justify; ">A recent study from Japan unveiled promising outcomes in the stride to effectively manage Prurigo Nodularis (PN) which is a chronic inflammatory skin condition. The findings of this study were published in the <i>British Journal of Dermatology.</i></p><p style="text-align: justify; ">Prurigo Nodularis is characterized by intensely itchy nodules on the skin and has long posed challenges for patients and clinicians due to limited treatment options. Hiroo Yokozeki and team undertook this study to explore the potential of nemolizumab in reducing the burden of PN.&nbsp;</p><p style="text-align: justify;">This 16-week, double-blind, phase II/III trial focused on evaluating the efficacy and safety of nemolizumab which a potential treatment for PN. The study enrolled patients over the age of 13 years by assigning them randomly to receive either nemolizumab at doses of 30 mg or 60 mg or a placebo. Also, all the participants continued concomitant topical corticosteroid treatment every four weeks throughout the trial.<br></p><p style="text-align: justify; ">The primary endpoint of the study was the percentage change in the weekly mean Peak Pruritus Numerical Rating Scale (PP-NRS) score by quantifying the severity of itching. The results at week 16 showed remarkable improvements in the patients who were receiving nemolizumab, with reductions of 61.1% and 56.0% in the 30 mg and 60 mg groups, respectively when compared to only 18.6% in the placebo group.</p><p style="text-align: justify; ">The secondary endpoints revealed additional benefits of the nemolizumab treatment. The patients underwent marked enhancements in the number and severity of prurigo nodules, as well as improvements in sleep quality and overall quality of life by underlining the holistic impact of this therapy. Importantly, both the doses of nemolizumab demonstrated favorable tolerability profiles which reassures the safety of long-term treatment.</p><p style="text-align: justify; ">These findings mark a significant breakthrough in the management of Prurigo Nodularis by offering hope to the individuals with its relentless symptoms. Nemolizumab represents a potential impact in the treatment landscape for PN by addressing the itching, the underlying severity of the condition and its impact on daily life. Continued research and regulatory approvals on the basis of this study could pave the way for further advancements in dermatological care.&nbsp;</p><p style="text-align: justify;">Reference:</p><p style="text-align: justify; ">Yokozeki, H., Murota, H., Matsumura, T., Komazaki, H., Watanabe, D., Sakai, H., Igawa, S., Kamiya, H., Katsunuma, T., Kume, A., Igawa, K., Katagiri, K., Muto, J., Yagami, A., Sugiura, K., Imafuku, S., Seishima, M., Mizutani, Y., … Kato, A. (2024). Efficacy and safety of nemolizumab and topical corticosteroids for prurigo nodularis: Results from a randomised, double-blind, placebo-controlled, phase II/III clinical study in patients aged ≥13 years. In British Journal of Dermatology. Oxford University Press (OUP). <a href="https://academic.oup.com/bjd/advance-article/doi/10.1093/bjd/ljae131/7647034?login=false" rel="nofollow">https://doi.org/10.1093/bjd/ljae131</a></p>

76. Gastroesophageal reflux disease and dietary habits linked to erosive tooth wear, reveals study

    Wed, 15 May 2024 15:45:14 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/06/237599-a-severe-dental-erosion-associated-to-gerd-and-extrinsic-factors-in-a-44-years-old-male.webp' /><p style="text-align: justify; ">Gastroesophageal reflux disease and dietary habits linked to erosive tooth wear reveal study published in the Journal of Dentistry.<br></p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">Erosive tooth wear is a multifactorial condition. This systematic review and meta-analysis aimed to identify key risk factors for erosive tooth wear in permanent dentition.</p><p dir="ltr" style="text-align: justify; ">Methodological quality and risk of bias were assessed using the modified Newcastle-Ottawa scale for cross-sectional studies. Risk factors were visually presented in a heatmap, and where possible, random-effects meta-analyses were performed for the odds ratios (ORs) of risk factors. A total of 87 publications reporting on 71 studies were included in the systematic review. The studies examined a variety of anamnestic risk factors (n = 80) that were categorized into ten domains (socio-demographics, socio-economics, general health, oral diseases, medication, oral hygiene, food, beverages, dietary habits, and leisure-related risk factors). Meta-analyses revealed significant associations between erosive tooth wear and male gender (padj.&lt;0.001; OR=1.30, 95 % CI: 1.16–1.44), regurgitation (padj.=0.033; OR=2.27, 95 % CI: 1.41–3.65), digestive disorders (padj.&lt;0.001; OR=1.81, 95 % CI: 1.48–2.21), consumption of acidic foods (padj.=0.033; OR=2.40, 95 % CI: 1.44–4.00), seasoning sauces (padj.=0.003; OR=1.28, 95 % CI: 1.13–1.44), nutritional supplements (padj.=0.019; OR=1.73, 95 % CI: 1.28–2.35), and carbonated drinks (padj.=0.019; OR=1.43, 95 % CI: 1.17–1.75). Most included studies exhibited low bias risk. Observational studies investigated a variety of anamnestic risk factors for erosive tooth wear. Future studies should employ validated questionnaires, particularly considering the most important risk factors. Erosive tooth wear is a prevalent condition. Clinicians should concentrate primarily on symptoms of gastroesophageal reflux disease and dietary factors when screening patients at risk for erosive tooth wear.</p><div style="text-align: justify;"><br></div><p dir="ltr" style="text-align: justify; ">Reference:</p><p dir="ltr" style="text-align: justify; ">Felix Marschner, Philipp Kanzow, Annette Wiegand. Anamnestic risk factors for erosive tooth wear: Systematic review, mapping, and meta-analysis. Journal of Dentistry, Volume 144,</p><p dir="ltr" style="text-align: justify; ">2024, 104962, ISSN 0300-5712, https://doi.org/10.1016/j.jdent.2024.104962.</p><p dir="ltr" style="text-align: justify; ">(https://www.sciencedirect.com/science/article/pii/S0300571224001325)</p><div style="text-align: justify;"><br></div><p dir="ltr" style="text-align: justify; ">Keywords:</p><p dir="ltr" style="text-align: justify; ">Gastroesophageal, reflux disease, dietary habits, erosive, tooth wear,Journal of Dentistry,Felix Marschner, Philipp Kanzow, Annette Wiegand, Erosive tooth wear; Risk factors; Permanent dentition; Meta-analysis</p><p dir="ltr" style="text-align: justify; "><br></p><div style="text-align: justify;"><br></div><div style="text-align: justify;"><br></div><div style="text-align: justify;"><br></div></div><p style="text-align: justify; "><br></p>

77. Offsprings born to women with HDP and gestational diabetes at increased risk of CVH in early adolescence: Study

    Wed, 15 May 2024 15:30:37 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/06/237601-nutrients-12-02792-g001.webp' /><p style="text-align: justify; ">Offsprings born to women with HDP and gestational diabetes at increased risk of CVH in early adolescence suggests a study published in the American Journal of Obstetrics and Gynecology.<br></p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">Adverse pregnancy outcomes, including hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM), influence maternal cardiovascular heath (CVH) long after pregnancy, but their relationship to offspring CVH following in utero exposure remains uncertain. This analysis used data from the prospective Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study from 2000 to 2006 and the HAPO Follow-Up Study from 2013 to 2016. This analysis included 3,317 mother-child dyads from 10 field centers, comprising 70.8% of HAPO Follow-Up Study participants. Those with pregestational diabetes and chronic hypertension were excluded. The exposures were having any HDP or GDM compared with not having HDP or GDM, respectively (reference). The outcome was offspring CVH at ages 10 to 14 years, based on four metrics: body mass index, blood pressure, total cholesterol level, and glucose level. Each metric was categorized as ideal, intermediate, or poor using a framework provided by the American Heart Association. The outcome was primarily defined as having at least one CVH metric that was non-ideal versus all ideal (reference), and secondarily as the number of non-ideal CVH metrics: at least one intermediate metric, one poor metric, or at least two poor metrics versus all ideal (reference). Modified Poisson regression with robust error variance was used and adjusted for covariates at pregnancy enrollment, including field center, parity, age, gestational age, alcohol or tobacco use, child's assigned sex at birth, and child's age at follow-up. RESULTS: Among 3,317 maternal-child dyads, the median (IQR) ages were 30.4 (25.6, 33.9) years for pregnant individuals and 11.6 (10.9, 12.3) years for children. During pregnancy, 10.4% of individuals developed HDP and 14.6% developed GDM. At follow-up, 55.5% of offspring had at least one non-ideal CVH metric. In adjusted models, having HDP (aRR 1.14; 95% CI 1.04, 1.25) or having GDM (aRR 1.10; 95% CI 1.02, 1.19) was associated with greater risk that offspring developed less-than-ideal CVH at ages 10 to 14 years. The above associations strengthened in magnitude as the severity of adverse CVH metrics increased (i.e., with the outcome measured as &gt;1 intermediate, 1 poor, and &gt;2 poor adverse metrics), albeit the only statistically significant association was with the "1-poor-metric" exposure. In this multi-national prospective cohort, pregnant individuals who experienced either HDP and GDM were at significantly increased risk of having offspring with worse CVH in early adolescence. Reducing adverse pregnancy outcomes and increasing surveillance with targeted interventions after an adverse pregnancy outcome should be studied as potential avenues to enhance long-term cardiovascular health in the offspring exposed in utero.</p><div style="text-align: justify;"><br></div><p dir="ltr" style="text-align: justify; ">Reference:</p><p dir="ltr" style="text-align: justify; ">Venkatesh, Kartik K., et al. "Impact of Hypertensive Disorders of Pregnancy and Gestational Diabetes Mellitus On Offspring Cardiovascular Health in Early Adolescence." American Journal of Obstetrics and Gynecology, 2024.</p><p dir="ltr" style="text-align: justify; ">Keywords:</p><p dir="ltr" style="text-align: justify; ">Offsprings born, women, HDP, gestational diabetes, increased risk, CVH, early adolescence, study, American Journal of Obstetrics and Gynecology</p><div style="text-align: justify;"><br></div></div><p style="text-align: justify; "><br></p>

78. Children sleep problems associated with psychosis in young adults, finds JAMA study

    Wed, 15 May 2024 15:15:28 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/02/24/232962-sleep-50.webp' /><p style="text-align: justify; ">Children who experience chronic lack of sleep from infancy may be at increased risk of developing psychosis in early adulthood, new research shows. </p><p style="text-align: justify;">Researchers at the University of Birmingham examined information on nighttime sleep duration from a large cohort study of children aged between 6 months and 7 years old. They found that children who persistently slept fewer hours, throughout this time period, were more than twice as likely to develop a psychotic disorder in early adulthood, and nearly four times as likely to have a psychotic episode. </p><p style="text-align: justify;">While previous research has highlighted links between sleep problems and psychosis at specific time points, this is the first study to show that persistent lack of sleep is a strong predictor of psychosis. </p><p style="text-align: justify;">Lead author, Dr Isabel Morales-Muñoz, said: “It’s entirely normal for children to suffer from sleep problems at different points in their childhood, but it’s also important to know when it might be time to seek help. Sometimes sleep can become a persistent and chronic problem, and this is where we see links with psychiatric illness in adulthood. </p><p style="text-align: justify;">“The good news is that we know that it is possible to improve our sleep patterns and behaviours. While persistent lack of sleep may not be the only cause of psychosis in early adulthood, our research suggests that it is a contributing factor, and it is something that parents can address.” </p><p style="text-align: justify; ">The results, published in<i> JAMA Psychiatry</i>, were based on data taken from the Avon Longitudinal Study of Parents and Children (ALSPAC), which includes records of 12,394 children from 6 months to 7 years, and 3,889 at 24 years old. </p><p style="text-align: justify;">While the association between lack of sleep in childhood and psychosis in early adulthood was robust in the study, the team have not proven a causal link and other factors associated with both childhood sleep and psychosis need to be explored. </p><p style="text-align: justify;">The team looked, for example, at overall immune system health in the children to see whether impairments in the immune system could also account for some of the associations between lack of sleep and psychosis. This was tested at nine-years-old by measuring levels of inflammation in blood samples. Results showed that a weakened immune system could partially explain the links between lack of sleep and psychosis, but other unknown factors are also likely to be important. </p><p style="text-align: justify; ">Dr Morales- Muñoz’ research is part of the Mental Health Mission Midlands Translational Centre, led by the University of Birmingham and funded by the National Institute for Health and Care Research. Its aim is to test and validate treatments in early psychosis and depression among children and young people. </p><p style="text-align: justify; "> "We know that early intervention is really important in helping young people with mental illness. One of the priorities of the Midlands Mental Health Mission Translational Research Centre of Excellence is to develop and test targeted interventions that could have a real impact on young people who have an illness or who are at risk of developing one. Understanding the role that good sleep hygiene plays in positive mental health could be a really important part of this process."&nbsp;</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Morales-Muñoz I, Marwaha S, Upthegrove R, Cropley V. Role of Inflammation in Short Sleep Duration Across Childhood and Psychosis in Young Adulthood. JAMA Psychiatry. Published online May 08, 2024. doi:10.1001/jamapsychiatry.2024.0796.</p>

79. Novel thrombectomy system safe and feasible in treating acute pulmonary embolism: Study

    Wed, 15 May 2024 15:00:15 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/04/237469-pulmonary-embolism-50.webp' /><p style="text-align: justify; ">Late-breaking data from the ENGULF trial showed that a novel dual-action thrombectomy device was effective and safe in treating acute pulmonary embolism (PE). The safety and effectiveness results were presented today as late-breaking science at the Society for Cardiovascular Angiography &amp; Interventions (SCAI) 2024 Scientific Sessions and simultaneously published in <i>JSCAI</i>. </p><p style="text-align: justify;">PE is a serious cardiovascular event where a blood clot causes issues with blood flow and oxygen levels in the lungs. It can be life-threatening, with up to 30% of individuals dying within one month of diagnosis. Despite recent advances in therapeutic options, PE still carries a high risk of mortality and morbidity with few FDA-cleared thrombectomy catheters available to physicians. </p><p style="text-align: justify;">The ENGULF trial is a prospective, single-arm, first-in-human, safety and feasibility study evaluating a novel embolectomy catheter system for the treatment of acute PE with a steerable and expandable funnel and an internal agitator, the Hēlo™ PE Thrombectomy System. Patients underwent a pre- and 48-hour post-procedural computed tomography (CT) scan. The primary efficacy outcome was the percent difference in the pre-to-post procedural right ventricle–to–left ventricle (RV/LV) ratios. The primary and secondary safety outcomes were all-cause mortality, major life-threatening bleeding, device-related serious adverse events, pulmonary or cardiac injury, and clinical decompensation at 48 hours and 30 days post-procedure. </p><p style="text-align: justify;">All 25 patients from eight centers underwent successful embolectomy. The mean RV/LV ratio was 1.53±0.27 at baseline and 1.15±0.18 at 48 hours post-procedure (23.2%±12.81% change). Of note, there were no major adverse events at 48 hours and no deaths at 30 days. </p><p style="text-align: justify; ">“Although more rigorous studies are needed, RV/LV ratio is the most important predictor of dysfunction and adverse outcomes in acute PE, and it is exciting to see that the RV/LV ratio reduction was just as much as other FDA-approved devices on the market without any large safety concerns in a new first-in-human device,” said Tai Kobayashi, MD, Assistant Professor of Clinical Medicine at Penn Medicine, and lead author of the study. “This technology represents the marriage between large and small-bore embolectomy, which allows for operators to travel through the heart with a smaller catheter but expand a larger funnel that matches the size of the large bore catheters-leaving a smaller footprint and lowering the risk of hemodynamic impact for the patient.” </p><p style="text-align: justify; ">“For the field of interventional PE therapies to fully reach its promise, continued innovation is needed to optimize our procedural workflows across the wide array of patients affected by this disease,” said Jay Giri MD, MPH, Director of the Cardiovascular Catheterization Laboratories at the Hospital of the University of Pennsylvania, senior author of the study, and national principal investigator of the study. “The ENGULF trial is an important step in this process, demonstrating that a novel, purpose-built PE thrombectomy catheter can achieve excellent results even among its earliest users.”</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Novel thrombectomy system demonstrates positive safety and feasibility results in treating acute pulmonary embolism, Society for Cardiovascular Angiography and Interventions, Meeting: SCAI 2024 Scientific Sessions.</p>

80. 3D MRI sequences useful for better evaluation of recess stenoses of spine: study

    Wed, 15 May 2024 14:15:25 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/15/238253-mri.webp' /><p style="text-align: justify; ">Since the 2010s, the isotropic submillimeter 3D sequences have become steadily more available with different MRI devices – these thin-slice sequences offer superior resolution as compared to the conventional thick-slice (roughly 3–4 mm) MRI sequences. However, the adoption of the 3D sequences to the everyday clinical setup has been rather slow, and conventional thick-slice protocols are still widely in use.<br></p><p style="text-align: justify; "><i>Nevalainen et al</i> conducted a systematic literature review on the diagnostic utility of 3D MRI sequences in the assessment of central canal, recess and foraminal stenosis in the spine. </p><p style="text-align: justify; ">The databases PubMed, MEDLINE (via OVID) and The Cochrane Central Register of Controlled Trials, were searched for studies that investigated the diagnostic use of 3D MRI to evaluate stenoses in various parts of the spine in humans. Three reviewers examined the literature and conducted systematic review according to PRISMA guidelines. </p><p style="text-align: justify; ">Key findings of the study were: </p><p style="text-align: justify;">• Thirty studies were retrieved from 2595 publications for this systematic review. </p><p style="text-align: justify;">• The overall diagnostic performance of 3D MRI outperformed the conventional 2D MRI with reported sensitivities ranging from 79 to 100% and specificities ranging from 86 to 100% regarding the evaluation of central, recess and foraminal stenoses. </p><p style="text-align: justify;">• In general, high level of agreement (both intra- and inter rater) regarding visibility and pathology on 3D sequences was reported. </p><p style="text-align: justify;">• Studies show that well optimized 3D sequences allow the use of higher spatial resolution, similar scan time and increased SNR and CNR when compared to corresponding 2D sequences. However, the benefit of 3D sequences is in the additional information provided by them and in the possibility to save total protocol scan times. </p><p style="text-align: justify;"> </p><p style="text-align: justify;">The authors commented - “Strengths of this review include the rigorous assessment of the literature by three academic medical experts: a neuroradiologist, a musculoskeletal radiologist and a medical physicist. Moreover, we applied the PRISMA recommendations for meticulous reporting of our findings. One limitation is that relevant articles might not have been included due to the limited number of databases used in the search or limitations in the search and screening strategy. The most obvious weakness within this systematic review is vast heterogeneity of the included studies, most importantly the lack of surgical gold standard is worrisome. Accordingly, there was no possibility of meta-analysis. Moreover, the fact that no studies on thoracic spine existed in the literature remains as minor weakness.” </p><p style="text-align: justify;">The authors concluded – “In conclusion, the literature of the 3D MRI assessment of spinal stenoses is largely heterogeneous with varying MRI protocols and diagnostic results. Generally, 3D sequences offer similar or superior detection of stenoses with high reliability explained by the better visualization of anatomic structures. Ultimately, the benefit of 3D MRI seems to be the better evaluation of recess stenoses which supports the clinical implementation of these sequences into everyday workflow.”  </p><p style="text-align: justify; "><br></p><p style="text-align: justify;">Further reading: </p><p style="text-align: justify;">Diagnostic utility of 3D MRI sequences in the assessment of central, recess and foraminal stenoses of the spine: a systematic review </p><p style="text-align: justify;">Mika T. Nevalainen et al </p><p style="text-align: justify;">Skeletal Radiology </p><p style="text-align: justify; ">https://doi.org/10.1007/s00256-024-04689-1</p>

81. Higher income reduces stroke mortality risk by a third, new study shows

    Wed, 15 May 2024 14:15:13 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/02/02/231399-stroke-50-1.webp' /><p style="text-align: justify; ">New research, presented at the 10th European Stroke Organisation Conference (ESOC) 2024, has revealed that high-income individuals have a 32% lower risk of post-stroke mortality. Additionally, those with a higher education have a 26% lower risk of death post-stroke, highlighting striking disparities in stroke survival based on key social determinants of health (SDoH). </p><p style="text-align: justify;">The register-based study analysed data from 6,901 stroke patients in Gothenburg, Sweden between November 2014 to December 2019 to examine the impact of SDoH factors on post-stroke mortality risk. The study focused on four SDoH factors: living area, country of birth, education and income. </p><p style="text-align: justify;">As well as identifying a significant connection between income, education level and post-stroke mortality risk, the study uncovered a concerning trend regarding the cumulative impact of SDoH factors. Patients with one unfavourable SDoH factor faced an 18% higher risk of mortality compared to patients without any unfavourable SDoH factors. This risk escalated to 24% for patients with two to four SDoH factors. </p><p style="text-align: justify;">Lead author Professor Katharina Stibrant Sunnerhagen, University of Gothenburg, Clinical Neuroscience, Gothenburg, Sweden, comments, “Our findings underscore a stark reality - an individual’s socioeconomic status can be a matter of life or death in the context of stroke, especially when they are confronted with multiple unfavourable SDoH factors. While our study was conducted in Gothenburg, we believe these insights resonate across Europe, where similar healthcare structures and levels of social vulnerability exist, highlighting a pervasive issue throughout the continent.” </p><p style="text-align: justify;">The study also found a link between increased mortality risk and additional risk factors like physical inactivity, diabetes, alcohol abuse and atrial fibrillation. </p><p style="text-align: justify;">Notably, insights emerged regarding gender disparities and the potential impact of risk factors when examining patient characteristics within the study cohort. The proportion of female patients increased with the number of unfavourable SDoH factors; 41% of the group with no unfavourable SDoH factors were female, whereas 59% of the group with two to four unfavourable SDoH factors comprised females. Additionally, smoking, whether current or within the past year, was more prevalent in the group with two to four unfavourable SDoH factors compared to those with none (19% versus 12%). </p><p style="text-align: justify;">Commenting on the actions required to reduce the future stroke burden, Professor Stibrant Sunnerhagen explains, “As the number of people affected by stroke in Europe is projected to rise by 27% between 2017 and 2047, the need for effective interventions is more pressing than ever.2 In light of our study’s findings, targeted strategies are essential. Policymakers, for instance, must tailor legislation and approaches to account for the specific circumstances and needs of diverse communities, while clinicians should consider identifying patients with unfavourable SDoH factors to prevent post-stroke mortality.” </p><p style="text-align: justify; ">“By addressing these disparities, we will not only support the principles of health equity, but also have the potential to significantly enhance public health outcomes.”</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Higher income reduces stroke mortality risk by a third, new study shows, Beyond, Meeting: European Stroke Organisation Conference (ESOC) 2024.</p>

82. Plastic wound protector scores over surgical gauze in surgical site infection reduction: unveils clinical trial

    Wed, 15 May 2024 14:00:40 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/04/25/236860-wound-protector.webp' /><p style="text-align: justify; ">Korea: In the realm of surgical procedures, minimizing postoperative complications remains a top priority for medical practitioners worldwide. Among the myriad of concerns, surgical site infections (SSIs) stand out as a significant threat to patient recovery and well-being. In a groundbreaking development, a randomized clinical trial (RCT) has shed light on a potential game-changer in the fight against SSIs in open gastrointestinal (GI) surgeries: the plastic wound protector.&nbsp;<br></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">The study, published in <em>JAMA Surgery, </em>has shown the effectiveness of plastic wound protectors in reducing surgical site infections in open gastrointestinal surgeries.</p><p style="text-align: justify; ">"In the RCT of 458 patients, the wound protector reduced SSI risk by 46.8% across bowel surgeries, with a 43.8% decrease for clean-contaminated wounds and 42.5% for superficial SSIs versus surgical gauze," the researchers reported. "Its effect on contaminated wounds was less certain." </p><p style="text-align: justify; ">SSIs are prevalent hospital-acquired infections with significant patient impacts and global healthcare burdens. The World Health Organization (WHO) recommends using wound protector devices in abdominal surgery as a preventive measure to lower SSI risk despite limited evidence. Considering this, Nina Yoo, The Catholic University of Korea, Seoul, Korea, and colleagues aimed to examine the efficacy of a dual-ring, plastic wound protector in reducing the SSI rate in open gastrointestinal (GI) surgery regardless of intra-abdominal contamination levels.</p><p style="text-align: justify; ">For this purpose, the researchers conducted a multicenter, patient-blinded, parallel-arm randomized clinical trial from 2017 to 2022 at 13 hospitals in an academic setting. Patients undergoing open abdominal bowel surgery (e.g. for bowel perforation) were eligible for inclusion.</p><p style="text-align: justify; ">Patients were randomized in a 1:1 ratio to a dual-ring, plastic wound protector to protect the incision site of the abdominal wall (experimental group) or a conventional surgical gauze (control group). The primary endpoint was the SSI rate within 30 days of open GI surgery. </p><p style="text-align: justify; ">A total of 458 patients were randomized; after one was excluded from the control group, 457 were included in the intention-to-treat analysis (mean age, 58.4 years; 56.0% male; 74.6% with a clean-contaminated wound): 228 in the surgical gauze group and 229 in the wound protector group. </p><p style="text-align: justify; ">The researchers reported the following findings:</p><ul><li style="text-align: justify; ">The overall SSI rate in the intention-to-treat analysis was 15.7%.</li><li style="text-align: justify; ">The SSI rate for the wound protector was 10.9% compared with 20.5% with surgical gauze.</li><li style="text-align: justify; ">The wound protector significantly reduced the risk of SSI, with a relative risk reduction (RRR) of 46.81%.</li><li style="text-align: justify; ">The wound protector significantly decreased the SSI rate for clean-contaminated wounds (RRR, 43.75%), particularly for superficial SSIs (RRR, 42.50%).</li><li style="text-align: justify; ">Length of hospital stay was similar in both groups (mean, 15.2 versus 15.3 days), as were the overall postoperative complication rates (20.1% versus 18.8%).</li></ul><p style="text-align: justify; ">In conclusion, the randomized clinical trial found a significant reduction in SSI rates when a plastic wound protector was used during open GI surgery versus surgical gaze, supporting the WHO recommendation for wound protector devices in abdominal surgery.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Yoo N, Mun JY, Kye B, et al. Plastic Wound Protector vs Surgical Gauze for Surgical Site Infection Reduction in Open GI Surgery: A Randomized Clinical Trial. JAMA Surg. Published online April 24, 2024. doi:10.1001/jamasurg.2024.0765</p></div><p style="text-align: justify; "><br></p>

83. Early diagnosis & treatment of PAD essential to improve outcomes, reduce amputation risk: Study

    Wed, 15 May 2024 13:45:35 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/15/238243-peripheral-artery-disease-50.webp' /><p style="text-align: justify; ">Timely diagnosis and proper management of peripheral artery disease (PAD), including coordinated care from a multispecialty team, are essential to help prevent amputation and other cardiovascular complications and to allow patients with PAD to live longer lives with better physical function and improved quality of life, according to a new joint guideline published today in the American Heart Association’s flagship, peer-reviewed journal <i>Circulation</i> and simultaneously in the Journal of the American College of Cardiology. </p><p style="text-align: justify;">The “2024 AHA/ACC Guideline on the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines” provides the latest, evidence-based recommendations to guide clinicians in the diagnosis and treatment of lower extremity PAD across its four clinical presentation subsets: asymptomatic disease, chronic symptomatic PAD, and the more severe subsets of chronic limb-threatening ischemia (CLTI) and acute limb ischemia (ALI). </p><p style="text-align: justify;">In addition to being led by the American Heart Association and the American College of Cardiology Joint Committee on Clinical Practice Guidelines, the guideline was developed with and endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation, the American Podiatric Medical Association, the Association of Black Cardiologists, the Society for Cardiovascular Angiography and Interventions, the Society for Vascular Medicine, the Society for Vascular Nursing, the Society for Vascular Surgery, the Society of Interventional Radiology and the Vascular &amp; Endovascular Surgery Society. </p><p style="text-align: justify;">PAD is a serious, progressive cardiovascular disease primarily caused by a buildup of fatty plaque in the blood vessels, or atherosclerosis. This plaque narrows the blood vessels and reduces blood flow to the legs and feet, which may significantly impair physical function, walking performance and quality of life. Approximately 10 million to 12 million adults ages 40 and older in the U.S. have PAD, which increases the risk of amputation, heart attack, stroke and death. Among those ages 65 and older, nearly 50% who underwent limb amputation died within one year after surgery, according to the 2024 Heart Disease and Stroke Statistics: A Report of U.S. and Global Data From the American Heart Association. Risk factors for PAD include smoking; having Type 1 or Type 2 diabetes, high blood pressure, high cholesterol, chronic kidney disease, atherosclerosis in other parts of the body (such as coronary artery disease); and being age 75 years or older. </p><h3 style="text-align: justify; ">Effective medical therapies and coordinated care </h3><p style="text-align: justify;">Once PAD is diagnosed, implementing a plan of care, including guideline-directed medical therapies and management of PAD-related risk amplifiers, is crucial to reduce the risk of progression to more symptomatic and limb-threatening clinical presentations of PAD and to reduce the risk of amputation, heart attack, stroke and death. Although there are highly effective medical, endovascular and surgical therapies for PAD, historically, many people with PAD have been undertreated or do not receive guideline-directed medical therapies at the same rate as peers with other cardiovascular diseases, such as coronary artery disease. </p><p style="text-align: justify;">“Because of the complexities of PAD, to improve outcomes and reduce the risk of limb loss for these patients, a multispecialty care team approach that is focused on comprehensively addressing risk factor management, foot care and revascularization is needed to promote collaboration, avoid duplication of care and optimize patient outcomes,” said Chair of the guideline writing committee Heather Gornik, M.D., FAHA, co-director of the Vascular Center at the University Hospitals Harrington Heart &amp; Vascular Institute and a professor of medicine at Case Western Reserve University School of Medicine, both in Cleveland, Ohio. </p><p style="text-align: justify;">Effective medical therapies for patients with PAD, including medications to prevent blood clotting, manage blood sugar and reduce high blood pressure and high cholesterol, should be prescribed to prevent major adverse cardiovascular events and reduce the risk of amputation. All patients with PAD should be treated with high-intensity statin therapy. For people with PAD who are not at an increased risk of bleeding, new evidence supports the use of low-dose rivaroxaban (2.5 mg twice daily) combined with low-dose aspirin (81 mg daily). </p><p style="text-align: justify;">For patients with PAD and Type 1 or Type 2 diabetes, clinicians should coordinate care to address diet, exercise, weight management, medications to control blood sugar, management of other cardiovascular risk factors and routinely check the feet of their patients for foot ulcer prevention. Foot care is important for patients across the four clinical presentation subsets of PAD. Comprehensive treatment includes patient education, preventive foot care, more intensive wound care and pressure off-loading to minimize amputation in patients with more severe forms of PAD. </p><p style="text-align: justify;">Health care professionals should also encourage patients to quit smoking or using other forms of tobacco to reduce the risk of developing PAD, to slow the progression of established PAD and to reduce the risk of limb-related conditions or death. Pharmacological and behavioral-based strategies often increase the smoking cessation rate in people with PAD, however, these strategies are underused. </p><p style="text-align: justify;">A core component of care for patients with symptomatic PAD is structured exercise therapy programs, including both community- and home-based programs, as well as supervised exercise therapy delivered in a clinic or hospital setting. Multiple studies have shown that these programs improve functional status, walking performance and quality of life compared to usual care. </p><p style="text-align: justify;">“Supervised exercise therapy, the gold standard exercise therapy for patients with PAD, is woefully underutilized despite its known health benefits and the fact that it is covered by Medicare and most health insurance plans,” said Gornik. “Rates of referral for supervised exercise therapy among PAD patients are incredibly low. It has been estimated that less than 5% of patients with PAD in the U.S. are prescribed to participate in a supervised exercise program.” </p><p style="text-align: justify;">If left untreated, PAD may progress to severe forms known as chronic limb-threatening ischemia (CLTI) and acute limb ischemia (ALI). Both are the result of severe blockage in the arteries of the legs that significantly reduces blood flow, causes pain in the legs at rest or with minimal activity, impairs physical function and significantly increases the risk of amputation and death. For these patients, timely diagnosis and treatments, including revascularization procedures to reconstruct diseased arteries, are essential to prevent tissue loss and preserve the limb. Endovascular (a catheter procedure), surgical or hybrid revascularization techniques may be performed to improve blood flow to the limb, with the goals of healing wounds, relieving PAD-associated pain, maintaining walking ability and preventing amputation. </p><h3 style="text-align: justify; ">Disparities in risk factors for PAD and health outcomes </h3><p style="text-align: justify;">The disparities in PAD care and outcomes are significant among people from under-resourced communities in the U.S. Black adults have a nearly 30% lifetime risk of developing PAD compared to 19% for white adults. Black adults with PAD in the U.S. are often identified at a more advanced stage and have a four-fold higher rate of major limb amputation, 30% higher heart disease mortality rate and 45% higher rate of stroke compared to white adults. </p><p style="text-align: justify;">Social determinants of health, and other factors such as race and ethnicity, disparities in housing, health care access, education and socioeconomic status, may also affect the prevalence of PAD and patient outcomes. </p><p style="text-align: justify;">“Racial and ethnic disparities in the detection, management and health outcomes of PAD have long been present in the U.S. and are an important public health issue to be addressed,” said Gornik. “These disparities highlight opportunities for initiatives focused on early disease detection and improving access to effective PAD treatments for people in under-resourced, at-risk communities.” </p><p style="text-align: justify;">Detection of PAD in most patients is accomplished through a thorough medical history, physical examination and resting ankle-brachial index (ABI), which measures the ratio of the systolic blood pressure at the ankle to the upper arm. The guideline recommends patient-centered efforts to address health disparities, such as intensified efforts to identify patients in at-risk populations for symptoms and signs of PAD, and equitable access to regular physical examinations including thorough assessment of the legs and feet. </p><h3 style="text-align: justify; ">Get with The Guidelines: The PAD National Action Plan </h3><p style="text-align: justify;">In 2021, the American Heart Association published the PAD National Action Plan, which is endorsed by the American College of Cardiology, that outlines six strategic goals to improve awareness, detection and treatment of PAD nationwide. In the plan, the Association proposed a goal of reducing nontraumatic limb amputation in the U.S. by 20% by 2030. </p><p style="text-align: justify;">The guideline writing committee notes that interventions are needed to address the disparity gap in amputation and revascularization procedures among people in diverse racial and ethnic populations and to improve limb and cardiovascular outcomes for all patients with PAD. </p><p style="text-align: justify;">“It’s important to recognize the signs and symptoms of PAD and move quickly to initiate treatment to improve outcomes and reduce risks,” said Gornik. “With these updated guidelines, we have the tools necessary to make a positive impact on outcomes in our patients with PAD. Now, we need to work together to implement them as broadly as possible.” </p><p style="text-align: justify; ">This joint guideline was prepared by a volunteer writing group on behalf of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines, and developed with and endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation, the American Podiatric Medical Association, the Association of Black Cardiologists, the Society for Cardiovascular Angiography and Interventions, the Society for Vascular Medicine, the Society for Vascular Nursing, the Society for Vascular Surgery, the Society of Interventional Radiology, and the Vascular &amp; Endovascular Surgery Society. This joint guideline provides the official clinical practice recommendations for the diagnosis and treatment of peripheral artery disease, or PAD.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Heather L. Gornik, Herbert D. Aronow, Philip P. Goodney, Shipra Arya, Luke Packard Brewster, Lori Byrd, Venita Chandra, Douglas E. Drachman, Jennifer M. Eaves, Jonathan K. Ehrman, 2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines, Circulation, https://doi.org/10.1161/CIR.0000000000001251.</p>

84. Limited tourniquet application in primary unilateral TKA may not increase incidence of perioperative complications: study

    Wed, 15 May 2024 13:30:43 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/04/26/236950-tourniquettourniquetsorthopaedicmedicineknee.webp' /><p style="text-align: justify; ">Limited tourniquet application in primary unilateral TKA does not increase the incidence of perioperative complications: study </p><p style="text-align: justify;">Tourniquet application in total knee arthroplasty (TKA) has many benefits and may have a role in the incidence of perioperative complications. <i>Doried Diri et al</i> conducted a study to examine the safety of applying a tourniquet for a limited amount of time during primary unilateral TKA (specifically, during cementation and final component fixation only) and to compare perioperative complications between the limited-application group and the full-application group. The study was conducted at Damascus University, Damascus, Syria. It has been published in ‘JBJS Open Access’. </p><p style="text-align: justify; ">The authors conducted a randomized controlled study of 62 patients undergoing primary unilateral TKA. Patients were randomly allocated to either the limited or full tourniquet application. The follow-up period was 6 months. They evaluated intraoperative, postoperative, total, and hidden blood loss as the primary outcome measures and clearance of the surgical field, operative duration, and perioperative complications as the secondary outcome measures. </p><p style="text-align: justify;">Key findings of the study were: </p><p style="text-align: justify;">• No patients were lost to follow-up and all patients attended their follow-up visits. </p><p style="text-align: justify;">• No significant differences in patient demographics and characteristics were found between treatment groups </p><p style="text-align: justify;">• Surgical field clearance, as evaluated by the surgeon, was significantly different between the groups. </p><p style="text-align: justify;">• There was no significant difference in total, hidden, or postoperative blood loss between the groups. </p><p style="text-align: justify;">• Mean intraoperative blood loss was significantly lower in the full-application group than in the limited-application group (171.742 ± 19.710 versus 226.258 ± 50.290 mL; p = 0.001). </p><p style="text-align: justify;">• The mean (and standard deviation) operative duration was 56.177 ± 6.075 minutes. Operative duration did not differ significantly between the groups </p><p style="text-align: justify;">• Perioperative complications, including allogeneic blood transfusion rates, did not significantly differ between the groups. </p><p style="text-align: justify;">The authors concluded – “The use of limited tourniquet application is safe for low-risk patients undergoing primary unilateral TKA performed by an expert surgeon. When compared with the full application regimen, the limited application regimen showed no increased rates of perioperative complications or total blood loss” </p><p style="text-align: justify; ">Level of Evidence: Therapeutic Level I.</p><p style="text-align: justify;">Further reading: </p><p style="text-align: justify;">Blood Loss in Primary Unilateral Total Knee Arthroplasty with Limited Tourniquet Application A Randomized Controlled Trial </p><p style="text-align: justify;"><i>Doried Diri et al </i></p><p style="text-align: justify;">JBJS Open Access 2023:e23.00020. </p><p style="text-align: justify; ">http://dx.doi.org/10.2106/JBJS.OA.23.00020</p>

85. Amidst NEET Paper Leak Scandal, Aspirants Demand Re-Exam

    Wed, 15 May 2024 13:11:53 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/02/16/232403-neet-ug-2024-1.webp' /><p style="text-align: justify; "><b>New Delhi:</b>&nbsp;Amidst the paper leak scandal involving the National Eligibility-cum-Entrance Undergraduate (NEET-UG) Exam, the centralised common entrance test for admission to the MBBS course, the aspirants have started demanding re-conduction of the examination.</p><p style="text-align: justify; ">Referring to instances where the government swiftly cancels the examinations for confirmed leaks, the candidates are urging the authorities to ensure justice by conducting a re-examination.</p><p style="text-align: justify; ">This comes after around 13 people, including four examinees and their family members were arrested in Bihar for their alleged involvement in the paper leak of NEET-UG exam. Patna police sources had earlier claimed that the NEET-UG question papers along with their answers were provided to around 20 aspirants a day before the date of the exam i.e. May 5, 2024.</p><p style="text-align: justify; ">Recently, the Economic Offences Unit (EOU) of Bihar Police, which took over the investigation, revealed that the brokers involved in the NEET paper leak scam took between Rs 30 lakh to Rs 50 lakh from each of the medical aspirants in exchange of giving them the question paper of the NEET UG 2024 question paper ahead of the examination.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-admissions/neet-paper-leak-scandal-rocks-bihar-questions-answers-allegedly-given-to-20-aspirants-day-before-exam-128376" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: NEET Paper Leak Scandal Rocks Bihar: Questions-Answers allegedly given to 20 Aspirants Day Before Exam</i></b></a></p><p style="text-align: justify; ">EOU had earlier mentioned in a release that as per the investigation, the question papers of NEET-UG and their answers were provided to around 35 aspirants before the May 5 exam.</p><p style="text-align: justify; "><b>Aspirants Demand Re-Examination:</b>&nbsp;</p><p style="text-align: justify; ">Amid the reports of NEET paper leak, the aspirants have started expressing their frustration at the social media platforms like X (formerly Twitter) and demanding a fair re-examination of NEET 2024. Photos of aspirants holding placards saying "We Demand a Fair Examination" have been circulating on social media platforms.</p><p style="text-align: justify; ">Questioning "where's the justice", an X user wrote, "Government of India is sleeping or busy with elections? Come out of your election otherwise the youth will crash you down. @NTA_Exams conduct re neet asap otherwise wait till the case goes to SC." The post also tagged the Prime Minister of India and the Union Education Minister.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-admissions/neet-candidates-paid-up-to-rs-50-lakhs-for-getting-question-papers-in-advance-bihar-eou-128444" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: NEET Candidates paid up to Rs 50 lakhs for getting Question Papers in Advance: Bihar EOU</i></b></a></p><p style="text-align: justify; ">Demanding re-neet, the user wrote in another post, "WE DEMAND RE NEET large number of aspirants got the paper a night before. Teachers solved aspirant's question paper at the hall itself And many more.... Is this a joke??"</p><p style="text-align: justify; ">Meanwhile, an user slammed the whole education system and wrote, "Nowadays this is the actual reality of whole education system...... Or i can say this is the reality of every system. Corruption on its peak."</p><p style="text-align: justify; ">An X page called NEET UG Leak also opined that the entire examination should be cancelled and it should be conducted fairly again. The X post stated, "It is requested to the government that the examination should be cancelled and it should be conducted fairly again. Unqualified students have been benefited by paper leak and its roots are very deep."</p><p style="text-align: justify; ">Raising the matter, socio political activist Mukesh Choudhary wrote, "The government should take a decision in the interest of the youth as soon as possible regarding the NEET UG paper leak." He questioned when the aspirants would get justice.<br></p><p style="text-align: justify; ">Extending support to the aspirants demanding re-conduction of the examination, another user questioned, "When it is accepted , even by almost all media that #NEET_PAPER_LEAK did happen then Why the Demand of #RENEET is being ignored ? The Students who studied hard and gave #NEETexam with honesty actually deserve #ReNeet2024."</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/state-news/bihar/neet-2024-cheating-scandal-more-than-24-culprits-including-14-impersonators-arrested-by-bihar-police-128256" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: NEET 2024 Cheating Scandal: More than 24 culprits including 14 impersonators arrested by Bihar Police</i></b></a></p><p><span style="text-align: justify;">Social activist Dr. Vivek Pandey also raised the matter and he questioned the stand of the National Testing Agency (NTA) denying claims of NEET paper leak. He wrote, "As per @NTA_Exams they don't have any strong evidence of paper leak. Patna police already said in their press release that paper was leaked, even they told the same to court. Then why NTA denying facts ?"</span></p><p style="text-align: justify; ">Opining that the charge of conducting NEET should be transferred to AIIMS, Dr. Pandey mentioned in another post, "Facing issues with NTA exams isn't new. From admit card glitches to paper leaks, students have endured. It's time to reconsider, perhaps shift Neet UG's authority from NTA to AIIMS."</p><p style="text-align: justify; ">Medical Dialogues had earlier reported that the Bihar Police had arrested more than two dozen individuals, including 14 impersonators and candidates for cheating in the NEET UG 2024 exam. Among those arrested, an FIR was registered against 14 people, who were accused of impersonating registered candidates during the examination. During the interrogation, the accused known as "solvers" had revealed that Rs 5-10 lakh each was given to several centres by the gang members.<br></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">Earlier the National Testing Agency (NTA) had issued a clarification ensuring fair conduct of the NEET 2024 examination and it allowed 120 candidates to reappear for the exam after the question papers were distributed incorrectly at an exam centre. While several social media posts claimed that NEET 2-24 question paper was leaked, NTA had denied such claims.</p><p style="text-align: justify; ">In the notice, NTA stated that "it assures the public that apart from this isolated incident, the NEET (UG) 2024 examination commenced smoothly and is being conducted peacefully at all other examination centres across the country. The NTA emphasizes that this incident has not compromised the integrity of the examination process at other centres."</p><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-admissions/incorrect-distribution-of-neet-2024-question-paper-nta-allows-120-aspirants-to-reappear-in-exam-denies-paper-leak-claims-128155" style="text-align: justify; background-color: rgb(255, 255, 255);"><b><i>Also Read: Incorrect distribution of NEET 2024 question paper, NTA allows 120 aspirants to reappear in exam, denies 'paper-leak' claims</i></b></a></p></div>

86. PCI issues Guidelines for Inspections of Pharmacy Institutions for academic year 2024- 2025

    Wed, 15 May 2024 12:30:54 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/15/238323-pci-issues-guidelines-for-inspections-of-pharmacy-institutions-for-academic-year-2024-2025.webp' /><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><b>New Delhi:</b> The Pharmacy Council of India (PCI) has issued comprehensive guidelines for the inspection process of pharmacy institutions for the academic year 2024-2025.</p><p style="text-align: justify; ">These guidelines are applicable to existing and new institutions applying for approval for the first time.</p><p style="text-align: justify; ">Referencing PCI circulars numbered 1.14-56/2022-PCI (Approval Process for 2024-25 a.s.) dated December 14, 2023, and subsequent updates, the guidelines aim to streamline the inspection and verification process for all stakeholders involved, including pharmacy institutions, examining authorities (universities/boards), and state governments.</p><p style="text-align: justify; ">The notice declared that all the institutions are requested to follow the guidelines during the inspection and verification process.</p><p style="text-align: justify; ">In this connection, the notice stated that the PCI will start the inspection process of the Pharmacy institutions for the 2024-2025 academic sessions at the earliest.</p><p style="text-align: justify; ">"All inspections will be done through the mobile inspection application only as provided in the Google Play Store (https://play.google.com/store/apps/details?id=cdg.com.pci inspection&amp;hl=en&amp;gl=U S&amp;pli=l)." the notice added.</p><p style="text-align: justify; "><b>In accordance with the notice, all institutions are requested to follow the below guidelines during the inspection and verification process:</b></p><p style="text-align: justify; "><b>Regarding Students:</b></p><ul class="hocalwire-editor-list"><li style="text-align: justify; ">Mandatory attendance for all the students enrolled in the institutions.</li><li style="text-align: justify; "> Mandatory registration for all the students on the PCI Portal.</li><li style="text-align: justify; ">All students are to have the Smart Card with them at the time of the inspection process.</li></ul><p style="text-align: justify; "><b>Regarding Faculties:</b></p><ul class="hocalwire-editor-list"><li style="text-align: justify; ">Mandatory attendance for all the faculties enrolled in the institutions.</li><li style="text-align: justify; ">Mandatory presence for all the faculties enrolled in the institutions, during the time of inspection process.</li><li style="text-align: justify; ">If any faculty is on leave, the leave letter is to be submitted to the inspectors and the same is to be documented on the app along with the reason for absence.</li><li style="text-align: justify; ">Mandatory registration for all the faculties on the PCI Portal.</li><li style="text-align: justify; ">All faculty members must have their Smart Card with them at the time of the inspection process.</li><li style="text-align: justify; "> All faculties must carry their relevant documents with them at the time of the inspection and verification process.</li></ul><p style="text-align: justify; "><b>Infrastructure:</b></p><ul class="hocalwire-editor-list"><li style="text-align: justify; "> Mandatory active QR code on the institutions' infrastructure comprising-</li></ul><p style="text-align: justify; ">• Institutions Classrooms,</p><p style="text-align: justify; ">• Institutions Laboratories,</p><p style="text-align: justify; ">• Institutions Common Facility,</p><p style="text-align: justify; ">• Institutions Computer Labs and other facilities,</p><p style="text-align: justify; ">• Institutions Amenities,</p><p style="text-align: justify; ">• Master's Degree Equipment,</p><p style="text-align: justify; ">• Bachelor's Degree Equipments,</p><p style="text-align: justify; ">• Others;</p><ul class="hocalwire-editor-list"><li style="text-align: justify; ">Mandatory active QR code on all the equipment present in the institutions during the inspection process.</li><li style="text-align: justify; "> If any infrastructure or equipment is found without the QR code or the QR code not working at the time of inspection, the institutions are to be counted in the deficiency list.</li></ul><p style="text-align: justify; "><b>Documents:</b></p><ul class="hocalwire-editor-list"><li style="text-align: justify; "> All faculties are to possess the relevant documents with them at the time of the inspection and verification process.</li><li style="text-align: justify; "> Institutions must possess all the relevant documents with them as information filled in Standard Inspection Format (SIF) at the time of inspection and verification process</li></ul><p style="text-align: justify; ">In addition, the notice added that the above points shall be applicable to all other information in the SIF filled by institutions.</p><p style="text-align: justify; "><b>To view the notice, click the below link:</b></p><div class="hocal-draggable" draggable="true" style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/circular-for-inspection-process-2024-2025-238083.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/circular-for-inspection-process-2024-2025-238083.pdf</a></div><p style="text-align: justify; ">Also Read:<a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-colleges/madras-medical-colleges-pharmacy-institute-likely-to-lose-approval-face-punitive-action-for-violating-pci-norms-report-127072">Madras Medical College's pharmacy institute likely to lose approval, face punitive action for violating PCI norms: Report</a></p></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div>

87. India new dietary guidelines limit sugar intake to 5 percent of daily calories

    Wed, 15 May 2024 12:11:40 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/13/238050-mdtv-4.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">The new dietary guidelines issued by the Indian Council of Medical Research-National Institute of Nutrition (ICMR-NIN) recommends no sugar for children under two years old and limiting sugar intake to 5% of daily calories for individuals over two. Another study by ICMR, in collaboration with Madras Diabetes Research Foundation, revealed that one in four Indians is diabetic, pre-diabetic, or obese, largely due to dietary habits and sedentary lifestyles.</div><div style="text-align: justify;">Feeding infants and young children with food products containing added sugar has been shown to increase their risk of early childhood obesity and non-communicable diseases later in life, the guidelines stated.</div><div style="text-align: justify;"><p><br></p></div></div>

88. SC pulls up IMA chief in Patanjali ads case

    Wed, 15 May 2024 11:58:01 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/15/238287-mdtv-2024-05-15t161558449.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">The Supreme Court on Tuesday i.e. May 14, 2024, reserved its verdict on the pending contempt proceedings against Patanjali Ltd., its managing Director Acharya Balkrishna, and co-founder Baba Ramdev, who were accused of publishing misleading medical advertisements in breach of a court undertaking.</div><div style="text-align: justify;">However, the top court bench dismissed the apology tendered by the president of the Indian Medical Association (IMA) Dr. RV Asokan, for his remarks on the court's ruling in the misleading ads case against Patanjali.</div><div></div></div>

89. Rajasthan Govt to utilize ODK app for real time monitoring of sesonal diseases

    Wed, 15 May 2024 11:45:28 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/15/238285-illness.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">Jaipur: The&nbsp;</span>Medical Department of Rajasthan have announced their plan to utilize a mobile application for monitoring seasonal diseases, aiming for real-time surveillance. &nbsp;&nbsp;</p><p style="text-align: justify;">Additional Chief Secretary of the Medical and Health Department Shubhra Singh said that the online monitoring of seasonal diseases will now be done by the department through the app, reported news agency PTI. &nbsp;</p><p style="text-align: justify;">She said that this innovation will enable real-time monitoring of seasonal diseases across the state and effective steps can be taken quickly for prevention and control. &nbsp;</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><b><i><a class="also-read-media-wrap" href="https://medicaldialogues.in/mdtv/healthshorts/up-health-dept-releases-guidelines-for-heat-related-illnesses-management-126896"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/mdtv/healthshorts/up-health-dept-releases-guidelines-for-heat-related-illnesses-management-126896">Also Read:UP Health Dept releases guidelines for heat-related illnesses management</a></i></b></p><div></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div></div><p style="text-align: justify;">“The main objective of the app is to reduce the cases of malaria, dengue and chikungunya,” she said. &nbsp;</p><p style="text-align: justify;">“The intensity of mosquito-borne diseases like malaria, dengue, and chikungunya usually remains from the beginning of the rainy season in July-August to October-November. In recent years, due to lifestyle and weather changes, the spread of seasonal diseases has started increasing,” she said.</p><p style="text-align: justify; ">According to a PTI report, she said, “Through the app, photographs of mosquito breeding sites and places where larvae are found will be taken and sent to the local self-government department or the Panchayati Raj Department… The concerned departments will carry out anti-larva and anti-mosquito activities at those places”.</p><p style="text-align: justify; ">Medical Dialogues team had earlier reported that the Uttarakhand health department has taken proactive measures to address the rising cases of dengue and chikungunya patients in the state by issuing comprehensive guidelines to all districts. Twenty key points have been communicated to District Magistrates and Chief Medical Officers (CMOs) to ensure effective prevention and treatment. Dr R Rajesh Kumar, Secretary of Health, has been conducting regular review meetings to strategize the prevention of dengue and chikungunya. In consultation with health experts, the department has formulated guidelines aimed at the treatment and prevention of these diseases.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><b><i><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/health/health-ministry-seeks-central-database-to-share-field-level-data-on-heatwaves-126749"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/health-ministry-seeks-central-database-to-share-field-level-data-on-heatwaves-126749">Also Read:Health Ministry seeks central database to share field level data on heatwaves</a></i></b></p></div></div>

90. NMC notifies its final decision on 158 applications to start new PG medical courses, increase PG medical seats

    Wed, 15 May 2024 11:44:58 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/15/238286-mdtv-2024-05-15t160056287.webp' /><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper" style="text-align: justify; ">The National Medical Commission (NMC) has notified its final decision on 158 more applications for starting new postgraduate medical courses and increasing postgraduate medical seats for the academic year 2024-2025. These applications were submitted by altogether 32 medical institutes.</div><div class="pasted-from-word-wrapper" style="text-align: justify;">Among these applications, altogether 105 applications were for starting new PG medical courses and 53 applications were for an increase of seats in existing PG medical courses.</div><div class="pasted-from-word-wrapper" style="text-align: justify;"><i><b>For more information click on the link below:</b></i></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/health-news/nmc/new-pg-medical-courses-increase-of-pg-seats-nmc-notifies-its-final-decision-on-158-applications-to-32-institutes-128492#:~:text=New%20Delhi%3A%20The%20National%20Medical,by%20altogether%2032%20medical%20institutes."><b>New PG Medical Courses, Increase Of PG Seats: NMC Notifies Its Final Decision On 158 Applications To 32 Institutes</b></a></i></div><div style="text-align: justify;"><p><br></p></div></div></div>

91. Health Bulletin 15/ May/ 2024

    Wed, 15 May 2024 11:37:34 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/15/238284-bulletin-11.webp' /><p><b style="text-align: justify;">Here are the top health stories for the day:</b><br></p><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>New PG medical courses, increase of PG seats: NMC notifies its final decision on 158 applications to 32 institutes</b></div></div><div class="pasted-from-word-wrapper" style="text-align: justify;">The National Medical Commission (NMC) has notified its final decision on 158 more applications for starting new postgraduate medical courses and increasing postgraduate medical seats for the academic year 2024-2025. These applications were submitted by altogether 32 medical institutes.</div><div class="pasted-from-word-wrapper" style="text-align: justify;">Among these applications, altogether 105 applications were for starting new PG medical courses and 53 applications were for an increase of seats in existing PG medical courses.</div><div class="pasted-from-word-wrapper" style="text-align: justify;"><b><i>For more information click on the link below:</i></b></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b><i><a href="https://medicaldialogues.in/health-news/nmc/new-pg-medical-courses-increase-of-pg-seats-nmc-notifies-its-final-decision-on-158-applications-to-32-institutes-128492#:~:text=New%20Delhi%3A%20The%20National%20Medical,by%20altogether%2032%20medical%20institutes.">New PG Medical Courses, Increase Of PG Seats: NMC Notifies Its Final Decision On 158 Applications To 32 Institutes</a></i></b></div><div style="text-align: justify;"><b><i><br></i></b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>Patanjali ads case: Supreme Court pulls up IMA chief as it refuses to accept apology. 'Can't sit on your…'</b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;">The Supreme Court on Tuesday i.e. May 14, 2024, reserved its verdict on the pending contempt proceedings against Patanjali Ltd., its managing Director Acharya Balkrishna, and co-founder Baba Ramdev, who were accused of publishing misleading medical advertisements in breach of a court undertaking.</div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;">However, the top court bench dismissed the apology tendered by the president of the Indian Medical Association (IMA) Dr. RV Asokan, for his remarks on the court's ruling in the misleading ads case against Patanjali.</div><div style="text-align: justify;"><br></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>Avoid tea, coffee before and after meals, advises Top medical body ICMR</b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;">While we all enjoy a warm cup of tea or coffee, did you know there are specific times recommended for consuming these beverages? The Indian Council of Medical Research (ICMR), in collaboration with the National Institute of Nutrition (NIN), has recently issued 17 new dietary guidelines to foster healthier eating habits across India. Among these guidelines, a moderate intake of tea and coffee is emphasized, considering their deep-rooted cultural significance in Indian society.</div><div style="text-align: justify;">The guidelines highlight the potential health risks associated with excessive consumption of these popular beverages. According to the ICMR, both tea and coffee contain caffeine, which not only stimulates the central nervous system but can also lead to physiological dependence. The research specifies that a 150ml cup of brewed coffee has about 80-120 mg of caffeine, while instant coffee contains 50-65 mg, and tea has 30-65 mg. The recommended daily intake of caffeine is capped at 300 mg.</div></div>

92. Essential Prenatal Checkups: A Comprehensive Guide for Expectant Mothers - Dr Samhitha Moturi

    Wed, 15 May 2024 11:26:07 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/15/238299-health-check-ups-for-young-mothers.webp' /><div class="pasted-from-word-wrapper"> <p>The most important checkup for the young mother is the first ever visit to the doctor after confirming pregnancy at home. At their first visit mostly at 5 to 6 weeks of pregnancy, we do an ultrasound scan which is called a dating scan, to make sure the fetus is in the uterus (womb), and not in the fallopian tubes (called ectopic pregnancy) and this scan also gives us a viability or the fetal heart rate, and the age of the fetus noted in weeks. </p><p>That is followed by blood check up with complete blood count, to ascertain haemoglobin and platelets, blood grouping and typing and serology to tule out infectious diseases like HIV and HbsAg. Screening blood glucose is done in the form of RBS and HbA1c.</p> <p>The following check-up will be within 11–14 weeks, for NT scan. It is a very important scan, not to be missed because, the NT measured will indirectly tell you whether the baby has any congenital anomalies or risk factors for birth defects, combined with that mother's blood is taken for double screening test which will predict risk for birth defects and syndromes. </p><p>Thyroid function test can be done any time in the first trimester, and abnormal values need to be corrected.</p> <p>Height and weight of the patient is calculated, and BMI estimation is done at the first visit. For a healthy pregnancy, there will be an increase of 9 to 10 kg of weight, maximum weight gain experienced in the third trimester.</p> <p>The most important scan at checkup is at 20 weeks, where an anomaly scan is done, which will tell us any birth defects for the baby in detail. The heart, lungs, brain and other vital structures are formed by then. At 22–24 weeks of pregnancy, a fetal echo is done to check baby's heart for any abnormality.</p> <p>In a regular normal pregnancy with no complications such as GDM (sugar) and hypertension (high BP), heart disease, a check-up to see the height of the uterus, and checking baby's heartbeat every four weeks is enough. Complicated pregnancies have to be followed up closely. Taking TT vaccine and vitamins supplements such as iron and folic acid, calcium are essential. </p> <p>The patient should come between 28–30 weeks of pregnancy, for a growth scan, to check for amniotic fluid levels also called liquor, and growth and weight of the baby. The blood supply to baby's heart and brain is checked in the form of dopplers. </p><p>After 32 weeks, a visit every two weeks is important for an NST or a non-stress test, which can be done on an OPD basis, which will tell baby's heart rate and pattern. 37 weeks which is called term pregnancy, frequent visits are mandated till mother develops pain.</p></div><div class="pasted-from-word-wrapper"><b><i>Disclaimer: The views expressed in this article are of the author and not of Medical Dialogues. The Editorial/Content team of Medical Dialogues has not contributed to the writing/editing/packaging of this article.</i></b></div><div class="pasted-from-word-wrapper"> </div>

93. Granules India reports 1.6 percent fall in Q4 revenue

    Wed, 15 May 2024 11:22:26 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/01/23/230787-granules-50.webp' /><p><b style="text-align: justify;">Bengaluru:</b><span style="text-align: justify; background-color: rgb(255, 255, 255);">&nbsp;</span>Granules India reported a 1.6% decrease in revenue for the fourth quarter on Wednesday, impacted by lower paracetamol sales and price reductions.<br></p><p><span style="text-align: justify; background-color: rgb(255, 255, 255);">The company's consolidated revenue fell year-on-year to 11.76 billion rupees (nearly $141 million) for the three months to March 31.</span><br></p><div class="pasted-from-word-wrapper"><div data-testid="paragraph-2" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; ">Granules, which focuses on making active pharmaceutical ingredients (API), holds 30% of the global market for Paracetamol. It makes the drug's API as well as the finished dosage - the ready-for-consumption product.</div><div data-testid="paragraph-2" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD"><div data-testid="paragraph-3" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; ">Still, weak sales of the drug and price erosion due to heightened competition hurt its revenue. This is despite analysts expecting Indian API makers, including Granules, to benefit from increasing demand from Europe and the U.S., the industry's biggest markets.</div><div data-testid="paragraph-4" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; ">Rivals Glenmark Life Sciences and Laurus Labs posted lower fourth-quarter profits.<br></div><div data-testid="paragraph-5" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD"><div data-testid="paragraph-6" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; ">Glenmark's revenue was hit by issues stemming from the Red Sea crisis while Laurus was challenged by multiple factors including a decline in selling prices of antiretroviral products.</div><div data-testid="paragraph-7" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; ">A 9.5% drop in Granules' raw material expenses, meanwhile, helped its quarterly profit climb 8.4% to 1.30 billion rupees.</div><div data-testid="paragraph-8" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; ">API makers use a variety of chemicals in their formulations, including hydrochloric acid and chloroform, accounting for a majority of the drug-makers' input costs.</div><div data-testid="paragraph-8" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; ">The easing costs had helped its profit marginally climb in the third quarter as well, before which profit fell for two straight quarters.<br></div></div></div></div><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/granules-india-arm-gets-usfda-nod-for-gout-flares-drug-colchicine-127861">Granules India arm gets USFDA nod for Gout flares drug Colchicine</a></i></b></p>

94. SPARSH Group of Hospitals expands its footprints with launch of 250-bed hospital in Yelahanka

    Wed, 15 May 2024 11:00:13 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/15/238261-untitled-design-2024-05-15t141533871.webp' /><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">Bengaluru: The SPARSH Group of hospitals, one of the largest multi-speciality healthcare providers in Karnataka, has launched its new cutting-edge super speciality hospital at Yelahanka, Bangalore.</p><p style="text-align: justify; ">With an investment of around Rs. 250 crores the hospital is equipped with 250 beds that includes 50+ critical care beds, a dedicated NICU with 20+ beds for newborns, two state-of-the-art Cath Labs and 10 advanced operation theatres to serve patients of all age groups.</p><p style="text-align: justify;">The hospital was inaugurated by Chief Guest Shri D. K. Shivakumar, Deputy Chief Minister of Karnataka in the presence of His Holiness JAGADGURU Shri Shivarathri Deshikendra Swamiji and Dr. Sharan Shivaraj Patil, Chairman and Chief Orthopaedic Surgeon, SPARSH Group of Hospitals, Bangalore.</p><p style="text-align: justify;"><b><i>Also read- <a href="https://medicaldialogues.in/news/health/hospital-diagnostics/sparsh-hospital-attains-50-successful-da-vinci-robotic-surgeries-120025" target="_blank">SPARSH Hospital Attains 50 Successful Da Vinci Robotic Surgeries</a></i></b></p><p style="text-align: justify;">Other prominent dignitaries present on the occasion included: Shri M.B. Patil, Minister of Infrastructure Development; Shri S.S. Mallikarjun, Minister of Mines &amp; Geology and Horticulture; Shri Sharanabasappa Darshanapur, Minister of Small-Scale Industries and Public Enterprises; Shri Jagadish Shettar, Former Chief Minister of Karnataka; Shri Basavaraj Bommai, Former Chief Minister of Karnataka, Justice Shivaraj V Patil, Former Judge, Supreme Court of India and Dr. Shamanur Shivashankarappa, MLA, Davanagere South.</p><p style="text-align: justify;">With 40 Specialties, the Hospital strives to provide comprehensive and specialized care spanning various medical disciplines. Through the Center’s of Excellence in Neurosciences, Cardiac Sciences, Gastro Sciences, Renal Sciences, Women &amp; Childcare, Head and Neck Surgery, Trauma Care, and Emergency Medicine amongst others, the facility ensures that every patient receives focused expert care, tailored to their unique healthcare requirements. The hospital also offers 24/7 Emergency Care &amp; Diagnostic Services and a drive-through pharmacy for convenient access.</p><p style="text-align: justify;">Speaking on the newly launched Hospital, Dr. Sharan Shivaraj Patil, Chairman and Chief Orthopaedic Surgeon, SPARSH Group of Hospitals, Bangalore said, “We take great pride in unveiling our Seventh super-speciality hospital in Yelahanka, Bengaluru.</p><p style="text-align: justify;">This new facility is a testament to our continued efforts to be a one-stop healthcare hub, offering a wide array of treatments, reaffirming our dedication to delivering world-class medical treatment accessible to all. As we expand our presence throughout Karnataka, our goal remains steadfast: to offer every citizen the comforting embrace of life's healing touch. At SPARSH we are committed to practising the art and science of medicine, while upholding our core values of Faith, Hope, and Love”.</p><p style="text-align: justify;">“The residents of Yelahanka and North Bangalore requires a highly specialised comprehensive medical facility in the region. With our devoted multi-disciplinary team of specialists, the hospital strives to redefine patient experience and achieve optimal clinical outcomes, thereby ensuring to fulfil all health care requirements of the people in this part of Bengaluru.” added Dr. Sharan.</p><p style="text-align: justify;">Ever since its inception, SPARSH Group of Hospitals, has carved a niche in the field of Healthcare &amp; Medical Education. By performing intricate surgeries, the brand strives daily to fulfil its mission of touching many lives. </p><p style="text-align: justify;"><b><i>Also read- <a href="https://medicaldialogues.in/mdtv/healthshorts/sparsh-hospital-chairman-dr-sharan-shivaraj-patil-appointed-as-president-of-indian-society-of-hip-and-knee-surgeons-110467" target="_blank">Sparsh Hospital Chairman Dr Sharan Shivaraj Patil appointed as President of Indian Society of Hip and Knee Surgeons</a></i></b></p></div>

95. Lawyers exempt from CPA, doctors not: SC calls for revisitation of judgment that brought doctors under Consumer Protection Act

    Wed, 15 May 2024 10:59:54 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/15/238307-security-for-doctors.webp' /><p style="text-align: justify; ">New Delhi:&nbsp;In a major observation, the Supreme Court has pointed out the requirement of revisiting the 1995 judgment in the case of Indian Medical Association v VP Shantha, which brought medical professionals in the country under the purview of the Consumer Protection Act. In the said judgment, the apex court had ruled that services rendered by doctors and medical practitioners are covered under the Act if they are paid services.</p><p style="text-align: justify; ">Referring the matter to the Chief Justice of India for further consideration, the Apex Court bench of Justices Bela Trivedi and Pankaj Mithal observed,<i> "...we are of the opinion that the decision of the three-judge bench, in case of Indian Medical Association vs. V.P Shantha (supra) deserves to be revisited and considered by a larger bench. We, therefore refer the matter to Hon’ble the Chief Justice of India for His Lordship’s consideration."</i></p><p style="text-align: justify; ">The judgment in question in the case of Indian Medical Association vs. V.P. Shantha &amp; Others was delivered by a three-judge Bench of the Supreme Court. It was held by the Apex Court that the wide amplitude of the definition of 'service' in the main part of Section 2(1) (o) would cover the services rendered by Medical Practitioners within the said Section 2(1)(o).&nbsp;</p><p>Section 2(1)(o) of The Consumer Protection Act says,&nbsp;<i>“service” means service of any description which is made available to potential users and includes, but not limited to, the provision of facilities in connection with banking, financing insurance, transport, processing, supply of electrical or other energy, board or lodging or both, housing construction, entertainment, amusement or the purveying of news or other information, but does not include the rendering of any service free of charge or under a contract of personal service.</i></p><p>In the 1995 judgment, the bench had concluded that<i> "Service rendered to a patient by a medical practitioner (except where the doctor renders service free of charge to every patient or under a contract of personal service), by way of consultation, diagnosis and treatment, both medicinal and surgical, would fall within the ambit of 'service' as defined in Section 2(1) (o) of the Act. (2) The fact that medical practitioners belong to the medical profession and are subject to the disciplinary control of the Medical Council of India and/or State Medical Councils constituted under the provisions of the Indian Medical Council Act would not exclude the services rendered by them from the ambit of the Act."</i></p><p>However, during the recent hearing, the bench called for a reconsideration of the judgment bringing doctors under the Consumer Protection Act.</p><blockquote style="text-align: justify; "><i>"However, in our humble opinion, the said decision deserves to be revisited having regard to the history, object, purpose and the scheme of the CP Act and in view of the opinion expressed by us hereinabove to the effect that neither the “Profession” could be treated as “business” or “trade” nor the services provided by the “Professionals” could be treated at par with the services provided by the Businessmen or the Traders, so as to bring them within the purview of the CP Act,"</i> opined the bench.</blockquote><div class="pasted-from-word-wrapper"><p>The Court made such observation while considering a batch of pleas concerning the legal question of whether a complaint alleging "deficiency in service" against Advocates practising Legal Profession, would be maintainable under the Consumer Protection Act, 1986 as re-enacted in 2019.</p><p>While pronouncing its verdict, the Court opined that the very purpose and object of the Consumer Protection Act 1986 as re-enacted in 2019 was to provide protection to consumers from unfair trade practices and unethical business practices only. <i>"There is nothing on record to suggest that the Legislature ever intended to include the Professions or the Professionals within the purview of the Act,"</i> the Court observed.</p><p>At this outset, the bench observed, <i>"...a “Profession” would require advanced education and training in some branch of learning or science. The nature of work is also skilled and specialised one, substantial part of which would be mental rather than manual. Therefore, having regard to the nature of work of a professional, which requires high level of education, training and proficiency and which involves skilled and specialized kind of mental work, operating in the specialized spheres, where achieving success would depend upon many other factors beyond a man’s control, a Professional cannot be treated equally or at par with a Businessman or a Trader or a Service provider of products or goods as contemplated in the CP Act. Similarly, the services rendered by a Businessman or a Trader to the consumers with regard to his goods or products cannot be equated with the Services provided by a Professional to his clients with regard to his specialized branch of profession."</i></p><p><i>"The legislative draftsmen are presumed to know the law and there is no good reason to assume that the legislature intended to include the Professions or the Professionals or the services provided by the professionals within the ambit of the CP Act. Any interpretation of the Preamble or the scheme of the Act for construing ‘Profession’ as ‘Business’ or ‘Trade’; or ‘Professional’ as ‘service provider’ would be extending the scope of the Act which was not intended, rather would have a counter productive effect,"</i> it further noted.</p></div><p style="text-align: justify; ">The bench noted in respect of the legal profession that role of the Advocates was unique and could not be compared with any other profession. Amongst the arguments put before the Court, it was also submitted that just because the medical profession had been included under the Act through VP Shantha's case, by the same logic, the legal profession could not be included.&nbsp;</p><p>The bench clarified that it does mean that the professionals could not be sued or held liable for their alleged misconduct or tortious or criminal acts. </p><div class="pasted-from-word-wrapper">“The fact that professionals are governed by their respective Councils like Bar Councils or Medical Councils also would not absolve them from their civil or criminal liability arising out of their professional misconduct or negligence. Nonetheless, as discussed hereinabove, we are of the opinion that neither the Professions nor the Professionals were ever intended to be brought within the purview of the CP Act either of 1986 or 2019,” it said.</div><p style="text-align: justify; "><i>To view the order, click on the link below:</i></p><p style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/supreme-court-consumer-protection-act-238258.pdf"><i>https://medicaldialogues.in/pdf_upload/supreme-court-consumer-protection-act-238258.pdf</i></a></p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/medico-legal/mens-rea-as-intent-not-necessary-in-medical-negligence-cases-following-established-procedure-is-supreme-court-80666" style="background-color: rgb(255, 255, 255);"><i style="">Also Read: Mens rea as intent not necessary in Medical negligence cases, Following Established procedure is: Supreme Court</i></a></p>

96. NEET PG 2024 Correction Window To Close Tomorrow

    Wed, 15 May 2024 10:15:59 -0000

    <img src='https://medicaldialogues.in/h-upload/2020/05/19/129036-correction-window.webp' /><p style="text-align: justify; "><b>New Delhi-</b> The correction window for NEET PG 2024 is going to close tomorrow i.e. May 16, 2024. Therefore candidates are advised to modify the errors/details in the online application form for NEET PG 2024 before the deadline.</p><p style="text-align: justify; ">Candidates who wish to modify any errors or details in their NEET PG 2024 exam application form can do so by visiting the official website of the National Board of Examination in Medical Sciences (NBEMS). However, any correction after the deadline will not be considered.</p><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-admissions/nbe-opens-neet-pg-2024-correction-window-till-may-16-128384"><b>Also Read:&nbsp;</b>NBE opens NEET PG 2024 correction window till May 16</a></div><p style="text-align: justify; "><b><u>HOW TO MAKE CORRECTION </u></b></p><p style="text-align: justify; "><b>STEP 1-</b> Go to the NBE’s official website. </p><p style="text-align: justify; "><b>STEP 2- </b>On the homepage, select the NEET PG option. </p><p style="text-align: justify; "><b>STEP 3- </b>Click on the NEET PG 2024 application form. </p><p style="text-align: justify; "><b>STEP 4-</b> Enter the login credentials. </p><p style="text-align: justify; "><b>STEP 5- </b>The application form will be displayed on the screen. </p><p style="text-align: justify; "><b>STEP 6- </b>Edit the form. </p><p style="text-align: justify; "><b>STEP 7-</b> Once the changes are made, click on submit. </p><p style="text-align: justify; "><b>STEP 8- </b>Download and take a printout. </p><p style="text-align: justify; ">As per the information bulletin, any information/document can be edited except name, nationality, email, mobile number and test city cannot be edited during the correction window. Candidates can edit their father's name, mother's name, gender, category, sub-category, photo, signature, caste certificate, income certificate and date of birth. </p><p style="text-align: justify; ">Later, rectification of Deficient/incorrect photographs, signatures and thumb impressions will also be done where the pre-final edit window will be from 28th May to 3rd June 2024 and the final window will be from 7th June to 10th June 2024. </p><p style="text-align: justify; ">NEET-PG is an eligibility-cum-entrance examination prescribed as the single entrance examination for admission to various MD and MS and PG Diploma Courses, Post MBBS DNB Courses, Post MBBS Direct 6-year DrNB courses and NBEMS diploma courses are also undertaken through NEET-PG. </p><p style="text-align: justify; ">NEET PG 2024 is scheduled to be conducted on June 23, 2024, on a computer-based platform at various examination centres across the country and the result will be declared by July 15, 2024. Meanwhile, the admit card will be released on 18th June 2024.</p><div class="pasted-from-word-wrapper"><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/education/medical-admissions/neet-pg-2024-registration-window-closing-tomorrow-apply-now-128080"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-admissions/neet-pg-2024-registration-window-closing-tomorrow-apply-now-128080"><b>Also Read:&nbsp;</b>NEET PG 2024 Registration window closing tomorrow, Apply now</a></div>

97. Study claims obese people take more sick days off work

    Wed, 15 May 2024 10:09:04 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/14/238159-mdtv-2024-05-14t161407939.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">Researchers from Vienna, studying over 122,000 individuals across Europe, have highlighted the significant impact of obesity on work absenteeism, signaling a growing concern for the labor market. These findings, presented at the European Congress on Obesity in Italy, underscore the urgent need for policymakers to prioritize initiatives promoting healthy weight maintenance.</div><div style="text-align: justify;">Although the study didn't include countries like the UK, France, Ireland, Malta, and Iceland due to insufficient data, the results from the 26 countries that were analyzed reveal that obesity increases the likelihood of taking sick leave, with the severity of obesity correlating with higher absenteeism rates. The research, partly sponsored by Novo Nordisk—a pharmaceutical company producing a weight-loss injection prescribed by the NHS—calls for immediate action.</div><div style="text-align: justify;"><p><br></p></div></div>

98. Zydus Wellness net sales up by 9.6 percent to Rs 778 crores in Q4

    Wed, 15 May 2024 09:52:37 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/15/238275-zydus-wellness-50.webp' /><p style="text-align: justify; "><span style="background-color: rgb(255, 255, 255);"><b>Ahmedabad:&nbsp;</b>Zydus Wellness Ltd. has reported net sales of Rs 778 crores, up by 9.6% f</span>or the fourth quarter ended March 31, 2024.<br></p><p style="text-align: justify; "><span style="background-color: rgb(255, 255, 255);">The company registered growth in EBIDTA of 12.2% y-o-y basis to Rs. 162 crores. The Company reported Profit after Tax of Rs.150 crores. Adjusted PAT after eliminating exceptional items and one-time deferred tax assets impact from comparable quarter of previous year, grew by 24.7% on a year-on-year basis. Total income from operations increased by 3.2 % y-o-y to 2328 crores during the financial year. Reported net profit stood at 267 crores for the financial year.</span></p><p style="text-align: justify; "><span style="background-color: rgb(255, 255, 255);"> With the continued thrust on marketing initiatives, several key brands including Glucon-D, Everyuth, and Nycil continued to perform well during the quarter. The personal care portfolio comprising of Everyuth and Nycil brand drove the growth for the quarter with 23% growth on a year-on-year basis. </span></p><p style="text-align: justify; "><span style="background-color: rgb(255, 255, 255);">The Food and Nutrition portfolio also registered a mid-single digit growth. All brands contributed to the performance with overall volume growing by close to 6 percent. The Sugar Free brand maintained its leadership in the sugar substitute category with a market share of 95.9 %*. </span></p><p style="text-align: justify; "><span style="background-color: rgb(255, 255, 255);">The Group has launched a new brand, I’mlite, a unique formulation of sugar blended with stevia to offer consumers 50% less calories than regular sugar. Glucon-D continues to maintain its number one position with 59.5%* market share at MAT level. The brand has entered the Ready to Drink beverage category with the pilot launch of Glucon-D Activors Electrolyte Energy drink in couple of key states during the quarter. </span></p><p style="text-align: justify; "><span style="background-color: rgb(255, 255, 255);">During the quarter, the Nutrition Drink Category has registered a growth of 6.4 %* at MAT level. Complan’s market share stood at 4.3%* . Nycil continues to be at number one position with a market share of 35%* in the prickly heat powder category. Everyuth Scrub has maintained its leadership position with a market share of 45.6 %* in the facial scrub category which is an increase of 369 basis points over the same period last year. Everyuth Peel off has held on to its number one position with a market share of 80.2%* , in the Peel off category which is an increase of 174 basis points over the same period last year. In the facial cleansing segment, Everyuth stood at the 5th position with a market share of 6.5%* .</span><br></p><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/zydus-lifesciences-dexamethasone-tablets-bags-usfda-okay-128419">Zydus Lifesciences Dexamethasone Tablets bags USFDA okay</a></i></b></p>

99. Medical Bulletin 15/ May/ 2024

    Wed, 15 May 2024 09:30:00 -0000

    <img src='https://medicaldialogues.in/h-upload/2024/05/15/238257-medical-bulletin-11.webp' /><p style="text-align: justify; "><b>Here are the top medical news for the day:</b></p><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>Commonly used antibiotics associated with increased complications- JAMA study</b></div><div style="text-align: justify;">According to a study published in the journal JAMA Internal Medicine, in patients with sepsis, the use of a combination of vancomycin and piperacillin-tazobactam is associated with increased mortality risk compared with a combination of vancomycin and cefepime. </div><div style="text-align: justify;">Piperacillin/tazobactam is a broad-spectrum antibiotic that is commonly administered for sepsis, a life-threatening complication from infection. In its absence, clinicians commonly use another antibiotic, cefepime, which has similar activity against common sepsis pathogens but, unlike piperacillin/tazobactam, has minimal effects on anaerobic gut bacteria.</div><div style="text-align: justify; ">In health, the gut microbiome is largely populated by anaerobic bacteria that rarely cause disease. Prior research has revealed that even a single dose of piperacillin/tazobactam kills most of these anaerobic gut bacteria, which play important roles in the body’s metabolism, immunity, and prevention of infections.</div><div style="text-align: justify;">In their study, Dr. Rishi Chanderraj and his multidisciplinary team from the University of Michigan's Division of Infectious Disease analysed patient records from a cohort of 7,569 individuals. They compared outcomes between 4,523 patients treated with piperacillin/tazobactam and 3,046 patients who received cefepime.</div><div style="text-align: justify; ">Their findings revealed significant disparities: patients treated with piperacillin-tazobactam experienced a 5 percent rise in 90-day mortality, longer durations on ventilators, and increased instances of organ failure. Moreover, opting for piperacillin/tazobactam over cefepime could potentially result in one additional fatality for every 20 septic patients treated. </div><div style="text-align: justify;">“These are powerful antibiotics that are administered to patients every day in every hospital nationwide. Clinicians use them because they are trying to treat every possible pathogen that might be causing their patients’ illnesses. But our results suggest that their effects on the microbiome might also have important effects on patient outcomes,” said Chanderraj. “Our previous research hinted at potential harm associated with piperacillin/tazobactam, but it was based on observational data with limitations. The drug shortage presented a unique opportunity, acting as a nearly perfect natural experiment to rigorously compare the outcomes of patients treated with these two drugs. Physicians should carefully consider the necessity of prescribing anti-anaerobic antibiotics.”</div><div style="text-align: justify;">Reference: Chanderraj R, Admon AJ, He Y, et al. Mortality of Patients With Sepsis Administered Piperacillin-Tazobactam vs Cefepime. JAMA Intern Med. Published online May 13, 2024. doi:10.1001/jamainternmed.2024.0581</div><div></div><div></div><div></div><div style="text-align: justify; "><b>Does obesity and metabolic syndrome affect a woman's risk of breast cancer? Study sheds light </b></div><div style="text-align: justify;">In the Women’s Health Initiative (WHI) randomized trial, adopting a low-fat diet was found to decrease breast cancer mortality, particularly among women with multiple metabolic syndrome components such as obesity, high blood pressure, elevated blood sugar, and abnormal cholesterol levels.</div><div style="text-align: justify;">The analysis, published in the journal Cancer, indicated that metabolic syndrome and obesity each have different associations with breast cancer subtypes and mortality risk.</div><div style="text-align: justify;">Obesity is a prevalent health concern among women worldwide, with its incidence steadily rising in recent years. Alongside its association with various metabolic disorders, including type 2 diabetes and cardiovascular disease, obesity has also been closely linked to an increased risk of cancer. In particular, obese women face a heightened likelihood of developing breast cancer, among other malignancies, due to the complex interplay of hormonal imbalances, chronic inflammation, and metabolic dysregulation associated with excess adiposity.</div><div style="text-align: justify;">Metabolic syndrome, characterized by a cluster of metabolic abnormalities including hypertension and hyperglycemia, poses a significant risk factor for cancer-related deaths in women. This syndrome contributes to a systemic environment conducive to tumor growth and progression. Insulin resistance, a hallmark feature of metabolic syndrome, leads to elevated levels of insulin and insulin-like growth factor 1 (IGF-1), both of which promote cell proliferation and inhibit apoptosis, thereby fostering the development and spread of cancer cells. </div><div style="text-align: justify; ">In the study, researchers analyzed data from 63,330 postmenopausal participants of the WHI clinical trial who had no history of breast cancer, along with normal entry mammograms and MetS scores ranging from 0 to 4. Following a median follow-up period of 23.2 years, the analysis revealed 4,562 new cases of breast cancer and 659 deaths attributed to breast cancer (breast cancer mortality).</div><div style="text-align: justify; ">The study found that a higher metabolic syndrome score, regardless of obesity, was linked to poorer prognosis, estrogen receptor (ER)-positive, progesterone receptor (PR)-negative breast cancers, and a 44% higher risk of breast cancer mortality. Obesity, irrespective of the metabolic syndrome score, was associated with better-prognosis, ER-positive, and PR-positive cancers. Only women with severe obesity faced a higher risk of breast cancer mortality.</div><div style="text-align: justify;">Reference: Rowan T. Chlebowski MD, PhD, Aaron K. Aragaki MS, Kathy Pan MD, Michael S. Simon MD, MPH, et al.; Breast cancer incidence and mortality by metabolic syndrome and obesity: The Women’s Health Initiative; CANCER; https://doi.org/10.1002/cncr.35318</div><div></div><div></div><div style="text-align: justify; "><b>Study finds Semaglutide's effects on long-term weight loss in individuals with obesity </b></div><div style="text-align: justify;">Two studies presented at the European Congress on Obesity investigated the long-term effects of semaglutide on weight loss and explored the relationship between cardiovascular benefits and initial weight or extent of weight loss.</div><div style="text-align: justify;">Semaglutide, a GLP-1 medication typically prescribed for adults with type 2 diabetes, is also approved for weight management in individuals with obesity or overweight who have at least one comorbidity. This medication class mimics the actions of the body's natural incretin hormones, aiding in post-meal blood sugar regulation. By modulating these hormone levels, semaglutide can induce a feeling of fullness, thereby reducing daily calorie consumption.</div><div style="text-align: justify;">In the SELECT trial spanning from October 2018 to June 2023, 17,604 adults aged 45 or older from 41 countries were given semaglutide (2.4mg) or placebo for an average of 40 months. They had overweight or obesity but no diabetes and a history of cardiovascular events. </div><div style="text-align: justify;">The findings are as follow: </div><div style="text-align: justify;">1. Semaglutide users saw a 20% lower risk of heart attack, stroke, or cardiovascular death and lost an average of 9.4% body weight. </div><div style="text-align: justify;">2. In the semaglutide group, weight loss persisted up to week 65 and was maintained for four years, with participants achieving an average body weight reduction of 10.2% and a waistline decrease of 7.7cm, compared to 1.5% and 1.3cm respectively in the placebo group. </div><div style="text-align: justify;">3. The semaglutide group experienced a significant 6.9% reduction in average waist circumference-to-height ratio, compared to 1% in the placebo group. After two years, over half (52%) of semaglutide-treated participants shifted to a lower BMI category, compared to 16% of those receiving placebo.</div><div style="text-align: justify;">4. Semaglutide treatment provided cardiovascular benefits regardless of initial weight or the extent of weight loss. This implies that even individuals with mild obesity or modest weight loss may experience improved cardiovascular outcomes with semaglutide therapy.</div><div style="text-align: justify;">“Our findings show that the magnitude of this treatment effect with semaglutide is independent of the amount of weight lost, suggesting that the drug has other actions which lower cardiovascular risk beyond reducing unhealthy body fat. These alternative mechanisms may include positive impacts on blood sugar, blood pressure, or inflammation, as well as direct effects on the heart muscle and blood vessels, or a combination of one or more of these,” said Professor John Deanfield from University College London, UK.</div><div style="text-align: justify;">Reference: Ryan, D.H., Lingvay, I., Deanfield, J. et al. Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial. Nat Med (2024). https://doi.org/10.1038/s41591-024-02996-7</div><div></div></div>

100. AIIMS NORCET 06 choice filling panel to close on May 21, details

     Wed, 15 May 2024 09:21:54 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/03/05/233622-norcet-2024.webp' /><p style="text-align: justify; "><b>New Delhi- </b>Through a notice, the All India Institute of Medical Sciences (AIIMS) has informed about the opening of the online choice-filling panel for applications for individual institute/ hospital by the Nursing Officer Recruitment Common Eligibility Test (NORCET- 06) Stage- II candidates.</p><p style="text-align: justify; ">As per the notice, the application panel for individual institution/hospital has already been opened from yesterday i.e. 14th May 2024 and will be valid till 05.00 PM on 21st May 2024. All provisionally eligible candidates are required to log in using credentials for online registration and sign up for the Institute application portal on the AIIMS official website, which is mentioned in the notice. No correspondence will be entertained after the date and time specified in the notice.</p><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/nursing/aiims-norcet-6-stage-i-results-released-details-127452"><b>Also Read:&nbsp;</b>AIIMS NORCET 6 Stage I Results released, details</a></div><p style="text-align: justify; ">As per the notice, “<i>With reference to Result Notification dated 8th May 2024 of Nursing Officer Recruitment Common Eligibility Test (NORCET- 06) Stage-II, Qualified and provisionally Eligible candidates based on preliminary verification based on details provided at the time of registration are hereby invited to apply online by filling choice of institute &amp; their order of preference against vacancy for the post of Nursing Officer of respective Institute as per eligibility based on NORCET- 06 Rank</i>”. </p><p style="text-align: justify; ">Selection is subject to fulfilment of eligibility criteria applicable for the respective institutes/hospitals and advertisement notice for NORCET-06, the notice added. </p><p style="text-align: justify; ">Moreover, all types of questions will be raised only through the link given in the Choice Portal. Candidates are requested to visit the official website of AIIMS, as all important information/corrigendum/addendum/updates etc. will be uploaded on the website only.</p><div class="pasted-from-word-wrapper"><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/education/nursing/aiims-norcet-6-stage-i-results-released-details-127452"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/nursing/aiims-norcet-6-stage-i-results-released-details-127452"><b>Also Read:&nbsp;</b>AIIMS NORCET 6 Stage I Results released, details</a></div><p style="text-align: justify; ">AIIMS recently declared the result of Stage I and II of the NORCET-6 for the 2024 session. The online (CBT) for stage I for NORCET Preliminary was held on Sunday, April 14, 2024, and the Online (CBT) for stage II for NORCET Mains was held on Sunday, May 5th, 2024. </p><p style="text-align: justify; "><b><u><i>To view the notice, click the link below</i></u></b></p><div class="pasted-from-word-wrapper"><a href="https://medicaldialogues.in/pdf_upload/aiims-opens-online-filling-choices-for-norcet-06-stage-ii-applicants-details-238263.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/aiims-opens-online-filling-choices-for-norcet-06-stage-ii-applicants-details-238263.pdf</a></div>

101. BHISHM portable hospital cubes tested for airdrop by Indian Air Force in Agra

     Wed, 15 May 2024 08:45:13 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/15/238256-hospital-1.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">Agra:&nbsp;</span>The Indian Air Force conducted a test of Bharat Health Initiative for Sahyog, Hita and Maitri (BHISHM) portable hospital cubes in Agra on Tuesday. This is the first time the Indian Air Force tested this portable hospital.</p><p>The objective behind this test was to ascertain the viability of deploying the portable hospital swiftly in response to emergencies across various locations.</p><p style="text-align: justify;">As per the Ministry of Information and Broadcasting, BHISHM portable cubes are a part of the broader initiative named "Project BHISHM" - Bharat Health Initiative for Sahyog, Hita and Maitri, which is tailored to treat up to 200 casualties, emphasising rapid response and comprehensive care, reports news agency ANI.&nbsp;</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/aiims-bhubaneswar-conducts-successful-trial-of-drone-supplying-blood-travelling-120-km-in-110-hours-123504"><b><i>Also Read:AIIMS Bhubaneswar conducts successful trial of drone supplying blood travelling 120 km in 1.10 hours</i></b></a></p><p style="text-align: justify; ">Notably, the Aid Cube is equipped with several innovative tools designed to enhance disaster response and medical support during emergencies. It also integrates Artificial Intelligence (AI) and data analytics to facilitate effective coordination, real-time monitoring, and efficient management of medical services in the field.</p></div><p style="text-align: justify;">The whole unit contains 72 easily transportable components that can be conveniently carried by hand, cycle, or even drone, providing unmatched flexibility. In the face of mass casualty incidents (MCIs), where requirements range from basic aid to advanced medical and surgical care, the Aid Cube stands out with its ability to be deployed within an astonishing 12 minutes.</p><p style="text-align: justify; ">According to an ANI report, These cubes are robust, waterproof, and light, designed for various configurations, making them ideal for diverse emergency scenarios. From airdrops to ground transportation, the cube can be rapidly deployed anywhere, ensuring immediate response capability.</p><p style="text-align: justify;">During the Pran Pratishtha ceremony held earlier this year on January 22 in Ayodhya, two Arogya Maitri Disaster Management Cube-BHISHM units were strategically deployed to enhance medical preparedness and response capabilities.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><b><i><a class="also-read-media-wrap" href="https://medicaldialogues.in/state-news/himachal-pradesh/icmr-explores-drone-use-for-medical-supply-transport-in-himachal-pradesh-119059"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/state-news/himachal-pradesh/icmr-explores-drone-use-for-medical-supply-transport-in-himachal-pradesh-119059">Also Read:ICMR explores drone use for medical supply transport in Himachal Pradesh</a></i></b></p></div></div>

102. Dr Manash Ranjan Sahoo takes charge as Vice Chancellor of Odisha University of Health Sciences

     Wed, 15 May 2024 07:45:21 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/15/238232-images-6.webp' /><p style="text-align: justify; ">Bhubaneshwar: Dr Manash Ranjan Sahoo, Professor and Head of Department of General Surgery at the All India Institute of Medical Sciences (AIIMS) Bhubaneswar was appointed as the new Vice-Chancellor of Odisha University of Health Sciences (OUHS) on Monday.</p><p>Raghubar Das, who serves as both the Governor and Chancellor of Universities has announced the appointment. &nbsp;</p><div class="pasted-from-word-wrapper"> <p style="text-align: justify; ">Dr Sahoo, currently serving as the Professor and Head of the Department of General Surgery at the All India Institute of Medical Sciences (AIIMS) Bhubaneswar, will assume his new role for a term of four years or until he attains the age of 70, as stipulated under subsection (6) of section 9 of the OUHS Act, 2021, or until further orders, whichever comes first. &nbsp;</p></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap" style="text-align: justify; "><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/health/hospital-diagnostics/new-principal-medical-superintendent-appointed-at-sms-medical-college-hospital-128326"><img class="also-read-media" data-src="https://medicaldialogues.in/h-upload/2024/05/10/237847-images-4.webp"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/new-principal-medical-superintendent-appointed-at-sms-medical-college-hospital-128326"><span class="read-this-also">Also Read:</span>New Principal, Medical Superintendent appointed at SMS Medical College Hospital</a><div></div></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">Dr Sahoo succeeded Datteswar Hota, who was the inaugural Vice-Chancellor of OUHS. Hota's term was limited to one year. The Odisha University of Health Sciences was inaugurated by Chief Minister Naveen Patnaik last March on the birth anniversary of Biju Patnaik, reports <a href="https://www.newindianexpress.com/amp/story/states/odisha/2024/May/14/manash-sahoo-new-vc-of-ouhs" target="_blank">The New Indian Express</a>. &nbsp; &nbsp;<br></p> <p style="text-align: justify; ">The Governor’s office, in a notification issued on Monday, confirmed Dr Sahoo’s appointment, highlighting his extensive background in medical education and surgery. Dr Sahoo completed his MBBS and MS from SCB Medical College and Hospital, Cuttack, followed by a fellowship in surgical gastroenterology from Sri Ram Chandra Medical College and Research Institute, Chennai. </p><p style="text-align: justify; ">With over 26 years of teaching experience and six years as a professor, Dr Sahoo also served as the Chairman of the Medical Board at AIIMS Bhubaneswar. He also has FIAGES and FMAS degrees to his credit. &nbsp; &nbsp; &nbsp;</p> <p style="text-align: justify; ">Dr Sahoo was instrumental in starting many new advanced Laparoscopic Surgeries in this part of the country many of which were done for the first time in Odisha. Dr Sahoo has trained nearly 150 Surgeons from across the country and SAARC countries in the art of Laparoscopic Surgery, currently at AIIMS Bhubaneswar.</p><p style="text-align: justify; "> Dr Sahoo is heading the advanced laparoscopic surgery training centre and is the Vice President of East in the Association of Minimal Access Surgeons of India and Treasurer of the Indian Association of Surgical Gastroenterology and a sitting member in some international laparoscopic surgical associations. He has authored one book chapter in an atlas and has 55 published indexed articles many of which are on laparoscopic surgery.</p> <p style="text-align: justify; ">The university aims to consolidate and enhance the quality of health education across the state by encompassing various medical colleges offering undergraduate and postgraduate degrees in fields such as modern medicine, dental science, ayurveda, homoeopathy, nursing, pharmacy, physiotherapy, and other allied health sciences. These institutions were brought under the university’s jurisdiction starting from the 2023-24 academic session, reports the Daily. &nbsp; &nbsp;</p> <p style="text-align: justify; ">The establishment of OUHS marks a significant step in the state’s efforts to streamline and improve health education. Dr Sahoo’s vast experience and leadership in the medical field are expected to drive the university toward achieving its goals of excellence in health sciences education and research. &nbsp; &nbsp;</p><p style="text-align: justify; "><a href="https://medicaldialogues.in/news/health/hospital-diagnostics/aiims-bhubaneswar-inaugurates-low-vision-clinic-for-visually-impaired-patients-127614" target="_blank">Also Read: AIIMS Bhubaneswar inaugurates Low Vision Clinic for visually impaired patients</a></p></div>

103. USFDA approves Roche HPV self-collection solution in US

     Wed, 15 May 2024 07:35:42 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/01/20/230600-roche-50.webp' /><p style="text-align: justify; ">Basel: Roche has announced the FDA approval of its human papillomavirus (HPV) self-collection solution, one of the first available in the United States. Screening for HPV can help identify women who are at risk of developing cervical cancer so that the disease can be found and treated early before cervical cancer has a chance to develop.<br></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">HPV self-collection offers an accessible screening option. In a healthcare setting, an individual collects their own vaginal sample, which is sent to a laboratory for analysis with Roche’s cobas molecular instrument. Those who receive a positive HPV result would then continue their care with a healthcare provider.</p><p style="text-align: justify; ">“With vaccinations, innovative diagnostic tools and screening programs, achieving the WHO’s goal of eliminating cervical cancer by 2030 is within reach,” said Matt Sause, CEO of Roche Diagnostics. “Our HPV self-collection solution helps support this goal by reducing barriers and providing access to HPV screening by allowing people to privately collect their own sample for HPV testing.”</p><p style="text-align: justify; ">More than half the patients diagnosed with cervical cancer in the U.S. have never been screened or have only been screened infrequently, and they do not participate in routine screening. Many factors can contribute to individuals not participating in cervical cancer screening programs, such as access to healthcare, social and economic barriers, history of traumatic experience, cultural concerns and embarrassment. Roche’s self-collection solution can help reduce these barriers by offering an alternative to clinician collection procedures, while also providing accurate and reliable results enabling clinicians to make patient care decisions. </p><p style="text-align: justify; ">Roche has collaborated with the National Cancer Institute (NCI), which is part of the National Institutes of Health (NIH), on the Cervical Cancer “Last Mile” Initiative. This public-private partnership has, in part, facilitated the regulatory pathway towards the approval.</p></div><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/roche-alecensa-gets-usfda-nod-for-alk-positive-early-stage-lung-cancer-127437">Roche Alecensa gets USFDA nod for ALK-positive early-stage lung cancer</a></i></b></p>

104. AIIMS INI CET July 2024 Admit Card OUT

     Wed, 15 May 2024 07:25:20 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/15/238250-ini-cet-july-2024-admit-card.webp' /><p style="text-align: justify; "><b>New Delhi-</b> All India Institute of Medical Sciences (AIIMS) has finally released the admit card for the candidates appearing in the Institute of National Importance Combined Entrance Test (INI-CET) for July 2024 scheduled to be held on May 19.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">As per the INI-CET July 2024 Information Bulletin, the admit Card will be available online only and can be downloaded from the link available at “MyPage” after logging in using the Registration ID, Password and Exam Unique Code (EUC) at the Completion of Application Zone for INI-CET July 2024. Applicants must note that the Examination Section, AIIMS, New Delhi does not send Admit Card through email or post. Admit Card will be issued only to the applicants who have completed all the Stages of Application Form for INI-CET July 2024.</p></div><div class="pasted-from-word-wrapper"><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/education/medical-admissions/aiims-ini-cet-july-2024-1290-seats-tentatively-available-for-candidates-details-127142"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-admissions/aiims-ini-cet-july-2024-1290-seats-tentatively-available-for-candidates-details-127142"><b>Also Read:&nbsp;</b>AIIMS INI CET July 2024: 1290 seats tentatively available for candidates, details</a></div><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; "><b><u>STEPS TO DOWNLOAD THE ADMIT CARD</u></b></p><p dir="ltr" style="text-align: justify; "><b>STEP 1-</b> Visit AIIMS's official website.</p><p dir="ltr" style="text-align: justify; "><b>STEP 2-</b> Click on “Academic Courses” and then click on the “INI CET (MD/MS/MCh(6yrs)/DM(6yrs))” link.</p><p dir="ltr" style="text-align: justify; "><b>STEP 3-</b> Next, click on the applicant login for the INI CET admit card download link.</p><p dir="ltr" style="text-align: justify; "><b>STEP 4-</b> Enter the required credentials i.e. registration ID, EUC code and password.</p><p dir="ltr" style="text-align: justify; "><b>STEP 5-</b> The INI CET hall ticket will be available on the screen.</p><p dir="ltr" style="text-align: justify; "><b>STEP 6-</b> Carefully check the details mentioned in the AIIMS INI CET admit card and take a printout of the same for future reference.</p><p dir="ltr" style="text-align: justify; ">The applicants must download the Admit Card and are required to carefully check the information related to the applicant such as INI CET Roll Number, Date of Birth, Gender Category of the candidate, Photograph, Signature and Thumb Impression. If any discrepancies or errors are observed by the applicant, then they must bring it to the notice of the Examination Section, AIIMS, New Delhi through the help/query section of the candidate dashboard “MyPage”</p><p dir="ltr" style="text-align: justify; ">Candidates must ensure to carry the INI CET 2024 admit card along with other important documents to the examination centre. INI-CET for the July 2024 session will be conducted on Sunday, May 19, 2024, and its examination centres will be held in all cities across India and the result will likely be declared on Saturday, May 25, 2024.</p></div><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-admissions/ini-cet-july-2024-at-nimhans-sctimst-check-seat-matrix-fee-details-here-127078"><b>Also Read:&nbsp;</b>INI CET July 2024 At NIMHANS, SCTIMST: Check seat matrix, fee details here</a></div><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; "><b><u>MODE AND SCHEME OF EXAMINATION</u></b></p><p dir="ltr" style="text-align: justify; ">The examination for INI-CET July 2024 will be conducted in a computer-based test (CBT) mode. </p><div dir="ltr"><table style="text-align: justify; "><colgroup><col width="161"><col width="463"></colgroup><tbody><tr><td><p dir="ltr">Duration.</p></td><td><p dir="ltr">3 hours (180 minutes)</p></td></tr><tr><td><p dir="ltr">Number of Questions.</p></td><td><p dir="ltr">200</p></td></tr><tr><td><p dir="ltr">Type of Questions.</p></td><td><p dir="ltr">Objective type of questions of varying types (including Single Correct Choice and Multiple Correct Choice questions.</p></td></tr><tr><td><p dir="ltr">Correct Answer.</p></td><td><p dir="ltr">One Mark (+1)</p></td></tr><tr><td><p dir="ltr">Incorrect Answer.</p></td><td><p dir="ltr">Minus one-third (-) 1/3</p></td></tr><tr><td><p dir="ltr">Unanswered / Marked for Review.</p></td><td><p dir="ltr">0 </p></td></tr></tbody></table></div></div>

105. MBBS Seat Fraud at Karakonam Medical College: ED files chargesheet

     Wed, 15 May 2024 07:00:35 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/01/14/198181-mbbs-admission-fraud.webp' /><p style="text-align: left;"><span style="text-align: justify;">Thiruvananthapuram: The Enforcement Directorate (ED) has filed a comprehensive chargesheet revealing the laundering of crores of black money in the pretext of arranging MBBS seats involving the former CSI (Church of South India) Bishop of the Karakonam Somervell Memorial CSI Medical College Hospital. </span></p><p style="text-align: left;"><span style="text-align: justify;">The chargesheet, submitted this week to the Prevention of Money Laundering Act (PMLA) court in Kaloor, Ernakulam, implicates former CSI Bishop allegedly accepted a bribe of Rs 7 crore from parents in exchange for MBBS seats.</span><br></p><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap" style="text-align: left;"></div></div><div class="pasted-from-word-wrapper"><p class="selectable-text" style="text-align: justify;">The ED's chargesheet highlights that Rs 7.22 crore was allegedly collected from the parents of 28 children under false promises of medical admissions. When these promises were not fulfilled, the college administration attempted to pacify the parents by returning the money. However, the church refused to compensate all affected individuals, and a significant portion of the funds was reportedly diverted to other church projects, reports the&nbsp;<a href="https://hindupost.in/crime/ed-submits-chargesheet-in-karakonam-csi-medical-college-hospital-corruption-case/" target="_blank">Hindu Post</a>.</p></div><div class="pasted-from-word-wrapper"><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/health/delhi-hc-tells-chief-secretary-to-implement-panel-recommendations-to-cure-defects-in-current-medical-system-to-avail-financial-assistance-128509"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/delhi-hc-tells-chief-secretary-to-implement-panel-recommendations-to-cure-defects-in-current-medical-system-to-avail-financial-assistance-128509">Also Read:Delhi HC tells Chief Secretary to Implement Panel Recommendations to cure defects in current medical system to avail financial assistance</a></div></div></div><div class="pasted-from-word-wrapper"><p class="selectable-text" style="text-align: justify;">The chargesheet further implicates college director Bennett Abraham and other officials, including former Sabha Secretary TT Praveen, former Finance Controller P Thankaraj, and Clerk PL Shiji. These individuals were found to be directly involved in the fraudulent activities.</p> <p class="selectable-text" style="text-align: justify;">The Karakonam Somervell Memorial CSI Medical College Hospital, one of the first four private medical colleges in Kerala, is owned by the South Kerala Medical Mission (SKMM) of the South Kerala Diocese (SKD), part of the Church of South India (CSI). Located approximately 35 kilometres south of Trivandrum City, the institution has been at the centre of a significant scandal. &nbsp; &nbsp;</p> <p class="selectable-text" style="text-align: justify;">Initially, the Kerala Police Crime Branch investigated the case but exempted top church officials when filing their chargesheet. This led the defrauded parents to approach the Kerala High Court, which subsequently directed the ED to take over the investigation from the Vellarada police, Thiruvananthapuram. &nbsp; &nbsp;&nbsp;</p> <p class="selectable-text" style="text-align: justify;">After starting the investigation, ED called the accused for questioning several times and conducted raids at Bishop House headquarters, Karakonam Medical College, and the houses of the accused. The investigation revealed that the collected bribes were smuggled abroad, violating foreign exchange regulations. Following questioning by the ED in July 2022, the accused attempted to flee to England but was intercepted by immigration authorities at Thiruvananthapuram Airport on the ED’s instructions, reports the Daily. &nbsp; &nbsp;&nbsp;</p> <p class="selectable-text" style="text-align: justify;">Two of the accused were noted for their connections with influential politicians in Kerala, including former Thiruvananthapuram Congress MP and Communist Party of India (CPI) candidate who contested the 2014 Lok Sabha elections. The chargesheet comes after investigations by Kerala’s Admission and Supervisory Committee for Medical Education, which reported that students had paid up to Rs 60 lakh for admissions, including aspirants from Tamil Nadu, who were ineligible for medical courses in Kerala. &nbsp; &nbsp;</p> <p class="selectable-text" style="text-align: justify;">The internal conflict within the CSI Church brought these corrupt practices to light. The Kerala High Court had previously questioned the state police on their inaction against the accused, with Justice P V Kunhikrishnan expressing concerns over the lack of arrests. The Pinarayi Vijayan government has faced criticism for its leniency towards the church, allegedly to secure political support. &nbsp;</p></div><p style="text-align: left;"><a href="https://medicaldialogues.in/news/health/kerala-money-laundering-case-ed-interrogates-karakonam-medical-college-director-97013" target="_blank">Also Read: Kerala money laundering case: ED interrogates Karakonam medical college Director</a></p>

106. What Are The Challenges Faced By New Mothers Diagnosed With Breast Cancer? - Dr Lakhan Kashyap

     Wed, 15 May 2024 06:43:20 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/15/238242-challenges-faced-by-new-mothers-diagnosed-with-breast-cancer.webp' /><div class="pasted-from-word-wrapper" align="justify"> <p>Motherhood is a rollercoaster of intense feelings and changes. Bringing a new life into the world is both beautiful and tough. A woman's body goes through big shifts that can be hard to understand at first. It's easy for a new mom to feel lost in all the baby duties. Breast cancer, can strike women at any age, making it a serious health concern worldwide.</p> <p>Being pregnant adds another layer of worry on top of the already difficult challenge. However, some hospitals specialise in helping pregnant women with cancer. Cancer-specific hospitals can provide the best care for both mom and baby, helping them get healthy and overcome cancer. There are challenges when new mothers are diagnosed with breast cancer. </p> <p>Pregnancy-associated breast cancer (PABC) is breast cancer diagnosed during pregnancy, within one year of delivery, or during lactation. This is a challenging situation as the welfare of both mother and fetus/newborn must be considered while planning evaluation and treatment. Pregnancy-associated breast cancer is an uncommon event. </p><p>The incidence of PABC is estimated to be around 15 to 30 per 100000 deliveries, with more cases diagnosed in the first year after delivery than during pregnancy. Women diagnosed with PABC often have similar prognoses when compared to women with breast cancer, however, the evaluation and management might pose certain challenges.</p> <p><u><b>Delay in Diagnosis </b></u></p> <p>Normal physiologic changes in breast during pregnancy and lactation make it difficult to identify lumps in breast. This can lead to a delay of two to three months in diagnosis. This may also result in advanced stages of breast cancer at diagnosis. As per one report from TMH Mumbai, nearly half of women with PABC have advanced breast cancer.</p> <p><b><u>Evaluation</u> </b></p> <p>Mammography cannot be done during pregnancy due to risk of radiation exposure to the fetus. The women with PABC need to undergo ultrasound or MRI. Similarly, PET-CT is contraindicated, and staging evaluation often requires MRI. This often results in an increased cost of evaluation.</p> <p><u><b>How does breast cancer in a pregnant woman progress? </b></u></p> <p>The body undergoes remarkable changes throughout pregnancy, with cells quickly dividing, which encourages the development of new life. Rapid cell activity, meanwhile, may sometimes result in unanticipated problems, like the possible emergence of breast cancer. Knowing this biological process will enable pregnant women to put their breast health first.</p> <p><u><b>Risks related to ageing and genetics</b></u></p> <p>Age and family history become significant on this journey. Women with a family history of breast cancer or those who become mothers later in life may be at higher risk. It's like learning one's way around a family history or understanding past health chapters and preparing for the coming ones.</p> <p><u><b>Treatment Decisions</b></u></p> <p>One of the most daunting challenges for pregnant women with breast cancer is determining the best course of treatment. Balancing the urgent need to eradicate cancer while safeguarding the health of the unborn baby requires careful consideration and expert medical guidance. </p> <p>Surgery (either breast conservation or mastectomy) for PABC in eligible women is safe and feasible during any trimester of pregnancy. The women with PABC can receive chemotherapy after the first trimester. However, biologic agents such as trastuzumab and endocrine therapy such as tamoxifen are contraindicated during pregnancy and breastfeeding. Radiation therapy is contraindicated during pregnancy and is often delayed till after delivery.</p> <p>Choosing the right treatment path is important for patients. A doctor can suggest various treatment options, such as lumpectomy (removal of the tumour and surrounding tissue) or mastectomy (removal of the entire breast), which may be considered depending on the size and location of the tumour.</p> <p>Chemotherapy uses powerful drugs to kill cancer cells. The timing and choice of chemotherapy drugs will be carefully tailored to minimise potential harm to the developing fetus. Also, radiation therapy uses high-energy beams to target and destroy cancer cells. It may be used post-surgery to eliminate any remaining cancer cells. </p><p>Although radiation treatment can be delayed till after delivery , if deemed necessary during pregnancy, specialised techniques, such as shielding the abdomen to protect the foetus, are employed to minimise radiation exposure to the unborn child. Such treatment options can be used for new mothers who have been diagnosed with breast cancer.</p> <p><u><b>Making tough decisions </b></u></p> <p>Women who are pregnant and have been diagnosed with breast cancer often have to make very personal and challenging decisions involving their treatment and the health of their unborn child. </p><p>Delaying treatment until after delivery or doing chemotherapy during pregnancy, requires careful consideration. Pregnant women who have breast cancer must have open discussions with their doctors about available treatments, risks, and benefits.</p> <p><u><b>Timing of delivery </b></u></p> <p>Timing of delivery with respect to chemotherapy is carefully considered and recovery of mother’s white blood cell counts, and platelet counts is ensured to prevent complications during delivery.</p> <p><b><u>Breastfeeding</u></b></p> <p>Breastfeeding - Breastfeeding is often possible from the opposite breast. However, patients receiving chemotherapy, biologic therapy, or endocrine therapy should not breastfeed infants. </p></div><div class="pasted-from-word-wrapper" align="justify"><b><i>Disclaimer: The views expressed in this article are of the author and not of Medical Dialogues. The Editorial/Content team of Medical Dialogues has not contributed to the writing/editing/packaging of this article.</i></b></div><div class="pasted-from-word-wrapper" align="justify"> </div>

107. Health Ministry directs PGI Chandigarh Director to expedite completion of Satellite Centres

     Wed, 15 May 2024 06:00:34 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238191-download-15.webp' /><p style="text-align: justify; ">Chandigarh: Taking cognizance of the delay in the completion of PGI’s satellite centres in Una and Ferozepur, the Ministry of Health and Family Welfare has issued a directive to the Postgraduate Institute of Medical Education and Research (PGI) Chandigarh director to ensure regular inspections and monitoring to accelerate the process. </p><p style="text-align: justify; ">This directive came from the latest meeting of the standing finance committee held in New Delhi.</p><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">The committee emphasized that to ensure cooperation and efficiency of the work process, the tenders for civil works and medical services need to be combined. Currently, these services are managed separately by the institute and this is creating delays in the completion of the work. The construction of PGI satellite centres in Ferozepur and Una was initially slated for completion by 2021. However, progress has been slow, and in 2022, the parliamentary committee of the Rajya Sabha criticized PGI for the delays, reports <a href="https://timesofindia.indiatimes.com/city/chandigarh/health-ministry-directs-pgi-to-expedite-satellite-units-in-una-and-ferozepur/articleshow/110046051.cms" target="_blank">Times of India</a>.</p></div><div class="pasted-from-word-wrapper"><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/health/doctors/pgis-prof-mandeep-singh-dhillon-retires-after-37-years-of-service-128440"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/pgis-prof-mandeep-singh-dhillon-retires-after-37-years-of-service-128440">Also Read:PGI's Prof Mandeep Singh Dhillon retires after 37 years of service</a></div><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">In February, the foundation stone for the Ferozepur satellite centre was laid by Prime Minister Narendra Modi virtually. This centre had an allocated budget of Rs 490.54 crores and it will feature 100 beds, including 30 for intensive care and high-dependency units. It will house 10 clinical speciality departments, five support departments, and multiple operation theatres. Additionally, the building will be a platinum-rated green hospital, utilizing modern construction techniques to ensure sustainability.</p> <p style="text-align: justify; ">The Una satellite centre is supposed to be a 300-bed hospital with the future plans of turning it into a medical college. Spread over 38 acres and costing Rs 491 crores, the facility will include multispeciality outpatient departments (OPDs), an intensive care unit (ICU), a blood bank, modular operation theatres, and consultant rooms. The campus will also house residential units for staff, a shopping complex, and a guest house for visiting faculty, reports the Daily.</p> <p style="text-align: justify; ">PGI received the land for the Una project in 2018, and the foundation stone was laid in 2019. Despite these early steps, construction has lagged, prompting the recent directives to accelerate progress. The health ministry's insistence on regular inspections and combined tenders aims to eliminate bottlenecks and ensure the timely completion of these critical healthcare facilities.&nbsp;</p> <p><a href="https://medicaldialogues.in/state-news/chandigarh/95-faculty-members-to-be-recruited-for-advanced-mother-and-child-centre-at-pgi-chandigarh-128391" target="_blank">Also Read: 95 faculty members to be recruited for Advanced Mother and Child Centre at PGI Chandigarh</a></p></div>

108. Novo Holdings to acquire majority stake in Single Use Support

     Wed, 15 May 2024 05:30:42 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/01/25/230947-acquisition-50-1.webp' /><p><b>Denmark</b>: Novo Holdings A/S has announced that it has agreed to acquire a majority stake in Single Use Support, a fast-growing life science tools company providing advanced technology solutions for the pharmaceutical production process.<br></p><div class="pasted-from-word-wrapper"><p>Novo Holdings will acquire an approximately 60% controlling stake, alongside the two company founders who will each retain 10% and Danaher which will retain 20% of the share capital.</p><p>Founded in 2017 in Kufstein, Austria by Johannes Kirchmair and Thomas Wurm, Single Use Support is at the forefront of transforming the production process for advanced pharmaceutical modalities with its equipment and consumables used in the bioprocessing value chain. With a focus on solutions for biological drug substances, cell and gene therapies, and mRNA vaccines, the company's customers include leading pharma companies, biotech companies and CDMOs.</p><p>Single Use Support's products have rapidly gained widespread adoption by enhancing operational efficiency, minimising leakage, and effectively mitigating contamination risks in the pharmaceutical production process.</p><p>Johan Hueffer, Senior Partner, Principal Investments, Novo Holdings, said: "We are pleased to announce the acquisition of a majority stake in Single Use Support, a leading provider of advanced fluid management solutions. This transaction marks an important and complimentary addition to our fast-growing life science tools &amp; diagnostics portfolio and represents our first control investment in the DACH region, a vital hub for life sciences. This investment also underscores our commitment to advancing leading healthcare therapies and technologies."</p><p>Tuomas Toiviainen, Partner, Principal Investments, Novo Holdings, added, "We are excited to partner with existing shareholders and management to support the next phase of growth and drive further innovation in the rapidly expanding bioprocessing market. This acquisition demonstrates our expertise and investment focus in backing high-quality life science tools companies. We look forward to working with the Single Use Support management team and employees who share our passion for innovation in the life science space."</p><p>Johannes Kirchmair and Thomas Wurm, founders of Single Use Support and board members, said,&nbsp;"Welcoming Novo Holdings as a partner marks a significant milestone in our growth journey at Single Use Support. We take pride in having nurtured and developed our company into a key player in the life sciences sector. As we embark on this new chapter, we are enthusiastic about the prospects of partnering with Novo Holdings, a global leader in life science investments. The collaboration aligns perfectly with our mission and complements our existing partnership with Danaher, which will continue as a valued partner. Together, we look forward to advancing our impact and innovation in the life sciences industry."</p><p>Chris Riley, Executive Vice President, Biotechnology Group, Danaher, said, "We are pleased to continue our involvement in Single Use Support and to partner with Novo Holdings as we take the company to the next level. At Danaher, we are focused on leveraging the power of science and technology to meaningfully improve human health, which makes Novo Holdings a very good long-term partner for us in the collaboration at Single Use Support and beyond."</p><p>Christian Praxmarer, CEO, Single Use Support, said,&nbsp;"Novo Holdings is joining us at a crucial moment as we prepare to further strengthen our global footprint, focusing on markets outside of Europe such as the US and Asia, and to engage with new customers. With significant insights into the life science tools sector and a comprehensive industry network, I am excited to work alongside Novo Holdings and make new strides in our shared mission of bringing better treatments to patients."</p><p>The transaction is subject to regulatory approvals. Kromann Reumert, DORDA, Linklaters and Wilson Sonsini served as legal advisors and William Blair served as financial advisor to Novo Holdings. E+H served as legal advisor while Jefferies LLC served as financial advisor to Single Use Support.</p></div><p><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/novo-nordisk-parent-invests-in-indias-manipal-hospital-chain-124128">Novo Nordisk parent invests in India's Manipal hospital chain</a></i></b></p>

109. Second NEET aspirant who went missing from Kota traced in Uttar Pradesh

     Wed, 15 May 2024 05:30:31 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/15/238247-missing-1.webp' /><p style="text-align: justify; "><b>Kota: </b>Two days after a second NEET aspirant went missing from his PG room in Kota, the city police traced him in Kushinagar, UP on Monday night and has been brought back to Kota for interrogation after a CCTV camera showed him riding a motorbike with another boy to reach Kota railway station.</p><p style="text-align: justify; ">The student's location was traced after the Kota police swung into action and through technical investigation and inquiry. Following this, the local police were contacted and the whereabouts of the missing teen were shared with them and they rescued him on Monday night, Kota city SP Amrita Duhan said on Tuesday. A team of Kota police was also dispatched to Khushinagar, she added.</p><p style="text-align: justify; ">Medical Dialogues team had recently reported that Another 19-year-old student who was preparing for the medical entrance exam in Kota had gone missing. This incident has happened nearly a week after a NEET aspirant left his PG room with Rs 8,000 in his pocket.</p><p style="text-align: justify; "><b>Also read- <a href="https://medicaldialogues.in/state-news/rajasthan/fearing-failure-in-neet-exam-another-neet-aspirant-goes-missing-from-kota-128495" target="_blank">Fearing Failure In NEET Exam, Another Aspirant Goes Missing From Kota</a></b></p><p style="text-align: justify; ">Bihar native Singh, who had been preparing for the entrance exam in the coaching hub for the last two years, left his paying guest room in Swarn Vihar colony on the intervening night of May 11 and 12.</p><p style="text-align: justify; ">Kunhari Circle inspector Arvind Bhrdwaj said the boy was traced on Monday night and has been brought to Kota by the city police. It is clear whether the student reached there by his wish. Further details will be ascertained after his statement is recorded here, added Bhardwaj.&nbsp;</p><p style="text-align: justify; ">On the basis of CCTV footage, it was found that Singh got onto a bike with another boy and reached Kota Railway Station from where he boarded a train, DSP Rajesh Soni told PTI.</p><p style="text-align: justify; ">Before the police traced him, Singh left a note behind in which he said that he couldn’t do well in the NEET exam and won’t be able to crack it. Further, he asked the readers to look for him near the Kota Barrage, located over the Chambal river but the police couldn’t find him there.</p><p style="text-align: justify; ">However, the police earlier declined the possibility of the boy committing suicide as no trace of him was found near the barrage. It was suspected that the student left the note in his room to misguide the police and his parents.</p><p style="text-align: justify; ">Circle Inspector Arvind Bhardhwaj told the <a href="https://indianexpress.com/article/cities/jaipur/second-neet-aspirant-who-went-missing-from-kota-found-in-up-9329304/" rel="nofollow">Indian Express</a>, “Meanwhile, we were searching for the CCTV footage in which it could be seen that the child went towards the railway station and not towards Kota Barrage. The Kota SP had informed the GRP and RPF about this case and had shared the student’s appearance and location with the Kushinagar police based on which he was detained safely."</p><p style="text-align: justify; "><b>Also read- <a href="https://medicaldialogues.in/news/education/i-am-leaving-home-will-be-gone-for-five-years-neet-aspirant-goes-missing-after-giving-exam-128332" target="_blank">I Am Leaving Home, Will Be Gone For Five Years: NEET Aspirant Goes Missing After Giving Exam</a></b></p>

110. Breaking the Chain: The Crucial Role of Prediabetes Screening in Preventing Diabetes and Its Complications

     Wed, 15 May 2024 05:11:22 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/15/238221-whatsapp-image-2024-05-14-at-55942-pm.webp' /><p style="text-align: justify; "><b>Preventing Diabetes -A Stitch in Time Saves Nine:</b></p><p style="text-align: justify; ">Diabetes prevention has become extremely critical, necessitating all healthcare stakeholders' actions. Many diabetes-preventative interventions continue to focus primarily on prediabetes. Data regarding prediabetes prevalence is useful in evaluating and predicting the present and potential future diabetes pandemics(1). </p><p style="text-align: justify; "><b>Prediabetes: Indian Scenario </b></p><p style="text-align: justify; ">The Indian Council of Medical Research–India Diabetes (ICMR-INDIAB) study emphasises the enormous burden of prediabetes, where the prevalence of prediabetes in India is estimated to be 136 million, higher than the prevalence of diabetes [101 million] (1).</p><p style="text-align: justify; "><u>Prediabetes Conversion to Diabetes:</u> The conversion rate from prediabetes to type 2 diabetes (T2D) is very high among Asian Indians (2). Mohan et al. reported more than 40% of Indian prediabetes patients developed T2DM within 8 years of follow-up(3). A recently published paper by K.M. Venkat Narayan et al indicated that among the Indian population, the annual transition probability from isolated impaired fasting glucose (i-IFG) to diabetes is 8.6%, while that from impaired glucose tolerance (IGT) to diabetes is 13.9%. The average time spent by Indians in IFG (impaired fasting glucose) and IGT are 9.7 and 6.1 years, respectively (4).</p><p style="text-align: justify; "><u>Prediabetes and Complications: </u>A study from India found that over 10% of people with prediabetes had vascular complications linked to diabetes, indicating that prediabetes is linked to an increased risk of vascular complications. Prediabetes also increases cardiovascular disease [incidence rate per 10,000 person-years: 58.3 for those with normal glucose regulation vs. 67.0 for those with prediabetes] and all-cause mortality [incidence rate per 10,000 person-years: 73.6 for those with normal glucose regulation vs. 81 for those with prediabetes] (5).</p><p style="text-align: justify; "><u>Why is Prediabetes Screening Crucial? </u>High insulin resistance is prominent in Asian Indians, which hastens the progression of diabetes (5). The average time spent by Indians with isolated impaired fasting glucose (i-IFG) and IGT is 9.7 and 6.1 years, respectively (4). Early screening, detection, and treatment of prediabetes are essential in the Indian population since they lower the risk of developing diabetes and its complications (2).</p><p style="text-align: justify; "><b>Prediabetes Screening &amp; Tools</b></p><p style="text-align: justify; ">The RSSDI(Research Society for Study of Diabetes in India) recommends screening of prediabetes in individuals presenting to health care settings for unrelated illnesses, family members of diabetes patients, antenatal care, dental care, overweight children and adolescents at the onset of puberty, and community screening wherever feasible (6). The RSSDI guideline and ADA (American Diabetes Association) 2024 diagnosed prediabetes in an individual having an A1C 5.7–6.4% (39–47 mmol/mol), IFG 100 mg/dL (5.6 mmol/L) to 125 mg/dL (6.9 mmol/L) and 2-h PG during 75-g OGTT (oral glucose tolerance test) 140 mg/dL (7.8 mmol/L) to 199 mg/dL [11.0 mmol/L] (6,7). </p><p style="text-align: justify; ">Non-invasive, easy-to-apply ancillary screening tools are needed for identifying and screening individuals with prediabetes (8). Mohan et al. developed a simple screening tool, the Indian Diabetes Risk Score (IDRS), to screen the population for diabetes. IDRS is computed using age, family history of diabetes, waist circumference, and a subject's physical activity level. The score ranges from 0 to 100; a score ≥60 denotes high risk, 30–60 denotes moderate, and a score &lt;30 in a subject denotes low risk of developing diabetes in the future (9). More recently, the International Diabetes Federation (IDF) has suggested the use of 1-h post-load plasma glucose ≥ 155 mg/dL (8.6 mmol/L) in people with normal glucose tolerance (NGT) during an OGTT to indicate prediabetes (10).</p><p style="text-align: justify; "><b>Risk Factors for the Development of Prediabetes</b></p><p style="text-align: justify; ">According to Indian Expert Group Consensus, the common risk factors for prediabetes in India include age (45 or older), positive family history of diabetes and gestational diabetes, high HbA1c, physical inactivity, poor high-density lipoprotein cholesterol (HDL-C) below 35 mg/dL, high triglycerides (TG) above 200 mg/dL, hypertension or being on hypertension medications (2).</p><p style="text-align: justify; "><b>Early Prediabetes Screening Helps in Early Identification &amp; Management</b></p><p style="text-align: justify; ">A meta-analysis of 7 interventional studies involving 26,389 patients assessed the benefits of effective interventions, which included lifestyle (including dietary and exercise recommendations) or drugs (including acarbose and metformin) on microvascular and macrovascular events in prediabetic patients. The results provided that early effective intervention significantly reduced all-cause mortality by 18% in prediabetic patients without a history of cardiovascular disease (95% CI=0.69~0.98, P=0.03) and retinopathy by 38% [95% CI 0.70-0.98] (11). Another cross-sectional study (n=2968) assessed the prevalence of prediabetes and undiagnosed diabetes in patients with cardiovascular disease according to the ADA criteria. The results showed about 32.4% of them had prediabetes, and up to one-third of those with undiagnosed prediabetes had already been diagnosed with cardiovascular complications (12). These suggest that an early diagnosis and interventions can benefit prediabetes patients. </p><p style="text-align: justify; ">A lifestyle change may reduce the number of prediabetic people who develop diabetes to 20% (13). The Indian Diabetes Prevention Program (IDPP) trial also noted this benefit in Asian Indians. A moderate-intensity exercise, just 150 minutes per week of brisk walking, enhanced insulin sensitivity among prediabetes. However, lifestyle interventions may not be effective and sufficient in all cases of prediabetes. Metformin is the only pharmacologic agent recommended for preventing or postponing T2D. The DCGI (Drug Controller General of India) approved the use of metformin in prediabetes, where lifestyle intervention is insufficiently effective in reducing body weight and improving glucose tolerance (2).</p><p style="text-align: justify; "><b>Take Home Messages</b></p><ul class="hocalwire-editor-list"><li style="text-align: justify;">Prediabetes needs to be the primary target for diabetes prevention. Indian population spends significant years in isolated impaired fasting glucose (i-IFG) and impaired glucose tolerance (IGT).</li><li style="text-align: justify;">Early screening, detection, and treatment of prediabetes lowers the risk of developing diabetes and its complications.</li><li style="text-align: justify;">Indian Diabetes Risk Score and 1-h post-load plasma glucose ≥ 155 mg/dL are simple, practical inexpensive screening tools suggested for the Indian population.</li><li style="text-align: justify;">Early interventions reduced cardiovascular disease by 18% and retinopathy by 38% in prediabetes.</li><li style="text-align: justify;">Lifestyle changes could delay the onset of diabetes, and Metformin is suggested where lifestyle changes are insufficient. Metformin is DCGI approved treatment for the management of prediabetes.</li></ul><p style="text-align: justify; "><b><u>References:</u></b></p><p style="text-align: justify; ">1. Anjana RM, Unnikrishnan R, Deepa M, Pradeepa R, Tandon N, Das AK, Joshi S, Bajaj S, Jabbar PK, Das HK, Kumar A, Dhandhania VK, Bhansali A, Rao PV, Desai A, Kalra S, Gupta A, Lakshmy R, Madhu SV, Elangovan N, Chowdhury S, Venkatesan U, Subashini R, Kaur T, Dhaliwal RS, Mohan V; ICMR-INDIAB Collaborative Study Group. Metabolic non-communicable disease health report of India: the ICMR-INDIAB national cross-sectional study (ICMR-INDIAB-17). Lancet Diabetes Endocrinol. 2023 Jul;11(7):474-489. doi: 10.1016/S2213-8587(23)00119-5. </p><p style="text-align: justify; ">2. Das AK, Mohan V, Ramachandran A, et al. An Expert Group Consensus Statement on “Approach and Management of Prediabetes in India”. J Assoc Physicians India 2022;70(12):69–78.</p><p style="text-align: justify; ">3. Mohan V, Deepa M, Anjana RM, Lanthorn H, Deepa R. Incidence of diabetes and pre-diabetes in a selected urban south Indian population (CUPS-19). J Assoc Physicians India. 2008 Mar;56:152-7. </p><p style="text-align: justify; ">4. Narayan KMV, Kondal D, Chang HH, Mohan D, Gujral UP, Anjana RM, Staimez LR, Patel SA, Ali MK, Prabhakaran D, Tandon N, Mohan V. Natural History of Type 2 Diabetes in Indians: Time to Progression. Diabetes Care. 2024 May 1;47(5):858-863. doi: 10.2337/dc23-1514</p><p style="text-align: justify; ">5. Madhu SV. Defying the Odds: Conquering Prediabetes for a Diabetes-Free Tomorrow. Indian J Endocrinol Metab. 2023 Jul-Aug;27(4):273-276. doi: 10.4103/2230-8210.388224. Epub 2023 Aug 29. </p><p style="text-align: justify; ">6. Chawla R, Madhu SV, Makkar BM, Ghosh S, Saboo B, Kalra S; RSSDI-ESI Consensus Group. RSSDI-ESI Clinical Practice Recommendations for the Management of Type 2 Diabetes Mellitus 2020. Indian J Endocrinol Metab. 2020 Jan-Feb;24(1):1-122. doi: 10.4103/ijem.IJEM_225_20. </p><p style="text-align: justify; ">7. American Diabetes Association Professional Practice Committee; 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2024. Diabetes Care 1 January 2024; 47 (Supplement_1): S20–S42. https://doi.org/10.2337/dc24-S002</p><p style="text-align: justify; ">8. Liu Y, Feng W, Lou J, Qiu W, Shen J, Zhu Z, Hua Y, Zhang M, Billong LF. Performance of a prediabetes risk prediction model: A systematic review. Heliyon. 2023 May 6;9(5):e15529. doi: 10.1016/j.heliyon.2023.e15529. </p><p style="text-align: justify; ">9. Mohan V, Deepa R, Deepa M, Somannavar S, Datta M. A simplified Indian Diabetes Risk Score for screening for undiagnosed diabetic subjects. J Assoc Physicians India. 2005 Sep;53:759-63.</p><p style="text-align: justify; ">10. Bergman M, Manco M, Satman I, Chan J, Inês Schmidt M, Sesti G, Vanessa Fiorentino T, Abdul-Ghani M, Jagannathan R, Kumar Thyparambil Aravindakshan P, Gabriel R, Mohan V, Buysschaert M, Bennakhi A, Pascal Kengne A, Dorcely B, Nilsson PM, Tuomi T, Battelino T, Hussain A, Ceriello A, Tuomilehto J. International Diabetes Federation Position Statement on the 1-hour post-load plasma glucose for the diagnosis of intermediate hyperglycemia and type 2 diabetes. Diabetes Res Clin Pract. 2024 Mar;209:111589. doi: 10.1016/j.diabres.2024.111589. </p><p style="text-align: justify; ">11. An X, Zhang Y, Sun W, Kang X, Ji H, Sun Y, Jiang L, Zhao X, Gao Q, Lian F, Tong X. Early effective intervention can significantly reduce all-cause mortality in prediabetic patients: a systematic review and meta-analysis based on high-quality clinical studies. Front Endocrinol (Lausanne). 2024 Mar 1;15:1294819. doi: 10.3389/fendo.2024.1294819</p><p style="text-align: justify; ">12. Cosic V, Jakab J, Pravecek MK, Miskic B. The Importance of Prediabetes Screening in the Prevention of Cardiovascular Disease. Med Arch. 2023 Apr;77(2):97-104. doi: 10.5455/medarh.2023.77.97-104. </p><p style="text-align: justify; ">13. Tuso P. Prediabetes and lifestyle modification: time to prevent a preventable disease. Perm J. 2014 Summer;18(3):88-93. doi: 10.7812/TPP/14-002.</p><style>div.insert_ads{display:none!important;}</style>

111. Doctors at MASSH Super Specialty Hospital treated 50-year-old woman with rare appendix cancer

     Wed, 15 May 2024 05:00:45 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238162-massh-super-specialty-hospital.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">New Delhi:&nbsp;</span>Doctors at the MASSH Super Specialty Hospital in the national capital have successfully treated a 50-year-old woman suffering from a rare form of appendix cancer, providing her with a new lease on life.</p><p>The woman initially sought medical attention due to persistent right lower abdominal pain and nausea lasting for 15 days. Upon examination, doctors discovered a large tubular, thick-walled cystic mass measuring 14.3 x 13.8 x 8.5 cm. This mass extended from the base of the caecum (a pouch connected to the junction of the small and large intestines) to the right adnexa in the pelvis, indicating a condition known as Mucocele of the appendix.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/doctors-at-apollo-cancer-centre-perform-minimally-invasive-robotic-surgery-on-patient-with-pseudomyxoma-peritonei-128317"><b><i>Also Read:Doctors at Apollo Cancer Centre perform Minimally invasive robotic surgery on patient with Pseudomyxoma Peritonei</i></b></a></p><p style="text-align: justify; ">As per a media report in IANS,"Mucocele of the appendix is a rare clinical entity, and its treatment requires meticulous care and precision, with no spillage technique. Mucocele of the appendix poses diagnostic and therapeutic challenges due to its rarity,” said Dr Sachin Ambekar, Director of Minimal Access Surgery, Surgical Oncology &amp; Medical Director at MASSH, on Monday.</p></div><p style="text-align: justify;">It is so uncommon and occurs in only 0.07-0.63 per cent of all appendectomy cases.</p><p style="text-align: justify;">The team resorted to 3D laparoscopy to ensure precise visualisation and meticulous dissection.</p><p style="text-align: justify;">During the procedure, adhesions were visualised in 360-degree depth perception not seen in conventional laparoscopy, and meticulous dissection was carried out without any mucinous spill.</p><p style="text-align: justify;">A cystic mass of the appendix (14.3 x 13.8 x 8.5 cm), with inflamed walls but without perforation was located in the right iliac fossa. Notably, no lesions were found in the peritoneal cavity, news agency IANS reported.</p><p style="text-align: justify; ">"3D Laparoscopy played a crucial role in this operation by enabling us to visualise and dissect with never before seen 360-degree in-depth precision. This technology offers significant advantages over conventional laparoscopy, particularly in delicate procedures such as this," Dr. Ambekar said.</p><p style="text-align: justify;">Remarkably, the patient experienced no complications during the postoperative period and was discharged from the hospital on the second day, the doctor said.&nbsp;</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><b><i><a class="also-read-media-wrap" href="https://medicaldialogues.in/surgery/cases/rare-case-viable-amputated-part-of-the-appendix-after-autoamputation-a-report-95290"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/surgery/cases/rare-case-viable-amputated-part-of-the-appendix-after-autoamputation-a-report-95290">Also Read:Rare case viable amputated part of the appendix after autoamputation: A report</a></i></b></p></div></div>

112. Persistence with tirzepatide key to effective weight loss, study suggests

     Wed, 15 May 2024 04:30:38 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/11/11/225177-tirzepatide.webp' /><p style="text-align: justify; ">USA: In the ever-evolving landscape of diabetes management, promising new findings suggest that persistence with tirzepatide-a novel investigational therapy-may significantly improve glycemic control and cardiovascular outcomes for patients with type 2 diabetes mellitus. This encouraging revelation underscores the importance of perseverance and tailored treatment strategies in optimizing diabetes care.<br></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">New post hoc data from Lilly's SURMOUNT-1 trial of overweight/obese people but without diabetes suggest that the drug will almost always produce at least 5% weight loss eventually, even among slow responders.</p><p style="text-align: justify; ">The findings presented at the American Association of Clinical Endocrinology (AACE) 2024 conference suggest patience may pay off when using tirzepatide (Zepbound, Eli Lilly) to treat obesity. </p><p style="text-align: justify; ">"Some obesity treatment guidelines suggest anti-obesity medication (AOM) discontinuation that fails to produce 5% or greater weight reduction within 12 weeks. Newer AOMs may take longer to achieve full weight-loss benefit given their recommended dose titration schedule," Kimberly Gudzune, MD, director of the Johns Hopkins Healthful Eating, Activity &amp; Weight Program, Baltimore, Maryland.</p><p style="text-align: justify; ">The analysis showed that among participants who had lost less than 5% of their body weight by week 12 of tirzepatide, nearly all went on to lose 5% or more by week 72. Thus, Gudzune said, "It is reasonable to consider treatment for longer than 12 weeks to determine weight loss response to tirzepatide, which takes at least 20 weeks to reach the highest dose."</p><p style="text-align: justify; ">The post hoc analysis included 1545 patients; they were randomly assigned to total tirzepatide doses of 5 mg, 10 mg, or 15 mg, and had data available at weeks 0, 12, 24, and 72. Among those, 1267 had lost at least 5% of their body weight by week 12, defined as "early responders," and 278 had lost less than 5% of body weight by then, called "slow responders." </p><p style="text-align: justify; ">The study led to the following findings:</p><ul><li style="text-align: justify; ">At baseline, slow responders were significantly more likely to be male (44.8% of slow versus 30.1% of early responders), have higher body weight (24.3 kg versus 21.8 kg), and have lower waist circumference (117.5 cm versus 113.4 cm).</li><li style="text-align: justify; ">There were no significant differences by age, body mass index, prediabetes status, or obesity duration.</li><li style="text-align: justify; ">By the end of dose titration at week 24, 70% of slow responders had achieved 5% or more of body weight reduction, as had 100% of early responders.</li><li style="text-align: justify; ">By 72 weeks, 90% of the slow responders had achieved at least 5% of body weight loss, and 30% had achieved at least 15% reduction.</li><li style="text-align: justify; ">Even in the group maintained on the lowest 5-mg dose throughout the trial, 87% had achieved at least 5% weight loss by week 72, with 15% achieving at least 15%. And in the group that had been titrated up to 15 mg tirzepatide, 94% of slow responders achieved at least 5% weight loss.</li><li style="text-align: justify; ">The mean time to reach 5% weight loss for slow responders who went to achieve 5% or greater weight loss was 24.8 weeks.</li><li style="text-align: justify; ">Of the total 1545 participants, there were 28 who had lost less than 5% of their overall body weight on tirzepatide. Of those, four had missed more than three consecutive doses, and 13 were on the lowest 5-mg dose.</li></ul><p style="text-align: justify; ">"Future studies are warranted for better understanding the variability in weight loss response to tirzepatide treatment," the researchers concluded. </p></div><p style="text-align: justify; "><br></p>

113. Alirocumab addition to statins fails to improve endothelial function in acute MI patients: PACMAN-AMI trial substudy

     Wed, 15 May 2024 04:30:29 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/11/14/225263-myocardial-infarction.webp' /><p style="text-align: justify; ">Switzerland: In a significant development in cardiovascular medicine, findings from a substudy of the PACMAN-AMI randomized clinical trial shed light on the potential benefits of alirocumab in improving endothelial function and reducing coronary atherosclerosis, in patients who have experienced myocardial infarction (MI). This substudy, conducted within the larger PACMAN-AMI trial framework, represents a crucial step forward in understanding the therapeutic potential of alirocumab in post-MI care.<br></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">The research, published in the <i>Atherosclerosis </i>journal, found no further improvement of flow-mediated dilation (FMD) with the addition of alirocumab among patients with acute myocardial infarction (AMI) than 52 weeks of secondary preventative medical therapy, including high-intensity statin therapy. FMD was significantly associated with baseline coronary plaque burden, but not lipid pool or fibrous cap thickness.</p><p style="text-align: justify; ">Myocardial infarction, commonly known as a heart attack, is a life-threatening condition characterized by the interruption of blood flow to the heart muscle, usually due to the obstruction of a coronary artery by a blood clot. Following a heart attack, patients are at increased risk of recurrent cardiovascular events, including further heart attacks and stroke, making effective secondary prevention strategies imperative.</p><p style="text-align: justify; ">Alirocumab, a monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9 (PCSK9), has garnered attention as a potential therapeutic agent for reducing low-density lipoprotein cholesterol (LDL-C) levels and lowering the risk of cardiovascular events. </p><p style="text-align: justify; ">Emrush Rexhaj, Department of Cardiology, Bern University Hospital Inselspital, Freiburgstrasse, Bern, Switzerland, and colleagues aimed to examine the effects of the PCSK9 inhibitor alirocumab added to high-intensity statin on FMD. They also investigated its association with coronary atherosclerosis in non-infarct-related arteries using near-infrared spectroscopy (NIRS), intracoronary intravascular ultrasound (IVUS), and optical coherence tomography (OCT).</p><p style="text-align: justify; ">For this purpose, the researchers conducted a pre-specified substudy among patients recruited at Bern University Hospital, Switzerland, for the randomized-controlled, double-blind, PACMAN-AMI trial that compared the effects of biweekly alirocumab 150 mg versus placebo added to rosuvastatin. At 4 and 52 weeks, brachial artery FMD was measured, and intracoronary imaging at baseline and 52 weeks. </p><p style="text-align: justify; ">The researchers reported the following findings:</p><ul><li style="text-align: justify; ">139/173 patients completed the substudy. There was no difference in FMD at 52 weeks in the alirocumab (n = 68, 5.44 ± 2.24%) <em>versus</em> placebo (n = 71, 5.45 ± 2.19%) group (difference = −0.21%).</li><li style="text-align: justify; ">FMD improved throughout 52 weeks in both groups similarly.</li><li style="text-align: justify; ">There was a significant association between 4 weeks FMD and baseline plaque burden (IVUS) (n = 139, slope = −1.00), but not with lipid pool (NIRS) (n = 139, slope = −7.36), or fibrous cap thickness (OCT) (n = 81, slope = −1.57).</li></ul><p style="text-align: justify; ">The study revealed improvement in endothelial function as evaluated by brachial artery FMD achieved throughout one year with guideline-based secondary preventative medical therapy, including a high-intensity statin in patients with AMI. However, adding PCSK9 inhibitor alirocumab did not further improve endothelial function. </p><p style="text-align: justify; ">FMD was significantly inversely related to non-infarct related arteries (non-IRA) intracoronary plaque burden before treatment initiation, but not to lipid pool or fibrous cap thickness.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Rexhaj E, Bär S, Soria R, Ueki Y, Häner JD, Otsuka T, Kavaliauskaite R, Siontis GC, Stortecky S, Shibutani H, Spirk D, Engstrøm T, Lang I, Morf L, Ambühl M, Windecker S, Losdat S, Koskinas KC, Räber L; PACMAN-AMI Investigators. Effects of alirocumab on endothelial function and coronary atherosclerosis in myocardial infarction: A PACMAN-AMI randomized clinical trial substudy. Atherosclerosis. 2024 May;392:117504. doi: 10.1016/j.atherosclerosis.2024.117504. Epub 2024 Mar 6. PMID: 38513436.</p></div><p style="text-align: justify; "><br></p>

114. Shares of Indegene listed with nearly 46 percent premium

     Wed, 15 May 2024 04:30:19 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/15/238255-shares-50.webp' /><p><span style="text-align: justify; background-color: rgb(255, 255, 255);"><b>New Delhi:&nbsp;</b></span><span style="text-align: justify;">Shares of Indegene Ltd, a healthcare technology company, debuted on the stock market Monday at a 45.95% premium over its issue price of Rs 452. The stock opened at Rs 659.70 on the BSE.</span><br></p><p><span style="background-color: rgb(255, 255, 255); text-align: justify;">At the NSE, it started the trade at Rs 655, registering a gain of 44.91 per cent.</span><br></p><div class="pasted-from-word-wrapper"><div style="text-align: justify;">The Initial Public Offer (IPO) of Indegene got subscribed 69.71 times on the closing day of bidding on Wednesday last week.</div><div style="text-align: justify;">The Rs 1,841.75 crore IPO had a fresh issue of up to Rs 760 crore and an offer-for-sale of up to 2,39,32,732 equity shares.</div><div style="text-align: justify;">The price band for the offer was Rs 430-452 a share.</div><div><div style="text-align: justify;">According to PTI, funds raised through the fresh issue would be used to pay debt, fund capital expenditure requirements, for payment of deferred consideration for one of its past acquisitions, funding inorganic growth and general corporate purposes.</div><div style="text-align: justify;"><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/cdsco-panel-opins-abbott-healthcare-to-conduct-phase-iii-ct-of-clarithromycin-er-tablets-1000mg-128510" style="background-color: rgb(255, 255, 255);">CDSCO Panel opins Abbott Healthcare to Conduct Phase III CT of Clarithromycin ER Tablets 1000mg</a></i></b></div></div></div><div class="pasted-from-word-wrapper"><div><div style="text-align: justify;">Founded in 1998, Indegene offers solutions that help enable biopharmaceutical, emerging biotech and medical devices companies to develop products, launch them in the market, and drive sales throughout their life cycle</div><div style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/indegene-appoints-pravin-rao-dr-ashish-gupta-and-jairaj-purandare-as-independent-directors-94388" style="background-color: rgb(255, 255, 255);">Indegene appoints Pravin Rao, Dr Ashish Gupta and Jairaj Purandare as Independent Directors</a></i></b></div></div></div>

115. Semaglutide tied to meaningful weight loss, waist size reduction and CV benefits in non diabetic overweight adults: Study

     Wed, 15 May 2024 04:30:07 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/03/06/233695-obesity-50-1.webp' /><p style="text-align: justify; ">Researchers have found in latest&nbsp; research&nbsp; that Semaglutide can produce clinically meaningful weight loss and reduce waist size for at least 4 years in adults with overweight or obesity who don’t have diabetes, and delivers cardiovascular benefits irrespective of weight lost.&nbsp;</p><p style="text-align: justify; ">Two important studies based on the largest and longest clinical trial of the effects of semaglutide on weight in over 17,000 adults with overweight and obesity but not diabetes find patients lost on average 10% of their body weight and over 7cm from their waistline after 4 years. </p><p style="text-align: justify;">Clinically meaningful weight loss was achieved by men and women of all races, ages, and body sizes, across all regions, with a lower rate of serious adverse events compared with placebo. </p><p style="text-align: justify;">Over half of adults taking semaglutide moved down at least one BMI category after 2 years compared to 16% receiving placebo; and 12% reached a healthy BMI (25 kg/m² or less) compared with 1% in the placebo group. </p><p style="text-align: justify;">Importantly, the findings also indicate that semaglutide delivers cardiovascular benefits irrespective of starting weight and the amount of weight lost-suggesting that even patients with mild obesity or those not losing weight are likely to gain some advantage. </p><p style="text-align: justify; ">Two important studies are being presented at this year’s European Congress on Obesity (ECO) in Venice, Italy (12-15 May), based on the landmark Semaglutide and Cardiovascular Outcomes (SELECT) trial from the same international author group. The first new study, led by Professor Donna Ryan from Pennington Biomedical Research Centre, New Orleans, USA, and being published simultaneously in <i>Nature Medicine</i>, examines the long-term weight effects of semaglutide. The second study led by led by Professor John Deanfield from University College London, UK, investigates whether the cardiovascular benefits are related to starting weight or the amount of weight lost. </p><p style="text-align: justify;">Semaglutide is a GLP-1 medication primarily prescribed for adults with type 2 diabetes but is also approved for weight loss in people with obesity or overweight who have at least one other health issue. This class of medications simulate the functions of the body’s natural incretin hormones, which help to lower blood sugar levels after a meal. Adjusting these hormone levels can also make people feel full, and in doing so, helps lower their daily calorie intake. </p><p style="text-align: justify;">In 2023, the SELECT trial reported that adults with overweight or obesity but not diabetes taking semaglutide for more than 3 years had a 20% lower risk of heart attack, stroke, or death due to cardiovascular disease, and lost an average 9.4% of their bodyweight [1]. </p><p style="text-align: justify;">Between October 2018 and June 2023, 17,604 adults (aged 45 or older; 72% male) from 804 sites in 41 countries with overweight or obesity (BMI of 27 kg/m² or higher) were enrolled and treated with Semaglutide (2.4mg) or placebo for an average of 40 months. They had previously experienced a heart attack, stroke and/or had peripheral artery disease, but did not have type 1 or type 2 diabetes when they joined the study. </p><p style="text-align: justify; ">The researchers examined markers of obesity that include body composition and fat distribution (waist circumference and waist circumference-to-height ratio [WHtR]), rather than just BMI alone, to help clarify the effect of semaglutide on central abdominal fat which has been proven to cause greater cardiovascular risk than general obesity. </p><h3 style="text-align: justify; ">Clinically meaningful weight loss in all sexes, races, body sizes, and regions </h3><p style="text-align: justify;">The first new study shows that once-weekly treatment with semaglutide can produce clinically meaningful and sustained weight loss and decrease waist size for at least 4 years in adults with overweight or obesity who do not have diabetes, with a lower rate of serious adverse events compared with placebo. </p><p style="text-align: justify;">Importantly, men and women of all races, ages, and body sizes, across all geographical regions were able to achieve sustained, clinically meaningful weight loss. </p><p style="text-align: justify;">“Our long-term analysis of semaglutide establishes that clinically relevant weight loss can be sustained for up to 4 years in a geographically and racially diverse population of adults with overweight and obesity but not diabetes,” says Professor Ryan. “This degree of weight loss in such a large and diverse population suggests that it may be possible to impact the public health burden of multiple obesity-related illnesses. While our trial focused on cardiovascular events, many other chronic diseases including several types of cancer, osteoarthritis, and anxiety and depression would benefit from effective weight management.” </p><p style="text-align: justify;">In the semaglutide group, weight loss continued to week 65 and was sustained for 4 years, with participants’ losing on average 10.2% of their body weight and 7.7cm from their waistline, compared with 1.5% and 1.3cm respectively in the placebo group. </p><p style="text-align: justify;">Similarly, in the semaglutide group, average WHtR fell by 6.9% compared with 1% in the placebo group. </p><p style="text-align: justify;">These improvements were seen across both sexes and all categories of race and age, irrespective of starting blood sugar (glycaemic) status or metabolically unhealthy body fat. However, women taking semaglutide tended to lose more weight on average than men, and Asian patients lost less weight on average than other races. </p><p style="text-align: justify;">Interestingly, after 2 years over half (52%) of participants treated with semaglutide had transitioned to a lower BMI category compared with 16% of those given placebo. For example, the proportion of participants with obesity (BMI 30kg/m² or higher) declined from 71% to 43% in the semaglutide group, and from 72% to 68% in the placebo group. Moreover, 12% of adults in the semaglutide group achieved a healthy weight (BMI 25kg/m² or less) compared with 1.2% in the placebo group </p><p style="text-align: justify;">For each BMI category (&lt;30, ≤30-&lt;35, ≤35-&lt;40, and ≥40 kg/m2) there were lower rates (events per 100 years of observation) of SAEs with semaglutide (43.23, 43.54, 51.0, 47.06) than with placebo (50.48, 49.66, 52.73, 60.85) respectively. </p><p style="text-align: justify;">There were no unexpected safety issues with semaglutide in the SELECT trial. The proportion of participants with serious adverse events (SAEs) was lower in the semaglutide group than the placebo group (33% vs 36%), mainly driven by differences in cardiac disorders (11.5% vs 13.5%). More patients receiving semaglutide discontinued the trial due to gastrointestinal symptoms, including nausea and diarrhoea, mainly during the 20-week dose escalation phase. Importantly, semaglutide did not lead to an increased rate of pancreatitis, but rates of cholelithiasis (stones in gallbladder) were higher in the semaglutide group. </p><h3 style="text-align: justify; ">Cardiovascular benefits irrespective of weight loss </h3><p style="text-align: justify;">The second study examined the relationship between weight measures at baseline, and change in weight during the study with cardiovascular outcomes. These included time to first major adverse cardiovascular event (MACE) and heart failure measures. </p><p style="text-align: justify;">The findings showed that treatment with semaglutide delivered cardiovascular benefits, irrespective of the starting weight and the amount of weight lost. This suggests that even patients with relatively mild levels of obesity, or those who only lose modest amount of weight, may have improved cardiovascular outcome. </p><p style="text-align: justify;">“These findings have important clinical implications”, says Professor Deanfield. “Around half of the patients that I see in my cardiovascular practice have levels of weight equivalent to those in the SELECT trial and are likely to derive benefit from taking Semaglutide on top of their usual level of guideline directed care.” </p><p style="text-align: justify;">He adds, “Our findings show that the magnitude of this treatment effect with semaglutide is independent of the amount of weight lost, suggesting that the drug has other actions which lower cardiovascular risk beyond reducing unhealthy body fat. These alternative mechanisms may include positive impacts on blood sugar, blood pressure, or inflammation, as well as direct effects on the heart muscle and blood vessels, or a combination of one or more of these.” </p><p style="text-align: justify;">Despite these important findings, the authors caution that SELECT is not a primary prevention trial so that the data cannot be extrapolated to all adults with overweight and obesity to prevent MACE; and despite being large and diverse, it does not include enough individuals from different racial groups to understand different potential effects.</p><p style="text-align: justify;">References:</p><p style="text-align: justify;">1. Ryan, D.H., Lingvay, I., Deanfield, J. et al. Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial. Nat Med (2024). https://doi.org/10.1038/s41591-024-02996-7</p><p style="text-align: justify;">2. Semaglutide can produce clinically meaningful weight loss and reduce waist size for at least 4 years in adults with overweight or obesity who don’t have diabetes, and delivers cardiovascular benefits irrespective of weight lost, European Association for the Study of Obesity, Meeting: European Congress on Obesity (ECO2024).</p>

116. MCD plans to set up new medical college complex at Rajan Babu Institute of Pulmonary Medicine and Tuberculosis

     Wed, 15 May 2024 04:00:57 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238101-new-medical-college-campus.webp' /><p style="text-align: justify; "><b>New Delhi-&nbsp;</b>The Municipal Corporation of Delhi (MCD) has planned to set up a new medical college complex at the cost of Rs 380 crore at Rajan Babu Institute of Pulmonary Medicine and Tuberculosis (RBIPMT) under the Civil Lines zone in North Delhi. The complex will be developed for MBBS and postgraduate medical college students.</p><p style="text-align: justify; ">As per TOI report, the present plan is to construct a proper medical college building with laboratories, hostels, staff quarters, a library, an auditorium, and hostel blocks on the RBIPMT Hospital campus.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-colleges/neighrihms-to-start-to-training-faculty-members-for-new-medical-college-128347" style="background-color: rgb(255, 255, 255);"><b>Also Read:&nbsp;</b>NEIGHRIHMS To Start to Training Faculty Members for New Medical College</a></p><p style="text-align: justify; ">According to the proposal submitted by the MCD commissioner, the corporation plans to allocate ₹95 crore annually over the next four years to develop the medical college campus, which will also have a provision for 150 MBBS students and 50 MD/MS seats, reports <a href="https://www.hindustantimes.com/cities/delhi-news/delhi-civic-body-to-develop-380-crore-new-medical-college-101715366776363.html" rel="nofollow">HT</a>.</p><p style="text-align: justify; ">Speaking to the <a href="https://timesofindia.indiatimes.com/city/delhi/mcd-plans-to-construct-medical-college-building-at-rajan-babu-hospital/articleshow/110021143.cms#google_vignette" target="_blank" rel="nofollow" style="background-color: rgb(255, 255, 255);">TOI</a>, an official said “<i style="background-color: rgb(255, 255, 255);">The proposal also includes increasing the number of MBBS students from 60 to 150 per year and introducing postgraduate courses by adding 50 students per year in a phased manner. A proposal for the construction of the building will be placed in the House for approval and expenditure sanction. It will also include making provisions for recurring expenditure of Rs 95 crore per year (approximately)</i>”, adding that the final nod will be received from the standing committee.</p><p style="text-align: justify; ">Once the scheme is incorporated, RBIPMT will function as a 'twin medical' facility with Hindu Rao Hospital, the largest tertiary care hospital run by the municipality. This is so, students will get the facility of a medical college at RBTB hospital and practice at Hindu Rao Hospital, the official said. </p><p style="text-align: justify; ">“<i>The distance from Hindu Rao to the proposed site for the college is about 5 km, hence, well within the National Medical Commission guidelines</i>,” the official added.</p><p>The communication submitted by the MCD commissioner said that a cost estimate of ₹380 crore has been prepared based on project reports of Atal Bihari Vajpayee Institute of Medical Sciences and Ram Manohar Lohia hospital with concept design of 250 admissions and per unit cost is estimated to be ₹1.9 crore, adds HT. The proposal said that the corporation may approve the increase in intake of students from 60 MBBS seats to 150 MBBS seats, construction of medical campus with laboratories, hostels, auditoriums, multi-speciality health block, library, staff quarters among other facilities and administrative approval of ₹380 crore for the project.</p><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-colleges/assam-to-set-up-new-medical-college-in-karimganj-with-100-mbbs-seats-125688"><b>Also Read:&nbsp;</b>Assam to set up New Medical College in Karimganj With 100 MBBS Seats</a></div>

117. Meta-analysis reveals insights into mRNA vaccine-induced thyroid diseases

     Wed, 15 May 2024 04:00:54 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/02/10/201267-covid-vaccination.webp' /><p style="text-align: justify; ">USA: In a groundbreaking meta-analysis presented at the American Association of Clinical Endocrinology (AACE) conference of 2024, researchers shed light on the rare phenomenon of mRNA vaccine-induced hyperthyroidism, particularly in the context of the SARS-CoV-2 vaccines. This comprehensive study delved into the incidence, risk factors, and outcomes linked to this condition, offering crucial insights for healthcare providers and vaccine recipients.<br></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">The meta-analysis revealed that the chance of new-onset thyroid disease following mRNA COVID-19 vaccine administration was rare but still noteworthy. </p><p style="text-align: justify; ">The researchers found that there were 77 cases of thyroid-related autoimmune diseases among people with no history of autoimmune disease before receiving the COVID-19 vaccine, with 39 cases of subacute thyroiditis (SAT), and 38 cases of Graves' disease (GD). </p><p style="text-align: justify; ">Additionally, these autoimmune diseases occurred more frequently in women than in men, "about a 2-1 breakdown, which is what we would expect as women tend to have more autoimmune disease overall than men," Vikram Gill, MBBS, of St. Peter's University Hospital/Rutgers University in New Brunswick, New Jersey, said at the poster presentation. </p><p style="text-align: justify; ">10 men and 28 women were diagnosed with Graves' disease, while 13 and 26, respectively, were diagnosed with SAT. The average ages of women and men who developed post-vaccination autoimmune diseases were around 44 and 41, respectively.</p><p style="text-align: justify; ">The emergence of mRNA vaccines, such as those developed against COVID-19, has revolutionized the field of immunization, providing potent protection against infectious diseases. However, as with any medical intervention, rare adverse events can occur. One such complication that has garnered attention is hyperthyroidism, an overactive thyroid gland, which has been reported following mRNA vaccination.</p><p style="text-align: justify; ">Previous research has revealed links between COVID-19 vaccination and autoimmune disorders, although other research has indicated that having a COVID-19 diagnosis raises the risk for these same disorders, but that vaccination can mitigate that risk. </p><p style="text-align: justify; ">The researchers searched for articles reporting GD and SAT following COVID-19 mRNA vaccinations from 2019 to November 2023. </p><p style="text-align: justify; ">The following were the key findings of the study:</p><ul><li style="text-align: justify; ">A GD diagnosis happened about 40 days after the first dose, with SAT emerging sooner, at about 11 days after the first jab.</li><li style="text-align: justify; ">In the group with GD, over half developed hyperthyroidism symptoms after the first dose of the mRNA vaccine, while around 45% showed symptoms after dose 2. Roughly 5% showed signs after the third dose.</li><li style="text-align: justify; ">In the SAT group, almost 54% showed hyperthyroidism symptoms after dose 1, as did about 44% after dose 2, and around 5% after dose 3.</li><li style="text-align: justify; ">Positive anti-TPO [anti-thyroid peroxidase] was only seen in five out of 32 patients who were tested (15.6%), and 32 patients (74.4%) were negative for anti-TPO.</li><li style="text-align: justify; ">Eleven out of 33 patients who were tested (33.3%) were positive for anti-Tg [antithyroglobulin], 22 patients (66.6 %) were negative,</li></ul><p style="text-align: justify; ">Moving forward, the findings of this meta-analysis will inform clinical practice and public health strategies surrounding mRNA vaccination. Enhanced awareness, coupled with tailored monitoring protocols, will ensure the continued safety and efficacy of these groundbreaking vaccines in combating infectious diseases like COVID-19. As the global vaccination effort progresses, studies like this serve as invaluable tools in optimizing healthcare delivery and promoting vaccine confidence.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; "><em>Gill V and Luo H "mRNA (SARS-CoV-2) vaccine-induced hyperthyroidism -- Learnings based on the meta-analysis" AACE 2024.</em></p></div><p style="text-align: justify; "><br></p>

118. Seralutinib effective in managing pulmonary arterial hypertension: Lancet

     Wed, 15 May 2024 04:00:14 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/06/02/211031-idiopathic-pulmonary-fibrosis.webp' /><p style="text-align: justify; ">In the field of pulmonary arterial hypertension (PAH), where morbidity and mortality rates remain alarmingly high, a new inhaled drug can greatly enhance the outcomes in patients. A recent study called as the TORREY trial unveiled promising results regarding the efficacy and safety of a new inhaled drug, the Seralutinib, in managing this life-threatening condition. The findings were published in <i>The Lancet Respiratory Medicine.&nbsp;</i></p><p style="text-align: justify; ">The TORREY trial revealed that Seralutinib, an inhaled kinase inhibitor, targets the crucial pathways involved in PAH progression. Seralutinib disrupts inflammatory, proliferative and fibrotic pathways driving pulmonary vascular remodeling in PAH by inhibiting platelet-derived growth factor receptor, the colony stimulating factor 1 receptor and mast or stem cell growth factor receptor kinases.</p><p style="text-align: justify; ">This phase 2, randomized, multicenter, double-blind, placebo-controlled study enrolled a total of 86 adult patients with PAH from various hospital and community sites. The participants were randomly assigned to receive either Seralutinib or a placebo via dry powder inhaler over a span of 24 weeks. The patients were already receiving standard background therapy for PAH. The primary endpoint of the trial was the change in pulmonary vascular resistance (PVR) from baseline to 24 weeks. </p><p style="text-align: justify; ">The results observed that patients treated with Seralutinib expressed a significant reduction in PVR when compared to the patients receiving the placebo. Also, the least squares mean difference in PVR change between the Seralutinib and placebo groups was clinically significant at -96.1 dyne·s/cm5 (p=0.03). While generally well-tolerated, the most common treatment-emergent adverse event in both groups was cough which was reported in 38% of the placebo group and 43% of the Seralutinib group.</p><p style="text-align: justify; ">These findings hold profound benefits for the management and treatment of PAH. This trial offers hope for patients with this debilitating condition by demonstrating the efficacy of inhaled Seralutinib in reducing PVR. The safety profile of the drug suggests its potential as a valuable addition to existing PAH therapies. Further investigation and development will guide forward this innovative therapy against pulmonary arterial hypertension by offering renewed prospects for patients throughout the globe.</p><p style="text-align: justify; ">Source:</p><p style="text-align: justify; ">Frantz, R. P., McLaughlin, V. V., Sahay, S., Escribano Subías, P., Zolty, R. L., Benza, R. L., Channick, R. N., Chin, K. M., Hemnes, A. R., Howard, L. S., Sitbon, O., Vachiéry, J.-L., Zamanian, R. T., Cravets, M., Roscigno, R. F., Mottola, D., Osterhout, R., Bruey, J.-M., Elman, E., … Ghofrani, H.-A. (2024). Seralutinib in adults with pulmonary arterial hypertension (TORREY): a randomised, double-blind, placebo-controlled phase 2 trial. In The Lancet Respiratory Medicine. Elsevier BV. <a href="https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00072-9/abstract" rel="nofollow">https://doi.org/10.1016/s2213-2600(24)00072-9</a></p>

119. SC refuses to accept IMA president's Apology, Reserves verdict on Patanjali Misleading Ads case

     Wed, 15 May 2024 04:00:01 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/12/02/192719-supreme-court-new.webp' /><p style="text-align: justify; "><b>New Delhi:</b>&nbsp;While considering the misleading ads case against Patanjali, the Supreme Court recently dismissed the apology tendered by the president of the Indian Medical Association (IMA), for his remarks on the top court's ruling.</p><p style="text-align: justify; ">Earlier this month, the Supreme Court bench had slammed the IMA Chief for targeting the apex court in a recent interview with PTI about Patanjali Ayurved's misleading advertisements case. Although Dr. Asokan expressed his unequivocal apologies by making his personal appearance, the bench was not pleased with his actions and dismissed the apology.</p><p style="text-align: justify; ">Meanwhile, during the hearing of the matter on Tuesday, the Apex Court bench Justices Hima Kohli and Ahsanuddin Amanullah reserved its verdict on the pending contempt proceedings against Patanjali Ltd., its Managing Director Acharya Balkrishna, and co-founder Baba Ramdev, who were accused of publishing misleading medical advertisements in breach of a court undertaking.</p><p style="text-align: justify; ">IMA had filed the plea against Patanjali's "smear campaign" and negative advertisements attacking modern medicines and especially the vaccination drive during the pandemic. Even though last year in November, Patanjali had assured the top court bench that no such statements would be made, the practice continued.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/supreme-court-slams-ima-president-128243" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: Supreme Court slams IMA President</i></b></a></p><p style="text-align: justify; "><b>Supreme Court Dismisses Apology by IMA Chief:</b>&nbsp;</p><p style="text-align: justify; ">During the case proceedings, the Patanjali lawyers brought to the Court's notice that the president of the Indian Medical Association- the petitioner in the contempt plea- gave a media interview criticizing the Court's observations regarding the need for IMA to take action on complaints of unethical practices by allopathic doctors as "vague" and "unfortunate". Consequently, the Court had allowed the Patanjali lawyers to bring the interview in question on record.</p><p style="text-align: justify; ">Recently, Patanjali filed a contempt plea against IMA. While issuing notice and seeking response from the Medical Association, the Apex Court bench had also condemned the interview given by the IMA President and impleaded him as a co-respondent.</p><p style="text-align: justify; ">Earlier this month, the Supreme Court bench slammed the IMA Chief R V Asokan for targeting the apex court in a recent interview with PTI about Patanjali Ayurved's misleading advertisements case. The court termed the statements as "very, very unacceptable".</p><p style="text-align: justify; ">In response to the notice issued on Patanjali Ayurved's plea, IMA President Dr. Asokan was personally present before the Court and he expressed his unequivocal apologies to the top court bench. However, the bench was not pleased with his actions and dismissed the apology issued by him.</p><p style="text-align: justify; "><a href="https://www.barandbench.com/news/we-dont-have-ego-rarely-take-action-supreme-court-ima-president-comments-patanjali-case" rel="nofollow">Bar and Bench</a> reports that unconvinced by the apology affidavit submitted by the IMA president, a Bench of Justices Hima Kohli and Ahsanuddin Amanullah observed, <i>"Dr. Asokan, you are also a citizen of this country. The amount of criticism judges face, why don't they react? Because personally we don't have much of an ego, we are magnanimous. We are entitled to take action, but very rarely we do."</i></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><i>"We do that seldom...We use our discretion with some sense of responsibility. But that does not mean you go to town with these kind of comments! What would you have done if other side made these kind of comments? You would have come running to this Court!"</i> the top court bench further noted.</p><p style="text-align: justify; ">Addressing the IMA President, who was present before the Court on Tuesday, the Apex Court bench noted, <i>"We would have expected more sense of responsibility from you."</i><br></p></div><p style="text-align: justify; ">Referring to the interview, the bench observed, <i>"You can't vent your feelings against the Court in the press like this. What made you go suddenly like this?"</i></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">Even though Dr. Asokan apologized unconditionally for his comments, the Court was unhappy with Dr. Asokan's affidavit. It noted, <i>"Whether we should accept your statements after such damaging statements? You are the one who dragged the other side to the Court saying they are denigrating you, but when you are put to test..."</i></p><p style="text-align: justify; ">Further, the bench questioned the IMA Chief for not issuing a public apology before he appeared before the Court. It questioned the IMA Chief, <i>"Why you did not give a public apology? Everything was written in black and white, why did you not make amends if you truly wanted to apologise? You could have gone to the same agency (PTI) and said what you are saying on affidavit now...What did you do to redeem yourself after the interview? Tell us."</i></p></div><div class="pasted-from-word-wrapper"><div class="arr--element-container story-element-card-m_element-container__1ZeJL story-element-card-m_dark__1AX15"><div data-test-id="text" class="arrow-component arr--text-element text-m_textElement__e3QEt text-m_dark__1TC18 "><p style="text-align: justify; ">While the Court contemplated taking judicial notice of the issue in order to send a message, Justice Kohli noted, <i>"We are the first one to uphold the freedom of free speech. But there are times when there should be self-restraint. As IMA President, you should have had self-restraint. We didn't see that in your interviews."</i></p><p style="text-align: justify; "><i>"You can't sit on a couch giving an interview to the press and lampooning the court,"</i> Justice Kohli observed, adding that Dr. Asokan's actions would have to be addressed in the same manner as Patanjali's, reports&nbsp;<a href="https://www.businesstoday.in/india/story/sc-rejects-ima-chiefs-apology-for-remarks-lampooning-the-court-in-patanjali-ayurved-misleading-ads-case-you-cant-sit-on-a-couch-giving-an-interview-429509-2024-05-14" rel="nofollow">Business Today</a>.</p><p style="text-align: justify; ">The bench further noted, <i>"We have the same to say for your apology, as we did for Patanjali. It's a subjudice matter in which you were party. Your counsel could have asked for expunging remarks. But you went to press. We are not at all happy. We can't condone so easy."</i><br></p></div></div></div><p style="text-align: justify; ">Expressing their disinterest to IMA's counsel, Senior Advocate PS Patwalia, the Supreme Court bench said, <i>"Mr Patwalia, we are not at this stage inclined to accept the apology tendered by your client."</i>&nbsp;</p><p style="text-align: justify; ">Recently, the Supreme Court strongly objected to the petitioner association i.e. IMA for alleged unethical acts where medicines are prescribed, which are "expensive and unnecessary".</p><p style="text-align: justify; ">Issuing caution to the petitioner medical association about the complaints of unethical practices by allopathic doctors, the Supreme Court bench of Justices Hima Kohli and Ahsanuddin Amanullah had observed, <i>"The petitioner (IMA) needs to put its own house in order regarding alleged unethical acts of the organisation where medicines are prescribed, which is expensive and unnecessary."</i></p><p style="text-align: justify; "><a href="https://medicaldialogues.in/news/health/doctors/ima-needs-to-put-its-house-in-order-sc-slams-allopathic-doctors-for-prescribing-expensive-unnecessary-medicines-127600" rel="nofollow"><b><i>Also Read: "IMA Needs To Put Its House In Order": SC Slams Allopathic Doctors For Prescribing Expensive, Unnecessary Medicines</i></b></a></p><p style="text-align: justify; "><b>Supreme Court Reserves Verdict:</b>&nbsp;<br></p><p style="text-align: justify; ">Meanwhile, the top court bench on May 14 also reserved its verdict on the contempt plea by IMA against Patanjali Ltd, its Managing Director Acharya Balkrishna and co-founder Baba Ramdev. The Apex Court bench comprising Justices Hima Kohli and Ahsanuddin Amanullah reserved the verdict after taking note of the submission by the counsel for Patanjali Senior Advocate Balbir Singh.</p><p style="text-align: justify; ">Advocate Singh informed the bench that complying with the Court's order, the original copies of apology notices have been filed and steps were underway regarding ads of those Patanjali products, the licenses for which were recently suspended by the State authorities.</p><p style="text-align: justify; ">Medical Dialogues had earlier reported that recently Uttarakhand State Licensing Authority (SLA) issued an order dated April 15, 2024 to Divya Pharmacy and Patanjali Ayurved Ltd. cancelling 14 of their products with immediate effect under Rule 159(1) of The Drugs and Cosmetics Rules, 1945 for repeated violations under the said Acts and Rules. The State authorities also filed a criminal complaint against Yoga Guru Ramdev, his aide Balkrishna, Divya Pharmacy and Patanjali Ayurved Ltd under sections 3, 4 and 7 of the Drugs and Magic Remedies (Objectionable Advertisements) Act.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/licences-of-14-products-suspended-patanjali-ayurved-calls-for-legal-action-against-uttarakhand-sla-128034" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: Licences of 14 products suspended: Patanjali Ayurved calls for legal action against Uttarakhand SLA</i></b></a></p><p style="text-align: justify; ">The 14 products which have been suspended with immediate effect include Swasari Gold, Swasari Vati, Bronchom, Swasari Pravahi, Swasari Avaleh, Mukta Vati Extra Power, Lipidom, Bp Grit, Madhugrit, Madhunashini Vati Extra Power, Livamrit Advance, Livogrit, Eyegrit Gold, Patanjali Drishti Eye Drop.</p><p style="text-align: justify; ">Earlier, the Supreme Court bench of Justices Hima Kohli and Ahsanyddin Amanullah came down heavily on the SLA for its "inaction" for six years in the matter, saying it had to be honest with the court if it wanted "sympathy and compassion".</p><p style="text-align: justify; ">During the hearing on Tuesday, noting the submissions Senior Advocate Balbir Singh for Patanjali, the Supreme Court bench pointed out that there were stocks already in circulation when licenses for 14 Patanjali products were suspended.&nbsp;</p><p style="text-align: justify; ">As per the latest media report by <a href="https://www.livelaw.in/top-stories/supreme-court-patanjali-misleading-ads-contempt-case-apology-order-reserved-257862?infinitescroll=1" rel="nofollow">Live Law</a>, the bench directed Patanjali to file an affidavit within 3 weeks, indicating steps being taken to recall ads of Patanjali products of which licenses have been suspended and also for recalling medicines wherever they have been sent for sale to stockists and other agencies.</p><p style="text-align: justify; ">Considering the request by Senior Advocate Mukul Rohtagi, the Court recorded the submission of Patanjali that the concerned affidavit would be without prejudice to its right of assailing the suspension order regarding the manufacturing licenses, before the appropriate forum. Meanwhile, the Apex Court bench also dispensed with the personal appearance of Baba Ramdev and Acharya Balkrishna.&nbsp;</p><p style="text-align: justify; ">On April 16, Ramdev and Balkrishna apologised to the Supreme Court for publishing misleading advertisements and making comments against allopathic medicines and Ramdev assured that he would "remain conscious about it in the future".</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/is-your-apology-the-same-size-as-your-advertisement-sc-slams-baba-ramdev-127548" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: Is your Apology the same size as your advertisement? SC slams Baba Ramdev</i></b></a></p><p style="text-align: justify; ">The apex court had warned Ramdev and Balkrishna against any attempt to "degrade allopathy" and permitted them to tender a "public apology and show contrition" within a week in the contempt proceedings in the misleading advertisements case against Patanjali Ayurved Ltd.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">Earlier, on two occasions, they tendered unconditional and unqualified apology concerning the issue of advertisement. However, the bench refused to accept their affidavits, tendering apologies, and slammed them for the misleading advertisements carried out by them and the company. The apex court also slammed the Uttarakhand government for being "hand-in-glove" with errant licencing officers who failed to take action against Patanjali for publishing misleading advertisements.</p><p style="text-align: justify; ">The top court had earlier also directed Patanjali not to publish false advertisements in the future and later issued contempt of court notices to the company, Ramdev and Balkrishna.</p></div><p style="text-align: justify; ">Live Law has reported that on April 30, the Supreme Court bench expressed its satisfaction with the latest apology tendered by Patanjali. However, it lamented that the original copies had not been filed as directed.</p><p style="text-align: justify; ">Giving time to the counsel for Patanjali to bring on record the first pages of each newspaper in which the apology had been published, the bench had noted, <i>"There has been a marked improvement from the last...two things, (earlier) it was small and there was only Patanjali...no names...now names have come. Language is adequate. It is a marked improvement. We appreciate that."</i></p><p style="text-align: justify; ">Further, the bench also conveyed its displeasure regarding the continuation of misleading ads on the internet, websites, and various channels, despite licenses to the relevant products having been suspended.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/mdtv/healthshorts/patanjali-ayurved-to-take-legal-action-against-uttarakhand-sla-128068" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: Patanjali Ayurved to take legal action against Uttarakhand SLA</i></b></a></p>

120. Staged bilateral FUS-STN safely improves motor features in Parkinsonism: JAMA

     Wed, 15 May 2024 03:30:50 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238218-download-13.webp' /><p style="text-align: justify; ">Staged bilateral FUS-STN safely improves motor features in Parkinsonism suggests a study published in the JAMA Neurology.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">Unilateral magnetic resonance imaging (MRI)–guided focused ultrasound subthalamotomy (FUS-STN) improves cardinal motor features among patients with asymmetrical Parkinson's disease (PD). The feasibility of bilateral FUS-STN is as yet unexplored. A study was done to assess the safety and effectiveness of staged bilateral FUS-STN to treat Parkinson's disease. This prospective, open-label, case series study was conducted between June 18, 2019, and November 7, 2023, at HM-CINAC, Puerta del Sur University Hospital, Madrid, Spain, and included 6 patients with Parkinson's disease who had been treated with unilateral FUS-STN contralateral to their most affected body side and whose parkinsonism on the untreated side had progressed and was not optimally controlled with medication. </p><p dir="ltr" style="text-align: justify; "> Primary outcomes were assessed 6 months after the second treatment and included safety (incidence and severity of adverse events after the second treatment) and effectiveness in terms of motor change (measured with the Movement Disorders Society Unified Parkinson’s Disease Rating Scale part III [MDS-UPDRS III]) in the off-medication state (ie, after at least 12 hours of antiparkinsonian drug withdrawal) compared with baseline (ie, prior to the first side ablation). Secondary outcomes included motor change in patients in the on-medication state (ie, after usual antiparkinsonian medication intake), motor complications (measured with the MDS-UPDRS IV), daily living activities (measured with the MDS-UPDRS I-II), quality of life (measured with the 39-item Parkinson’s Disease Questionnaire), change in dopaminergic treatment, patient’s global impression of change (measured with the Global Impression of Change [PGI-C] scale), and long-term (24-month) follow-up. Results: Of 45 patients previously treated with unilateral FUS-STN, 7 were lost to follow-up, and 4 were excluded due to adverse events. Of the remaining 34 patients, 6 (median age at first FUS-STN, 52.6 years [IQR, 49.0-57.3 years]; 3 women [50%]) experienced progression of parkinsonism on the untreated body side and were included. At the time of the first FUS-STN, patients’ median duration of disease was 5.7 years (IQR, 4.7-7.3 years). </p><p dir="ltr" style="text-align: justify; ">The median time between procedures was 3.2 years (IQR, 1.9-3.5 years). After the second FUS-STN, 4 patients presented with contralateral choreic dyskinesia, which resolved by 3 months. Four patients developed speech disturbances, which gradually improved but remained in a mild form for 2 patients at 6 months; 1 patient experienced mild imbalance and dysphagia during the first week after treatment, which subsided by 3 months. No behavioural or cognitive disturbances were found on neuropsychological testing. For patients in the off-medication state, MDS-UPDRS III scores improved by 52.6% between baseline and 6 months after the second FUS-STN (from 37.5 [IQR, 34.2-40.0] to 20.5 [IQR, 8.7-24.0]; median difference, 23.0 [95% CI, 7.0-33.7]; P = .03). The second treated side improved by 64.3% (MDS-UPDRS III score, 17.0 [IQR, 16.0-19.5] prior to the second treatment vs 5.5 [IQR, 3.0-10.2]; median difference, 9.5 [95% CI, 3.2-17.7]; P = .02). After the second procedure, all self-reported PGI-C scores were positive. Findings of this pilot study suggest that staged bilateral FUS-STN was safe and effective for the treatment of PD, although mild but persistent speech-related adverse events were observed among a small number of patients.</p><div style="text-align: justify;"></div><p dir="ltr" style="text-align: justify; ">Reference:</p><p dir="ltr" style="text-align: justify; ">Martínez-Fernández R, Natera-Villalba E, Rodríguez-Rojas R, et al. Staged Bilateral MRI-Guided Focused Ultrasound Subthalamotomy for Parkinson Disease. JAMA Neurol. Published online May 13, 2024. doi:10.1001/jamaneurol.2024.1220</p><div style="text-align: justify;"></div><div style="text-align: justify;"></div><div style="text-align: justify;"></div></div>

121. Study finds Semaglutide's effects on long-term weight loss in individuals with obesity

     Wed, 15 May 2024 03:00:48 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/15/238254-mdtv-2024-05-15t125135310.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">Two studies presented at the European Congress on Obesity investigated the long-term effects of semaglutide on weight loss and explored the relationship between cardiovascular benefits and initial weight or extent of weight loss.</div><div style="text-align: justify;">Semaglutide, a GLP-1 medication typically prescribed for adults with type 2 diabetes, is also approved for weight management in individuals with obesity or overweight who have at least one comorbidity. This medication class mimics the actions of the body's natural incretin hormones, aiding in post-meal blood sugar regulation. By modulating these hormone levels, semaglutide can induce a feeling of fullness, thereby reducing daily calorie consumption.</div><div style="text-align: justify;">In the SELECT trial spanning from October 2018 to June 2023, 17,604 adults aged 45 or older from 41 countries were given semaglutide (2.4mg) or placebo for an average of 40 months. They were overweight or obese but no diabetes and a history of cardiovascular events. </div><div style="text-align: justify;">The findings are as follows: </div><div style="text-align: justify;">1. Semaglutide users saw a 20% lower risk of heart attack, stroke, or cardiovascular death and lost an average of 9.4% body weight. </div><div style="text-align: justify;">2. In the semaglutide group, weight loss persisted up to week 65 and was maintained for four years, with participants achieving an average body weight reduction of 10.2% and a waistline decrease of 7.7cm, compared to 1.5% and 1.3cm respectively in the placebo group. </div><div style="text-align: justify;">3. The semaglutide group experienced a significant 6.9% reduction in average waist circumference-to-height ratio, compared to 1% in the placebo group. After two years, over half (52%) of semaglutide-treated participants shifted to a lower BMI category, compared to 16% of those receiving placebo.</div><div style="text-align: justify;">4. Semaglutide treatment provided cardiovascular benefits regardless of initial weight or the extent of weight loss. This implies that even individuals with mild obesity or modest weight loss may experience improved cardiovascular outcomes with semaglutide therapy.</div><div style="text-align: justify;">“Our findings show that the magnitude of this treatment effect with semaglutide is independent of the amount of weight lost, suggesting that the drug has other actions which lower cardiovascular risk beyond reducing unhealthy body fat. These alternative mechanisms may include positive impacts on blood sugar, blood pressure, or inflammation, as well as direct effects on the heart muscle and blood vessels, or a combination of one or more of these,” said Professor John Deanfield from University College London, UK.</div><div style="text-align: justify;">Reference: Ryan, D.H., Lingvay, I., Deanfield, J. et al. Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial. Nat Med (2024). https://doi.org/10.1038/s41591-024-02996-7</div><div></div></div>

122. Does obesity and metabolic syndrome affect a woman's risk of breast cancer? Study sheds light

     Wed, 15 May 2024 02:45:16 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/15/238252-mdtv-2024-05-15t124915071.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">In the Women's Health Initiative (WHI) randomized trial, adopting a low-fat diet was found to decrease breast cancer mortality, particularly among women with multiple metabolic syndrome components such as obesity, high blood pressure, elevated blood sugar, and abnormal cholesterol levels.</div><div style="text-align: justify;">The analysis, published in the journal <i>Cancer</i>, indicated that metabolic syndrome and obesity each have different associations with breast cancer subtypes and mortality risk.</div><div style="text-align: justify;">Obesity is a prevalent health concern among women worldwide, with its incidence steadily rising in recent years. Alongside its association with various metabolic disorders, including type 2 diabetes and cardiovascular disease, obesity has also been closely linked to an increased risk of cancer. In particular, obese women face a heightened likelihood of developing breast cancer, among other malignancies, due to the complex interplay of hormonal imbalances, chronic inflammation, and metabolic dysregulation associated with excess adiposity.</div><div style="text-align: justify;">Metabolic syndrome, characterized by a cluster of metabolic abnormalities including hypertension and hyperglycemia, poses a significant risk factor for cancer-related deaths in women. This syndrome contributes to a systemic environment conducive to tumor growth and progression. Insulin resistance, a hallmark feature of metabolic syndrome, leads to elevated levels of insulin and insulin-like growth factor 1 (IGF-1), both of which promote cell proliferation and inhibit apoptosis, thereby fostering the development and spread of cancer cells. </div><div style="text-align: justify;">In the study, researchers analyzed data from 63,330 postmenopausal participants of the WHI clinical trial who had no history of breast cancer, along with normal entry mammograms and MetS scores ranging from 0 to 4. Following a median follow-up period of 23.2 years, the analysis revealed 4,562 new cases of breast cancer and 659 deaths attributed to breast cancer (breast cancer mortality).</div><div style="text-align: justify;">The study found that a higher metabolic syndrome score, regardless of obesity, was linked to poorer prognosis, estrogen receptor (ER)-positive, progesterone receptor (PR)-negative breast cancers, and a 44% higher risk of breast cancer mortality. Obesity, irrespective of the metabolic syndrome score, was associated with better prognosis, ER-positive, and PR-positive cancers. Only women with severe obesity faced a higher risk of breast cancer mortality.</div><div style="text-align: justify;">Reference: Rowan T. Chlebowski MD, PhD, Aaron K. Aragaki MS, Kathy Pan MD, Michael S. Simon MD, MPH, et al.; Breast cancer incidence and mortality by metabolic syndrome and obesity: The Women’s Health Initiative; CANCER; https://doi.org/10.1002/cncr.35318</div><div></div></div>

123. Commonly used antibiotics associated with increased complications- JAMA study

     Wed, 15 May 2024 02:30:57 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/15/238251-mdtv-2024-05-15t124421106.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">According to a study published in the journal<i> JAMA Internal Medicine</i>, in patients with sepsis, the use of a combination of vancomycin and piperacillin-tazobactam is associated with increased mortality risk compared with a combination of vancomycin and cefepime. </div><div style="text-align: justify;">Piperacillin/tazobactam is a broad-spectrum antibiotic that is commonly administered for sepsis, a life-threatening complication from infection. In its absence, clinicians commonly use another antibiotic, cefepime, which has similar activity against common sepsis pathogens but, unlike piperacillin/tazobactam, has minimal effects on anaerobic gut bacteria.</div><div style="text-align: justify;">In health, the gut microbiome is largely populated by anaerobic bacteria that rarely cause disease. Prior research has revealed that even a single dose of piperacillin/tazobactam kills most of these anaerobic gut bacteria, which play important roles in the body’s metabolism, immunity, and prevention of infections.</div><div style="text-align: justify;">In their study, Dr. Rishi Chanderraj and his multidisciplinary team from the University of Michigan's Division of Infectious Disease analysed patient records from a cohort of 7,569 individuals. They compared outcomes between 4,523 patients treated with piperacillin/tazobactam and 3,046 patients who received cefepime.</div><div style="text-align: justify;">Their findings revealed significant disparities: patients treated with piperacillin-tazobactam experienced a 5 percent rise in 90-day mortality, longer durations on ventilators, and increased instances of organ failure. Moreover, opting for piperacillin/tazobactam over cefepime could potentially result in one additional fatality for every 20 septic patients treated. </div><div style="text-align: justify;">“These are powerful antibiotics that are administered to patients every day in every hospital nationwide. Clinicians use them because they are trying to treat every possible pathogen that might be causing their patients’ illnesses. But our results suggest that their effects on the microbiome might also have important effects on patient outcomes,” said Chanderraj. “Our previous research hinted at potential harm associated with piperacillin/tazobactam, but it was based on observational data with limitations. The drug shortage presented a unique opportunity, acting as a nearly perfect natural experiment to rigorously compare the outcomes of patients treated with these two drugs. Physicians should carefully consider the necessity of prescribing anti-anaerobic antibiotics.”</div><div style="text-align: justify;">Reference: Chanderraj R, Admon AJ, He Y, et al. Mortality of Patients With Sepsis Administered Piperacillin-Tazobactam vs Cefepime. JAMA Intern Med. Published online May 13, 2024. doi:10.1001/jamainternmed.2024.0581</div><div></div></div>

124. Use of restorations on vertically prepared teeth suitable option to classical horizontal preparations: Study

     Wed, 15 May 2024 02:30:50 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238217-1-s20-s0022391315006733-gr11-1.webp' /><p style="text-align: justify; ">The use of restorations on vertically prepared teeth suitable for classical horizontal preparations suggests a study published in the Journal of Dentistry.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">A study was done to evaluate the clinical conditions of single-unit posterior restorations on teeth prepared without a finishing line, after 5.6 years of clinical service. 50 crowns (25 zirconia-based (Zr) and 25 porcelain-fused-to-metal (PFM)) were selected from 34 patients. The restorations were evaluated according to the California Dental Association (CDA) Quality Criteria, and periodontal variables were studied in the abutment teeth compared with the unrestored contralateral teeth. Variables were examined using Mann-Whitney and Pearson´s Chi-Square tests (α = 0.05). The success of the prosthesis was calculated using the Kaplan-Meier test. Results: CDA Quality Criteria was considered satisfactory- excellent in all restorations except for one of them, due to chipping on a PFM crown. At, 66 months, the success rates for PFM and Zr crowns were 85.7% and 100%, respectively. The plaque index (PI) showed that the restored abutment teeth accumulated significantly less plaque than the control teeth, but the gingival index (GI) was statistically higher in the abutment teeth. In 80% of cases, the probing depth (PB) was ≤ 3mm. In addition, in 21% of the cases, gingival recession was less than 2mm. The restoration material had a statistically significant effect on GI and PB, with Zr crowns showing less inflammation and fewer deep pockets than PFM restorations. On the contrary, greater gingival recession was found at the margins of the Zr crowns when compared to the PFM. No statistical differences were found between the two materials in the GI. Cemented crowns on vertical preparations show good clinical behavior after 5 years. The periodontal parameters (PI, GI, PD) of the Zr restorations are significantly better than those of PFM, with the exception of gingival recession. The use of restorations on vertically prepared teeth is a suitable alternative to classical horizontal preparations.</p><div style="text-align: justify;"><span style="background-color: rgb(249, 249, 249);">Reference:</span></div><p dir="ltr" style="text-align: justify; ">M Gonzalez-Bonilla, S Berrendero, B Moron-Conejo, F Martinez-Rus, MP Salido, Clinical evaluation of posterior zirconia-based and porcelain-fused-to-metal crowns with a vertical preparation technique: an up to 5-year retrospective cohort study., Journal of Dentistry, 2024, 104953, ISSN 0300-5712, <a href="https://doi.org/10.1016/j.jdent.2024.104953.">https://doi.org/10.1016/j.jdent.2024.104953.</a> (https://www.sciencedirect.com/science/article/pii/S0300571224001234)</p><div style="text-align: justify;"></div></div>

125. Chronic stress during adolescence may reduce fertility in adulthood, suggests study

     Wed, 15 May 2024 02:15:10 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/11/237917-stress-50.webp' /><p style="text-align: justify; ">Male rats exposed to moderate and repeated stress during adolescence may have reduced fertility, according to research presented at the 26th European Congress of Endocrinology in Stockholm. This study sheds light on the harmful effects that early-life stress has on health and could help to uncover future prevention strategies for children and adolescents. </p><p style="text-align: justify; ">While hormone levels fluctuate pathologically-especially during life stages such as puberty-stress can cause too much or too little of a hormone in the bloodstream. This hormonal imbalance negatively impacts puberty and the reproduction system, with effects on libido, ovulation function and sperm cell production. However, the long-term reproductive effects of chronic stress in adolescents are largely unknown. </p><p style="text-align: justify;">In this study, researchers from the V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Science of Ukraine, examined male and female rats, aged 6 months, after individually placing about half of them in enclosed spaces for one hour every morning for two weeks during adolescence (30–45 days old). They compared the rats who had been exposed to these stressful conditions to the control group and found that chronic stress during puberty delayed sexual maturity in females, and males gained weight more slowly. In adult males, sperm count fell by 25.9%, some sperm were abnormally shaped and sluggish or became immobile, and the breathing process by which sperm cells derive energy slowed down. Additionally, males had almost two times lower levels of corticosterone – the main stress hormone in rats, equivalent to cortisol in humans. </p><p style="text-align: justify;">“Our work is the first to report to show that even moderate and repetitive stress in adolescence has a long-lasting negative impact on the endocrine system of reproduction and adaptation of the body to changing living conditions,” said lead investigator, Professor Aleksander Reznikov. </p><p style="text-align: justify;">“Our results make it possible to predict the development of anomalies in reproduction and bodily adaptation systems and are the basis for finding methods for their prevention.” </p><p style="text-align: justify;">Professor Reznikov added: “We discovered for the first time that lipid peroxidation (a process in which oxidants like free radicals attack lipid membranes of cells and eventually damage them) in the ovaries and testes was significantly increased. This, however, needs further investigation.”</p>

126. Study Reveals Relationship Between Peak Expiratory Flow Changes and Asthma Exacerbations in Children

     Tue, 14 May 2024 16:30:50 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/07/08/213749-asthma-in-children-2.webp' /><p style="text-align: justify; ">China: A recent study published in <em>BMC Pediatrics</em> has unveiled crucial insights into the relationship between changes in peak expiratory flow (PEF) and asthma exacerbations in pediatric patients. Conducted with a focus on asthmatic children, the research underscores the significance of PEF monitoring as a valuable tool in predicting and preventing asthma exacerbations.<br></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">Researchers uncovered a crucial early warning sign for pediatric asthma exacerbations: children with asthma exhibited a decline in PEF approximately 1.34 days before the onset of symptoms. Upper respiratory tract infections emerged as the primary trigger for acute asthma exacerbations, and air pollution exhibited a significantly higher impact on PEF variation versus other factors.</p><p style="text-align: justify; ">Asthma, a chronic respiratory condition characterized by airway inflammation and hyperresponsiveness, affects millions of children worldwide, posing a significant burden on both patients and healthcare systems. Asthma exacerbations, marked by sudden worsening of symptoms, represent a major concern due to their potential to escalate into severe respiratory distress and hospitalization.</p><p style="text-align: justify; ">In patients with poor perception, identifying acute asthma exacerbations by clinical asthma score, asthma control test, or asthma control questionnaire is difficult. Considering this, Kunling Shen, Department of Respiratory, Shenzhen Children Hospital, Shenzhen, China, and colleagues aimed to analyze whether children with asthma have changes in peak expiratory flow before an acute asthma exacerbation. They also evaluated the relationship between PEF and asthma exacerbation. </p><p style="text-align: justify; ">For this purpose, the researchers collected basic information (including age, sex, atopy, etc.) and clinical information of asthmatic children who registered in the Electronic China Children’s Asthma Action Plan (e-CCAAP) from 2017 to 2021. Subjects with fourteen consecutive days of PEF measurements were eligible. The study subjects were categorized into an exacerbation group and a control group. They analyzed the relationship between changes in PEF% pred and asthma symptoms.</p><p style="text-align: justify; ">The study included 194 children with asthma who met the inclusion criteria, including 74.2% males and 25.8% females, with a male-to-female ratio of 2.88:1. The subjects' mean age was 9.51 ± 2.5 years. </p><p style="text-align: justify; ">The researchers reported the following findings:</p><ul><li style="text-align: justify; ">There were no significant differences in sex, age, allergy history, or baseline PEF between the two groups.</li><li style="text-align: justify; ">There was no significant difference between the variation in PEF at 14 days in children with and without a history of allergy. </li><li style="text-align: justify; ">Patients who only had a reduction in PEF but no symptoms of asthma exacerbation had the greatest decrease in PEF compared to the other groups.</li><li style="text-align: justify; ">The most common cause of acute exacerbations of asthma is upper respiratory tract infection.</li><li style="text-align: justify; ">Among the causes of acute exacerbations of asthma, the variation in PEF caused by air pollution was significantly higher than that of other causes.</li><li style="text-align: justify; ">In acute exacerbations, the decrease in PEF was significantly greater in the exacerbation group than in the control group.</li><li style="text-align: justify; ">In children with asthma symptoms, there was a decrease in PEF approximately 1.34 days before the onset of the symptoms.</li></ul><p style="text-align: justify; ">The findings revealed that children with asthma show a decrease in PEF 1.34 days before the onset of asthma symptoms.</p><p style="text-align: justify; ">"We recommend that asthmatic children who show PEF reduction should step up asthma therapy," the researchers wrote. "The most common cause of asthma' acute exacerbations was upper respiratory tract infections, and PEF variation caused by air pollution was significantly higher than that caused by other factors."</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Chen, X., Han, P., Kong, Y. et al. The relationship between changes in peak expiratory flow and asthma exacerbations in asthmatic children. BMC Pediatr 24, 284 (2024). https://doi.org/10.1186/s12887-024-04754-7</p></div><p style="text-align: justify; "><br></p>

127. Low testosterone in men associated with higher risk for death, reveals study

     Tue, 14 May 2024 16:15:07 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/01/18/230426-heart-disease-50.webp' /><p style="text-align: justify; ">A systematic review and meta-analysis found that a low baseline (endogenous) serum testosterone concentration in men is associated with increased risk for all-cause mortality, and a very low baseline testosterone with increased risk of cardiovascular death. According to the authors, this study clarifies previous inconsistent findings on the influence of sex hormones on key health outcomes in aging men. The findings are published in<i> Annals of Internal Medicine</i>. </p><p style="text-align: justify;">Researchers from the University of Western Australia, collaborating with researchers from Australia, Europe, and North America, reviewed 11 studies comprising more than 24,000 participants to clarify associations of sex hormones with mortality and cardiovascular disease (CVD) risk in aging men. Eligible studies were prospective cohort studies, previously identified in a published systematic review, of community-dwelling men with total testosterone concentrations measured using mass spectrometry and at least 5 years of follow-up. Individual patient data (IPD) was used to summarize relationships between baseline hormone concentrations (total testosterone; sex hormone-binding globulin, luteinizing hormone, dihydrotestosterone, and estradiol) and relative risk for CVD events, CVD deaths, and all-cause mortality. The data showed that only men with low total testosterone concentrations had higher risks for all-cause mortality. A key finding was that men with a testosterone concentration below 7.4 nmol/L (&lt;213 ng/dL) had higher risk for all-cause mortality, regardless of LH concentration. Men with a testosterone concentration below 5.3 nmol/L (&lt;153 mg/dL) had increased risk of cardiovascular death. </p><p style="text-align: justify; ">The author of an accompanying editorial from the University of Washington suggests that this meta-analysis is particularly valuable because of its rigorous methodology. The study is the first of its kind to perform IPD meta-analysis of major prospective cohort studies which used mass spectrometry, the most accurate method of testosterone measurement that can also be used to measure DHT and estradiol accurately. In addition, to perform the IPD meta-analysis, the authors obtained raw data from 9 of the included studies and then reanalyzed the combined data. This method allowed for more sophisticated analysis of combined data from multiple studies and provided more robust testing for associations.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Bu B. Yeap, Ross J. Marriott, Girish Dwivedi, Robert J. Adams,&nbsp; Leen Antonio, Christie M. Ballantyne, Douglas C. Bauer, Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men, Annals of Internal Medicine, https://doi.org/10.7326/M23-2781.</p>

128. Gabapentinoid prescriptions in Isolated Low Back Pain patients by primary care physicians not useful: Study

     Tue, 14 May 2024 15:30:10 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/04/237508-gabapentinoids-and-cancer-pain.webp' /><p style="text-align: justify; ">Gabapentinoids have been increasingly studied as a non-narcotic option for neuropathic and postoperative pain. However, there is evidence suggesting that off-label use of these medications for the treatment of isolated LBP is not effective.<br></p><p style="text-align: justify; ">Low back pain (LBP) remains one of the leading causes of disability worldwide. In wake of the ongoing opioid epidemic, reducing narcotic use is a high priority for patients, physicians, and systems. For some indications, non narcotic analgesic alternatives exist – such as gabapentinoids – however, evidence does not support their use for axial LBP.</p><p style="text-align: justify; "><i>Maloy et al</i> conducted a study to evaluate prescription patterns for gabapentinoids among patients with isolated low back pain. The study has been published in ‘Global Spine Journal.’ </p><p style="text-align: justify; ">Adult patients with LBP were abstracted from the dataset using International Classification of Diseases (ICD-10) code M54.5. Patients were excluded if they had a diagnosis of neurologic symptoms, history of spinal surgery, spinal fracture, or conditions for which gabapentinoids are FDA approved. Gabapentinoid and narcotic prescriptions within one year of LBP diagnosis were identified. Patient characteristics and prescriber specialty were extracted from the dataset and predictors of gabapentinoid prescriptions were determined using univariate and multivariate analyses. </p><p style="text-align: justify;">Key findings of the study: </p><p style="text-align: justify;">• Among the 1,158,875 isolated LBP patients, gabapentinoids were prescribed for 11% (gabapentin for 85%, pregabalin for 12% pregabalin, and both for 3%), narcotics for 8%, and both for 3%. </p><p style="text-align: justify;">• The most common prescriber specialties included: primary care physicians (45%), nurse practitioners (15%), pain management physicians (5%), neurology (4%), physical medicine and rehabilitation (4%), psychiatry (3%), rheumatology (2%), orthopedic surgery (2%), unknown (11%), and other fields (9%). </p><p style="text-align: justify;">• Independent predictors of gabapentinoid prescriptions included: female sex, region of the country, and insurance type (P-values &lt;0.001). </p><p style="text-align: justify; ">The authors concluded - “In sum, of nearly 1.2 million isolated LBP patients identified, 14.2% were prescribed gabapentinoids within one year of their LBP diagnosis, a number greater than narcotics and prescribed most commonly be primary care physicians. Several factors were identified as independent predictors of gabapentinoid prescription, include patient sex, region of residence, and insurance plan. While clinicians are being encouraged to shift away from the use of narcotics for isolated LBP, evidence does not well support gabapentinoids for this indication and its off label use for this population may be questioned.”</p><p style="text-align: justify;">Further reading: </p><p style="text-align: justify; ">Characterizing Gabapentinoid Use Among Patients With Isolated Low Back Pain Gwyneth C. Maloy et al Global Spine Journal 2024 DOI: 10.1177/21925682231224390</p>

129. Bariatric Surgery Decreases Risk of Ocular Morbidity and Mortality finds study

     Tue, 14 May 2024 15:00:53 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/28/233199-bariatric-surgery-50.webp' /><p style="text-align: justify;">Researchers have found that bariatric surgery, a treatment for morbid obesity, is associated with a decreased risk of future ocular morbidity and mortality. This large retrospective cohort study examined the effects of bariatric surgery on postoperative disease incidence, highlighting the potential benefits of surgery beyond weight loss. This study was published in the journal <i>Eye</i> by Russell and colleagues.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify;">Bariatric surgery is widely used to treat morbid obesity, with known short-term effects on ocular pathology. However, the long-term impact of surgery on the incidence of postoperative ocular diseases remains largely unknown. This study aims to evaluate the relationship between bariatric surgery and the risk of various ocular conditions.</p><p dir="ltr" style="text-align: justify;">The study analyzed data from the TriNetX United States Collaborative Network national database. Patients with an ICD-10 code for morbid obesity and a procedural code for bariatric surgery were matched to those with morbid obesity but without surgery, resulting in two cohorts of 42,408 patients each. The study tracked the incidence of several ocular conditions after surgery, including:</p><p dir="ltr" style="text-align: justify;">• Diabetic retinopathy</p><p dir="ltr" style="text-align: justify;">• Age-related macular degeneration</p><p dir="ltr" style="text-align: justify;">• Glaucoma</p><p dir="ltr" style="text-align: justify;"><span>•&nbsp;</span>Low vision and blindness</p><p dir="ltr" style="text-align: justify;">Outcomes were assessed using relative risk (RR) with 95% confidence intervals (CI).</p><p dir="ltr" style="text-align: justify;">The key findings of the study were:</p><p dir="ltr" style="text-align: justify;">• Bariatric surgery was associated with a significant reduction in the future risk of diabetic retinopathy (RR: 0.283; 95% CI: 0.252-0.319).</p><p dir="ltr" style="text-align: justify;">• Patients who underwent bariatric surgery had a lower risk of developing macular edema (RR: 0.224; 95% CI: 0.170-0.297).</p><p dir="ltr" style="text-align: justify;">• The risk of vitreous hemorrhage was also reduced (RR: 0.459; 95% CI: 0.323-0.653).</p><p dir="ltr" style="text-align: justify;">• Bariatric surgery was linked to lower rates of ocular hypertension (RR: 0.387; 95% CI: 0.387-0.487) and glaucoma (RR: 0.360; 95% CI: 0.326-0.399).</p><p dir="ltr" style="text-align: justify;">• The surgery was associated with a reduced risk of age-related macular degeneration (RR: 0.628; 95% CI: 0.447-0.882).</p><p dir="ltr" style="text-align: justify;">• The risk of low vision and blindness was lower in the surgery group (RR: 0.328; 95% CI: 0.294-0.365).</p><p dir="ltr" style="text-align: justify;">The findings suggest that bariatric surgery not only aids in weight loss but also may have substantial protective effects against future ocular diseases. This could lead to a potential shift in how bariatric surgery is viewed as a comprehensive treatment for both obesity and ocular health.</p><p dir="ltr" style="text-align: justify;">Bariatric surgery is associated with a decreased risk of future ocular morbidity and mortality, including diabetic retinopathy, age-related macular degeneration, and glaucoma, among others. These findings highlight the importance of considering bariatric surgery not just as a weight loss intervention, but also as a potential preventive measure for various ocular conditions.</p><p dir="ltr" style="text-align: justify;">Reference:</p><p dir="ltr" style="text-align: justify;">Russell, M. W., Kumar, M., Li, A., Singh, R. P., &amp; Talcott, K. E. (2024). Incidence of ocular pathology following bariatric surgery for with morbid obesity across a large United States National Database. Eye. <a href="https://doi.org/10.1038/s41433-024-03088-z">https://doi.org/10.1038/s41433-024-03088-z</a></p></div>

130. Which is better local anesthesia technique for mesotherapy for Hair Regrowth in the Temporal Region?

     Tue, 14 May 2024 14:30:54 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/07/237608-botox-for-female-pattern-hair-loss.webp' /><p style="text-align: justify; ">Recently published research paper investigates the efficacy of mesotherapy for hair regrowth in the temporal region, specifically focusing on the use of platelet-rich plasma (PRP) and vitamins. The injection techniques for mesotherapy involve the administration of zygomaticotemporal nerve blocks, supratrochlear nerve blocks, and supraorbital nerve blocks. The study conducted a comparative analysis of two different local anesthesia techniques for mesotherapy and found that the use of zygomaticotemporal nerve blocks, in addition to supratrochlear and supraorbital nerve blocks, resulted in better pain control and reduction during and after the procedure.</p><p style="text-align: justify;">“Comparative Study on Pain Control”</p><p style="text-align: justify;">The researchers conducted a prospective comparative study with 100 participants divided into two groups (group I and group II). Group I received zygomaticotemporal, supratrochlear, and supraorbital nerve blocks, while group II received supratrochlear and supraorbital nerve blocks. The pain was assessed using a visual analog scale (VAS), and the study found that group I experienced significantly less pain during and after the procedure compared to group II.</p><p style="text-align: justify;">History and Development of Mesotherapy”</p><p style="text-align: justify;">The paper discusses the history and development of mesotherapy as a minimally invasive medical procedure for a wide range of medical and cosmetic issues, including hair regrowth. It elaborates on the technique of mesotherapy, which involves injecting a mixture of vitamins, minerals, amino acids, and pharmaceutical and homeopathic remedies directly into the middle layer of the skin to promote cellular regeneration and therapeutic benefits.</p><p style="text-align: justify;">“Findings of Zygomaticotemporal Nerve Blocks”</p><p style="text-align: justify;">The findings of the study demonstrated that the addition of zygomaticotemporal nerve blocks to supratrochlear and supraorbital nerve blocks resulted in better pain control during PRP mesotherapy in the temporal region. The paper also discusses the potential broader applications of zygomaticotemporal blocks in other medical procedures and the importance of further research in this area. It concludes by emphasizing the need for larger sample sizes and diverse injection technique comparisons to enhance the understanding of mesotherapy.</p><p style="text-align: justify;">Efficacy of Mesotherapy for Hair Regrowth</p><p style="text-align: justify;">In conclusion, the paper provides detailed insights into the efficacy of mesotherapy for hair regrowth in the temporal region, specifically focusing on the use of different nerve blocks for local anesthesia techniques. It underscores the importance of zygomaticotemporal nerve blocks in enhancing pain control during PRP mesotherapy and highlights the potential applications of this technique in other medical procedures. The study's findings contribute to the understanding of mesotherapy and its potential for treating alopecia in the temporal region.</p><p style="text-align: justify;">Key Points</p><p style="text-align: justify;">1. The paper investigates the efficacy of mesotherapy for hair regrowth in the temporal region, specifically focusing on the use of platelet-rich plasma (PRP) and vitamins. It discusses injection techniques for mesotherapy, which involve the administration of zygomaticotemporal nerve blocks, supratrochlear nerve blocks, and supraorbital nerve blocks. The study found that the use of zygomaticotemporal nerve blocks, in addition to supratrochlear and supraorbital nerve blocks, resulted in better pain control and reduction during and after the procedure.</p><p style="text-align: justify;">2. The researchers conducted a prospective comparative study with 100 participants divided into two groups. Group I received zygomaticotemporal, supratrochlear, and supraorbital nerve blocks, while group II received only supratrochlear and supraorbital nerve blocks. The pain was assessed using a visual analog scale (VAS), and it was found that group I experienced significantly less pain during and after the procedure compared to group II. This comparative study emphasized the advantage of using zygomaticotemporal nerve blocks in enhancing pain control during mesotherapy.</p><p style="text-align: justify;">The paper provides detailed insights into the efficacy of mesotherapy for hair regrowth in the temporal region, focusing on the use of different nerve blocks for local anesthesia techniques, and underscores the importance of zygomaticotemporal nerve blocks in enhancing pain control during PRP mesotherapy.</p><p style="text-align: justify;">Reference-</p><p style="text-align: justify;">Nagaja S A, John R S, Kumar S P, et al. (April 17, 2024) Comparison of the Efficacy of Two Different Local Anesthesia Techniques for Mesotherapy in Temporal Region Alopecia. Cureus 16(4): e58498. DOI 10.7759/cureus.58498</p><p style="text-align: justify;"><br></p>

131. JAMA Study Reveals Risks in Prescription of QT-Prolonging Medications for Hemodialysis Patients

     Tue, 14 May 2024 14:30:48 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/01/237275-medication-prescription.webp' /><p style="text-align: justify; ">USA: A recent study sheds light on the potential dangers associated with the prescription and dispensation of QT-prolonging medications to individuals undergoing hemodialysis. The research, published in<em> JAMA Network Open</em>, highlights the need for heightened awareness and caution among healthcare providers when managing medication regimens for this vulnerable patient population.<br></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">This cross-sectional study of 20 761 adults 60 years or older revealed that non-nephrology clinicians (and from nonacute settings) commonly prescribe QT-prolonging medications for patients with dialysis-dependent kidney failure. Prescriptions for potentially interacting medications often originated from different prescribers. </p><p style="text-align: justify; ">The study findings suggest the need for clinician- and health system–level strategies aimed at minimizing high-risk medication–prescribing practices in the population undergoing dialysis. </p><p style="text-align: justify; ">Hemodialysis, a life-sustaining treatment for individuals with end-stage renal disease, involves the removal of waste products and excess fluids from the blood. However, patients undergoing hemodialysis often experience electrolyte imbalances, particularly in potassium and magnesium levels, which can predispose them to cardiac arrhythmias, including QT prolongation.</p><p style="text-align: justify; ">QT prolongation, characterized by an abnormal QT interval prolongation on an electrocardiogram (ECG), increases the risk of potentially fatal ventricular arrhythmias, such as torsades de pointes. Certain medications, known as QT-prolonging drugs, can exacerbate this risk by further disrupting cardiac repolarization.</p><p style="text-align: justify; ">Against the above background, Virginia Wang, Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, and colleagues aimed to examine dispensation and prescription patterns of QT-prolonging medications with known torsades de pointe (TdP) risk and selected interacting medications prescribed to individuals receiving hemodialysis.</p><p style="text-align: justify; ">The study included patients enrolled in Medicare Parts A, B, and D receiving in-center hemodialysis from January 1 to December 31, 2019. </p><p style="text-align: justify; ">Exposures were new-user prescriptions for the seven most frequently filled QT-prolonging medications characterized by the timing of the new prescription relative to acute care encounters, the type of prescribing clinician and pharmacy that dispensed the medication, and concomitant selected medications used known to interact with the seven most frequently filled QT-prolonging medications with known TdP risk.</p><p style="text-align: justify; ">The main outcomes were the new-use episodes and frequencies of the most commonly filled QT-prolonging medications; prescribers and dispensing pharmacy characteristics for new use of medications; the timing of medication fills relative to acute care events; and the frequency and types of new-use episodes with concurrent use of potentially interacting medications. </p><p style="text-align: justify; ">Following were the study’s key findings:</p><ul><li style="text-align: justify; ">Of 20 761 individuals receiving hemodialysis in 2019 (mean age, 74 years; 51.1% male), 52.9% filled a study drug prescription.</li><li style="text-align: justify; ">Approximately 80% (from 78.6% for odansetron to 93.9% for escitalopram) of study drug new-use prescriptions occurred outside of an acute care event.</li><li style="text-align: justify; ">Between 36.8% and 61.0% of individual prescriptions originated from general medicine clinicians.</li><li style="text-align: justify; ">Between 16.4% and 26.2% of these prescriptions occurred with the use of another QT-prolonging medication.</li><li style="text-align: justify; ">Most potentially interacting drugs were prescribed by different clinicians (46.3%-65.5%).</li></ul><p style="text-align: justify; ">As the prevalence of end-stage renal disease continues to rise globally, addressing the complexities of medication management in hemodialysis patients remains paramount in reducing the burden of cardiovascular morbidity and mortality in this vulnerable population.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Wang V, Wang C, Assimon MM, Pun PH, Winkelmayer WC, Flythe JE. Prescription and Dispensation of QT-Prolonging Medications in Individuals Receiving Hemodialysis. JAMA Netw Open. 2024;7(4):e248732. doi:10.1001/jamanetworkopen.2024.8732</p></div><p style="text-align: justify; "><br></p>

132. Endotracheal tube versus reinforced laryngeal mask- which is better for endoscopic sinus surgery?

     Tue, 14 May 2024 14:30:20 -0000

     <img src='https://medicaldialogues.in/h-upload/2021/03/23/150555-functional-endoscopic-sinus-surgery.webp' /><p style="text-align: justify; ">Recently published study provides valuable insights into the effectiveness of RLMA as an alternative airway technique for sinus surgery and suggests potential benefits such as reduced anesthesia duration and postoperative adverse events, contributing to the understanding of the impact of different airway techniques on emergence characteristics in sinus surgery.</p><p style="text-align: justify; ">The study compared the use of reinforced laryngeal mask airway (RLMA) versus an endotracheal tube (ETT) with a throat pack during elective sinus surgery. The researchers conducted a randomized controlled trial of 72 patients and measured the primary outcome of emergence time and secondary outcomes including time to removal of airway device, remifentanil use, procedure times, mean arterial pressure (MAP), and postoperative adverse events.</p><p style="text-align: justify; ">Comparison of RLMA and ETT for Sinus Surgery</p><p style="text-align: justify; ">The study found that there was no significant difference in emergence time between the ETT and RLMA groups. However, remifentanil use was significantly higher in the ETT group, and the ETT group showed a significantly increased total anaesthetic time. Mean arterial pressure (MAP) did not show significant differences between the two groups. The reinforced laryngeal mask airway (RLMA) had lower rates of postoperative adverse events, such as cough and throat pain.</p><p style="text-align: justify; ">Findings and Outcomes</p><p style="text-align: justify; ">The findings indicate that RLMA was comparable to ETT in terms of emergence time, with lower remifentanil use, anaesthesia duration, and fewer postoperative adverse events. The study also highlighted the potential advantages of RLMA, including smoother emergence from anaesthesia and decreased upper airway stimulation. The RLMA group also required less rescue dosing with fentanyl or metaraminol, suggesting improved ease of maintaining a stable anaesthetic.</p><p style="text-align: justify; ">In conclusion, the study demonstrated that using RLMA for endoscopic sinonasal surgery was comparable to ETT in terms of emergence time, remifentanil use, and adverse events such as sore throat. The study provides valuable insights into the effectiveness of RLMA as an alternative airway technique for sinus surgery and suggests potential benefits such as reduced anaesthesia duration and postoperative adverse events. The findings contribute to the understanding of the impact of different airway techniques on emergence characteristics in sinus surgery.</p><p style="text-align: justify; ">Key Points -</p><p style="text-align: justify; ">- A randomized controlled trial compared the use of reinforced laryngeal mask airway (RLMA) versus an endotracheal tube (ETT) with a throat pack during elective sinus surgery among 72 patients.</p><p style="text-align: justify; ">- The study found no significant difference in emergence time between the ETT and RLMA groups, but remifentanil use was significantly higher in the ETT group, and the ETT group showed a significantly increased total anaesthetic time. RLMA had lower rates of postoperative adverse events, such as cough and throat pain.</p><p style="text-align: justify; ">- The findings indicate that RLMA was comparable to ETT in terms of emergence time, with lower remifentanil use, anaesthesia duration, and fewer postoperative adverse events. The study suggests potential benefits of RLMA, including smoother emergence from anaesthesia and decreased upper airway stimulation.</p><p style="text-align: justify; ">Reference –</p><p style="text-align: justify;">Raokadam, Vasanth; Thiruvenkatarajan, Venkatesan; Bouras, George S.; Zhang, Alex1; Psaltis, Alkis. Emergence characteristics comparing endotracheal tube to reinforced laryngeal mask airway during endoscopic sinus surgery – A randomised controlled study. Indian Journal of Anaesthesia 68(5):p 460-466, May 2024. | DOI: 10.4103/ija.ija_966_23.</p><p style="text-align: justify;"><br></p>

133. Greater adiposity measures during childhood linked to increased risk of PCOS: Study

     Tue, 14 May 2024 14:15:53 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/12/237955-imagefornews76700117024635502292012.webp' /><p style="text-align: justify; ">Greater adiposity measures during childhood linked to increased risk of PCOS suggests a study published in the Pediatrics.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">Polycystic Ovary Syndrome (PCOS) is common among females, with significant metabolic and reproductive comorbidities. We describe PCOS development in a pediatric population. They assessed cardiometabolic biomarkers and adiposity at the mid-childhood (mean 7.9 y), early teen (mean 13.1 y), and midteen (mean 17.8 y) visits among 417 females in the prospective Project Viva cohort. We defined PCOS via self-reported diagnosis or ovulatory dysfunction with hyperandrogenism in mid-late adolescence. We used multivariable logistic regression to assess associations of metabolic and adiposity markers at each visit with PCOS. RESULTS: Adolescents with PCOS (n = 56, 13%) versus without had higher mean (SD) BMI z-score and truncal fat mass at the mid-childhood (0.66 [0.99] vs 0.30 [1.04]; 3.5 kg [2.6] vs 2.7 [1.5]), early teen (0.88 [1.01] vs 0.25 [1.08]; 9.4 kg [6.7] vs 6.1 [3.4]), and midteen (0.78 [1.03] vs 0.33 [0.97]; 11.6 kg [7.2] vs 9.1 [4.9]) visits as well as lower adiponectin to leptin ratio at the early (0.65 [0.69] vs 1.04 [0.97]) and midteen (0.33 [0.26] vs 0.75 [1.21]) visits. </p><p dir="ltr" style="text-align: justify; ">In models adjusted for maternal PCOS, education and child race and ethnicity (social factors), we found higher odds of PCOS per 1-SD increase in truncal fat at mid-childhood (odds ratio [OR] 1.42; 95% confidence interval [CI] 1.03–1.95) and early teen visits (OR 1.61; 95% CI 1.14–2.28) and lower odds per 1-SD increase in adiponectin/leptin ratio at the midteen visit (OR 0.14; 95% CI 0.03–0.58). Childhood excess adiposity and adipose tissue dysfunction may be the first signs of later PCOS risk.</p><div style="text-align: justify;"></div><p dir="ltr" style="text-align: justify; ">Reference:</p><p dir="ltr" style="text-align: justify; ">Rachel C. Whooten, Sheryl L. Rifas-Shiman, Wei Perng, Jorge E. Chavarro, Elsie Taveras, Emily Oken, Marie-France Hivert; Associations of Childhood Adiposity and Cardiometabolic Biomarkers With Adolescent PCOS. Pediatrics May 2024; 153 (5): e2023064894. 10.1542/peds.2023-064894</p><div style="text-align: justify;"></div><div style="text-align: justify;"></div><div style="text-align: justify;"></div><div style="text-align: justify;"></div></div>

134. Delhi HC tells Chief Secretary to Implement Panel Recommendations to cure defects in current medical system to avail financial assistance

     Tue, 14 May 2024 13:11:39 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/09/24/186188-delhi-high-court.webp' /><p style="text-align: justify; "><b>New Delhi:</b>&nbsp;For the patients seeking free medical treatment under various government schemes in the hospitals in Delhi, the High Court has directed the Chief Secretary of the Delhi Government to ensure the implementation of the recommendations given by a seven-member committee in this regard.</p><p style="text-align: justify; ">The High Court division bench comprising Acting Chief Justice Manmohan and Justice Manmeet PS Arora has issued directions to the Chief Secretary of GNCTD to convene monthly meetings till all the recommendations get implemented. Further, the Court has directed the Chief Secretary to file action taken report on or before 15th October 2024.</p><p style="text-align: justify; ">Upgradation of Government hospital websites, the appointment of nodal officers by all Public hospitals, implementation of single window mechanism etc. are some of the recommendations made by the Committee set up by the High Court.</p><p style="text-align: justify; ">The HC bench set up the Committee during the proceedings of the plea filed by a man seeking direction upon the authorities including the All India Institute of Medical Sciences (AIIMS) to perform the hip and knee replacement surgery on the Petitioner free of cost.</p><p style="text-align: justify; ">His dire need for surgical intervention arose from his affliction with Reiter’s Syndrome, alternatively known as reactive arthritis, which led to his immobilization.</p><p><span style="text-align: justify;">Accordingly, the HC set up the committee to devise recommendations for alleviating and curing the defects in the current medical system to avail financial assistance.</span><br></p><p style="text-align: justify; ">In this regard, the HC bench had mentioned in the order dated 20.09.2023,<i> "The procedure required for availing free medical treatment must be streamlined, including various surgeries, as well as surgeries for implants / devices and to put in place a single-window mechanism with designated nodal officers at each hospital in Delhi."</i></p><p style="text-align: justify; ">Through that order, the HC had stipulated the terms of reference for the committee. Consequently, the counsel for GNCTD handed over the recommendation of the said Committee and the Court took it on record.</p><p style="text-align: justify; "><b>Recommendations Made by the Committee:</b>&nbsp;</p><ul class="hocalwire-editor-list"><li style="text-align: justify;"><b style="color: rgb(68, 68, 68); background-color: rgb(255, 255, 255);">&nbsp;Upgradation of Hospital Website:</b><span style="color: rgb(68, 68, 68); background-color: rgb(255, 255, 255);">&nbsp;</span></li></ul><p style="text-align: justify; ">The Committee recommended to upgrade the website of each and every Government Hospital of Delhi as dynamic website for real time updates on available medicine, implants and devices with the help of NIC/selected vendors</p><p style="text-align: justify; ">Similarly All Public hospitals must ensure the Electronic Display System accessible to visitors/patients for the dynamic information of list of drugs, implants and devices on the website of concerned departments, which may be revised frequently, the panel suggested.</p><ul class="hocalwire-editor-list"><li style="text-align: justify; "><b>Appointment of Nodal Officers:</b>&nbsp;</li></ul><p style="text-align: justify; ">The HC Committee recommended appointing Nodal Officers by all Public Hospitals- Delhi government hospitals/Central Government hospitals/MCD hospitals/ Autonomous hospitals including AIIMS situated in NCT of Delhi for all the schemes (DAK. RAN &amp; HMCPF) who will ensure all the due requisite required for availing financial assistance.</p><ul class="hocalwire-editor-list"><li style="text-align: justify; "><b>Single Window Mechanism:</b>&nbsp;</li></ul><p style="text-align: justify; ">The Panel suggested implementing/enhancing the Single Window mechanism in all Hospitals- Delhi Government hospitals/Central Government hospitals/MCD hospitals/ Autonomous hospitals including AIIMS situated in the NCT of Delhi for the convenience of patients.</p><p style="text-align: justify; ">"The software may be developed with help of NIC (as recommended above) for Delhi Arogya kosh also so that details will be available and repeated patient/beneficiary appearance can be avoided. Similarly RAN IT platform shall be extended to Delhi Government hospitals and MCD hospitals," the panel recommended.</p><p style="text-align: justify; ">It further mentioned, "Till the time the software is developed, E-office can be utilised by all the hospitals and E-file for the concerned patient can be prepared from the hospital itself with all the requisites as per schemes and transferred to concerned DAK/RAN offices. This will expedite the process and also help in maintain transparency."</p><ul class="hocalwire-editor-list"><li style="text-align: justify; "><b>Prepare Rate Cards Through CPA:</b>&nbsp;</li></ul><p style="text-align: justify; ">The HC panel further recommended immediately preparing the rate card through CPA for fixing rates of all types of equipment- including implants, and medicines through Government procurement system for the diseases covered under scheme as well as for all types of treatment.</p><p style="text-align: justify; ">It opined that the process may take 3 months to be completed. It further stated that there may still be certain medicines/consumables etc which are not part of Essential drug list and rate card is not available for these, hospital/institute shall continue to procure these locally through their procurement system following the GFR guidelines and funds can be obtain from their own allocated budget for EWS patients or funds can be taken from the DAK/RAN. As there is no role of patient/ its relative in the procurement, they shall not be called upon to do under any circumstances.</p><p style="text-align: justify; ">Pointing out that the Medical Directors of the Govt. Hospitals have been conferred the powers of H.O.D who may be authorized to pass the application for emergency treatment, the panel said that the patient will not be asked to get the quotation for estimated treatment cost and genuineness of estimate &amp; cost of implants etc. as it will be the responsibility of H.O.D(MS/MD of concerned Hospital).</p><p style="text-align: justify; ">It recommended that the hospitals be advised to be more proactive for treatment of such patients and expedite the process for approval preferable within 7 days. The Committee also recommended that DAK should sanction such case preferably within 7 days. Till such time hospitals may continue to take care of these patients through available resources with them, it opined.</p><ul class="hocalwire-editor-list"><li style="text-align: justify; "><b>Sensitizing Hospital Staff Responsible for Implementing These Schemes:</b>&nbsp;</li></ul><p style="text-align: justify; ">It has been recommended by the HC Committee that the hospital staff responsible for implementation of these scheme may be sensitized on creating a patient-friendly environment and shall be trained in communication skills.</p><p style="text-align: justify; ">Issuing directions to the GNCTD Chief Secretary to oversee implementation of the recommendations by the panel, the Court listed the matter for compliance on 22nd October 2024.</p><p style="text-align: justify; ">Medical Dialogues had earlier reported that the Delhi High Court had directed the Chief Secretary and the Principal Health Secretary to implement the "immediate measures" proposed by a six-member expert committee within 30 days to enhance medical services in the government hospitals.</p><p style="text-align: justify; ">"The chief secretary and the principal health secretary shall also indicate a roadmap as to how they intend to implement the intermediate and long-term measures within the timeline stipulated by the expert committee. Let an action taken-cum-status report be filed by the principal health secretary within four weeks," a bench of Acting Chief Justice Manmohan and Justice Manmeet PS Arora said in a recent order.</p><p style="text-align: justify; "><b><i>To view the recent HC order, click on the link below:</i></b></p><p style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/delhi-hc-order--238173.pdf" target="_blank" style="background-color: rgb(255, 255, 255);"><b><i>https://medicaldialogues.in/pdf_upload/delhi-hc-order--238173.pdf</i></b></a></p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/poor-infrastructure-at-govt-hospitals-hc-orders-implementation-of-immediate-measures-suggested-by-expert-panel-127349" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: Poor Infrastructure at Govt Hospitals: HC orders implementation of immediate measures suggested by expert panel</i></b></a></p>

135. CDSCO Panel opins Abbott Healthcare to Conduct Phase III CT of Clarithromycin ER Tablets 1000mg

     Tue, 14 May 2024 12:30:40 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/06/231651-abbott-50.webp' /><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><b>New Delhi:</b> Citing that there is no specific unmet medical need, the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) has opined the drug major Abbott Healthcare to conduct Phase-III clinical trial of Clarithromycin extended released (ER) Tablets 1000mg.</p><p style="text-align: justify; ">This came after Abbott Healthcare presented a bioequivalence (BE) report along with justification for the waiver of the Phase-III clinical trial before the committee. </p><p style="text-align: justify; ">The committee noted that proposed drug, Clarithromycin ER tablet 1000mg is presently not approved anywhere in the world.</p><p style="text-align: justify; ">"Clarithromycin ER tablet 1000mg had been approved in the year 2005. However, later on the same was withdrawn from the US market due to unknown reasons." the expert panel noted.</p><p style="text-align: justify; ">Furthermore, the committee stated that there is no specific unmet medical need of proposed formulation.</p><p style="text-align: justify; ">Clarithromycin is a macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.</p><p style="text-align: justify; ">Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.</p><p style="text-align: justify; ">At the recent SEC meeting for antimicrobial and antiviral held on 9th May 2024, the expert panel reviewed the BE report along with justification for waiver of Phase-III clinical trial of the antimicrobial drug Clarithromycin ER Tablets.</p><p style="text-align: justify; ">After detailed deliberation, the committee reiterated its earlier SEC recommendation to conduct a Phase-III clinical trial. </p><p style="text-align: justify; ">Accordingly, the expert panel suggested that the firm should submit Phase-III clinical trial protocol to CDSCO for further review by the committee.</p><p style="text-align: justify; ">Also Read: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/submit-data-on-paracetamol-tapentadol-combination-cdsco-panel-tells-msn-laboratories-128418">Submit Data on Paracetamol-Tapentadol Combination: CDSCO Panel tells MSN Laboratories</a></p></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div>

136. Maharashtra reports 91 cases of new Covid subvariant FLiRT

     Tue, 14 May 2024 12:13:14 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238156-mdtv-2024-05-14t160436251.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">The Maharashtra government has identified 91 cases of the new Covid-19 Omicron subvariant KP.2, surpassing the previously dominant JN.1 variant as the main contributor to cases in several countries. Pune has reported the highest incidence with 51 cases, followed by Thane with 20 cases. Despite the increase in cases, there has been no rise in hospitalizations or severe cases.</div><div style="text-align: justify;">In addition to Pune and Thane, Amravati and Aurangabad each reported seven cases, while Solapur recorded two cases, and Ahmednagar, Nashik, Latur, and Sangli each reported one case of the KP.2 variant. Mumbai reported no cases. The FLiRT group of variants, primarily comprising KP.1.1 and KP.2, are named for specific mutations they carry. KP.2, first identified globally in January, is now the dominant strain in the United States.</div><div style="text-align: justify;"><p><br></p></div></div>

137. Over 37,000 medical students respond to NMC survey, confirm suffering from mental health issues

     Tue, 14 May 2024 12:03:57 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238158-mdtv-2024-05-14t161150454.webp' /><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper" style="text-align: justify; ">The shocking picture concerning the mental health of medical students has come to light as more than 37,000 medical students have submitted applications before the government authority, indicating that they are suffering from mental stress, Live Mint has reported.</div><div class="pasted-from-word-wrapper" style="text-align: justify;">Taking cognisance of this, the apex medical education authority has prescribed several measures including regulating the duty hours of the students and initiating a suicide watch. These recommendations by the National Medical Commission (NMC) will be submitted before the Union Health Ministry for further implementation across the medical colleges in the country.</div><div class="pasted-from-word-wrapper" style="text-align: justify; "><i><b>For more information click on the link below:</b></i></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/news/education/medical-courses/more-than-37000-medicos-respond-to-nmc-survey-confirm-suffering-from-mental-health-issues-128443"><b>More Than 37,000 Medicos Respond To NMC Survey, Confirm Suffering From Mental Health Issues</b></a></i></div><div style="text-align: justify;"><p><br></p></div></div></div>

138. Criminal Proceedings Quashed: HC Relief to Gynaecologist Accused of Leaving Sponge Inside Patient

     Tue, 14 May 2024 11:54:37 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/04/13/207433-madhya-pradesh-hc-indore.webp' /><p style="text-align: justify; "><b>Indore:</b>&nbsp;Granting relief, the Indore bench of Madhya Pradesh High Court recently quashed criminal proceedings against a doctor who was earlier accused of leaving a sponge inside the stomach of a patient during a childbirth operation in 2016.</p><p style="text-align: justify; ">The HC bench of Justice Subodh Abhyankar opined that there was no document on record to demonstrate that the time for which the sponge remained in the patient's stomach was relatable to the time when the doctor operated on her. Therefore, the bench opined that no purpose would be served to allow the trial to proceed further against the petitioner doctor.</p><p style="text-align: justify; ">Back in 2016, the patient, with labour pain, was taken to the Government Hospital Shujalpur and the concerned doctor, posted as a gynaecologist at the hospital, initially advised the family to admit her to a private hospital. However, since the complainant's family insisted, the doctor operated on the patient on 27.12.2016 and consequently, she was discharged a few days later.</p><p style="text-align: justify; ">After giving birth to the child, as she was suffering from constant pain, she got herself examined through various investigating agencies and her CT scan was also conducted. It was found that she had some foreign body lying in her stomach. So, she was again operated on 11.03.2017 by Dr. Jain of SNG Hospital.</p><p style="text-align: justify; ">It was alleged that the second doctor found that cotton (sponge) was left behind in the earlier operation, which had been contained and had started to rot. The patient claimed that after the surgery, she had been continuously suffering from various problems and she was also required to defecate through an artificial outlet, which resulted in serious suffering on the part of the complainant. </p><p style="text-align: justify; ">Therefore, she lodged an FIR against the first treating doctor under Sections 269, 337, 336 and 308 of the Indian Penal Code, 1860 and the consequent criminal proceedings arising out of Crime No.134/2017. Challenging the criminal case, the doctor filed a plea under Section 482 of the Cr.P.C. and approached the Madhya Pradesh High Court seeking relief. Back then, the petitioner had pleaded that the Investigating Officer had not adhered to the decision rendered by the Supreme Court in the case of Jacob Matthew.</p><p style="text-align: justify; ">The Court allowed and disposed of the plea on 04.09.2017 directing the investigating officer to adhere to all the documents available in the record of the hospital related to the disputed operation and strictly follow the direction of the Court passed in the case of Dr.B.C. Jain and Jacob Mathew. Later, the petitioner doctor filed another plea seeking intervention from the court.</p><p style="text-align: justify; ">Subsequently, as per the court order, a Medical Board was formed and in the report dated 24.04.2018, the Board opined that although, it was found that a sponge was indeed left in the petitioner's stomach at the time of her delivery, it could not be said positively whether it was left in the first pregnancy or the second pregnancy.</p><p style="text-align: justify; ">The report also referred to the medical test by Dr. K.K. Agarwal and other doctors, in which it was stated that a sterilized sponge can remain in the stomach without any difficulty for years together and it can cause problems after the subsequent operation and had there been any FSL report, it would have been helpful to fix the liability of the petitioner and in the absence of the same, no positive opinion could be submitted.</p><p style="text-align: justify; ">Relying on the report, the doctor's counsel submitted that the medical team comprising three senior doctors clearly opined that it was not possible to find out if the negligence was of the petitioner or of the other doctor who had operated upon the petitioner during her first pregnancy and in such circumstances, no purpose would be served to prosecute the petitioner. It was further argued that a case under Section 308 of IPC would not be made out since the petitioner doctor had no intention to cause such injury to the complainant.</p><p style="text-align: justify; ">While considering the matter, the Court observed that there was no dispute regarding the fact that some sponge was left in the complainant's stomach, which resulted in extreme pain to the patient. Therefore, the only question was whether the petitioner, who was the treating doctor of the complainant in her second pregnancy, could be prosecuted for the offences alleged against her.</p><p style="text-align: justify; ">The Court took note of the medical opinion given by the Medical Board of Ujjain and the Medical Board, Indore on 08.04.2020. Referring to the report by the Ujjain Medical Board, the HC bench observed, <i>"It is found that in the earlier report, only a possibility has been expressed that such sponge might have been left by the petitioner, although it was also stated that it is not possible to opine as to how old was the sponge and the sponge be sent for forensic report, which was taken out by Dr. *** Jain in a surgery, which took place on 11.03.2017 and as per the Histopathology report, it was found to be a sponge whereas, the report prepared by the Medical Board at Ujjain is a detailed report also emphasizing that as per the medical journals that a sterilized sponge can remain in the stomach without any difficulty for years together, however, it can cause trouble in the subsequent operation and it could have been verified only in the FSL report and in the absence of the same, it is difficult to give any positive opinion."</i></p><p style="text-align: justify; "><i>"Thus, in both the reports, the doctors have emphasized on requisitioning the FSL report, which admittedly, is not available on record, as the sponge was never sent to the forensic laboratory,"</i> the Court noted.</p><p style="text-align: justify; ">The Court observed that in order to fix the criminal liability on the petitioner, it was required to note whether there was sufficient material available on record to bring home the charges levelled against her. At this outset, the bench referred to the Supreme Court's decision in the case of Jacob Mathre (Supra), where the Apex Court also dealt upon the degree of proof in civil and criminal liability.</p><p style="text-align: justify; ">Perusing the records, the High Court observed that after the investigation, the charge-sheet was filed on the premise that the negligence to leave the sponge in the complainant's stomach was on account of negligence of the petitioner.&nbsp;</p><p style="text-align: justify; "><i>"...however, in the absence of the FSL report of the sponge, it is impossible to establish that the sponge was left behind by the petitioner after operation of the complainant,"</i> the Court observed.</p><p style="text-align: justify; ">Therefore, the Court opined that the charges framed against the petitioner would not be made out. It noted, </p><blockquote style="text-align: justify; "><i>"In such circumstances, this Court is of the considered opinion that the charges so framed against the petitioner would not be made out even assuming the case of the prosecution to be correct as the Medical Board in its report dated 24.04.2018, after citing various journals has clearly opined that a sterilized sponge can remain in stomach for years together without any complication to the patient, however, it may cause trouble in the second operation. The Board has also opined that had the specimen obtained from the petitioner’s stomach been sent to FSL, in that case, the period of time for which the sponge was left in the stomach could have been ascertained, however, in the absence of the FSL report, such finding is not possible and not justifiable."</i></blockquote><p style="text-align: justify; ">Opining that no purpose would be served to allow the trial to proceed further against the petitioner, </p><blockquote style="text-align: justify; "><i>"In such facts and circumstances of the case, this Court is of the considered opinion that no purpose would be served to prosecute the petitioner when the prosecution itself has not filed any document on record to demonstrate that the time for which the sponge remained in the complainant’s stomach was relatable to the time when the petitioner performed operation on the complainant. In such circumstances, even though various allegations have been levelled by the complainant in the FIR, this Court is of the considered opinion that no purpose would be served to allow the trial to proceed further against the petitioner."</i></blockquote><p style="text-align: justify; ">Allowing the plea, the High Court bench quashed the FIR dated 31.03.2017 lodged at Crime No.134/2017 at Police Station Shujalpur, District Shajapur under Sections 269, 337, 336 and 308 of the Indian Penal Code, 1860, along with the charge-sheet and consequent criminal proceedings.</p><p style="text-align: justify; ">However, the bench allowed the complainant to avail the civil remedies and ordered, <i>"... this Court is also of the considered opinion that the degree of proof in criminal trial which is beyond reasonable doubt is much more stringent than the degree of proof as is required in a civil case, which is preponderance of probability. In such circumstances, liberty is reserved to the complainant to proceed against the petitioner by taking recourse of the civil remedies available to her under law, if not already initiated, in which, the time spent in prosecuting the criminal proceedings shall stand excluded from the period of limitation."</i></p><p style="text-align: justify; "><b><i>To view the Court order, click on the link below:</i></b></p><p style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/mp-high-court-238154.pdf"><b><i>https://medicaldialogues.in/pdf_upload/mp-high-court-238154.pdf</i></b></a></p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/medico-legal/hc-relief-to-doctor-says-doctors-accused-of-medical-negligence-cannot-be-prosecuted-without-expert-committee-report-125954" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: HC Relief to doctor, says Doctors Accused of Medical Negligence Cannot be Prosecuted without Expert Committee Report</i></b></a></p>

139. NEET paper leak scam: Candidates paid up to Rs 50 lakhs for getting question papers in advance, reveals Bihar EOU

     Tue, 14 May 2024 11:53:53 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238155-mdtv-2024-05-14t155723219.webp' /><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper" style="text-align: justify; ">The brokers involved in the NEET paper leak scam took between Rs 30 lakh to Rs 50 lakh from each of the medical aspirants in exchange of giving them the question paper of the National Eligibility-cum-Entrance Test Undergraduate (NEET-UG) 2024 ahead of the examination on May 5th, 2024, the Economic Offences Unit (EOU) of Bihar Police has revealed.</div><div class="pasted-from-word-wrapper" style="text-align: justify;">EOU has seized several documents, including bank cheques, roll codes of candidates and other papers from the flats of Nitish Kumar and Amit Anand, who were arrested by the Patna Police on May 5.</div><div class="pasted-from-word-wrapper" style="text-align: justify; "><i><b>For more information click on the link below:</b></i></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/news/education/medical-admissions/neet-candidates-paid-up-to-rs-50-lakhs-for-getting-question-papers-in-advance-bihar-eou-128444"><b>NEET Candidates Paid Up To Rs 50 Lakhs For Getting Question Papers In Advance: Bihar EOU</b></a></i></div></div></div>

140. NEET 2024 Answer Key To Release Soon, Here's How to Check

     Tue, 14 May 2024 11:47:29 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/09/01/184811-answer-key.webp' /><p style="text-align: justify; "><b>New Delhi-</b> After giving the National Eligibility cum Entrance Test for Undergraduate (NEET-UG) exam 2024, candidates are eagerly waiting for their results and the National Testing Agency (NTA) is soon going to release the provisional answer key of the NEET-UG exam 2024 on its official website. These provisional answer keys will help the students to check their answers with the correct answers provided.</p><p style="text-align: justify; ">NEET UG Answer Key serves as a valuable resource for medical aspirants who have appeared for the NEET-UG exam 2024. This helps them evaluate their performance in the exam and estimate their potential score. By comparing their answers with the answer key, students can identify any mistakes they may have made during the exam. This includes errors in understanding questions, calculation mistakes, or misinterpretation of concepts. </p><p style="text-align: justify; ">Along with the NEET answer key 2024, NTA will also release the NEET OMR response sheet of the candidates.</p><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/state-news/bihar/neet-2024-cheating-scandal-more-than-24-culprits-including-14-impersonators-arrested-by-bihar-police-128256"><b>Also Read:&nbsp;</b>NEET 2024 Cheating Scandal: More than 24 culprits including 14 impersonators arrested by Bihar Police</a></div><p style="text-align: justify; "><b><u>STEPS TO DOWNLOAD THE NEET UG 2024 ANSWER KEY </u></b></p><p style="text-align: justify; "><b>STEP 1- </b>Visit the Exam NTA official website. </p><p style="text-align: justify; "><b>STEP 2-</b> On the homepage, click on the link that reads, "Click Here for Answer Key" or "Download Answer Key." </p><p style="text-align: justify; "><b>STEP 3- </b>A new window will open, enter your login details such as Application Number and Date of Birth. </p><p style="text-align: justify; "><b>STEP 4-</b> The NEET UG 2024 Answer Key will be displayed on the screen. </p><p style="text-align: justify; "><b>STEP 5-</b> Download the provisional answer key and get its printout for further use. </p><p style="text-align: justify; ">The National Testing Agency conducted the National Eligibility-cum-Entrance Test [(NEET (UG)] – 2024 on 05 May 2024 from 02:00 P.M. to 05:20 P.M. throughout the country and 14 cities outside India in Pen &amp; paper (offline) mode. The NEET UG 2024 saw record-high registrations this year, with over 24 lakh students registering, the highest ever, with over 10 lakh male students, and over 13 lakh female students.</p><div class="pasted-from-word-wrapper"><a class="also-read-media-wrap" href="https://medicaldialogues.in/state-news/delhi/3-arrested-in-delhi-4-in-rajasthan-for-impersonating-candidates-in-neet-2024-128265"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/state-news/delhi/3-arrested-in-delhi-4-in-rajasthan-for-impersonating-candidates-in-neet-2024-128265"><b>Also Read:&nbsp;</b>3 arrested in Delhi, 4 in Rajasthan for impersonating candidates in NEET 2024</a></div>

141. Health Bulletin 14/ May/ 2024

     Tue, 14 May 2024 11:37:51 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238149-bulletin-10.webp' /><p style="text-align: justify; "><b>Here are the top health news for the day:</b><br></p><p style="text-align: justify; "><b>NEET candidates paid up to Rs 50 lakhs for getting question papers in advance</b><br></p><div class="pasted-from-word-wrapper"><p><span style="text-align: justify; background-color: rgb(255, 255, 255);">The brokers involved in the NEET paper leak scam took between Rs 30 lakh to Rs 50 lakh from each of the medical aspirants in exchange of giving them the question paper of the National Eligibility-cum-Entrance Test Undergraduate (NEET-UG) 2024 ahead of the examination on May 5th, 2024, the Economic Offences Unit (EOU) of Bihar Police has revealed.</span><br></p></div><div class="pasted-from-word-wrapper" style="text-align: justify;">EOU has seized several documents, including bank cheques, roll codes of candidates and other papers from the flats of Nitish Kumar and Amit Anand, who were arrested by the Patna Police on May 5.</div><div class="pasted-from-word-wrapper" style="text-align: justify;"><b><i>For more information click on the link below:</i></b></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b><i><a href="https://medicaldialogues.in/news/education/medical-admissions/neet-candidates-paid-up-to-rs-50-lakhs-for-getting-question-papers-in-advance-bihar-eou-128444">NEET Candidates Paid Up To Rs 50 Lakhs For Getting Question Papers In Advance: Bihar EOU</a></i></b></div><div style="text-align: justify;"><b><i><br></i></b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>Maharashtra records 91 cases of new Covid subvariant 'FLiRT'</b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;">The Maharashtra government has identified 91 cases of the new Covid-19 Omicron subvariant KP.2, surpassing the previously dominant JN.1 variant as the main contributor to cases in several countries. Pune has reported the highest incidence with 51 cases, followed by Thane with 20 cases. Despite the increase in cases, there has been no rise in hospitalizations or severe cases. </div><div style="text-align: justify;">In addition to Pune and Thane, Amravati and Aurangabad each reported seven cases, while Solapur recorded two cases, and Ahmednagar, Nashik, Latur, and Sangli each reported one case of the KP.2 variant. Mumbai reported no cases. The FLiRT group of variants, primarily comprising KP.1.1 and KP.2, are named for specific mutations they carry. KP.2, first identified globally in January, is now the dominant strain in the United States.</div><div style="text-align: justify;"><br></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>More than 37,000 medicos respond to NMC survey, confirm suffering from mental health issues</b></div></div><div class="pasted-from-word-wrapper" style="text-align: justify;">The shocking picture concerning the mental health of medical students has come to light as more than 37,000 medical students have submitted applications before the government authority, indicating that they are suffering from mental stress, Live Mint has reported.</div><div class="pasted-from-word-wrapper" style="text-align: justify;">Taking cognisance of this, the apex medical education authority has prescribed several measures including regulating the duty hours of the students and initiating a suicide watch. These recommendations by the National Medical Commission (NMC) will be submitted before the Union Health Ministry for further implementation across the medical colleges in the country.</div><div class="pasted-from-word-wrapper" style="text-align: justify;"><b><i>For more information click on the link below:</i></b></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b><i><a href="https://medicaldialogues.in/news/education/medical-courses/more-than-37000-medicos-respond-to-nmc-survey-confirm-suffering-from-mental-health-issues-128443">More Than 37,000 Medicos Respond To NMC Survey, Confirm Suffering From Mental Health Issues</a></i></b></div><div style="text-align: justify;"><b><i><br></i></b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>Obese people take more sick days off work, study claims</b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;">Researchers from Vienna, studying over 122,000 individuals across Europe, have highlighted the significant impact of obesity on work absenteeism, signaling a growing concern for the labor market. These findings, presented at the European Congress on Obesity in Italy, underscore the urgent need for policymakers to prioritize initiatives promoting healthy weight maintenance.</div><div style="text-align: justify;">Although the study didn't include countries like the UK, France, Ireland, Malta, and Iceland due to insufficient data, the results from the 26 countries that were analyzed reveal that obesity increases the likelihood of taking sick leave, with the severity of obesity correlating with higher absenteeism rates. The research, partly sponsored by Novo Nordisk—a pharmaceutical company producing a weight-loss injection prescribed by the NHS—calls for immediate action.</div></div>

142. Walk In Interview For SR Post At AIIMS Jodhpur: Apply Now

     Tue, 14 May 2024 11:30:03 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/11/18/191380-aiims-jodhpur-vacancies.webp' /><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><b>Jodhpur</b>: The All India Institute of Medical Sciences (AIIMS Jodhpur) has announced vacancies for the Senior Resident post in different departments on a Contract Basis. The selection will be done based on interviews.</p><p style="text-align: justify;">AIIMS Jodhpur is one of the 6 new AIIMS established by the Ministry of Health &amp; Family Welfare, Government of India under the Pradhan Mantri Swasthya Suraksha Yojna (PMSSY) to correct regional imbalances in quality tertiary level healthcare in the country and attain self-sufficiency in graduate and postgraduate medical education.</p><p style="text-align: justify;">AIIMS Jodhpur Vacancy Details:</p><h2 style="text-align: justify;">Total No of Vacancies: 31</h2><p style="text-align: justify; ">The Vacancies are in the Department of - Anaesthesiology and Critical Care, Biochemistry, Burns &amp; Plastic Surgery, Gastroenterology, General Surgery, Medical Oncology, Microbiology, Obstetrics &amp; Gynaecology, and Trauma &amp; Emergency.</p><h2 style="text-align: justify;">Date of Walk-In-Interview: 16th May 2024.</h2><p style="text-align: justify;">Reporting Time and Venue: Medical College of AIIMS, Jodhpur (Rajasthan) from 11:00 AM.</p><h2 style="text-align: justify;"><b><i>For more details about Qualifications, Age, Pay Allowance, and much more, click on the given link:<br></i></b></h2><h2><b><i><a href="https://medicaljob.in/jobs.php?post_type=&amp;job_tags=AIIMS+Jodhpur&amp;location=&amp;job_sector=all">https://medicaljob.in/jobs.php?post_type=&amp;job_tags=AIIMS+Jodhpur&amp;location=&amp;job_sector=all</a></i></b></h2><p style="text-align: justify;"><b>Documents To Be Produced In Original At The Time of Interview:-</b></p><p style="text-align: justify;">The Candidate should bring following original documents and one set of self-attested photocopies at the time of Interview with application form:-</p><p style="text-align: justify;">i. Identity Proof (PAN Card, Passport, Driving License, Voter Card, Aadhar Card etc.) and Address Proof.</p><p style="text-align: justify;">ii. Certificate showing Date of Birth (Passport/Birth Certificate/Driving License). No Age relaxation would be available to SC/ST/OBC candidates applying for unreserved vacancies.</p><p style="text-align: justify;">iii. Class 10th &amp; 12th Marksheet and Certificates. iv. Qualifying degree1. MBBS/M.Sc Marksheet and degree certificates.</p><p style="text-align: justify;">2. MD/DNB/MS/Ph.D degree certificate.</p><p style="text-align: justify;">3. DM/M.Ch/DNB degree certificates.</p><p style="text-align: justify;">v. Attempt and Internship Certificate.</p><p style="text-align: justify;">vi. Registration with Medical Council of India/State Medical Council.</p><p style="text-align: justify;">vii. Experience Certificate (if have).</p><p style="text-align: justify;">viii. FMGE certificate conducted by NBE (For foreign graduate).</p><p style="text-align: justify;">ix. Reservation category Certificate (OBC*/SC/ST/PwBD) (*Candidate should belong to non-creamy layer of Central List of OBC).</p><p style="text-align: justify;">x. In case of OBC candidate, the OBC certificate must be issued within one year (Older certificate will not be entertained).</p><p style="text-align: justify;">xi. No Objection Certificate (NOC), if candidate is working in Government Institution.</p><p style="text-align: justify;">xii. Publications.</p><p style="text-align: justify;">Note: Candidates who do not produce the above mentioned original documents at the time of interview will not be considered for selection.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify;"><b><i><a class="also-read-media-wrap" href="https://medicaldialogues.in/jobs/sr-specialist-super-specialist-post-at-esic-delhi-check-out-walk-in-interview-details-here-128380"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/jobs/sr-specialist-super-specialist-post-at-esic-delhi-check-out-walk-in-interview-details-here-128380">Also Read:SR, Specialist, Super Specialist Post At ESIC Delhi: Check Out Walk In Interview Details Here</a></i></b></p></div></div>

143. How night shift work can raise risk of diabetes and obesity, finds study

     Tue, 14 May 2024 11:20:24 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/11/237934-how-night-shift-work-can-raise-risk-of-diabetes-obesity.webp' /><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">Just a few days on a night shift schedule throws off protein rhythms related to blood glucose regulation, energy metabolism and inflammation, processes that can influence the development of chronic metabolic conditions.</div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;">The finding, from a study led by scientists at Washington State University and the Pacific Northwest National Laboratory, provides new clues as to why night shift workers are more prone to diabetes, obesity and other metabolic disorders.</div><div style="text-align: justify;"><i><b>For more information click on the link below:</b></i></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/diabetes-endocrinology/news/how-night-shift-work-can-raise-risk-of-diabetes-and-obesity-reveals-new-study-128320"><b>How Night Shift Work Can Raise Risk Of Diabetes And Obesity, Reveals New Study</b></a></i></div><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/diabetes-endocrinology/news/how-night-shift-work-can-raise-risk-of-diabetes-and-obesity-reveals-new-study-128320"><b><br></b></a></i></div><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/diabetes-endocrinology/news/how-night-shift-work-can-raise-risk-of-diabetes-and-obesity-reveals-new-study-128320"><b><br></b></a></i></div><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/diabetes-endocrinology/news/how-night-shift-work-can-raise-risk-of-diabetes-and-obesity-reveals-new-study-128320"><b><br></b></a></i></div></div></div>

144. Muskmelon-sized adrenal tumour removed via robotic surgery at Fortis Hospital Noida

     Tue, 14 May 2024 11:15:07 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238157-fortis-hospital-noida.webp' /><div class="pasted-from-word-wrapper"><p>New Delhi: In a groundbreaking surgical feat, doctors at Fortis Hospital Noida successfully removed a muskmelon-sized adrenal tumor from a 59-year-old man, Ajit Kumar Verma, utilizing cutting-edge robotic surgery techniques.</p><p>Despite exhibiting no symptoms, Verma's incidental discovery of the Adrenal Incidentaloma, measuring a substantial 12x11.5 x 8 cm, during a routine ultrasound underscores the importance of thorough medical screenings.&nbsp;</p><p>"Surgical removal is often necessary when these tumours exceed 4cm in size.</p><div class="pasted-from-word-wrapper"><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/167-kgs-gunny-bag-tumour-removed-from-27-year-old-mans-back-at-fmri-gurugram-128018"><b><i>Also Read:16.7 kgs gunny bag tumour removed from 27-year-old man's back at FMRI Gurugram</i></b></a></p><p>These tumours are often highly vascular and pose surgical challenges due to their location near the spleen, pancreas, and kidney," said Dr. Piyush Varshney, Additional Director of Urology, at Fortis who used the da Vinci robotic system to tackle the challenging tumour, reports news agency IANS.</p></div><p>"The da Vinci system's precision allowed us to successfully remove the entire tumour in under two hours with minimal blood loss, and we discharged the patient on the second postoperative day," he added.</p><p>Further, Dr. Varshney explained that an adrenal tumour is a growth on the adrenal gland located deep within the abdomen above the kidneys, near vital organs.</p><p>According to IANS report, Approximately 70 per cent of adrenal tumours exceeding 4 cm in size are typically benign, while the remaining 30 per cent are malignant, indicating cancerous growth. These tumours are relatively prevalent, impacting up to 7 per cent of individuals aged 70 and above.</p><p>Although the precise causes remain elusive, genetic factors sometimes play a role in their development. The patient has been discharged and is doing well now, the doctor said.</p><p>Medical Dialogues team had earlier reported that in a remarkable feat of medical innovation and collaborative healthcare, a team of doctors at AIIMS Bhubaneswar has successfully treated a middle-aged man by removing a rare scalp tumour, marking a significant milestone. According to an official release from AIIMS Bhubaneswar, "The 51-year-old man identified as Rabindra Bishui from West Bengal was saved through a collaborative endeavour led by a dedicated team of medical professionals."</p><div class="pasted-from-word-wrapper"><p><b><i><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/health/hospital-diagnostics/fortis-healthcare-launches-ai-powered-adayu-app-for-mental-healthcare-127738"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/fortis-healthcare-launches-ai-powered-adayu-app-for-mental-healthcare-127738">Also Read:Fortis Healthcare launches AI-powered 'Adayu' app for mental healthcare</a></i></b></p></div></div>

145. Four more Hospitals in Delhi receive bomb threat emails

     Tue, 14 May 2024 11:15:03 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238160-bomb-threat.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">New Delhi: Four more hospitals in Delhi r</span>eceived bomb threat email on Tuesday morning days after similar messages were sent to the Delhi Airport and over half a dozen government hospitals in the city. However, after investigation, Delhi Fire Services (DFS) officials confirmed that these threats were indeed hoaxes.</p><p style="text-align: justify;">According to Delhi Fire Service officials, they received calls from the Deep Chand Bandhu Hospital, GTB Hospital, Dada Dev Hospital, and Hedgewar Hospital about the bomb threat emails.&nbsp;</p><p style="text-align: justify;">Bomb disposal squads along with personnel of the fire department and local police rushed to the spot and conducted searches, reports news agency ANI.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/bomb-scare-in-delhi-20-hospitals-receive-threat-e-mails-days-after-scare-at-schools-128420"><b><i>Also Read:Bomb Scare In Delhi: 20 Hospitals receive threat e-mails days after scare at schools</i></b></a></p><p>In response to the series of threats, the Delhi Police launched an investigation to determine the source of the emails, and security measures were bolstered at the four hospitals as a precautionary measure.</p><p style="text-align: justify;">On Sunday, the Indira Gandhi International (IGI) Airport and over half a dozen government hospitals in the national capital received bomb threats through emails. Delhi police said that nothing suspicious was found.<br></p></div><p style="text-align: justify;">According to Delhi Police, IGI Airport received an email from an unidentified account on Sunday afternoon about the presence of an explosive device inside the premises.</p><p style="text-align: justify; ">Initially, similar emails were received at two government hospitals, including Burari Government Hospital, and Mangolpuri's Sanjay Gandhi Hospital on Sunday afternoon, DCP North Manoj Meena.</p><p style="text-align: justify;">The Delhi Police acted swiftly and started an investigation.</p><p style="text-align: justify;">While Delhi Police and Fire Services Department teams were carrying out search operations at these places, five other government hospitals in the national capital also reported receiving bomb threats through emails on Sunday evening, prompting a search operation at all locations simultaneously.</p><p style="text-align: justify;">The hospitals that got bomb threat emails included-- Dada Dev Hospital in Dabri, Deen Dayal Upadhyay (DDU) Hospital in Hari Nagar, Guru Teg Bahadur (GTB) Hospital in Dilshad Garden, Hindu Rao Hospital in Malka Ganj, and Aruna Asaf Ali Govt Hospital of Rajpur Road.</p><p>These recent threats echo the alarming trend witnessed nearly two weeks prior when numerous schools in Delhi-NCR received similar email threats</p><p style="text-align: justify;">According to the Delhi Police, a total of 131 schools received threat emails on May 1. Later, the Ministry of Home Affairs (MHA) issued an official statement calling the email a 'hoax.' &nbsp;</p><p>As per a media report in <a href="https://indianexpress.com/article/cities/delhi/hoax-bomb-threat-more-hospitals-probe-on-email-9327936/" rel="nofollow">The Indian Express</a>, Officials at Deep Chand Bandhu and Delhi State Cancer Institute (DSCI) said the Delhi Police and a bomb squad were inspecting the premises. The mail was received on Monday night but the hospital authorities saw it in the morning and immediately informed the police. The outpatient department (OPD) registrations at both hospitals had been stopped, but the admitted patients were still inside, they said.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><b><i><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/health/hospital-diagnostics/after-delhi-six-bengaluru-hospitals-get-hoax-bomb-threat-128485"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/after-delhi-six-bengaluru-hospitals-get-hoax-bomb-threat-128485">Also Read:After Delhi, Six Bengaluru hospitals get hoax bomb threat</a></i></b></p></div></div>

146. Merck discontinues Vibostolimab, Pembrolizumab coformulation arm of Phase 3 KeyVibe-010 trial in Melanoma

     Tue, 14 May 2024 10:47:35 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/03/231498-merck-50.webp' /><p><b style="text-align: justify;">Rahway:</b><span style="text-align: justify;">&nbsp;Merck, known as MSD outside of the United States and Canada, has announced the discontinuation of the vibostolimab and pembrolizumab coformulation arm of the Phase 3 KeyVibe-010 trial. The trial is evaluating the investigational coformulation of vibostolimab, an anti-TIGIT antibody, and pembrolizumab (KEYTRUDA), Merck’s anti-PD-1 therapy, compared to KEYTRUDA alone, as adjuvant treatment for patients with resected high-risk melanoma (Stage IIB-IV).</span><br></p><p style="text-align: justify; ">At a pre-planned analysis, data showed that the primary endpoint of recurrence-free survival (RFS) met the pre-specified futility criteria. A higher rate of discontinuation of all adjuvant therapy by patients in the coformulation arm versus the KEYTRUDA-only arm, primarily due to immune-mediated adverse experiences, rendered it highly unlikely that the trial could achieve a statistically significant improvement in RFS. Based on the recommendation of an independent Data Monitoring Committee (DMC), Merck is unblinding the study and recommends that patients receiving the vibostolimab and pembrolizumab coformulation be offered the option to be treated with KEYTRUDA monotherapy. Data analysis from this study is ongoing. Results will be shared with the scientific community and communicated to regulatory agencies.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">“Through our clinical development program, we continue to ask the tough questions in an effort to fully explore the potential of novel coformulations and combinations that build on the foundation of KEYTRUDA, with a goal to improve upon current standards of care and help even more patients with cancer,” said Dr. Marjorie Green, senior vice president and head of oncology, global clinical development, Merck Research Laboratories. “We are grateful to the patients and investigators for their participation and will leverage insights from this trial as we rapidly advance our diverse pipeline of novel mechanisms, including further study of this coformulation in lung cancer.”</p><p style="text-align: justify; ">"Merck is committed to the development of new treatment options for patients with melanoma, including in earlier stages of disease, which build upon the current standard of care. The program includes the ongoing Phase 3 V940-001 study, in collaboration with Moderna, evaluating V940 (mRNA-4157), an investigational individualized neoantigen therapy (INT), in combination with KEYTRUDA as adjuvant treatment in patients with resected high-risk (Stage IIB-IV) melanoma," the release stated.</p><p style="text-align: justify; ">In the U.S., KEYTRUDA has two approved indications in melanoma: for the treatment of patients with unresectable or metastatic melanoma, and for the adjuvant treatment of adult and pediatric (12 years and older) patients with stage IIB, IIC, or III melanoma following complete resection.</p><p style="text-align: justify; ">Vibostolimab is Merck’s investigational anti-TIGIT antibody that restores antitumor activity by blocking the TIGIT receptor from binding to its ligands (CD112 and CD155), thereby activating T lymphocytes that help destroy tumor cells. Merck has an extensive clinical development program evaluating the safety and efficacy of the vibostolimab and pembrolizumab coformulation alone and in combination with other agents in over 3,000 patients.</p><p style="text-align: justify; ">Ongoing Phase 3 studies evaluating the vibostolimab and pembrolizumab coformulation in lung cancer, which are routinely monitored by external data monitoring committees, include KeyVibe-003, KeyVibe-006, KeyVibe-007 and KeyVibe-008. Interim external data monitoring committee safety reviews have not resulted in any safety-related study modifications to date. No changes to these studies are anticipated based on the KeyVibe-010 findings.</p></div><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/phase-3-trial-evaluating-keytruda-in-endometrial-cancer-misses-primary-survival-endpoint-merck-128363">Phase 3 trial evaluating Keytruda in endometrial cancer misses primary survival endpoint: Merck</a></i></b></p>

147. How To Improve Your Lung Health?- Dr Ajith Kumar B.R

     Tue, 14 May 2024 10:17:22 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238146-improving-lung-health.webp' /><div class="pasted-from-word-wrapper" align="justify"> <p>Improving lung health is crucial for overall well-being and vitality. I advocate for adopting a holistic approach that encompasses lifestyle modifications, environmental awareness and medical interventions to optimize lung function and minimize respiratory risks.</p> <p>Firstly, lifestyle habits play a very significant role in lung health. In the research, individuals to quit smoking and avoid exposure to second-hand smoke, as tobacco use is the leading cause of lung-related diseases like lung cancer and chronic obstructive pulmonary disease. Popularly known as COPD. Regular physical activities such as aerobic exercises and breathing techniques can strengthen respiratory muscles and enhance lung capacity.</p> <p>Additionally, maintaining a balanced diet rich in fruits, vegetables and lean proteins, while staying hydrated supports optimal lung function and reduces inflammation. Environmental factors also impact lung health, advised individuals to minimize exposure to indoor and outdoor pollutants, such as air pollution, dust and chemical fumes, which can irritate the lungs and exacerbate respiratory conditions, proper ventilation and air purification systems can help mitigate indoor air pollutants, while avoiding outdoor activities during times of high pollution levels is advisable.</p> <p>Medical interventions play a vital role in managing lung health. Regular health checkups with health care providers allow for early detection and management of respiratory conditions, vaccinations such as the influenza and pneumococcal vaccines protect against respiratory infections.</p> <p>Research and treatments described by health care professionals can help manage conditions like asthma and COPD, improving symptoms and quality of life. In summary, improving lung health involves a multifaceted approach that includes lifestyle modifications, environmental considerations and medical interventions. </p><p>By promoting healthy habits, raising awareness about environmental risks and providing access to medical care, we can empower individuals to prioritize their lung health and live life to the fullest.</p></div><div class="pasted-from-word-wrapper" align="justify"><b><i>Disclaimer: The views expressed in this article are of the author and not of Medical Dialogues. The Editorial/Content team of Medical Dialogues has not contributed to the writing/editing/packaging of this article.</i></b></div><div class="pasted-from-word-wrapper" align="justify"> </div>

148. Medical Bulletin 14/ May/ 2024

     Tue, 14 May 2024 09:30:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238111-medical-bulletin-10.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; "><b>Here are the top medical news for the day:</b></div><div style="text-align: justify; "><b>Study links blood sugar level at gestational diabetes to harmful outcomes for mothers and babies</b></div><div style="text-align: justify;">According to research presented at the 26th European Congress of Endocrinology, the higher the blood sugar level in pregnant women when first diagnosed with diabetes, the higher the risk of complications around and after birth.</div><div style="text-align: justify;">Gestational diabetes — a condition in which women have elevated blood sugar, or glucose, levels during pregnancy — affects around 20 million pregnancies worldwide and poses increased health risks for both mothers and their babies. For example, mothers are more likely to develop type 2 diabetes and to give birth to especially large babies who face a high risk of birth injuries or even obesity later in life. Women are diagnosed with gestational diabetes if their fasting (pre-meal) blood glucose levels are above 92 mg/dL in the first trimester or their 2-hour oral post-meal glucose levels (OGTT) in the second trimester is above 153 mg/dL.</div><div style="text-align: justify;">For every 5mg/L above the diagnosis threshold, the risk of newborns having low blood sugar levels, or a large birth weight, rises by 9% and 6%, respectively, while mothers have a 31% higher risk of diabetes after birth. </div><div style="text-align: justify;">In the study, researchers analysed data on blood sugar levels and birth complications of 6,927 pregnant women, aged 30-37 years old, who were diagnosed with gestational diabetes between 2012 and 2017. The researchers found that for every 5mg/L increase in their blood sugar levels, there was a 9% higher risk of low blood sugar (hypoglycemia) and a 6% higher risk of large birth weight (large for gestational age) in newborns and a 31% higher risk of maternal high blood levels (hyperglycemia) after birth.</div><div style="text-align: justify;">The findings suggested that high-risk women with gestational diabetes should be classified further to limit these complications for both mothers and newborns.</div><div style="text-align: justify;">“While it is not surprising that high glucose levels are associated with these adverse outcomes in mothers and newborns, our study shows for the first time how much increase in risk there is with 5 mg/dL of increase in the mother’s blood glucose levels when first diagnosed with gestational diabetes. The magnitude of elevated risk can be calculated with our measurements and, in practice, could be used to identify and stratify women at higher risk of developing these complications.” said co-lead researcher Dr Catarina Cidade-Rodrigues.</div><div style="text-align: justify;">Reference: Dr Catarina Cidade-Rodrigues. Et al.; Blood sugar level at gestational diabetes diagnosis linked to harmful outcomes for mothers and babies; EUROPEAN SOCIETY OF ENDOCRINOLOGY; MEETING: European Congress of Endocrinology</div><div></div><div></div><div></div><div></div><div></div><div></div><div></div><div></div><div style="text-align: justify;"><b>Does practising yoga strengthen the hearts of heart failure patients? Study sheds light</b></div><div style="text-align: justify;">According to research presented at Heart Failure 2024, a scientific congress of the European Society of Cardiology (ESC), yoga focused on breathing, meditation, and relaxation is linked with symptom improvement in patients with heart failure.</div><div style="text-align: justify;">Heart Failure affects vast numbers of people – more than 64 million globally2 – and can have devastating impacts on quality of life, with patients feeling tired and breathless, and being unable to participate in their usual activities. While previous studies have shown the short-term benefits of yoga in patients with heart failure, this study provides new information about the long-term effects.</div><div style="text-align: justify;">Yoga holds promise as an adjunctive therapy for heart failure patients owing to its multifaceted physiological and psychological benefits. Through its emphasis on controlled breathing, postures, and meditation, yoga can enhance autonomic nervous system regulation, improving cardiac function. Moreover, yoga's stress-reducing properties mitigate sympathetic overactivity and cortisol release, thereby lowering the adverse effects of chronic stress on cardiovascular health. </div><div style="text-align: justify;">In the study, conducted at Kasturba Hospital in Manipal, India, researchers enrolled heart failure patients aged 30 to 70 who had undergone cardiac procedures within the past six months to one year and were on guideline-recommended medications. Out of 85 participants, 40 were assigned to the yoga group, while 45 were in the control group. The yoga group received training in pranayama, meditation, and relaxation techniques and practised at home once a week under supervision. </div><div style="text-align: justify;">Researchers assessed heart structure and function at baseline, six months, and one year in both the yoga and control groups. Measurements included left ventricular ejection fraction and right ventricular function. Additionally, blood pressure, heart rate, body weight, body mass index, symptom burden, and functional capacity were evaluated using the New York Heart Association classification system. </div><div style="text-align: justify;">The results revealed that compared to the control group, the yoga group demonstrated significantly greater improvements in all measurements at six months and one year relative to baseline.</div><div style="text-align: justify;">“Patients who did yoga had healthier hearts and were more able to carry out ordinary activities such as walking and climbing stairs than those who only took medications. Patients with heart failure should speak to their doctor before starting yoga and should then receive training from an experienced instructor. Prescribed medications should be continued as before. Yoga may be unsuitable for heart failure patients with severe symptoms, who were excluded from our study,” said study author Dr. Ajit Singh of the Indian Council of Medical Research (ICMR), Manipal Academy of Higher Education, India.</div><div style="text-align: justify;">Reference: Dr. Ajit Singh, the Indian Council of Medical Research (ICMR), Manipal Academy of Higher Education, India; ‘Impact of yoga therapy on long-term outcomes in heart failure patients using functional and echocardiographic parameters’ ‘Chronic heart failure - treatment 16 Session’</div><div></div><div></div><div></div><div></div><div></div><div style="text-align: justify;"><b>Source of sugar may be more significant in the development of obesity among children, finds study </b></div><div style="text-align: justify;">New research being presented at the European Congress on Obesity (ECO) suggested that the source of sugar is more important than the amount of sugar when it comes to the development of obesity in children.</div><div style="text-align: justify;">High consumption of sugary foods is recognised as a risk factor for childhood overweight and obesity, prompting recommendations for reduced intake of sugar-rich foods like cakes, and sugar-sweetened beverages. Instead, children are encouraged to consume more fruit and unsweetened dairy products such as milk and yoghurt. However, despite being perceived as healthy choices, these foods contain significant amounts of intrinsic sugars—naturally occurring sugars within the food itself—rather than added sugars. </div><div style="text-align: justify;">The intrinsic sugars found these food products can still contribute to obesity if consumed excessively. While these dairy products offer essential nutrients like protein, calcium, and vitamins, they also contain lactose, a type of sugar. When consumed in moderation as part of a balanced diet, the intrinsic sugars in milk and yogurt are typically metabolized efficiently by the body. However, overconsumption of these dairy products can lead to an excessive intake of calories from sugars, which may contribute to weight gain and obesity over time.</div><div style="text-align: justify;">In the study, researchers analysed data from the GEKCO Drenthe study, between April 2006 and April 2007 and aimed to investigate the relationship between early childhood sugar intake and weight-related outcomes. A food intake questionnaire completed by parents of 891 children at age 3 provided data on total sugar intake and sugar intake from various sources. Height and weight measurements were used to calculate BMI Z-scores and weight status at age 10.</div><div style="text-align: justify;">The study found that while the average total daily sugar intake was 112g, it wasn't associated with BMI, weight gain, or weight status. However, higher sugar intake from sugary snacks correlated with a higher BMI Z-score at 10 years. Conversely, greater sugar intake from whole fruit was linked to a lower BMI Z-score and less weight gain. </div><div style="text-align: justify;">Similarly, higher sugar intake from unsweetened liquid dairy products was associated with a reduced risk of developing overweight/obesity, with children having a 67% lower risk compared to those with lower intake.</div><div style="text-align: justify;">“When it comes to developing obesity in childhood, the source of sugar seems to be more important than the amount. Children should be encouraged to have fruit and milk instead of sweetened milk and yoghurt drinks, sweets, cakes and other foods rich in added sugar,” said lead researcher Junyang Zou, of the Department of Epidemiology, University of Groningen and University Medical Center Groningen, The Netherlands.</div><div style="text-align: justify;">Reference: Junyang Zou, University of Groningen and University Medical Center Groningen, The Netherlands, et al.; Source of sugar may be more important than amount when it comes to the development of obesity in children; EUROPEAN ASSOCIATION FOR THE STUDY OF OBESITY; MEETING: European Congress on Obesity (ECO2024)</div><div></div><div></div><div></div></div>

149. South Delhi Doctor Murder Case: 60-year-old help among three arrested

     Tue, 14 May 2024 09:15:31 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/08/12/216316-arrested-3.webp' /><p style="text-align: justify; "><b>New Delhi:</b>&nbsp;A house help working for 24 years is alleged to be the mastermind behind the gruesome murder of a 63-year-old general physician in Delhi's Jangpura. The police have arrested the latter along with two of her aids in connection with the murder. &nbsp;</p><p style="text-align: justify; ">The accused have been identified as Basanti, the house help from Nepal, her brother Akash Joshi and Himanshu, a priest at Haridwar's Birla Ghat. Besides the arrest of these three accused, at least 5 people are absconding including Basanti's friend.</p><p style="text-align: justify; ">The Delhi Police team probing the incident found that Basanti, who is in her early sixties, had beforehand shown her associates the inside of the house through video calls using a messenger application for the smooth execution of the crime.</p><p style="text-align: justify; ">Medical Dialogues team recently reported that Dr Yogesh Chander Paul, a 63-year-old physician was murdered by four men who broke into his house, tied his hands and feet up, and strangled him to death on May 10. &nbsp;</p><p style="text-align: justify; "><b>Also read- <a href="https://medicaldialogues.in/news/health/doctors/murder-in-south-delhi-elderly-physician-found-tied-up-strangled-to-death-on-kitchen-floor-at-his-residence-128377" target="_blank">Murder In South Delhi: Elderly Physician Found Tied Up, Strangled To Death On Kitchen Floor At His Residence</a></b></p><p style="text-align: justify; ">The doctor’s body was discovered by his wife who was away when the intruders broke into their house, situated in a relatively quiet area and committed the heinous act. The intruders also locked the doctor's two dogs in the bathroom.</p><p style="text-align: justify; ">He was found dead on the kitchen floor with his hands and feet tied up. Preliminary reports suggest that there were visible signs of strangulation on his neck and indications of physical assault on his face.</p><p style="text-align: justify; "> According to police, the accused beat up Paul, gagged him and tied him to a chair. They dragged the chair with Paul tied to it to the kitchen where they hit him on the head with a blunt object and strangulated him with a dog leash. </p><p style="text-align: justify; "> The accused had locked Paul's two dogs in the bathroom. They then ransacked the house before fleeing, the police said. </p><p style="text-align: justify; "> Deputy Commissioner of Police (Southeast) Rajesh Deo said, "Basanti, who is the mastermind of this murder, used to video call her associates to show them the inside of the house. Her aides already knew how the house of the doctor looked from inside and where they could execute their plan." </p><p style="text-align: justify; "> The DCP asserted that the identity verification of domestic help is an important step for everyone. </p><p style="text-align: justify; "> The police said the family members of Paul never suspected Basanti as she had been working with their family for the last 24 years. </p><p style="text-align: justify; "> While Basanti and two of her aides have been arrested, a hunt for at least five others is underway in connection with the doctor's murder, they said. </p><p style="text-align: justify; "> "Basanti's friends Varsha, Bheem, Vishwaroop Sai and two Nepal citizens are still on the run and we suspect that they have managed to cross the Nepal border. We have formed different teams who are working round the clock and the rest of the accused will be arrested soon," Deo said. </p><p style="text-align: justify; "> Describing the incident, the DCP said, "After his wife first noticed the body in kitchen, she informed the police about the matter and teams reached the spot. We checked the CCTV footage and later got to know that six people came out of his house in batches of two." </p><p style="text-align: justify; "> "After the incident, Basanti was missing and our team arrested her first, She broke down during interrogation and revealed the entire matter," he said. </p><p style="text-align: justify; ">As per a <a href="https://timesofindia.indiatimes.com/city/delhi/delhi-house-help-of-24-years-two-aides-held-for-doctors-murder/articleshow/110066409.cms" rel="nofollow">TOI </a>news report, the accused Basanti dreamed of living a luxury life after enduring a miserable life. Having been a house help to the doctor for many years, she was well aware of his wealth. To obtain it, she hatched a plan and secretly shared information with her associates, who allegedly had criminal backgrounds and unpaid debts.&nbsp;</p><p style="text-align: justify; "> "CCTV footage confirmed that he was trailed by two people who also entered the house and later four more people in two different groups. Investigation revealed that the suspects stayed in a hotel in Delhi. They were carrying out reccee of the area from May 5 and killed the doctor on May 10. Our teams are working round the clock and the rest of the accused will be arrested soon," said the DCP.</p><p style="text-align: justify; ">"The breakthrough was the result of an analysis of the footage from over 100 cameras besides technical surveillance. Our teams were able to gather crucial leads within 12 hours of the crime and cracked the case within 24 hours," a senior officer told the Daily.</p><p style="text-align: justify; "><b>Also read- <a href="https://medicaldialogues.in/news/health/doctors/ap-orthopaedician-kills-wife-2-kids-mother-before-killing-self-at-residence-127952" target="_blank">AP Orthopaedician Kills Wife, 2 Kids, Mother Before Killing Self At Residence</a></b></p>

150. New PG medical courses, Increase of PG seats: NMC notifies its Final Decision on 158 Applications to 32 Institutes

     Tue, 14 May 2024 09:12:07 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/12/04/226891-nmc.webp' /><p style="text-align: justify; "><b>New Delhi:</b>&nbsp;The National Medical Commission (NMC) has notified its final decision on 158 more applications for starting new postgraduate medical courses and increasing postgraduate medical seats for the academic year 2024-2025. These applications were submitted by altogether 32 medical institutes.</p><p style="text-align: justify; "> Among these applications, altogether 105 applications were for starting new PG medical courses and 53 applications were for an increase of seats in existing PG medical courses.</p><p style="text-align: justify; ">NMC, the Apex Medical Regulator in the country, has communicated its final decision in respect of these applications to the concerned medical institutes through e-mail.</p><p style="text-align: justify; ">Issuing a notice in this regard on 13.05.2024, NMC mentioned, <i>"In continuation of MARB’s Public Notice dated the 28th April 2024, with reference to applications from medical institutions for start or increase of PG medical courses/seats, it is informed that final decision of MARB in respect of 158 more applications (for starting of new PG Medical courses and increase of seats in PG Medical courses for the Academic year: 2024-25) has been communicated through e-mail IDs (as mentioned in online applications) to the Medical Institutions/Colleges concerned for information and necessary action by them within the stipulated timeline."</i></p><p style="text-align: justify; "><i>"A list containing application number of each of the aforesaid 158 applications (105 applications for starting of new PG Medical courses and 53 applications for increase of seats in PG Medical courses) is attached with this public notice for general information,"</i> it further mentioned.</p><p style="text-align: justify; ">Medical Dialogues had earlier reported that recently through a notice dated 28.04.2024, NMC had sent its final decision to 18 medical colleges in respect of 101 applications for the starting of new PG medical courses and an increase of seats for the academic year 2024-2025. At that time, the Commission had informed that communications of the final decision in respect of remaining applications would be sent in due course. Again on 04.05.2024, NMC issued another notice and communicated its final decision to 31 medical institutes in respect of 153 applications.</p><p style="text-align: justify; ">Referring to its earlier notices, the Commission mentioned, <i>"It may be recalled that vide MARB’s Public notice of even number dated the 28th April 2024 &amp; 4th May 2024, it was informed that final decision in respect of 101 &amp; 153 online PG Medical course applications (82 &amp; 110 applications for starting of new PG Medical courses and 19 &amp; 43 applications for increase of seats in PG Medical courses) had already been communicated through the email IDs (as mentioned in online applications) to the Medical Institutions/Colleges concerned."</i></p><p style="text-align: justify; "><i>"Final decision in respect of remaining applications received online will be sent in due course. This issues with the approval of the Competent Authority,"</i> NMC further mentioned in the order.</p><p><b><i>To read the notice, click on the link below:</i></b></p><p><a href="https://medicaldialogues.in/pdf_upload/nmc-notice-pg-medical-courses-238138.pdf"><b><i>https://medicaldialogues.in/pdf_upload/nmc-notice-pg-medical-courses-238138.pdf</i></b></a></p><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/health-news/nmc/nmc-decides-on-153-applications-to-start-increase-pg-medical-seats-notifies-31-medical-colleges-128248" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: NMC decides on 153 Applications to Start, Increase PG Medical Seats, notifies 31 Medical colleges</i></b></a></p>

151. Guwahati Assistant Professor hangs self after betrayal in love affair

     Tue, 14 May 2024 08:00:53 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/02/20/202286-doctor-suicide.webp' /><p style="text-align: justify; "><b>Guwahati: </b>In an unfortunate incident, an assistant professor working at the Rahman Institute of Nursing and Paramedical Sciences in Guwahati allegedly committed suicide by hanging herself from the ceiling at her rented accommodation in the Pithaguri area in the Lokhra.&nbsp;</p><p style="text-align: justify; ">The doctor was reportedly in a relationship with a man who betrayed her, resulting in her tragic death.</p><p style="text-align: justify; ">According to several media reports, the family of the deceased believes that the doctor died by suicide because of a love affair. Her mother told the media that the doctor was in distress due to conflicts in her relationship.&nbsp;</p><p style="text-align: justify; ">The discovery of her suicide note revealed the extent of the betrayal she experienced in her relationship, as her partner had been unfaithful to her with another woman. It is believed that a heated confrontation occurred between them, addressing the man's infidelity before the doctor took the extreme step of ending her life. &nbsp;</p><p style="text-align: justify; "><b>Also read- <a href="https://medicaldialogues.in/news/health/doctors/stressed-over-alleged-work-pressure-dm-cardiology-student-commits-suicide-at-salem-govt-hospital-128288" target="_blank">Stressed Over Alleged Work Pressure: DM Cardiology Student Commits Suicide At Salem Govt Hospital</a></b></p><p style="text-align: justify; ">Besides being an assistant professor, the deceased practised at Rahman Hospital in Guwahati. She was a native of Pathsala in Assam‘s Bajali district.</p><p style="text-align: justify; ">After her lifeless body was discovered, the district magistrate and Basistha police were informed. When they arrived at the scene, a preliminary investigation was conducted leading to the discovery of her suicide note. Later, her body was sent to Gauhati Medical College Hospital (GMCH) for postmortem.</p><p style="text-align: justify; ">Based on the note, the family members registered an FIR at the Garhchuk police station as reported by <a href="https://www.indiatodayne.in/assam/story/assam-guwahati-doctors-suicide-linked-to-betrayal-by-lover-confirms-report-1004819-2024-05-12" rel="nofollow">India Today NE</a> and launched an investigation in this regard.</p><p style="text-align: justify; ">Earlier, speaking to the media, the deceased mother said, “She was a normal human being, there was nothing unusual until she came into a relationship with a boy from Kakinada in Andhra Pradesh. After residing in Andhra Pradesh for six years, she relocated to Assam upon securing a job opportunity. Following the recent voting, she confided in me about her distress, stating that the mentioned boy persistently raises topics that irritate her, leading to heightened emotions and hindering her ability to focus on her work.”</p><p style="text-align: justify; ">“We believe that the boy has mentally harassed or blackmailed her for something of which we are still not aware,” she added quoted by <a href="https://nenow.in/north-east-news/assam/assam-25-year-old-woman-doctor-found-dead-in-guwahati.html" rel="nofollow">Northeast Now</a>.&nbsp;</p><p style="text-align: justify; "><b>Also read-<a href="https://medicaldialogues.in/news/health/doctors/ap-orthopaedician-kills-wife-2-kids-mother-before-killing-self-at-residence-127952" target="_blank"> AP Orthopaedician Kills Wife, 2 Kids, Mother Before Killing Self At Residence</a></b></p>

152. Indian Chest Society launches special booklet on cough management

     Tue, 14 May 2024 08:00:40 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238139-the-indian-chest-society-unveils-special-booklet-on-cough-management-50.webp' /><p><span style="text-align: justify;">The Indian Chest Society (ICS) has unveiled a special booklet titled 'Guidelines For Cough Management in India,' focusing on the comprehensive management of cough in India. The special booklet is part of ICS’ medical initiative supported by Dr. Reddy’s Laboratories Limited, a global pharmaceutical company headquartered in Hyderabad, India as a scientific partner.</span><br></p><div class="pasted-from-word-wrapper"> <p style="text-align: justify; ">Through this booklet, ICS aims to illuminate the prevalence of cough, explore its diverse causes, and provide insights into its diagnosis and management.</p><p style="text-align: justify; "> With dedicated sections on both dry and wet cough management, considerations regarding red flags, appropriate times for specialist referral, the relevance of fixed-dose combinations (FDCs), and a critical examination of banned FDCs in India, the booklet offers evidence-based strategies for clinicians to tailor their treatment approaches accordingly.</p> <p style="text-align: justify; ">To enhance informed decision-making in clinical practice, the booklet also includes a section on fixed-dose combinations which are better alternatives to codeine-based combinations for managing dry cough, and sheds light on appropriate Beta-2 receptor agonists for wet cough management.</p> <p style="text-align: justify; ">The distinguished panel of eight pulmonologists, comprising Dr. R Vijai Kumar, Vice President of ICS, Dr. Deepak Talwar, Honorary Secretary of ICS, Dr. Pradyut Waghray, Dr. Maulik Sanghvi, Dr. S Z Jafrey, Dr. Mahavir Modi, Dr. Meghana Subhash, and Dr. Visweswaran, has been instrumental in shaping the content of this booklet</p> <p style="text-align: justify; ">Speaking about the initiative, Dr. R Vijai Kumar from ICS said, “We believe that this initiative will serve as a valuable resource for healthcare professionals across the country, contributing to enhanced patient care and improved outcomes in cough management. We would also like to thank Dr. Reddy’s for providing scientific support.”</p> <p style="text-align: justify; ">The booklet will be available on ICS’ website soon.</p></div><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/dr-reddys-laboratories-gets-cdsco-panel-nod-for-babe-study-of-ketorolac-tromethamine-sustained-release-tablet-128362">Dr. Reddy's Laboratories gets CDSCO Panel Nod for BA/BE study of Ketorolac Tromethamine Sustained Release Tablet</a></i></b></p>

153. 'LiverDoc' Dr Abby Philips summoned by police as Homeopath alleges defamation of AYUSH treatment on social media platform X

     Tue, 14 May 2024 07:55:51 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/03/15/204890-doctor.webp' /><p style="text-align: justify; "><b>New Delhi:</b>&nbsp;Dr Cyriac Abby Philips, better known as 'The Liver Doc' on X is once again facing legal troubles as the Inspector of Crime Branch, Raebareli, Uttar Pradesh sent a summons to him asking him to show up at their police station within 3 days.</p><p style="text-align: justify; ">According to the summons notice shared by the Kerala-based doctor on his social media platform X, he was asked to appear at the Crime Branch Office, District Rae Bareli, in Uttar Pradesh within 3 days after receiving the notice. </p><p style="text-align: justify; ">"...you are directed to come to the Crime Branch Office, District Rae Bareli within 03 days after receiving the notice in relation to the said allegation and if you.want to provide any evidence in defense of the allegations leveled against you, then present and provide it. Be sure to mark your statement. If you do not appear within the stipulated time and get your statement recorded, then it will be understood that you-have nothing to say regarding the allegations made against you and the allegations made are acceptable to you. Legal action will be taken without waiting for your arrival," stated the summons issued to the doctor.</p><p style="text-align: justify; ">The police action has been initiated against Dr Philips, a Kerala-based hepatologist, after a Homeopathy Practitioner Singh filed a complaint against him in September 2023 for defaming the AYUSH mode of treatment on social media platforms.</p><p style="text-align: justify; ">Sharing a copy of the police complaint on his X (formerly Twitter) handle, Dr. Philips wrote, "These are the people I have to deal with in this country. Complete disasters. Total waste of my time and money."</p><p style="text-align: justify; ">Previously, the doctor made some statements that resulted in the suspension of his Twitter account. This action was taken after Himalaya Wellness Corporation filed a lawsuit in Bengaluru's civil court, accusing the doctor of making defamatory accusations against their products. However, later, the court directed the restoration of his account.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/hc-disposes-of-petition-by-liver-doc-dr-abby-philips-allows-continued-access-to-his-x-account-till-lower-court-order-comes-119991" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: HC disposes of petition by 'Liver Doc' Dr Abby Philips, allows continued access to his X account till lower court order comes</i></b></a></p><p><span style="text-align: justify;">Meanwhile, the Homeopath Dr Singh requested the Raebareli police to register an FIR against Dr. Philips for "abusing, defaming and attacking personally the AYUSH mode of treatment on social media platform like X by the account the liver Doc openly inspite of concentrating on his own way of practice."</span></p><p style="text-align: justify; ">Dr. Singh further pointed out in his complaint that Dr. Philips made a PIL in the Supreme Court of India. Terming it "baseless", Dr. Singh further pointed out that Dr. Philips was not an expert in Ayurveda or Homeopathy.&nbsp;</p><p style="text-align: justify; ">"I therefore request you to a FIR against the respective doctor and prevent such type of personal attacks on every Ayush as well as Government vision for Ayush," further read the complaint.</p><p style="text-align: justify; ">Sharing a copy of the complaint on his X handle, Dr. Philips mentioned, "Inspector of Crime Branch, Raebareli, Uttar Pradesh, sent summons giving 3 days to show up at their police station. At first I thought some child had written it and it was fake. But its not. Detailed official complaint (shown in pic) was made in September 2023 by a Homeopathy practitioner, Mr. ***Singh .. who himself claimed that Homeopathy can cure Covid pandemic."</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/liver-doc-dr-abby-philips-saves-breathless-mans-life-on-akasa-flight-wins-hearts-123309" style="background-color: rgb(255, 255, 255);"><i><b>Also Read: 'Liver doc' Dr Abby Philips saves breathless man's life on Akasa flight, wins hearts!</b></i></a></p><p style="text-align: justify; ">He mentioned that the complaint copy was sent to the Chief Minister of Uttar Pradesh, the National President of the ruling BJP, and the National Organizing Secretary of BJP, as well as the Chief Minister of Kerala.</p><p style="text-align: justify; ">Dr. Philips further highlighted that he was earlier summoned in connection to an investigation into his publications on Ayush's liver injury. "This is not new, I was summoned and had to waste an outpatient day after Kerala Police Commissioner's office started an investigation into my publications on Ayush liver injury, because an Ayurveda practitioner sent a complaint directly to the State Chief Ministers Office," he mentioned.</p><p style="text-align: justify; ">He alleged that such "petty, frivolous and trash complaints to the higher offices from people bent over to the ruling regime, are entertained without in depth review, and end up being investigated for no actual reasons, just for harassing anyone who speaks the truth."</p><p style="text-align: justify; ">"I am a medical science communicator and my work, research and public health activities also include educating public on unscientific practices such as Ayurveda/ Homeopathy. If this is what a doctor like me, who has good support, has to face here, imagine the plight of others, the common people, the ones without the support or strength?" he questioned and further expressed his frustration over the matter by adding that "Being Indian is a punishment for them."</p><p style="text-align: justify; ">Medical Dialogues had earlier reported that last year, Dr. Philips posted some serious accusations against an Ayurvedic company in a new thread on 'X' in which he claimed that a patient developed chronic liver disease after consuming their supplements.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/liver-doc-back-in-action-on-twitter-takes-on-ayurvedic-health-supplements-like-aloe-vera-and-ashwagandha-calls-them-garbage-120653" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: Liver Doc back in action on twitter, Takes on Ayurvedic health supplements like Aloe Vera and Ashwagandha, calls them garbage</i></b></a></p>

154. AstraZeneca Pharma India, Vaayu Chest & Sleep Center collaborate to enhance respiratory care for severe asthma patients in Bengaluru

     Tue, 14 May 2024 07:07:34 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/20/232622-astrazeneca-50-1.webp' /><p><b>Bengaluru:</b>&nbsp;AstraZeneca Pharma India Ltd., a science-led biopharmaceutical company, has partnered with Vaayu Chest &amp; Sleep Center to elevate the standard of respiratory care for severe asthma patients in Bengaluru.<br></p><div class="pasted-from-word-wrapper"><p>Severe asthma poses a significant challenge as a prevalent non-communicable disease in India, contributing to premature morbidity and mortality. Recent data indicates that approximately 22 lakhs of individuals in Karnataka are grappling with asthma, placing the state seventh in terms of asthmatic population in India.&nbsp;</p><p>The Centers of Excellence (COEs) for severe asthma, aligned with the Global Initiative for Asthma (GINA) guidelines, are designed to offer a systematic and uniform approach to managing patients with severe asthma. "Since the start of this year, AstraZeneca's Severe Asthma COEs have screened over 3000 patients nationwide, accurately assessing disease severity and providing tailored treatment through skilled healthcare professionals engaged in AstraZeneca's educational initiatives. The company aims to establish 20 clinics across India by the end of 2024, anticipating to screen over 10,000 COE patients," the release stated.</p><p>Dr. Anil Kukreja, Vice President - Medical Affairs &amp; Regulatory, AstraZeneca India, said, “Severe asthma continues to have a debilitating impact for people living with the disease. At AstraZeneca, we are committed to transforming care for some of the most debilitating and chronic respiratory and immune-mediated diseases. Our collaboration with Vaayu Center underscores our commitment to providing innovative solutions and improving patient outcomes. We are dedicated to filling this gap through our COE network, which not only monitors patients but also educates healthcare providers, offering comprehensive respiratory care solutions to enhance the quality of life for those with NCDs.”</p><p>NCDs such as severe asthma can become a socio-economic burden for the patients, their families, and the healthcare system due to the various treatment costs involved. As a result, effective disease management requires specialized care from a multidisciplinary team of healthcare professionals and caregivers. The establishment of specialized asthma clinics represents a leap forward in technological advancements and holistic disease management.</p><p>Dr. Ravindra Mehta, Director and Head and Dr. Sameer Bansal, Clinical Head at Vaayu Chest and Sleep Specialists said, “World Asthma Day 2024 has an interesting theme "Asthma Education Empowers". One wonders why? It is crucial to understand that knowledge is power, and empowerment is therapy when it comes to managing this respiratory condition. Asthma affects millions worldwide, and in India, its prevalence is significant, with Bangalore infamously dubbed as “Asthma Capital of India”. India accounts for 13.9% of global asthma burden, while contributing to 42% of global asthma related deaths. However, with the right information and proactive measures, individuals can lead fulfilling lives despite this chronic illness. Our aim at Vaayu in 2024 is Knowledge, Education and Commitment to beat the Asthma pandemic.”</p><p>At Vaayu’s Severe Asthma Clinic, focus is on holistic asthma management with expert team of doctors for both, adult and pediatric patients, point-of-care advanced testing such as lung capacity test, airway inflammation and allergy testing, integrated pulmonary wellness and rehabilitation services, preventive clinics such as adult vaccination services, smoking cessation and comprehensive sleep clinic, and access to advanced treatment modalities such as high-end injections and procedures.</p><p><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/astrazeneca-concludes-equity-investment-agreement-with-cellectis-128139">AstraZeneca concludes equity investment agreement with Cellectis</a></i></b></p></div>

155. After Delhi, Six Bengaluru hospitals get hoax bomb threat

     Tue, 14 May 2024 06:45:47 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238121-bomb-threat.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">Bengaluru:&nbsp;</span>Following a spate of hoax bomb threat emails targeting over 20 hospitals in New Delhi, six hospitals within the St Philomena Hospital chain in Bengaluru also received similar threats on Sunday.</p><p><span style="text-align: justify;">Six private hospitals here received a bomb threat via email which turned out to be a hoax, police said on Monday.</span><br></p><p style="text-align: justify;">Police began an extensive search operation along with dog and bomb disposal teams in these city hospitals.&nbsp;</p><p style="text-align: justify;">According to a PTI report, "However, no suspicious object was found inside the premises of these hospitals", a senior police official said.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><b><i><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/health/hospital-diagnostics/bomb-scare-in-delhi-20-hospitals-receive-threat-e-mails-days-after-scare-at-schools-128420"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/bomb-scare-in-delhi-20-hospitals-receive-threat-e-mails-days-after-scare-at-schools-128420">Also Read:Bomb Scare In Delhi: 20 Hospitals receive threat e-mails days after scare at schools</a></i></b></p><div></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div></div><p style="text-align: justify; ">"It was a hoax threat," he said.</p><p>According to the report, Bengaluru Police’s Special Branch got an e-mail on Sunday which claimed that the explosive materials were placed inside the hospital. The mail did not specify the branch and police rushed to all hospital branches. After proper combing operation, the threat is declared as a hoax. An investigation has already been launched by Bengaluru Police to catch the culprits behind it, reports<a href="https://www.hindustantimes.com/cities/bengaluru-news/bengaluru-hospitals-receive-bomb-threat-police-declare-it-as-hoax-later-101715577767883.html" rel="nofollow"> HT</a>.&nbsp;</p><p style="text-align: justify;">The email to the hospitals on Sunday claimed, "I have placed explosive devices in your building. They will explode in the following hours. This isn't a threat, you have a few hours to disarm the bomb or else the blood of the innocent people inside of the building will be on your hands."</p><p style="text-align: justify;">Medical Dialogues team recently reported that days after over 150 schools in Delhi-NCR received an identical threat email claiming that explosives had been planted on their premises, triggering massive evacuations and searches before it was declared a hoax, twenty hospitals too received similar threats on Sunday. While threats to schools were received from a Russia-based mailing service, Sunday’s threats to hospitals and two other installations were received from a Europe-based mailing service company ‘beeble.com’, officials said. &nbsp;</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><b><i><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/health/hospital-diagnostics/bomb-threat-at-chacha-nehru-hospital-turns-out-to-be-hoax-127925"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/bomb-threat-at-chacha-nehru-hospital-turns-out-to-be-hoax-127925">Also Read:Bomb threat at Chacha Nehru Hospital turns out to be hoax</a></i></b></p></div></div>

156. Do not Charge MBBS Fees in Advance: FRA directs Nagpur's Medical College

     Tue, 14 May 2024 06:38:45 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/09/21/220496-fee-1500x900.webp' /><p style="text-align: justify; "><b>Nagpur:</b>&nbsp;The Fee Regulating Authority (FRA) has asked a medical college in Nagpur not to ask for academic fees in advance from the MBBS students. FRA has directed the dean of the medical college to submit an undertaking in this regard, promising that they would not charge any advance fees.</p><p style="text-align: justify; ">This comes after the fee panel received a complaint in this regard from the father of a second-year student at NKP Salve Institute of Medical Sciences. Writing to FRA, the father of the medico claimed that the medical college asked them to pay the tuition fees for three academic years within 18-20 months of the admission.<br></p><p style="text-align: justify; ">Although FRA issued the directive in March, it was revealed only recently in the minutes of the meeting released by the authority.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/mos-health-informs-parliament-on-steps-to-regulate-fees-in-medical-colleges-124950" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: MoS Health Informs Parliament on Steps to Regulate Fees in Medical Colleges</i></b></a></p><p style="text-align: justify; ">As per the latest media report by the <a href="https://www.freepressjournal.in/mumbai/nagpur-medical-college-told-to-cease-advance-fee-demands-by-maharashtra-fee-regulating-authority" rel="nofollow">Free Press Journal</a>, the college claimed that it has since 'resolved' the said grievance. Despite this, FRA has asked the institute to submit an affidavit to undertake that it would comply with the Maharashtra Unaided Private Professional Educational Institutions (Regulation of Admissions and Fees) Act, 2015.</p><p style="text-align: justify; ">Apart from this, the authority also asked the institute for publishing the fee payment schedule for the entire four-and-a-half-year duration of the course, as was requested by the complainant.</p><p style="text-align: justify; ">Under the 2015 Act, professional colleges cannot collect more than a year's fee in an academic year. Further, the Act specifies that the excess amount amount demanded by the college would be considered as a capitation fee, possibly inviting action against the institute.</p><p style="text-align: justify; ">Even though the college has not accepted or refuted the student's allegation in any of the records during the proceedings of the FRA hearing, the representative of the institute told the authority that the complainant had agreed to withdraw its grievance as there was a "miscommunication" and "misunderstanding".</p><p style="text-align: justify; ">The college claimed that the complainant had requested for disposing of the complaint. In fact, the complainant/student's father did not appear before the authority on the designated hearing date and he had also written an e-mail to FRA in March stating that he had decided to withdraw the complaint "considering the prospects and professional career" of his son. He mentioned that he decided not pursuing the matter as his identity had been revealed.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-colleges/charges-increased-from-rs-35k-to-rs-75k-mgims-medicos-file-complaint-over-sudden-mid-course-fee-hike-127339" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: Charges increased from Rs 35k to Rs 75k: MGIMS medicos file complaint over Sudden Mid-Course Fee Hike</i></b></a></p>

157. JnJ to sell remaining 9.5 percent stake in Kenvue

     Tue, 14 May 2024 06:00:36 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/10/231958-johnson-and-johnson-50-1.webp' /><p>Kenvue, the producer of Tylenol said on Monday that Johnson &amp; Johnson will be selling off its remaining 9.5% stake in the company. This decision follows roughly one year after the healthcare conglomerate separated and listed its consumer health business.</p><p><span style="text-align: justify; background-color: rgb(255, 255, 255);">Based on Kenvue stock's last close, the offering of 182.3 million shares would be worth about $3.75 billion, according to Reuters calculation.</span><br></p><div class="pasted-from-word-wrapper"><div data-testid="paragraph-2" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; ">Kenvue's shares were down 1.2% in premarket trading. J&amp;J shares were largely unchanged.</div><div data-testid="paragraph-2" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD"><div data-testid="paragraph-3" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; ">J&amp;J finalized the biggest shake-up in its 137-year history to focus on its pharmaceutical and medical devices businesses. The company in May last year sold 172.8 million shares in Kenvue to raise $3.8 billion, and lowered its stake over the next three months.</div><div data-testid="paragraph-4" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; ">J&amp;J will exchange its holding to Goldman Sachs and J.P. Morgan Securities for its debt, Kenvue said on Monday. Goldman Sachs, J.P. Morgan and BofA Securities are the joint lead book-running managers.</div><div data-testid="paragraph-4" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; ">The Band-Aid maker has focused on its 15 priority brands since the spinoff and earlier this month said it would cut 4% of its global workforce.<br></div></div><div data-testid="paragraph-2" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD"><div data-testid="paragraph-6" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/jnj-submits-regulatory-applications-to-ema-for-tremfya-for-treatment-of-patients-with-ulcerative-colitis-crohns-disease-128082" style="background-color: rgb(255, 255, 255);">JnJ submits regulatory applications to EMA for Tremfya for treatment of patients with ulcerative colitis, Crohn's disease</a></i></b></div></div></div>

158. 28 Km in 44 Minutes: Green corridor helps liver reach Max Saket from Fortis Hospital

     Tue, 14 May 2024 05:30:04 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238096-fortis-shalimar-bagh.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">New Delhi:&nbsp;</span>In a profound demonstration of courage and compassion, the family of a 76-year-old road accident victim has extended the gift of life to a 30-year-old man suffering from liver cirrhosis. This act, facilitated by the skilled medical team at Fortis Hospital Shalimar Bagh, Delhi, stands as a testament to the profound impact of organ donation.</p><p><span style="text-align: justify;">Dr Sonal Gupta, Director, and HOD Neurosurgery at Fortis Hospital Shalimar Bagh, recounted the harrowing circumstances that led to the organ donation.</span></p><p><span style="text-align: justify;">According to a PTI report, a 28-km green corridor in the national capital was created from Shalimar Bagh to Saket to transport a liver to save the life of a 30-year-old man battling&nbsp;</span>liver cirrhosis.</p><p>The elderly man died on May 3 and a green corridor set up to transport his liver reached Max Hospital, Saket in 44 minutes, according to a statement.&nbsp;</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/167-kgs-gunny-bag-tumour-removed-from-27-year-old-mans-back-at-fmri-gurugram-128018"><b><i>Also Read:16.7 kgs gunny bag tumour removed from 27-year-old man's back at FMRI Gurugram</i></b></a></p><p style="text-align: justify; ">"Despite the emergency intervention, the patient suffered brain haemorrhage due to the gravity of the head injury following the accident and multiple clots in the brain. Sadly, he could not be revived despite critical care interventions and ventilator support," Gupta said, reports news agency ANI.</p></div><p style="text-align: justify;">"We salute the deceased donor and deeply appreciate the generosity of his family in recognizing the value of organ donation and giving the gift of life to those in need. The seamless collaboration between our dedicated doctors and the police made this life-saving donation possible. We hope this heartwarming example inspires more people to register for organ donation and make a difference," she added.</p><p style="text-align: justify;">According to the doctors, the road accident victim after the incident was rushed to Fortis Shalimar Bagh hospital with severe head injury and oral bleeding in the first week of May. On admission, the patient was conscious, but within, half an hour he lost consciousness due to a rapidly enlarging clot in the brain. An urgent CT scan of the head revealed a large clot (Subdural Hematoma) in the brain.</p><p style="text-align: justify;">An emergency brain surgery was conducted to remove the clot and bone on the right side of the skull to create extra space for the swollen injured brain. After the surgery, he was placed in the ICU on a ventilator, where a multi-disciplinary team of doctors provided intensive care. Despite vigorous efforts and medications to reduce brain swelling, the victim unfortunately succumbed to his injuries.</p><p style="text-align: justify;">Amidst profound sorrow and grief, the family of the deceased displayed courage and generosity by consenting to donate their loved one's liver to a 30-year-old man suffering from liver cirrhosis. The entire process of multi-organ retrieval surgery took around 2 hours and 35 minutes. A green corridor to transport the liver was created from Fortis Shalimar Bagh to Max Hospital, Saket covering a distance of 28.4 km in just 44 minutes.</p><p style="text-align: justify;">Deepak Narang, Facility Director at Fortis Hospital Shalimar Bagh, expressed gratitude towards the donor's family and emphasized the importance of organ donation in saving lives.</p><p style="text-align: justify;">"We remain indebted to the family for their magnanimity amid grief. The clockwork precision of all internal and external medical teams made this donation a reality. This should encourage more people to come forward and get themselves registered for organ donation to save more lives," Narang said.</p><p style="text-align: justify; ">According to NOTTO (National Organ and Tissue Transplant Organization), once a patient is declared brain dead, the hospital can counsel the family for organ donation. NOTTO protocol and guidelines stipulate that the treating hospital provide all details and obtain necessary clearances for a possible organ donation. In this case, the No Objection Certificate in a Medico-Legal Case (NOC-MLC) was obtained and a request for a green corridor was made.</p><p style="text-align: justify;">According to an ANI report, It is estimated that almost 5 lakh Indians face organ failure every year and only 2-3 percent receive a life-saving transplant. As per data available with NOTTO, in 2022, 11 cadaver donations have been made with the successful retrieval of 30 organs in Delhi.</p><p style="text-align: justify;">Every year, hundreds of people die in India, waiting for an organ transplant. Due to a lack of awareness and misconceptions, there is a shortage of organ donors, and with each passing year, the gap between the number of organs donated and the number of people waiting for transplants is growing wider. Timely cadaveric organ donation can save many lives and more people would come forth and pledge their organs if they receive more information and are educated on the benefits of organ donation.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><b><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/health/hospital-diagnostics/fortis-hospital-doctors-treat-pregnant-woman-suffering-from-spinal-tb-paralysis-124786"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/fortis-hospital-doctors-treat-pregnant-woman-suffering-from-spinal-tb-paralysis-124786">Also Read:Fortis Hospital doctors treat pregnant woman suffering from spinal TB, paralysis</a></b></p></div></div>

159. Fearing failure in NEET exam, Another aspirant goes missing from Kota

     Tue, 14 May 2024 05:30:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/03/03/203845-missing.webp' /><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">Kota: Another 19-year-old student who was preparing for the medical entrance exam in Kota has gone missing. This incident has happened nearly a week after a NEET aspirant left his PG room with Rs 8,000 in his pocket.</p><p style="text-align: justify;">Bihar native Singh, who had been preparing for the entrance exam in the coaching hub for the last two years, left his paying guest room in Swarn Vihar colony on the intervening night of May 11 and 12, the police informed PTI.</p><p style="text-align: justify;">Singh left a note behind in which he said that he couldn’t do well in the NEET exam and won’t be able to crack it, they said. On May 6, a student went missing from his PG room. Medical DIalogues had earlier reported that he sent a text message to his parents saying that he did not want to study any further and was leaving home for five years. Meena wrote that he had Rs 8,000 with him and would contact his family or other relatives if need be.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/i-am-leaving-home-will-be-gone-for-five-years-neet-aspirant-goes-missing-after-giving-exam-128332"><i><b>Also Read:I am leaving home, will be gone for five years: NEET Aspirant goes missing after giving exam</b></i></a></p><p style="text-align: justify; ">Singh, in his note, asked the readers to look for him near the Kota Barrage, located over the Chambal river. However, police declined the possibility of the boy committing suicide as no trace of him was found near the barrage, according to police.</p></div><p style="text-align: justify;">On the basis of CCTV footage, it was found that Singh got onto a bike with another boy and reached Kota Railway Station from where he boarded a train, DSP Rajesh Soni informed PTI.</p><p style="text-align: justify;">It is suspected that the student left the note in his room to misguide the police and his parents, he said, adding that Singh will be traced soon.</p><p style="text-align: justify;">Earlier this month, Singh’s younger brother also came to Kota to prepare for NEET and started living with him, Kunhari Circle inspector Arvind Bhardwaj said.</p><p style="text-align: justify;">His brother told police that around 1 am on the intervening night of May 11 and 12, Singh managed to go out of the PG. When he woke up around an hour later, he found his brother missing, but saw a note and his mobile lying on the bed, the officer said.</p><p style="text-align: justify;">In the note, the student said that he was stressed as he couldn’t do well in the NEET exam and won’t be able to qualify, Bhardwaj said.</p><p style="text-align: justify; ">The police have lodged a report in the matter and efforts are underway to trace the student, the DSP said, adding that Singh’s parents, natives of Munger district in Bihar, also reached Kota on Sunday.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><i><b><a class="also-read-media-wrap" href="https://medicaldialogues.in/state-news/uttar-pradesh/up-shocker-missing-mbbs-student-found-dead-near-railway-track-batchmate-arrested-probe-on-127750"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/state-news/uttar-pradesh/up-shocker-missing-mbbs-student-found-dead-near-railway-track-batchmate-arrested-probe-on-127750">Also Read:Missing MBBS student found dead near railway track, batchmate arrested, Probe On</a></b></i></p></div></div>

160. Study explores potential of oral melatonin in treating stubborn melasma

     Tue, 14 May 2024 04:45:30 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/05/27/210581-melasma.webp' /><p style="text-align: justify; ">India: Melasma, a common skin condition characterized by hyperpigmentation, has long been a challenge to treat effectively. However, a recent study published in the <em>International Journal of Dermatology</em> has sparked hope by investigating the use of oral melatonin as a potential therapy for recalcitrant cases of melasma. The findings of this research offer a promising glimpse into a novel approach to managing this stubborn dermatological condition.<br></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">The study suggests considering oral melatonin as a well-tolerated off-label treatment for patients with recalcitrant melasma, although additional research is required. </p><p style="text-align: justify; ">Melasma, referred to as the "mask of pregnancy," typically manifests as dark patches on the face, particularly on the cheeks, forehead, and upper lip. While various topical treatments and procedures exist, recalcitrant cases—those resistant to conventional therapies—present a significant clinical dilemma for dermatologists and patients alike.</p><p style="text-align: justify; ">The study conducted by Rashmi Sarkar, Lady Hardinge Medical College and Maulana Azad Medical College, New Delhi, India, and colleagues aimed to evaluate the efficacy of oral melatonin supplementation in reducing the severity of melasma and improving patients' quality of life.</p><p style="text-align: justify; ">Melatonin, a hormone primarily known for its role in regulating sleep-wake cycles, has garnered increasing attention for its potential antioxidant and anti-inflammatory properties. Researchers hypothesized that oral melatonin supplementation could modulate melanogenesis, the process by which melanin is produced in the skin, thereby mitigating hyperpigmentation associated with melasma. </p><p style="text-align: justify; ">The researchers presented data from 7 patients with recalcitrant melasma treated with oral melatonin. All patients previously received treatment with either topical creams, including topical combination cream, oral tranexamic acid, or chemical peels without significant improvements.</p><p style="text-align: justify; ">Following a 4-week washout period, all patients received daily 3-mg melatonin tablets and used sunscreen for 12 weeks. All patients reported lightening of pigmentation, and there was an improvement from baseline in the Melasma Area and Severity Index scores. </p><p style="text-align: justify; ">The findings underscore the potential of oral melatonin as a safe and effective adjunctive therapy for individuals struggling with stubborn melasma. By harnessing melatonin's antioxidant and anti-inflammatory properties, dermatologists may have a valuable tool in their arsenal for addressing this challenging condition.</p><p style="text-align: justify; ">While further research is needed to elucidate the optimal dosage, duration, and long-term effects of oral melatonin supplementation in melasma management, the study represents a significant step forward in expanding treatment options for patients with recalcitrant cases.</p><p style="text-align: justify; ">In conclusion, the investigation into the use of oral melatonin in recalcitrant melasma offers renewed hope for individuals seeking relief from this distressing skin condition. As dermatologists continue to explore innovative therapeutic approaches, oral melatonin stands out as a promising avenue for improving outcomes and enhancing the quality of life for those affected by melasma.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Sarkar, R., Verma, B., &amp; Mendiratta, V. Use of oral melatonin in recalcitrant melasma. International Journal of Dermatology. https://doi.org/10.1111/ijd.17201</p></div><p style="text-align: justify; "><br></p>

161. Physiology-guided complete revascularization desirable in older patients with MI and multivessel disease despite HBR: JAMA

     Tue, 14 May 2024 04:30:36 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/11/10/190424-hybrid-coronary-revascularization.webp' /><p style="text-align: justify; ">Italy: In a landmark randomized clinical trial, researchers have delved into a crucial aspect of cardiac care: the optimal approach to revascularization in older patients experiencing myocardial infarction (MI) and possessing a high risk of bleeding. The study, published in <em>JAMA Cardiology</em>, sheds light on a debate that has long perplexed cardiologists and aims to provide clarity for practitioners and patients alike.<br></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">The prespecified analysis of the FIRE randomized clinical trial (RCT), including 1445 patients, revealed that high bleeding risk (HBR) status was common in older patients with MI, and is correlated with a significant rise in ischemic and bleeding complications risk. Physiology-guided complete revascularization effectively improves outcomes and reduces complication rate, regardless of HBR status.</p><p style="text-align: justify; ">Based on the findings, the researchers suggest that HBR status alone should not deter applying physiology-guided complete revascularization in older patients with MI and multivessel disease.</p><p style="text-align: justify; ">Myocardial infarction, commonly known as a heart attack, is a life-threatening condition characterized by a blood flow blockage to the heart muscle. Revascularization, blood flow restoration to the affected area, is a cornerstone of treatment. However, the optimal extent of revascularization has been a subject of ongoing debate, particularly in older patients with additional risk factors such as a high propensity for bleeding.</p><p style="text-align: justify; "> Patients with high bleeding risk have a poor prognosis, and whether they may benefit from complete revascularization after myocardial infarction is not known. Considering this, Andrea Erriquez, Cardiology Unit, Azienda Ospedaliero Universitaria di Ferrara, Ferrara, Italy, and colleagues aimed to investigate the benefit of physiology-guided complete revascularization versus a culprit-only strategy in patients with HBR, MI, and multivessel disease. </p><p style="text-align: justify; ">FIRE was an investigator-initiated, open-label, multicenter trial. Researchers enrolled patients aged 75 years or older with MI and multivessel disease at 34 European centers from 2019 to 2021. Physiology treatment was performed either by angiography- or wire-based assessment. Patients were divided into HBR or non-HBR categories per the Academic Research Consortium HBR document.</p><p style="text-align: justify; ">Patients were randomized to either physiology-guided complete revascularization or culprit-only strategy.</p><p style="text-align: justify; ">The primary outcome comprised a composite of death, stroke, MI, or revascularization at one year. Secondary outcomes included a composite of MI or cardiovascular death and Bleeding Academic Research Consortium (BARC) types 3 to 5. </p><p style="text-align: justify; ">The following were the key findings of the study:</p><ul><li style="text-align: justify; ">Among 1445 patients (mean age, 81 years; 63% male), 71% met HBR criteria.</li><li style="text-align: justify; ">Patients with HBR were at higher risk for the primary end point (hazard ratio [HR], 2.01), cardiovascular death or MI (HR, 1.89), and BARC types 3 to 5 (HR, 3.28).</li><li style="text-align: justify; ">There was a significant reduction in the primary endpoint with physiology-guided complete revascularization than the culprit-only strategy in patients with HBR (HR, 0.73).</li><li style="text-align: justify; ">There was no indication of interaction between revascularization strategy and HBR status for primary and secondary endpoints.</li></ul><p style="text-align: justify; ">The findings suggest that HBR status was common in older patients with MI and was linked with a higher risk of ischemic and bleeding complications, including death. Physiology-guided complete revascularization emerged as an effective method to reduce ischemic complications, including myocardial infarction and cardiovascular death, and should be considered in treating patients with HBR.</p><p style="text-align: justify; ">In conclusion, the randomized clinical trial comparing complete versus culprit-only revascularization in older patients with myocardial infarction and high bleeding risk represents a significant advancement in the field of cardiology. These findings are poised to inform guidelines and shape clinical practice, ultimately improving the quality of care for individuals navigating the complexities of cardiovascular disease.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Erriquez A, Campo G, Guiducci V, et al. Complete vs Culprit-Only Revascularization in Older Patients With Myocardial Infarction and High Bleeding Risk: A Randomized Clinical Trial. JAMA Cardiol. Published online May 08, 2024. </p><p style="text-align: justify; ">doi:10.1001/jamacardio.2024.0804</p><p style="text-align: justify; "><br></p><p style="text-align: justify; "><br></p></div><p style="text-align: justify; "><br></p>

162. High Arsenic Levels in Water may Increase Risk of Type 2 Diabetes suggests Study

     Tue, 14 May 2024 04:30:23 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/04/19/174518-drinking-water.webp' /><p style="text-align: justify; ">A recent research conducted as part of the Strong Heart Family Study (SHFS) and the Multi-Ethnic Study of Atherosclerosis (MESA) unveiled a concerning association between arsenic levels in water and the incidence of Type 2 Diabetes (T2D) within American Indian and diverse urban communities in the United States. The findings were published in the <i>Diabetes Care</i> journal.</p><p style="text-align: justify;">This study examined data from a total of 1,791 participants in SHFS and 5,777 participants in MESA to assess the impact of arsenic exposure from both federally regulated community water systems (CWSs) and unregulated private wells on T2D incidence. The participants were free of T2D at the beginning of the study between 2000 and 2003 and were followed over several years until 2010 for SHFS and 2019 for MESA. </p><p style="text-align: justify; ">The findings revealed that the T2D incidence rates were significantly influenced by arsenic levels in water. In the SHFS cohort, there were 24.4 cases per 1,000 person-years, while in MESA, the rate was 11.2 per 1,000 person-years. The meta-analysis encompassed both cohorts and observed that, for every doubling in arsenic concentration in CWS, the hazard ratio for T2D incidence increased by 10%. Similar patterns were observed for arsenic from private wells, although the association was weaker.<br></p><p style="text-align: justify; ">These findings suggest that even low to moderate levels of arsenic in water (defined as being below 10 µg/L) were linked to an increased risk of developing T2D. The association between arsenic exposure and T2D incidence was noted to be more pronounced among certain demographic groups. The individuals with a Body Mass Index (BMI) below 25 kg/m² and female participants expressed larger magnitude hazard ratios that suggests a increased vulnerability to the effects of arsenic on diabetes risk.</p><p style="text-align: justify; ">These findings underline the importance of monitoring and regulating arsenic levels in water sources. Access to clean and safe drinking water is a fundamental human right and efforts to reduce arsenic contamination should be prioritized to safeguard public health. It becomes increasingly evident that environmental factors play an important role in shaping health outcomes. We can take significant steps towards preventing and managing chronic diseases like Type 2 Diabetes by identifying and addressing these risk factors.</p><p style="text-align: justify; ">Source:</p><p style="text-align: justify; ">Spaur, M., Galvez-Fernandez, M., Chen, Q., Lombard, M. A., Bostick, B. C., Factor-Litvak, P., Fretts, A. M., Shea, S. J., Navas-Acien, A., &amp; Nigra, A. E. (2024). Association of Water Arsenic With Incident Diabetes in U.S. Adults: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Study. In Diabetes Care. American Diabetes Association. <a href="https://diabetesjournals.org/care/article-abstract/doi/10.2337/dc23-2231/154524/Association-of-Water-Arsenic-With-Incident?redirectedFrom=fulltext" rel="nofollow">https://doi.org/10.2337/dc23-2231</a></p>

163. Teprotumumab: A game-changer in thyroid eye disease treatment, treats across phenotypes, study finds

     Tue, 14 May 2024 04:30:20 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/13/237963-thyroid-eye-disease.webp' /><p style="text-align: justify; ">USA: In a groundbreaking development for patients suffering from thyroid eye disease (TED), recent clinical trials have demonstrated the remarkable efficacy of Teprotumumab across various phenotypes of the condition. The findings, presented during an oral presentation at the American Association of Clinical Endocrinology, offer new hope to individuals grappling with the debilitating symptoms of this autoimmune disorder.<br></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">The new data from the post-hoc analysis suggests that teprotumumab (Tepezza) works equally well in older and younger patients with thyroid eye disease, irrespective of TED duration. </p><p style="text-align: justify; ">The researchers observed comparable improvements with teprotumumab among patients with age-related phenotypic I or II thyroid eye disease. </p><p style="text-align: justify; ">"At 24 weeks, 81% of patients with phenotypic I thyroid eye disease (younger than 40 years) and 73.7% of those with phenotypic II disease (40 and older) had overall improvements with teprotumumab, a difference that was not statistically significant," Soheab Ugradar, MD, of Thrive Health in Beverly Hills, California, reported. </p><p style="text-align: justify; ">Results were comparable between the older and younger patients for diplopia, clinical activity score, proptosis, and Graves' Ophthalmology Quality of Life score.</p><p style="text-align: justify; ">Thyroid eye disease, also known as Graves' orbitopathy, is a distressing condition characterized by inflammation and swelling of the tissues around the eyes. It commonly affects individuals with thyroid disorders, particularly those with Graves' disease, an autoimmune condition causing hyperthyroidism. TED can lead to significant visual impairment, disfigurement, and decreased quality of life for patients.</p><p style="text-align: justify; ">Phenotypic I thyroid eye disease involves orbital fat expansion and proptosis with minimal to no periorbital inflammation or diplopia, with low dysthyroid optic neuropathy. Phenotypic II thyroid eye disease involves extraocular muscle enlargement and fibrosis, periorbital inflammation, and diplopia, with higher dysthyroid optic neuropathy rates. </p><p style="text-align: justify; ">Teprotumumab, a monoclonal antibody developed by Horizon Therapeutics, has emerged as a promising therapeutic option for individuals battling TED. The drug works by targeting the insulin-like growth factor 1 receptor (IGF-1R), which plays an important role in the pathogenesis of the disease. By inhibiting IGF-1R signaling, Teprotumumab effectively reduces inflammation and tissue expansion around the eyes.</p><p style="text-align: justify; ">For this analysis, Ugradar and the team identified patients in the randomized OPTIC trial and the open-label OPTIC-X trial, in which patients received eight infusions of teprotumumab. </p><p style="text-align: justify; ">The study comprised 121 patients, 22 with phenotypic 1 disease and 99 with phenotypic 2 disease. The mean age for patients with type I disease was 32.8, 59.1% were women, the mean time since diagnosis was 8.6 months, and the mean clinical activity score was 4.1. For the patients with type II disease, the mean age was 54.5, 72.7% were women, the mean clinical activity score was 4.8, and the mean time since diagnosis was 7.7 months. </p><p style="text-align: justify; ">The following were the key findings of the study:</p><ul><li style="text-align: justify; ">At 24 weeks, the least squares mean change in proptosis was -3.46 mm for the younger patients and -3.22 mm for the older patients. A change of 3 mm, considered the usual correction achieved with surgery, was clinically meaningful.</li><li style="text-align: justify; ">For the quality-of-life score, the total least squares mean change at week 24 was 19.09 points in the younger patients and 15.96 points in the older patients.</li><li style="text-align: justify; ">For 42 patients with longer-duration thyroid eye disease and clinical activity scores of ≤1 (mean age 32 for the younger patients and 56.1 for the older patients), responses at week 24 were similar between the younger and older patients for proptosis (61.5% versus 62.1%, respectively) and diplopia (50% versus 40%).</li><li style="text-align: justify; ">The least squares mean change in proptosis was -2.0 mm for the younger patients and -2.6 mm for the older patients, and the least squares mean change in quality-of-life score appearance subscale was 12.95 points and 8.32 points, respectively, and 5 points and 8.68 points for the visual function subscale.</li></ul><p style="text-align: justify; ">The promising results of these clinical trials have ignited excitement within the medical community and among patients alike. With Teprotumumab poised to become a cornerstone of thyroid eye disease management, individuals grappling with this challenging condition can look forward to improved outcomes and enhanced quality of life. As further research unfolds, the potential of this groundbreaking therapy to transform the landscape of TED treatment appears increasingly tangible.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Ugradar S, et al "Efficacy of teprotumumab in phenotype I vs type II thyroid eye disease" AACE 2024.</p></div><p style="text-align: justify; "><br></p>

164. Radial arterial access superior to femoral access in PCI: Study

     Tue, 14 May 2024 04:30:14 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/05/19/210022-radial-artery.webp' /><p style="text-align: justify; ">USA: In a groundbreaking investigation into the comparative outcomes of radial versus femoral arterial access for percutaneous coronary intervention (PCI) in the United States, the study, published in the<em> Journal of the Society for Cardiovascular Angiography &amp; Interventions,</em> has unveiled compelling insights into temporal trends and clinical implications. This pioneering research sheds new light on the evolving landscape of interventional cardiology and offers valuable guidance for healthcare practitioners and policymakers alike.<br></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">The study found a 2.8-fold increase in the use of radial access for PCI in the US over the past decade and represents the dominant form of access across all procedural indications. Based on instrumental variable analysis, a technique used to support causal inference, radial access was tied to lower in-hospital mortality, major access bleeding, and other major vascular complication rates than femoral access but with a slightly higher ischemic stroke risk. </p><p style="text-align: justify; ">New data presented at the Society for Cardiovascular Angiography &amp; Interventions (SCAI) 2024 Scientific Sessions demonstrated the superiority of radial arterial access over femoral arterial access for coronary interventions. </p><p style="text-align: justify; ">Percutaneous coronary intervention (PCI), commonly known as angioplasty, is a minimally invasive procedure used to open blocked or narrowed coronary arteries, typically performed to treat coronary artery disease (CAD) and relieve symptoms of angina or prevent heart attacks. The choice of arterial access—radial (via the wrist) or femoral (via the groin)—has long been debatable among interventional cardiologists, with each approach carrying its own set of benefits and limitations. </p><p style="text-align: justify; ">Clinical practice guidelines recommend radial access for PCI because of superior outcomes compared with femoral access. Historically, the adoption of radial access in the United States has lagged behind much of the rest of the world, however, there is a lack of contemporary data on access site selection across the spectrum of clinical presentations and its association with outcomes. </p><p style="text-align: justify; ">To fill this knowledge gap, Reza Fazel, Beth Israel Deaconess Medical Center, Brookline, MA, and colleagues aimed to examine temporal trends in the utilization of radial versus femoral arterial access for PCI and to evaluate associated clinical outcomes. </p><p style="text-align: justify; ">For this purpose, the research team conducted a retrospective cohort study from the National Cardiovascular Data Registry’s CathPCI Registry, including PCIs performed between 2013 and 2022. They evaluated the comparative safety of radial versus femoral access for PCI using instrumental variable analysis exploiting operator variation in access preferences. </p><p style="text-align: justify; ">The following were the key findings of the study:</p><ul><li style="text-align: justify; ">During the study period, 2,244,115 PCI procedures were performed, of which 61.6% were performed via radial access, increasing from 23.9% in 2013 to 68.2% in 2022. This increase was seen in all geographic regions and across the full spectrum of presentations, with the largest relative increase seen in patients with ST-segment elevation myocardial infarction.</li><li style="text-align: justify; ">In instrumental variable analyses, radial access was associated with lower in-hospital mortality (absolute risk difference [ARD] -0.15%), major access site bleeding (ARD -0.64%), and other major vascular complications (ARD -0.21%) but a higher risk of ischemic stroke (ARD 0.05%).</li><li style="text-align: justify; ">There was no association with the falsification endpoint of gastrointestinal or genitourinary bleeding (ARD 0.00%).</li></ul><p style="text-align: justify; ">As the field of interventional cardiology continues to evolve, studies like this play a pivotal role in informing best practices and shaping the future of cardiovascular care. By leveraging real-world data and rigorous analysis, researchers aim to drive innovation and improve outcomes for patients undergoing percutaneous coronary intervention.</p><p style="text-align: justify; ">“The study demonstrates a sea change in which PCI is performed in the US in response to trial data but also highlights the continued opportunity for practice improvement with dramatic interoperator variation,” said Dr. Fazel.</p><p style="text-align: justify; ">“It confirms that the benefit observed for radial access in RCTs has also been seen in real-world practice, including the largest benefits for the highest-risk patients. Finally, it shows a highly credible novel finding on the increased stroke risk.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">DOI: https://doi.org/10.1016/j.jscai.2024.101866</p></div><p style="text-align: justify; "><br></p>

165. Curcumin exhibits Cardioprotective Potential Against Diabetic Cardiomyopathies, Reveals Comprehensive Study

     Tue, 14 May 2024 04:15:20 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/02/237349-diabetic-cardiomyopathy.webp' /><p style="text-align: justify; ">China: In a groundbreaking systematic review and meta-analysis, researchers have unveiled compelling evidence of the cardioprotective properties of curcumin against diabetic cardiomyopathies. Published in <i>Phytomedicine </i>journal, this study consolidates preclinical research findings, shedding light on curcumin's therapeutic potential in managing cardiovascular complications associated with diabetes.<br></p><p style="text-align: justify; ">The study found that curcumin may exert cardioprotective effects in diabetic cardiomyopathy (DCM) through its anti-inflammatory, antioxidant, anti-apoptotic, and autophagy-enhancing effects. The protective effect of curcumin was found to be proportional to the dose, and the efficacy may be increased further at a concentration of above 200 mg/kg, and there is a need for further validation. </p><p style="text-align: justify; ">Diabetic cardiomyopathy (DCM) is a common complication of diabetes that often leads to further damage to the heart muscle. Curcumin has been proven to have various cardioprotective effects, however, no systematic review has been conducted on the protective effect against DCM. </p><p style="text-align: justify; ">Against the above background, Wujiao Wang, University of Chinese Medicine, Beijing, China, and colleagues aimed to analyze the preclinical (animal model) evidence of curcumin's therapeutic effects in DCM. </p><p style="text-align: justify; ">For this purpose, the researchers searched eight databases and two registry systems from the time of library construction to 1 November 2023. Rigorous data extraction and quality assessment was performed. Using the SYRCLE RoB tool, the methodological quality of the included studies was appraised. Statistical analyses were carried out using RevMan 5.4 software, and Egger's test and Funnel plots were performed using Stata 17.0 software to assess publication bias. This study included 32 trials with 681 animals. </p><p style="text-align: justify; ">Meta-analysis showed that curcumin significantly improved cardiac function indices (LVFS, LVEF, and LVSd), decreased markers of myocardial injury, HW/BW ratio, and randomized blood glucose compared to the control group, in addition to showing beneficial effects on mechanistic indices of inflammation, myocardial oxidation, apoptosis, and autophagy. </p><p style="text-align: justify; ">“Our study is the first meta-analysis of preclinical studies of curcumin for DCM treatment, and our results suggest that curcumin may play a cardioprotective role in DCM through its anti-inflammatory, antioxidant, autophagy-enhancing, and anti-apoptotic effects,” the researchers wrote. </p><p style="text-align: justify; ">The meta-analysis further elucidated the dose-dependent relationship between curcumin supplementation and its cardioprotective effects, providing valuable insights for future clinical studies and therapeutic applications. </p><p style="text-align: justify; ">As the prevalence of diabetes continues to escalate globally, the quest for effective strategies to prevent and manage diabetic complications becomes paramount. The findings of this systematic review offer compelling evidence supporting the therapeutic potential of curcumin in mitigating diabetic cardiomyopathies, paving the way for further research and clinical translation in cardiovascular medicine. </p><p style="text-align: justify; ">Reference: </p><p style="text-align: justify; ">Wang, W., Chang, P., Jin, J., Pu, F., Li, D., Bai, Y., Dong, K., Yang, Q., &amp; Li, T. (2024). Cardioprotective effects of curcumin against Diabetic Cardiomyopathies: A systematic review and meta-analysis of preclinical studies. Phytomedicine, 129, 155619. https://doi.org/10.1016/j.phymed.2024.155619 </p><p style="text-align: justify; "><br></p>

166. Eating disorder symptoms highly prevalent among people with insulin-dependent diabetes: Study

     Tue, 14 May 2024 04:00:23 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/21/232692-eating-disorder-50.webp' /><p style="text-align: justify; ">One in four patients with insulin-dependent diabetes aged 16 years and older also exhibit some kind of eating disorder symptoms, according to a recent meta-analysis conducted at the University of Eastern Finland. In addition to typical eating disorder symptoms, such as binge eating and food restriction, insulin-dependent diabetes is also associated with insulin omission, i.e., a unique form of disordered eating where insulin doses are intentionally restricted or skipped entirely due to fears of weight gain. </p><p style="text-align: justify;">“Intentional skipping or restriction of insulin doses will lead to weight loss, but this also maintains high blood glucose, throwing the management of diabetes off balance,” Doctoral Researcher Pia Niemelä of the University of Eastern Finland says. </p><p style="text-align: justify;">According to the meta-analysis, one in five patients reported intentional insulin omission. </p><p style="text-align: justify; ">Published in<i> Eating Behaviors</i>, the meta-analysis compiled findings from 45 previous studies. The data included a total of 11,592 individuals with insulin-dependent diabetes, of whom 2,521 exhibited eating disorder symptoms. </p><p style="text-align: justify;">Eating disorder symptoms were more common in women than in men, which is an observation that has previously been made in young people as well. Age, however, was not a significant factor, as eating disorders occurred regardless of age group. </p><p style="text-align: justify;">“Eating disorder symptoms are often thought to affect adolescents and young adults. However, our meta-analysis shows that adults, too, suffer from eating disorder symptoms, which is why it is important to learn to identify patients with eating disorders. Here in Finland, for example, we currently don’t have a care pathway for patients who have both diabetes and eating disorders. Understanding the clinical picture and its prevalence is the first step in developing treatment and care pathways,” Niemelä says. </p><p style="text-align: justify; ">Diabetics with eating disorder symptoms have a higher risk of comorbidities and complications associated with diabetes. Eating disorder symptoms are screened using various surveys, including the most commonly used DEPS-R, which in the current meta-analysis was positive in 27 per cent of the subjects.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Pia E. Niemelä, Hanna A. Leppänen, Ari Voutilainen, Essi M. Möykkynen, Kirsi A. Virtanen, Anu A. Ruusunen, Reeta M. Rintamäki, Prevalence of eating disorder symptoms in people with insulin-dependent-diabetes: A systematic review and meta-analysis, Eating Behaviors, <a href="https://doi.org/10.1016/j.eatbeh.2024.101863">https://doi.org/10.1016/j.eatbeh.2024.101863</a></p><p style="text-align: justify; "><br></p>

167. INI SS July 2024: AIIMS reschedules Stage II Departmental Assessment For MCh Plastic and Reconstructive Surgery, details

     Tue, 14 May 2024 04:00:02 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/04/07/207075-ini-ss.webp' /><p style="text-align: justify; "><b>New Delhi-</b> Through a notice, All India Institute of Medical Sciences (AIIMS) has informed about the revised date of For Stage II Departmental Assessment for 1 M.Ch Course i.e. Plastic and Reconstructive Surgery.</p><p style="text-align: justify; ">Recently, AIIMS declared the result of Stage- I of the Institute of National Importance Super-Specialty Entrance Examination (INI-SS) for admission to DM, M.Ch and MD (Hospital Administration) courses at AIIMS and PGIMER Chandigarh for the July 2024 session.</p><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-admissions/ini-ss-july-2024-dates-revised-for-stage-ii-departmental-assessment-for-2-dm-courses-128370"><b>Also Read:&nbsp;</b>INI SS July 2024- Dates Revised For Stage II Departmental Assessment for 2 DM Courses</a></div><p style="text-align: justify; ">In the result, the date of Stage II (Departmental Assessment) was indicated against the course and, as per the notice, the plastic and reconstructive surgery was scheduled to be held on 15th May 2024. However, the dates in the said course have been revised and it has now been decided to conduct it on 16th May 2024. However, the rest of the dates remain unchanged. </p><p style="text-align: justify; ">Medical Dialogues had earlier reported that a total of 800 candidates had qualified in DM and MCh, however, no candidates were qualified in MD (Hospital Administration) courses for Stage II. Of these, 39 candidates were from the sponsored category and 8 candidates were foreign nationals. Meanwhile, no candidate applied for 5 DM courses i.e. High Altitude Medicine, Pediatric Cardiology, Pediatric Pulmonology &amp; Intensive Care, Pain Medicine and Virology.</p><div class="pasted-from-word-wrapper"><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/education/medical-colleges/ini-ss-july-2024-stage-i-result-declared-total-800-candidates-qualify-for-stage-ii-128343"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-colleges/ini-ss-july-2024-stage-i-result-declared-total-800-candidates-qualify-for-stage-ii-128343"><b>Also Read:&nbsp;</b>INI SS JULY 2024 Stage I Result Declared, Total 800 Candidates Qualify For Stage II,</a></div><p style="text-align: justify; ">The written examination through online (CBT) mode for INI SS was held on Saturday, 27th April 2024 in 16 cities of India like Ahmedabad, Puducherry, Bhopal, Bhopal. The course is scheduled to resume from 01 July 2024. INI-SS entrance exam was related to admission to DM, M.Ch and MD (Hospital Administration) courses for AIIMS, PGIMER, NIMHANS, SCTIMST and JIPMER for July 2024 session. </p><p style="text-align: justify; ">Meanwhile, an official notice on this has directed students to regularly visit the official website of AIIMS for guidelines, number of seats, eligibility criteria, detailed information etc. as well as all subsequent corrigendum and addendum will also be uploaded to the website. </p><p style="text-align: justify; "><b><u><i>To view the notice, click the link below</i></u></b></p><div class="pasted-from-word-wrapper"><a href="https://medicaldialogues.in/pdf_upload/corrigendum-plastic-surgery-238122.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/corrigendum-plastic-surgery-238122.pdf</a></div>

168. KGMU notifies on workshop organised by IISE Lucknow, Science-Tech Institute, Faculties, residents can participate

     Tue, 14 May 2024 04:00:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/03/20/234683-workshop.webp' /><p style="text-align: justify; "><b>Uttar Pradesh-</b> International Institute for Special Education (IISE), Lucknow in collaboration with Science-Tech Institute, Lucknow is going to organise a 5th One week Online Workshop on Optimising Statistical Insights: Advanced Data Analysis with SPSS. On this, King George Medical University (KGMU) has shared a detailed information about the program through an advertisement.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">This workshop will be held from May 21-27, 2024 from 6:30 pm to 8:30 pm.</p></div><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/techniques-in-physiological-sciences-aiims-organizes-hands-on-workshop-to-upskill-medicos-126807"><b>Also Read:&nbsp;</b>Techniques in Physiological Sciences: AIIMS organizes hands-on workshop to upskill medicos</a></div><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">Interested and eligible candidates can register through the link given in the advertisement. The last date for registration is 20th May 2024 till midnight. Meanwhile, candidates will have to pay the registration fee while registering for the program, where Indian participants will have to pay Rs 600/- and foreign participants will have to pay USD($) 10/-. However, the registration fee is non-refundable for both the Indian and Foreign participants. </p><p dir="ltr" style="text-align: justify; ">After successful registration, the participants will receive a confirmation via email. Candidates are instructed to keep on checking the spam folder of the email as the bulk email sent may end up in the spam folder. An official group has also been made for communication with the participants on “WhatsApp.“ The link to join the official group will also be provided in the confirmation mail.</p></div><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-colleges/jipmer-to-hold-workshop-on-mixed-methods-research-in-april-details-126190"><b>Also Read:&nbsp;</b>JIPMER to hold Workshop on Mixed Methods Research in April, Details</a></div><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; "><b><u>WHO CAN PARTICIPATE?</u></b></p><p dir="ltr" style="text-align: justify; ">Faculties, Residents from Medical Colleges, Nursing Colleges, Agriculture College, Law College and Engineering, College, SIHFW and Demographers, Epidemiologists, Statistical officers, Data Analyst and other researchers who are interested in learning data from Govt. and Pvt. organisations are eligible to apply and also all Faculty members (regular/adhoc/temporary/guest) from any Indian/Foreign University/College, PhD (Research Scholars) and UG, PG Students of MBBS &amp; MD, B. Tech &amp; M. Tech. , B.Sc.&amp; M. Sc. BCA &amp; MCA, B. Com. &amp; M. Com. LLB and LLM of all the disciplines.</p><p dir="ltr" style="text-align: justify; "><b><u>PROGRAMME SCHEDULE</u></b></p><div dir="ltr"><table style="text-align: justify; "><colgroup><col width="50"><col width="67"><col width="104"><col width="403"></colgroup><tbody><tr><td><p dir="ltr" style="text-align: center; "><b>S.NO</b></p></td><td><p dir="ltr" style="text-align: center; "><b>DAY</b></p></td><td><p dir="ltr" style="text-align: center; "><b>DATE</b></p></td><td><p dir="ltr" style="text-align: center; "><b>COURSE</b></p></td></tr><tr><td><p dir="ltr">1</p></td><td><p dir="ltr">Day- 1</p></td><td><p dir="ltr">21 May, 2024</p></td><td><p dir="ltr">1Descriptive Statistics.</p><p dir="ltr">2 Graphical representation of Data.</p><p dir="ltr">3 Testing of Normality.</p><p dir="ltr">4 Testing of Homogeneity.</p></td></tr><tr><td><p dir="ltr">2</p></td><td><p dir="ltr">Day- 2</p></td><td><p dir="ltr">22 May, 2024</p></td><td><p dir="ltr">1 One sample t-test.</p><p dir="ltr">2 Independent t-test.</p><p dir="ltr">3 Paired t-test.</p><p dir="ltr">4 ANOVA.</p><p dir="ltr">5 Repeated measures ANOVA.</p></td></tr><tr><td><p dir="ltr">3</p></td><td><p dir="ltr">Day- 3</p></td><td><p dir="ltr">23 May, 2024</p></td><td><p dir="ltr">1 Mann Whitney U-test.</p><p dir="ltr">2 Wilcoxon Rank Signed test.</p><p dir="ltr">3 Kruskal Wallis Test.</p><p dir="ltr">4 Friedman ANOVA.</p><p dir="ltr">5 Chi-square test.</p></td></tr><tr><td><p dir="ltr">4</p></td><td><p dir="ltr">Day- 4</p></td><td><p dir="ltr">24 May, 2024</p></td><td><p dir="ltr">1 Bivariate Regression Analysis.</p><p dir="ltr">2 Logistic Regression Analysis.</p><p dir="ltr">3 Multinomial Logistic Regression Analysis.</p></td></tr><tr><td><p dir="ltr">5</p></td><td><p dir="ltr">Day- 5</p></td><td><p dir="ltr">25 May, 2024</p></td><td><p dir="ltr">1 Exploratory Factor Analysis.</p><p dir="ltr">2 Interpretation of Exploratory Factor Analysis. </p></td></tr><tr><td><p dir="ltr">6</p></td><td><p dir="ltr">Day- 6</p></td><td><p dir="ltr">26 May, 2024</p></td><td><p dir="ltr">1 Cluster Analysis.</p><p dir="ltr">2 Interpretation of Cluster Analysis. </p></td></tr><tr><td><p dir="ltr">7</p></td><td><p dir="ltr">Day- 7</p></td><td><p dir="ltr">27 May, 2024</p></td><td><p dir="ltr">1 Discriminant Analysis.</p><p dir="ltr">2 Interpretation of Discriminant Analysis.</p></td></tr></tbody></table></div></div><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/world-tb-day-artemis-hospital-organizes-public-awareness-workshop-126226"><b>Also Read:&nbsp;</b>World TB Day: Artemis Hospital organizes public awareness workshop</a></div><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; "><b><u>OBJECTIVE</u></b></p><p dir="ltr" style="text-align: justify; ">The course will explain the fundamental concepts of advanced statistical data Analysis techniques using SPSS. It will be delivered through video lectures and reading materials. </p><p dir="ltr" style="text-align: justify; "><b><u>METHODOLOGY</u></b></p><p dir="ltr" style="text-align: justify; ">The methodology of the course will comprise of: </p><p dir="ltr" style="text-align: justify; ">1 Online lecture </p><p dir="ltr" style="text-align: justify; ">2 Participatory discussion </p><p dir="ltr" style="text-align: justify; ">3 Demonstrations </p><p dir="ltr" style="text-align: justify; ">4 Problem-solving (exercises and data analysis in each session).</p><p dir="ltr" style="text-align: justify; "><b><u><i>To view the advertisement, click the link below</i></u></b></p></div><div class="pasted-from-word-wrapper"><a href="https://medicaldialogues.in/pdf_upload/kgmu-workshop-236465.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/kgmu-workshop-236465.pdf</a></div><div class="pasted-from-word-wrapper"><div></div></div>

169. Probiotics formulations may be used as complementary treatment for depressive disorders, claims study

     Tue, 14 May 2024 03:15:55 -0000

     <img src='https://medicaldialogues.in/h-upload/2020/06/23/130819-probiotics.webp' /><p style="text-align: justify;">A recent study&nbsp;highlighted the potential of probiotics as a supplementary treatment for depression, while also uncovering the impact of metabolic factors on their effectiveness. The key findings of this study were published in the recent edition of <i>Nutrients Journal.</i></p><p style="text-align: justify; ">This research included a total of 116 participants who were diagnosed with depression. These individuals were randomly assigned to receive either a probiotic preparation containing Lactobacillus helveticus Rosell®-52 and Bifidobacterium longum Rosell®-175 or a placebo over a span of 60 days. The study utilized a parallel-group, prospective, randomized, double-blind, controlled design to ensure the reliability of the findings.<br></p><p style="text-align: justify; ">Throughout the intervention period, the psychometric data of the participants were assessed at five different time points. Also, various metabolic parameters such as blood pressure, body weight, waist circumference and serum levels of C-reactive protein, cholesterol, triglycerides and fasting glucose were measured at the outset of the study.</p><p style="text-align: justify; ">While the overall depression scores did not show a significant advantage for the probiotics group over the placebo group, this study revealed a marked trend. The participants supplemented with probiotics expressed a higher rate of minimum clinically important differences when compared to the participants on placebo which indicated potential benefits. This effect was particularly pronounced in the subgroup of participants who also received antidepressant treatment.<br></p><p style="text-align: justify; ">The study also brought to light a crucial factor that influenced the efficacy of probiotics in treating depression which was metabolic abnormalities. The research found that individuals with more advanced metabolic issues, such as overweight, excess central adipose tissue and liver steatosis underwent lower improvements in psychometric scores. Also, the individuals with higher baseline stress levels showed better improvements by suggesting a complex interplay of factors at play.<br></p><p style="text-align: justify; ">The study illuminated that while probiotics show promise as complementary treatments for depressive disorders, they may not suffice as standalone interventions. The findings highlight the need for a precise approach to depression treatment in cases where metabolic abnormalities are present.</p><p style="text-align: justify; ">This study marks a crucial step forward in improving the existing understanding of the potential role of probiotics in mental health. Further research with in depth focus into the intricate connections between gut health, metabolism and depression are imperative as new avenues for more effective treatment strategies may emerge to offer better management of this debilitating condition.</p><p style="text-align: justify; ">Source:</p><p style="text-align: justify; ">Gawlik-Kotelnicka, O., Margulska, A., Płeska, K., Skowrońska, A., &amp; Strzelecki, D. (2024). Metabolic Status Influences Probiotic Efficacy for Depression—PRO-DEMET Randomized Clinical Trial Results. In Nutrients (Vol. 16, Issue 9, p. 1389). MDPI AG. <a href="https://www.mdpi.com/2072-6643/16/9/1389" rel="nofollow">https://doi.org/10.3390/nu16091389</a></p>

170. Individuals of all ages with positive skin or blood test must receive preventive treatment for TB: LANCET

     Tue, 14 May 2024 03:15:47 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/01/23/230765-tuberculosis-50.webp' /><p style="text-align: justify; ">Preventive treatment for tuberculosis (TB) can stop latent TB infections from developing into deadly TB disease. Despite TB infection being fully treatable, there is no global consensus as to which subgroups of individuals exposed to TB should be prioritized for preventive treatment, nor whether the benefits of this treatment vary based on factors such as age or confirmed infection. </p><p style="text-align: justify;">A new study led by a Boston University School of Public Health (BUSPH) researcher provides clarity to this issue, finding that exposed individuals with confirmed TB infection-i.e. a positive skin or blood test-should receive priority treatment in settings with a low prevalence of the disease, regardless of their age. </p><p style="text-align: justify;">However, in high-burden settings, all exposed individuals should be considered for preventative treatment, even without a confirmed infection, according to the findings published in<i> The Lancet Respiratory Medicine. </i></p><p style="text-align: justify;">This strategy can help end the tuberculosis epidemic and support global public health efforts to reduce TB mortality by 95 percent by 2035 (from 2015 estimates). In 2022, there were more than 10 million cases of active TB worldwide, resulting in 1.5 million deaths. </p><p style="text-align: justify;">"Tuberculosis affects tens of millions of people every year and has long-term lasting effects, even after people recover,” says study lead and corresponding author Dr. Leonardo Martinez, assistant professor of epidemiology at BUSPH. “Finding ways to optimize prevention is really important to tackle the epidemic." </p><p style="text-align: justify;">For the study, Dr. Martinez and colleagues conducted a comprehensive review and analysis to identify new cases of TB among people who were in close contact with individuals diagnosed with the disease, and compared the effectiveness of preventive treatment in these exposed individuals based on age, infection status, and burden of TB in their settings. </p><p style="text-align: justify;">Among 439,644 participants, the team found that preventive TB treatment was 49 percent effective among the 2,496 individuals who developed TB, but particularly among individuals with a positive skin or blood test (for which the effectiveness was 80 percent). </p><p style="text-align: justify;">Notably, the researchers found that preventive TB treatment was not effective in most individuals who did not show evidence of infection, except for children under 5. </p><p style="text-align: justify;">For those who did have a positive skin or blood test, the effectiveness of the treatment was comparable among individuals of all age groups-adults, children ages 5-17, and children under 5-and the treatment was more effective among individuals in high-burden settings than low-burden settings. </p><p style="text-align: justify;">The team also estimated the number of individuals needed to receive treatment (NNT) in order to prevent one person from developing TB disease. Regardless of infection status, the NNT was lower in high-burden settings (29 to 43 people) versus low-burden settings (213 to 455 people). Despite the fact that individuals with negative blood or skin tests do not seem to benefit from preventive treatments, the researchers say the overall low NNT may justify prioritizing this treatment to all exposed contacts in areas where testing for TB infection is inaccessible. </p><p style="text-align: justify; ">“While it is critical to find and treat people who are spreading TB in the community, the threat of global TB will never end until people with latent TB receive treatment,” says study coauthor Dr. C. Robert Horsburgh, professor of global health. “The results of this study show just how effective such treatment can be.”&nbsp;</p><p style="text-align: justify;">Reference:</p><p style="text-align: justify;">Leonardo Martinez, James A Seddon, Prof C Robert Horsburgh, Prof Christoph Lange, Prof Anna M Mandalakas, Effectiveness of preventive treatment among different age groups and Mycobacterium tuberculosis infection status: a systematic review and individual-participant data meta-analysis of contact tracing studies, The Lancet Respiratory Medicine, DOI:https://doi.org/10.1016/S2213-2600(24)00083-3.</p>

171. Multifrequency tympanometry useful aid for diagnosing Meniere disease, claims study

     Tue, 14 May 2024 03:15:14 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/09/237824-multifrequency-tympano.webp' /><p>Multifrequency tympanometry useful aid for diagnosis of Meniere disease, claims study published in the Journal of Clinical Medicine.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">Meniere's disease (MD) is a disease of the inner ear, presenting with episodes of vertigo, hearing loss, and tinnitus.This study aims to examine the role of multifrequency tympanometry (MFT) in the diagnosis of Ménière’s disease. A systematic review of MEDLINE (via PubMed), Scopus, Google Scholar, and the Cochrane Library was performed, aligned with the PRISMA guidelines. Only studies that directly compare ears affected by Ménière’s disease with unaffected or control ears were included. Random-effects model meta-analyses were performed.</p><p dir="ltr" style="text-align: justify; "> Results: Seven prospective case-control studies reported a total of 899 ears, 282 of which were affected by Ménière’s disease (affected ears-AE), 197 unaffected ears in patients with Ménière’s disease (UE), and 420 control ears (CE) in healthy controls. No statistically significant differences between the groups were observed regarding resonant frequency (RF). The pure tone audiometry average of the lower frequencies (PTA basic) was significantly greater in affected ears when compared with unaffected ears. The conductance tympanogram at 2 kHz revealed a statistically significantly greater G width of 2 kHz in the affected ears when compared to both unaffected and control ears, while control ears had a statistically significant lesser G width of 2 kHz compared to both the other two groups. multifrequency tympanometry, and specifically G width at 2 kHz, could be an important tool in the diagnosis of Ménière’s disease.</p><div style="text-align: justify;"></div><p dir="ltr" style="text-align: justify; ">Reference:</p><p dir="ltr" style="text-align: justify; ">Tsilivigkos C, Vitkos EN, Ferekidis E, Warnecke A. Can Multifrequency Tympanometry Be Used in the Diagnosis of Meniere’s Disease? A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2024; 13(5):1476. <a href="https://doi.org/10.3390/jcm13051476">https://doi.org/10.3390/jcm13051476</a></p><div style="text-align: justify;"></div><div style="text-align: justify;"></div><div style="text-align: justify;"></div><div style="text-align: justify;"></div></div>

172. Source of sugar may be more significant in the development of obesity among children, finds study

     Tue, 14 May 2024 03:00:21 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238109-mdtv-2024-05-14t113115403.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">New research being presented at the European Congress on Obesity (ECO) suggested that the source of sugar is more important than the amount of sugar when it comes to the development of obesity in children.</div><div style="text-align: justify;">High consumption of sugary foods is recognised as a risk factor for childhood overweight and obesity, prompting recommendations for reduced intake of sugar-rich foods like cakes, and sugar-sweetened beverages. Instead, children are encouraged to consume more fruit and unsweetened dairy products such as milk and yoghurt. However, despite being perceived as healthy choices, these foods contain significant amounts of intrinsic sugars—naturally occurring sugars within the food itself—rather than added sugars. </div><div style="text-align: justify;">The intrinsic sugars found these food products can still contribute to obesity if consumed excessively. While these dairy products offer essential nutrients like protein, calcium, and vitamins, they also contain lactose, a type of sugar. When consumed in moderation as part of a balanced diet, the intrinsic sugars in milk and yogurt are typically metabolized efficiently by the body. However, overconsumption of these dairy products can lead to an excessive intake of calories from sugars, which may contribute to weight gain and obesity over time.</div><div style="text-align: justify;">In the study, researchers analysed data from the GEKCO Drenthe study, between April 2006 and April 2007 and aimed to investigate the relationship between early childhood sugar intake and weight-related outcomes. A food intake questionnaire completed by parents of 891 children at age 3 provided data on total sugar intake and sugar intake from various sources. Height and weight measurements were used to calculate BMI Z-scores and weight status at age 10.</div><div style="text-align: justify;">The study found that while the average total daily sugar intake was 112g, it wasn't associated with BMI, weight gain, or weight status. However, higher sugar intake from sugary snacks correlated with a higher BMI Z-score at 10 years. Conversely, greater sugar intake from whole fruit was linked to a lower BMI Z-score and less weight gain. </div><div style="text-align: justify;">Similarly, higher sugar intake from unsweetened liquid dairy products was associated with a reduced risk of developing overweight/obesity, with children having a 67% lower risk compared to those with lower intake.</div><div style="text-align: justify;">“When it comes to developing obesity in childhood, the source of sugar seems to be more important than the amount. Children should be encouraged to have fruit and milk instead of sweetened milk and yogurt drinks, sweets, cakes, and other foods rich in added sugar,” said lead researcher Junyang Zou, of the Department of Epidemiology, University of Groningen and University Medical Center Groningen, The Netherlands.</div><div style="text-align: justify;">Reference: Junyang Zou, University of Groningen and University Medical Center Groningen, The Netherlands, et al.; Source of sugar may be more important than amount when it comes to the development of obesity in children; EUROPEAN ASSOCIATION FOR THE STUDY OF OBESITY; MEETING: European Congress on Obesity (ECO2024)</div><div></div></div>

173. Rare Disease Show: Episode 2 Understanding Budd Chiari Syndrome with Dr Shrihari Anikhindi

     Tue, 14 May 2024 03:00:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238123-mdtv-2-2.webp' /><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">Medical Dialogues presents a rare disease series, focusing on uncommon medical conditions. Rare diseases are medical conditions that affect only a small percentage of the population. Throughout this series, we'll discuss these rare diseases in various episodes, with medical experts providing clear explanations and insights. </p><p style="text-align: justify;">Rare Disease Show Episode 2- In today's show we will cover Budd Chiari Syndrome. Budd-Chiari Syndrome is a rare disorder characterized by the obstruction of the hepatic veins that drain blood from the liver. </p><p style="text-align: justify; "> In this episode, Dr. Shrihari Anikhindi, Associate Consultant at the Institute of Liver Gastroenterology &amp; Pancreatico Biliary Sciences at Sir Ganga Ram Hospital, Delhi shares his insights by addressing the following questions-</p></div><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">1. Can you provide an overview of Budd-Chiari Syndrome, talking about how rare this syndrome is? What are its causes, symptoms, and risk factors?</div><div style="text-align: justify; ">2.How is Budd-Chiari Syndrome diagnosed, and what diagnostic tests are typically conducted to confirm the condition?</div><div style="text-align: justify; ">3. What are the treatment options available for Budd-Chiari Syndrome, and how is the choice of treatment determined?</div><div style="text-align: justify; ">4. Are there any lifestyle changes or dietary modifications recommended for individuals with Budd-Chiari Syndrome?</div><div style="text-align: justify; ">5. Can you discuss the prognosis of Budd-Chiari Syndrome and the long-term outlook for patients receiving treatment?</div><div style="text-align: justify; ">6. Are there any ongoing research efforts or clinical trials aimed at improving the diagnosis and treatment of Budd-Chiari Syndrome</div><div style="text-align: justify; "></div></div><div class="pasted-from-word-wrapper"></div>

174. Endotracheal tube cuff lignocaine prevents postextubation cough in children undergoing elective surgery: Study

     Tue, 14 May 2024 02:45:25 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/11/30/226675-intubation-in-coma-patients.webp' /><p style="text-align: justify;">Recently published research paper investigates the efficacy of using intracuff lignocaine in preventing postextubation cough in pediatric patients undergoing elective surgeries. The study, conducted in India, involved 120 pediatric patients randomized into two groups: one with intracuff air and the other with intracuff 2% lignocaine. The incidence of postextubation cough was significantly lower in the group with intracuff lignocaine compared to the group with intracuff air. The study also found a significant increase in heart rate in patients with intracuff air compared to those with intracuff lignocaine. Furthermore, the study demonstrated that the diffusion of lignocaine through the cuff was sufficient to provide an adequate localized effect on the tracheal mucosa.<br></p><p style="text-align: justify;">Surgery Duration and Cough Occurrence </p><p style="text-align: justify;">The research also explored the relationship between the duration of surgery and the occurrence of cough in patients with reduced end-operative cuff pressure. It was found that as the duration of surgery increases, more time is available for the diffusion of lignocaine through the cuff at lower cuff pressure to produce the desired effect on the tracheal mucosa. The study highlighted a few limitations, including the lack of assessment of plasma concentration of lignocaine and the duration of action of intracuff lignocaine on the tracheal mucosa. The findings suggest that intracuff lignocaine significantly reduces postextubation cough in pediatric patients and mitigates adverse haemodynamic responses compared to intracuff air. </p><p style="text-align: justify;">Future Considerations </p><p style="text-align: justify;">Overall, the research contributes valuable insights into the potential of intracuff lignocaine in preventing postextubation cough and adverse events in pediatric patients undergoing elective surgeries. The study provides important considerations for future research, such as the assessment of plasma levels of lignocaine, the duration of action of intracuff lignocaine, and the exploration of alkalinised lignocaine as a superior option for cuff inflation in pediatric patients. </p><p style="text-align: justify;">Key Points </p><p style="text-align: justify;">- The research explored the relationship between the duration of surgery and the occurrence of cough in patients with reduced end-operative cuff pressure. It was observed that as the surgery duration increased, more time was available for the diffusion of lignocaine through the cuff at lower cuff pressure to produce the desired effect on the tracheal mucosa. The study did note some limitations, including the lack of assessment of plasma concentration of lignocaine and the duration of action of intracuff lignocaine on the tracheal mucosa. </p><p style="text-align: justify;">- Overall, the study highlighted the potential of intracuff lignocaine in reducing postextubation cough and adverse events in pediatric patients undergoing elective surgeries. It also provided important considerations for future research, such as the assessment of plasma levels of lignocaine, the duration of action of intracuff lignocaine, and the exploration of alkalinized lignocaine as a superior option for cuff inflation in pediatric patients.</p><p style="text-align: justify;">Reference - </p><p style="text-align: justify;">Kavyashree, M. B.; Kundra, Pankaj; Vinayagam, Stalin. Efficacy of endotracheal tube cuff lignocaine in the prevention of postextubation cough in children undergoing elective surgeries – A randomised controlled trial. Indian Journal of Anaesthesia 68(5):p 486-491, May 2024. | DOI: 10.4103/ija.ija_1013_23</p>

175. Does practising yoga strengthen the hearts of heart failure patients? Study sheds light

     Tue, 14 May 2024 02:45:03 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238106-mdtv-2024-05-14t113024296.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">According to research presented at Heart Failure 2024, a scientific congress of the European Society of Cardiology (ESC), yoga focused on breathing, meditation, and relaxation is linked with symptom improvement in patients with heart failure.</div><div style="text-align: justify;">Heart Failure affects vast numbers of people – more than 64 million globally2 – and can have devastating impacts on quality of life, with patients feeling tired and breathless, and being unable to participate in their usual activities. While previous studies have shown the short-term benefits of yoga in patients with heart failure, this study provides new information about the long-term effects.</div><div style="text-align: justify;">Yoga holds promise as an adjunctive therapy for heart failure patients owing to its multifaceted physiological and psychological benefits. Through its emphasis on controlled breathing, postures, and meditation, yoga can enhance autonomic nervous system regulation, improving cardiac function. Moreover, yoga's stress-reducing properties mitigate sympathetic overactivity and cortisol release, thereby lowering the adverse effects of chronic stress on cardiovascular health. </div><div style="text-align: justify;">In the study, conducted at Kasturba Hospital in Manipal, India, researchers enrolled heart failure patients aged 30 to 70 who had undergone cardiac procedures within the past six months to one year and were on guideline-recommended medications. Out of 85 participants, 40 were assigned to the yoga group, while 45 were in the control group. The yoga group received training in pranayama, meditation, and relaxation techniques and practised at home once a week under supervision. </div><div style="text-align: justify;">Researchers assessed heart structure and function at baseline, six months, and one year in both the yoga and control groups. Measurements included left ventricular ejection fraction and right ventricular function. Additionally, blood pressure, heart rate, body weight, body mass index, symptom burden, and functional capacity were evaluated using the New York Heart Association classification system. </div><div style="text-align: justify;">The results revealed that compared to the control group, the yoga group demonstrated significantly greater improvements in all measurements at six months and one year relative to baseline.</div><div style="text-align: justify;">“Patients who did yoga had healthier hearts and were more able to carry out ordinary activities such as walking and climbing stairs than those who only took medications. Patients with heart failure should speak to their doctor before starting yoga and should then receive training from an experienced instructor. Prescribed medications should be continued as before. Yoga may be unsuitable for heart failure patients with severe symptoms, who were excluded from our study,” said study author Dr. Ajit Singh of the Indian Council of Medical Research (ICMR), Manipal Academy of Higher Education, India.</div><div style="text-align: justify;">Reference: Dr. Ajit Singh, the Indian Council of Medical Research (ICMR), Manipal Academy of Higher Education, India; ‘Impact of yoga therapy on long-term outcomes in heart failure patients using functional and echocardiographic parameters’ ‘Chronic heart failure - treatment 16 Session’</div><div></div></div>

176. Higher dietary intake of several nutrients may slow progression of Geographic Atrophy: Study

     Tue, 14 May 2024 02:30:50 -0000

     <img src='https://medicaldialogues.in/h-upload/2020/09/28/135151-amd1.webp' /><p style="text-align: justify;">Researchers have found that specific nutrients in the diet may have a significant impact on the progression of geographic atrophy (GA) in age-related macular degeneration (AMD), according to new data presented at the 2024 <i>Association for Research in Vision and Ophthalmology</i> (ARVO). GA is a form of advanced AMD characterized by the degeneration of cells in the macula, leading to central vision loss. Elvira Agron, MS, DECA, and colleagues from the National Eye Institute investigated the association between dietary nutrient intake and GA progression towards the central macula.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify;">Out of the 347 participants included in the study, a total of 413 eyes with non-central geographic atrophy (GA) were analyzed. Among these eyes, GA was already present in 88 cases, while it occurred incidentally in 326 cases. The researchers identified specific nutrients that were strongly associated with a reduction in GA progression. These nutrients included lutein/zeaxanthin, β-carotene, zinc, and omega-3 fatty acids. Participants with the highest intake of these nutrients showed significantly slower GA progression compared to those with lower intake levels.</p><p dir="ltr" style="text-align: justify;">• Comparisons between the highest and lowest intake cohorts demonstrated significantly slower GA progression per year for zinc (34.8 vs. 45.5 µm/y), β-carotene (29.8 vs. 46.6 µm/y), lutein/zeaxanthin (32.9 vs. 47.5 µm/y), and EPA (35.5 vs. 43.7 µm/y).</p><p dir="ltr" style="text-align: justify;">• higher intake levels of lutein/zeaxanthin, β-carotene, zinc, and omega-3 fatty acids were associated with slower GA progression towards the FCP. These nutrients are known for their antioxidant and anti-inflammatory properties, which may help protect retinal cells from degeneration.</p><p dir="ltr" style="text-align: justify;"><span>•&nbsp;</span>Adherence to the Mediterranean diet, which is rich in fruits, vegetables, whole grains, and healthy fats, did not show a strong association with decreased GA progression. This suggests that specific nutrients within the diet may have a more significant impact on AMD progression than overall dietary patterns.</p><p dir="ltr" style="text-align: justify;">The findings highlight the potential role of dietary nutrients in slowing GA progression in AMD. Patients with non-central GA may benefit from dietary advice targeting specific nutrients, such as lutein/zeaxanthin, β-carotene, zinc, and omega-3 fatty acids, to potentially alter the natural course of the disease. Further research is needed to explore the efficacy of nutrient-rich diets as part of AMD management strategies.</p><p dir="ltr" style="text-align: justify;">Reference:</p><p dir="ltr" style="text-align: justify;">Agron E, Keenan TDL, Vitale S, Chew EY. Associations between Dietary Nutrient Intake and Geographic Atrophy Progression towards the Central Macula. Poster presented at the Association for Research in Vision and Ophthalmology (ARVO) 2024 Meeting, May 5–9, 2024.</p><div style="text-align: justify;"></div></div>

177. Study links blood sugar level at gestational diabetes to harmful outcomes for mothers and babies

     Tue, 14 May 2024 02:30:32 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/14/238105-mdtv-2024-05-14t112950196.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">According to research presented at the 26th European Congress of Endocrinology, the higher the blood sugar level in pregnant women when first diagnosed with diabetes, the higher the risk of complications around and after birth.</div><div style="text-align: justify;">Gestational diabetes — a condition in which women have elevated blood sugar, or glucose, levels during pregnancy — affects around 20 million pregnancies worldwide and poses increased health risks for both mothers and their babies. For example, mothers are more likely to develop type 2 diabetes and to give birth to especially large babies who face a high risk of birth injuries or even obesity later in life. Women are diagnosed with gestational diabetes if their fasting (pre-meal) blood glucose levels are above 92 mg/dL in the first trimester or their 2-hour oral post-meal glucose levels (OGTT) in the second trimester is above 153 mg/dL.</div><div style="text-align: justify;">For every 5mg/L above the diagnosis threshold, the risk of newborns having low blood sugar levels, or a large birth weight, rises by 9% and 6%, respectively, while mothers have a 31% higher risk of diabetes after birth. </div><div style="text-align: justify;">In the study, researchers analysed data on blood sugar levels and birth complications of 6,927 pregnant women, aged 30-37 years old, who were diagnosed with gestational diabetes between 2012 and 2017. The researchers found that for every 5mg/L increase in their blood sugar levels, there was a 9% higher risk of low blood sugar (hypoglycemia) and a 6% higher risk of large birth weight (large for gestational age) in newborns and a 31% higher risk of maternal high blood levels (hyperglycemia) after birth.</div><div style="text-align: justify;">The findings suggested that high-risk women with gestational diabetes should be classified further to limit these complications for both mothers and newborns.</div><div style="text-align: justify;">“While it is not surprising that high glucose levels are associated with these adverse outcomes in mothers and newborns, our study shows for the first time how much increase in risk there is with 5 mg/dL of increase in the mother’s blood glucose levels when first diagnosed with gestational diabetes. The magnitude of elevated risk can be calculated with our measurements and, in practice, could be used to identify and stratify women at higher risk of developing these complications.” said co-lead researcher Dr Catarina Cidade-Rodrigues.</div><div style="text-align: justify;">Reference: Dr Catarina Cidade-Rodrigues. Et al.; Blood sugar level at gestational diabetes diagnosis linked to harmful outcomes for mothers and babies; EUROPEAN SOCIETY OF ENDOCRINOLOGY; MEETING: European Congress of Endocrinology</div></div>

178. Source of sugar more important than amount for development of obesity in children, reveals study

     Tue, 14 May 2024 02:30:26 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/03/29/235192-sugar-50.webp' /><p style="text-align: justify; ">New research being presented at the European Congress on Obesity (ECO) in Venice, Italy (12-15 May) suggests that the source of sugar is more important than the amount of sugar when it comes to the development of obesity in children. </p><p style="text-align: justify;">The study found that the total amount of sugar consumed when very young was not associated with weight at age 10 or 11. </p><p style="text-align: justify;">However, children who got a higher proportion of their sugar from unsweetened liquid dairy products (milk and buttermilk) were less likely to go on to live with overweight or obesity. </p><p style="text-align: justify;">Similarly, getting more sugar from fruit was associated with less weight gain. However, getting a lot of sugar from sweet snacks such as cakes, confectionery and sweetened milk and yoghurt drinks, such as chocolate milk, was linked to being of higher weight. </p><p style="text-align: justify;">“The high consumption of sugary foods is considered a risk factor for childhood overweight and obesity and so children are advised to consume less sugar-rich foods, such as confectionery, cakes and sugar-sweetened drinks, and eat more fruit and unsweetened dairy products, such as milk and yoghurt,” says lead researcher Junyang Zou, of the Department of Epidemiology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands. </p><p style="text-align: justify;">“But while fruit and unsweetened dairy products are considered healthy, they contain high amounts of intrinsic sugars-sugar that occurs naturally in the food, rather than being added. We wanted to know if the source of sugar, added versus intrinsic, as well as the amount, affects the likelihood of developing overweight or obesity. </p><p style="text-align: justify;">“While this has been studied before, the results are inconsistent and there is a lack of high quality research on the topic.” </p><p style="text-align: justify;">To address this, Ms Zou and colleagues used data from the GEKCO Drenthe study1, an ongoing longitudinal study of a cohort of children born in Drenthe, in the northern Netherlands, between April 2006 and April 2007, to explore the association between total sugar intake in early childhood and the intake of sugar from different sources on weight, weight gain and the development of overweight and obesity. </p><p style="text-align: justify;">The answers to a food intake questionnaire filled in by the parents of 891 children (448 males) when the children were 3 years were used to calculate daily total sugar intake and the daily sugar intake from 13 food groups [vegetables; fruits (whole fruit only); cereals; starchy vegetables; nuts; legumes; meat, eggs, vegetarian meat substitutes, and oil, butter, and margarines; milk and milk products; coffee and tea, and coffee and tea-based drinks; sugar-sweetened beverages (including fruit juice, lemonade and sweetened milk and yoghurt drinks); savoury products including homemade and ready meals and soup; sugary snacks such as cakes, confectionery and chocolate; toppings/sauces/sugars]. </p><p style="text-align: justify;">Height and weight, as measured by trained nurses, were used to calculate BMI Z-scores, the change in this score between 3 and 10/11 years and weight status at 10/11 years (normal weight/overweight/obese, as defined by International Obesity Task Force 2012 criteria).</p><p style="text-align: justify;">BMI Z-scores are a widely used measure of weight in childhood and adolescence. They show how a young person’s BMI compares to the average BMI for their age and sex, with higher values representing a higher weight. </p><p style="text-align: justify;">All 891 children were included in the BMI-Z score at 10/11y and change in BMI-Z score analyses. 817 of the children (414 males) were included in the weight status analysis (74/891 were living with overweight or obesity at age 3 and were excluded from this analysis). </p><p style="text-align: justify;">Average total daily sugar intake was 112g. This made up around a third (32%) of the total daily energy intake of 1,388 calories. </p><p style="text-align: justify;">The main sources of sugar were fruit (average daily intake = 13g), dairy products (18.6g), sugar-sweetened beverages (41.7g) and sugary snacks (13.1g). </p><p style="text-align: justify;">At 10/11 years of age, 102 children with normal weight at the age of 3 had developed overweight or obesity. </p><p style="text-align: justify;">Total sugar intake at 3 years was not related to BMI Z-score, weight gain or weight status 10/11 years. </p><p style="text-align: justify;">However, a higher intake of sugar from sugary snacks was related to a higher BMI Z-score at 10/11. </p><p style="text-align: justify;">In contrast, a higher daily sugar intake from fruit (whole fruit only) was related to a lower BMI Z-score at 10/11 years and less weight gain. (No significant association was found between fruit juice and weight.) </p><p style="text-align: justify;">And a higher sugar intake from unsweetened liquid dairy products (milk and buttermilk) was related to a lower odds of developing overweight/obesity at age 10/11. Children with the highest intake of these products aged 3 had a 67% lower risk of going on to have overweight/obesity, compared to those with the lowest intake. </p><p style="text-align: justify;">The study didn’t look at why these foods affected weight differently. However, possible explanations include slower release of sugar from pieces of fruit than from sugary snacks and differences in how the sugars in the different foods (sucrose in cakes and confectionery, fructose in fruit and lactose in dairy) act on the body. </p><p style="text-align: justify;">The researchers conclude that when it comes to developing obesity in childhood, the source of sugar seems to be more important than the amount. </p><p style="text-align: justify; ">Ms Zou adds: “Children should be encouraged to have fruit and milk instead of sweetened milk and yoghurt drinks, sweets, cakes and other foods rich in added sugar.”</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Source of sugar may be more important than amount when it comes to the development of obesity in children, European Association for the Study of Obesity, Meeting: European Congress on Obesity (ECO2024).</p>

179. Heart failure patients who do yoga have stronger hearts and can be more active: Study

     Tue, 14 May 2024 02:30:04 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/22/232781-yoga-50.webp' /><p style="text-align: justify; ">Yoga focused on breathing, meditation, and relaxation is linked with symptom improvement in patients with heart failure, according to research presented today at Heart Failure 2024, a scientific congress of the European Society of Cardiology (ESC).</p><p style="text-align: justify;">“Patients who practised yoga on top of taking their medications felt better, were able to do more, and had stronger hearts than those who only took drugs for their heart failure,” said study author Dr. Ajit Singh of the Indian Council of Medical Research (ICMR), Manipal Academy of Higher Education, India. “The findings suggest that yoga can be a beneficial complementary therapy in patients with heart failure.” </p><p style="text-align: justify; ">Heart Failure affects vast numbers of people-more than 64 million globally-and can have devastating impacts on quality of life, with patients feeling tired and breathless, and being unable to participate in their usual activities. While previous studies have shown the short-term benefits of yoga in patients with heart failure, this study provides new information about the long-term effects. </p><p style="text-align: justify; ">The study enrolled patients aged 30 to 70 years with heart failure from the cardiology outpatient department of Kasturba Hospital in Manipal, India. All participants had undergone a cardiac procedure within the past six months to one year and were taking guideline-recommended heart failure medications. Patients with severe symptoms were excluded.</p><p style="text-align: justify;">The study included 85 patients. The average age was 49 years and 70 (82%) were men. In a non-randomised fashion, 40 patients were assigned to the yoga group and 45 patients were allocated to the control group. All participants continued taking guideline-recommended heart failure medications throughout the study. </p><p style="text-align: justify;">Experienced faculty in the hospital’s Department of Yoga demonstrated pranayama (yogic breathwork), meditation, and relaxation techniques to patients in the yoga group.6 Participants were supervised for one week and then advised to continue self-administered yoga at home once a week for 50 minutes. Patients spoke to an instructor after each home session to check progress. </p><p style="text-align: justify; ">At baseline, six months, and one year, the researchers assessed heart structure and function in the yoga and control groups using echocardiography. The measurements included the ability of the heart to pump blood (left ventricular ejection fraction), and assessment of right ventricular function. The researchers also examined blood pressure, heart rate, body weight, and body mass index. Symptom burden and the ability to do ordinary activities such as walking and climbing stairs were assessed using the New York Heart Association classification system. </p><p style="text-align: justify;">Compared to the control group, the yoga group demonstrated significantly greater improvements in all measurements at six months and one year relative to baseline. </p><p style="text-align: justify;">Dr. Singh said: “Patients who did yoga had healthier hearts and were more able to carry out ordinary activities such as walking and climbing stairs than those who only took medications. Patients with heart failure should speak to their doctor before starting yoga and should then receive training from an experienced instructor. Prescribed medications should be continued as before. Yoga may be unsuitable for heart failure patients with severe symptoms, who were excluded from our study.”</p>

180. Fingers Grip as good as Conventional Pen-Holding Grip for holding Endotracheal tube before Intubation - Study

     Tue, 14 May 2024 02:00:53 -0000

     <img src='https://medicaldialogues.in/h-upload/2020/04/06/126283-intubation.webp' /><p style="text-align: justify; ">Recent study compared the efficacy of the between-the-fingers grip with the conventional pen-holding grip to hold an endotracheal tube (ETT) for orotracheal intubation. A total of 300 patients undergoing elective surgeries under general anesthesia were randomized into two groups: Group C (conventional grip) and Group M (modified, between-the-fingers grip). A designated anaesthetist blinded to the groups performed laryngoscopy, and upon revealing the group, intubation was done accordingly. It was found that single-attempt intubation was comparable between the groups, but the usage of external assistance as BURP and the time taken for intubation were significantly reduced in the modified grip group. The study concluded that the between-the-fingers grip seems as effective as the standard grip to hold the ETT during intubation while reducing the requirement for external assistance in BURP.</p><p style="text-align: justify;">Primary and Secondary Objectives of the Study </p><p style="text-align: justify;">The primary objective of the study was to compare the number of attempts required for orotracheal intubation and the comparison of the requirement of external assistance in the form of the backward upward rightward pressure maneuver (BURP) to perform endotracheal intubation (ETI). The secondary objectives were to compare the time taken for ETI for each grip and the haemodynamic parameters (heart rate (HR) and mean arterial pressure (MAP)) in the two groups. The study was conducted on patients aged between 18 and 60 years posted for elective surgeries under general anesthesia with ETT. A total of 276 patients completed the study, and in the final analysis, 143 patients in Group C and 133 in Group M were included. The demographic distribution of the study patients, including airway variables, was comparable between the two study groups. The number of patients with a single attempt for intubation was 97.2% versus 99.3% in Group C and Group M, respectively. The requirement of assistance, in the form of BURP, was significantly lower in the modified grip group (0.75% versus 6.99%). Time taken for tracheal intubation was also less in the modified grip group than in the conventional group. The haemodynamic parameters, including HR and MAP, were statistically comparable in both groups. </p><p style="text-align: justify;"> Conclusion and Limitations </p><p style="text-align: justify;">The study concluded that the between-the-finger grip proved to be an equally good method to hold the endotracheal tube for orotracheal intubation as compared to the standard method. The findings suggest that this modified grip can reduce the requirement for external assistance in BURP and decrease the time necessary to accomplish the ETI. However, the study had some limitations, such as being a single-center trial and a lack of available literature to guide the sample size calculation. Nevertheless, the modified grip's efficacy was demonstrated, and the study suggests its potential as an alternative to the conventional pen-holding grip for ETT placement during orotracheal intubation. </p><p style="text-align: justify;">Key Points</p><p style="text-align: justify;">1. The primary objective of the study was to compare the number of attempts required for orotracheal intubation and the comparison of the requirement of external assistance in the form of the BURP maneuver to perform endotracheal intubation. The secondary objectives were to compare the time taken for intubation for each grip and the haemodynamic parameters (heart rate and mean arterial pressure) in the two groups. The study found that the modified grip group had a significantly lower requirement for assistance in the form of BURP and a reduced time for tracheal intubation compared to the conventional group. The haemodynamic parameters were statistically comparable in both groups, and the demographic distribution of the study patients was also comparable between the two study groups.</p><p style="text-align: justify;">2. The study concluded that the between-the-finger grip proved to be an equally effective method to hold the endotracheal tube for orotracheal intubation compared to the standard method. The findings suggest that this modified grip can reduce the requirement for external assistance in BURP and decrease the time necessary to accomplish the intubation. However, the study had some limitations, such as being a single-center trial and a lack of available literature to guide the sample size calculation. Nevertheless, the modified grip's efficacy was demonstrated, and the study suggests its potential as an alternative to the conventional pen-holding grip for ETT placement during orotracheal intubation.</p><p style="text-align: justify;">Reference –</p><p style="text-align: justify;">Thakur S, Tewari P, Shamshery C, Mishra P. To compare the efficacy of the between the fingers grip with the conventional pen holding grip to hold an endotracheal tube for orotracheal intubation: A randomised controlled trial. Indian J Anaesth 2024;68:527-32. </p><p style="text-align: justify;"><br></p>

181. Dapagliflozin promising in providing nephroprotectin in children with CKD, reveals study

     Tue, 14 May 2024 02:00:34 -0000

     <img src='https://medicaldialogues.in/h-upload/2021/05/24/154299-dapagliflozin.webp' /><p style="text-align: justify; ">A retrospective single-center study published in the <i>American Journal of Nephrology</i> highlighted a potential treatment in pediatric chronic kidney disease (CKD) treatment. The study found promising results of an SGLT2 inhibitor, the dapagliflozin, among the pediatric patients with CKD.</p><p style="text-align: justify; ">Nephroprotection in pediatric CKD has long been a crucial concern to preserve the residual renal function and enhance the quality of life while delaying the need for renal replacement therapy. The treatment options for pediatric CKD have been predominantly limited to angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-receptor blockers so far. However, recent trials conducted in adults with CKD have suggested that SGLT2 inhibitors might offer significant benefits to pediatric patients.&nbsp;</p><p style="text-align: justify; ">The retrospective study by Olil Van Reeth and team assessed the safety profile and potential renal protective effects of dapagliflozin among pediatric CKD patients. The study included 7 patients with an average age of 13.3 years who were already undergoing treatment with ACE inhibitors for identified glomerulopathy that leads to CKD.</p><p style="text-align: justify; ">During the 15-month observation period, all patients reported dapagliflozin as easy to use. Also, after an initial decline, the slope of estimated glomerular filtration rate (eGFR) stabilization was observed in all patients. The urinary albumin over creatinine ratio displayed a strong tendency to decrease after six months of treatment by indicating potential renal protection. Systolic blood pressure also showed a tendency to decrease after the same duration of treatment. Also, no significant side effects were reported by any of the patients which highlights the tolerability of dapagliflozin in this population.</p><p style="text-align: justify; ">The findings of this study illuminate the potential of SGLT2 inhibitors in pediatric CKD management. While larger, randomized-controlled trials are imperative to further elucidate their effectiveness and safety profile in this specific demographic, these preliminary results represent a significant step forward in the quest for enhanced treatments for pediatric CKD. The outcomes offer hope for thousands of children worldwide with CKD by paving the way for more tailored and effective interventions to enhance their quality of life and long-term health outcomes.</p><p style="text-align: justify; ">This research help in the management of pediatric CKD by potentially delaying the progression of the disease and improving the quality of life for affected children. Future studies might find dapagliflozin and similar SGLT2i drugs to emerge as valuable additions to the existing treatments for pediatric CKD for improving nephroprotection for young patients with this chronic condition.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Van Reeth, O., Caliment, A., de la Fuente Garcia, I., &amp; Niel, O. (2024). Safety profile and effectiveness of dapagliflozin in pediatric patients with chronic kidney disease. American Journal of Nephrology. <a href="https://www.unboundmedicine.com/medline/citation/38735286" rel="nofollow">https://doi.org/10.1159/000539300</a></p>

182. Thrombectomy promising for Stroke with Large Infarct of Unrestricted Size, unravels study

     Tue, 14 May 2024 02:00:07 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/01/231348-mechanical-thrombectomy-2.webp' /><p style="text-align: justify; ">France: In medical breakthroughs, the recent trial focusing on thrombectomy for stroke with a large infarct of unrestricted size has ignited hope among healthcare professionals and patients alike. This groundbreaking study, conducted by a consortium of leading medical institutions, has unveiled promising results that could potentially revolutionize the treatment landscape for individuals grappling with debilitating strokes.<br></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">The LASTE trial showed that thrombectomy plus medical care resulted in better functional outcomes and lower mortality than medical care alone but led to a higher incidence of symptomatic intracerebral hemorrhage in patients with acute stroke and a large infarct of unrestricted size. </p><p style="text-align: justify; ">"At 90 days, the median modified Rankin scale score was 4, indicating moderately severe disability, in the thrombectomy group versus 6 in the control group, indicating death (generalized OR 1.63)," the researchers reported in the <i>New England Journal of Medicine</i>. Scores of 5 and 6 were combined into one score in the analysis.</p><p style="text-align: justify; ">Death from any cause occurred in 36.1% of patients in the thrombectomy group compared with 55.5% of those in the control group (adjusted relative risk [aRR] 0.65, 95% CI 0.50-0.84) at 90 days. The benefits of thrombectomy were sustained at 180 days. </p><p style="text-align: justify; ">The trial, meticulously designed and executed with precision, sought to address a critical gap in stroke management: the lack of effective treatment options for patients with large infarcts of unrestricted size. Traditional thrombectomy procedures have typically been deemed ineffective or risky in such cases, leaving healthcare providers grappling with limited therapeutic avenues and patients facing bleak prognoses.</p><p style="text-align: justify; ">Caroline Arquizan, MD, of the Hôpital Gui de Chauliac in Montpellier, France, and colleagues aimed to investigate the use of thrombectomy in patients with acute stroke and a large infarct of unrestricted size. </p><p style="text-align: justify; ">For this purpose, the researchers included patients with proximal cerebral vessel occlusion in the anterior circulation and a large infarct (as defined by an Alberta Stroke Program Early Computed Tomographic Score of ≤5; values range from 0 to 10) detected on magnetic resonance imaging (MRI) or computed tomography within 6.5 hours after symptom onset. They were randomized in a 1:1 ratio to undergo endovascular thrombectomy and receive medical care (thrombectomy group) or medical care alone (control group). </p><p style="text-align: justify; ">The study's primary outcome was the score on the modified Rankin scale at 90 days (scores range from 0 to 6, with higher scores suggesting greater disability). The primary safety outcome was death from any cause at 90 days, and an ancillary safety outcome was symptomatic intracerebral hemorrhage. </p><p style="text-align: justify; ">Three hundred and thirty-three patients were assigned to either the thrombectomy group (166 patients) or the control group (167 patients); because of consent withdrawal or legal reasons, 9 were excluded from the analysis. </p><p style="text-align: justify; ">The researchers reported the following findings:</p><ul><li style="text-align: justify; ">The trial was stopped early because the results of similar trials favored thrombectomy.</li><li style="text-align: justify; ">Approximately 35% of the patients received thrombolysis therapy. The median modified Rankin scale score at 90 days was 4 in the thrombectomy group and 6 in the control group (generalized odds ratio, 1.63).</li><li style="text-align: justify; ">Death from any cause at 90 days occurred in 36.1% of the patients in the thrombectomy group and 55.5% of those in the control group (adjusted relative risk, 0.65), and the percentage of patients with symptomatic intracerebral hemorrhage was 9.6% and 5.7%, respectively (adjusted relative risk, 1.73).</li><li style="text-align: justify; ">Eleven procedure-related complications occurred in the thrombectomy group.</li></ul><p style="text-align: justify; ">The findings showed that in patients with acute stroke and a large infarct of unrestricted size, thrombectomy plus medical care resulted in lower mortality and better functional outcomes than medical care alone but led to a higher incidence of symptomatic intracerebral hemorrhage. </p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Costalat V, et al "Trial of thrombectomy for stroke with a large infarct of unrestricted size" N Engl J Med 2024; DOI: 10.1056/NEJMoa2314063</p></div><p style="text-align: justify; "><br></p>

183. Breast Milk Enemas Improve Neonatal Outcomes in Premature Infants: JAMA

     Tue, 14 May 2024 01:45:14 -0000

     <img src='https://medicaldialogues.in/h-upload/2021/01/15/146030-neonatal-abstinence-syndrome.webp' /><p style="text-align: justify; ">A recent study conducted at the Shengjing Hospital of China Medical University in Shenyang found that breast milk enemas may significantly improve the health outcomes of preterm infants by speeding up meconium evacuation and the initiation of full enteral feeding. The key findings of the study were published in the <i>Journal of American Medical Association.</i></p><p style="text-align: justify; ">This study was conducted from September 1, 2019 to September 30, 2022 and included a total of 286 premature infants born between 23 and 30 weeks of gestation. The randomized, open-label clinical trial compared the effects of administering breast milk enemas against normal saline enemas 48 hours after birth. The primary measures of the study were the duration taken to complete meconium evacuation and the time to establish full enteral feeding. Additional factors such as the length of hospital stay, the weight of infants at discharge and the duration of total parenteral nutrition were also evaluated.</p><p style="text-align: justify; ">The results indicated a significant reduction in the time to clear meconium in the group that received breast milk enemas, averaging a decrease of 2.2 days when compared to the saline group. Also, infants in the breast milk group achieved full enteral feeding, approximately 4.6 days sooner than the infants who received saline enemas. The requirement for total parenteral nutrition similarly reduced by an average of 4.6 days in the breast milk group that potentially reduces complications associated with prolonged intravenous feeding.<br></p><p style="text-align: justify; ">The findings suggest that breast milk enemas could play a crucial role in the management of premature infants who are often susceptible to the complications due to delayed meconium passage and feeding issues. While the use of breast milk for enemas is a new approach, it appears to be safe and more effective than saline in these fragile patients. This could represent a pivotal step forward in neonatal care by offering a simple yet effective intervention that harnesses the natural properties of breast milk.<br></p><p style="text-align: justify; ">No significant differences were observed in other secondary outcomes, including safety metrics that further supports the potential of breast milk enemas as a feasible treatment option in neonatal care settings. The outcomes call for further studies to explore the effectiveness of this intervention across different gestational ages and to determine the long-term benefits of earlier meconium evacuation.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Zheng, L., Gai, L., Wu, Y., Kong, C., Sun, F., Gao, J., Yuan, W., Liu, M., Jiang, H., Tuo, N., &amp; Yang, F. (2024). Breast Milk Enema and Meconium Evacuation Among Preterm Infants. In JAMA Network Open (Vol. 7, Issue 4, p. e247145). American Medical Association (AMA). <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2817858" rel="nofollow">https://doi.org/10.1001/jamanetworkopen.2024.7145</a></p>

184. Pediatric ICU Nurse Honored With 3 Employee Awards

     Wed, 15 May 2024 23:46:48 -0000

     

     Meet Ali Orlandi, MSN, RN, CPN, who was honored last year with three of Stanford Medicine Children’s Health’s employee awards.

     <div><img width="450" height="450" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275-450x450.jpg" class="attachment-450x450 size-450x450 wp-post-image" alt="Ali Orlandi, MSN, RN, CPN at Stanford Medicine Children&#039;s Health" style="margin-bottom: 15px;" decoding="async" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275-450x450.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275-300x300.jpg 300w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275-600x600.jpg 600w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275-125x125.jpg 125w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275-24x24.jpg 24w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275-48x48.jpg 48w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275-96x96.jpg 96w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275-150x150.jpg 150w" sizes="(max-width: 450px) 100vw, 450px" /></div> <p>A passionate leader of nurses’ self-care and resiliency, an enthusiastic advocate of continuing education, and a dedicated caregiver to critically ill children in the Pediatric Intensive Care Unit (PICU).</p> <figure class="wp-block-image size-large"><img decoding="async" width="900" height="476" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275-900x476.jpg" alt="Ali Orlandi, MSN, RN, CPN at Stanford Medicine Children's Health" class="wp-image-25054" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275-900x476.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275-450x238.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275-768x407.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/ali-orlandi-1275.jpg 1275w" sizes="(max-width: 900px) 100vw, 900px" /></figure> <p>Meet Ali Orlandi, MSN, RN, CPN, who was honored last year with three of Stanford Medicine Children’s Health’s employee awards.</p> <p>The 11-year employee, affectionally known as Ali, was the first nurse to receive all three awards honoring staff. She said she was humbled and grateful to receive the Grace Award, given to the employee of the year; the Annual Gold Rose Award; and the Nightingale Excellence Award for Excellence in Nursing Innovation.</p> <p>“I was really surprised and very much appreciate it,” said Ali, the day-shift charge nurse in the Pediatric ICU. “I would not be where I am if it wasn’t for this organization. I owe all my opportunities to <a href="https://www.stanfordchildrens.org/en/lucile-packard-childrens-hospital#toppick">Lucile Packard Children’s Hospital Stanford</a>.”</p> <p>Ali was also recognized for her tireless energy and spirit, as well as for helping to shape nursing practices and patient care services. She was lauded for giving back to the field of nursing and for helping colleagues excel at their jobs, both professionally and personally. Among the many ways she gives back is by co-chairing the Nurse Executive Council, co-chairing the HEART Council, and initiating the Heart Carts project, which makes self-care more accessible for nurses by offering comfort measures, resiliency tools, and resources to reduce stress during their shifts.</p> <h2 class="wp-block-heading">A dedicated leader</h2> <p>“In Allison, we find a shining example of dedication, leadership, and a deep commitment to community service,” said Jesus Cepero, PhD, RN, NEA-BC, senior vice president of Patient Care Services and chief nursing officer, in presenting the award. “She embodies the very spirit of the Employee of the Year Award (Grace Award), and we are privileged to celebrate her outstanding contributions. Her journey from a patient companion to a Clinical Nurse IV is an inspiration to us all, and her unwavering dedication to nursing is truly exemplary.”</p> <p>Nursing is a second career for Ali, who started out as a fashion designer but felt unfulfilled and wanted more. “My cup just wasn’t filled,” she said with a smile. She returned to school to earn her second bachelor&#8217;s degree in nursing, graduating with a bachelor of science degree in 2015. She then went on to complete her master’s degree in 2022. While she was in school full-time, she also worked as a patient companion and nursing assistant at Lucile Packard Children’s Hospital Stanford. She is grateful that the organization helped with tuition.</p> <p>“When I was applying to nursing school, I wanted some experience in the field and applied to be a patient companion,” she said. The daughter of a nurse, Pamela Orlandi, who co-leads the Children’s Surgery Quality Program with the Stanford Medicine Children’s Health surgeon in chief, Karthik Balakrishnan, MD, Ali said she always knew she wanted to work at Lucile Packard Children’s Hospital Stanford. “I grew up at Packard. It was like family to me. I was inspired by the nurses. It is an incredible profession.”</p> <h3 class="wp-block-heading">An advocate for self-care</h3> <p>Ali encourages others to have incredible careers and advocates for nurses to practice self-care to minimize fatigue and burnout.</p> <p>“I always advise my colleagues to remember why they wanted to be a nurse. It’s easy to be overwhelmed, especially here, because the kids are so sick, and treatment is complicated. It can weigh on you,” she said. “I encourage nurses to remember that they’re going to learn, and to lean on their colleagues. We want you to succeed.”</p> <p>She continued, “We’re lucky here because we have a lot of support. We’re taking care of such sick kids, and the acuity is a strain that can weigh on people. I always encourage colleagues to take the time to take a breath, utilize the Heart Cart. Seek opportunities you are passionate about to give back, such as community service, as it supports well-being and builds resiliency.” Ali also expressed her gratitude to the PICU leadership for supporting her Shared Governance activities.</p> <p>In her role as a nursing champion, Ali is always the first to help plan nursing recognition and events, including Nurses Week, wellness fairs, and awards programs like the DAISY Award, which she also has to her credit. “Nurses do extraordinary things and do not even realize that they are doing it. These programs allow us to take a minute to pause; to take space and care for ourselves.”</p> <p>Ali is grateful to work with so many supportive colleagues and mentors, especially those who nominated her for her awards: Luanne Smedley, MHA, BSN, RN, executive director and associate chief nursing officer; and Gilleen Del Rosario, MSN, RN, CCRN, a clinical nurse IV in the Pediatric ICU.</p> <h3 class="wp-block-heading">A champion of giving back</h3> <p>Ali continues to partner with Kristine Taylor, DNP, MPH, RN, CENP, executive director, and Mari Olmos, MA, programs coordinator, from the Center for Professional Excellence &amp; Inquiry, to get funding and grants that support nurses, including the continuation of the organization-wide Heart Carts and the Heart of Nursing Award to promote professional excellence in nursing by working in underserved communities around the country. Giving back in this way, she said, builds resiliency. Ali volunteered at <a href="https://www.jacobsheart.org/camp" target="_blank" rel="noreferrer noopener">Camp Heart + Hands</a> in Santa Cruz, a program for children and families facing cancer, and has served on its planning board. “A <a href="https://pubmed.ncbi.nlm.nih.gov/34550106/" target="_blank" rel="noreferrer noopener">study</a> out of the camp showed how participating in a camp setting outside a hospital increases nurse resiliency,” she said.</p> <p>Her current extracurricular projects include studying to work on the ski patrol and advancing her knowledge in wilderness medicine to help others in and out of the hospital setting.</p> <p>When she’s not at work, Ali enjoys the outdoors, especially skiing, surfing, trail running, and backpacking with her husband, Ian, and their Australian shepherd, Yeti. “It keeps me balanced, recharged, and motivated,” she said.</p> <p>As she looks back on how far nursing has advanced over the years, Ali feels satisfaction that nurses have become more valued partners of clinical care teams and are relied on by the interprofessional care team members. “Nurses are the people at the bedside all the time. They are the face of the care team. When the clinical team leaves and the family has a question, nurses are the ones they ask. There are many blessings in these moments. To be able to have these experiences is extraordinary.”</p> <p><strong>Learn more about our nurses by visiting: <a href="https://nursing.stanfordchildrens.org">https://nursing.stanfordchildrens.org</a> > </strong></p> <p><a id="_msocom_1"></a></p> <p></p> <p><a id="_msocom_2"></a></p> <p></p>

185. Celebrating Hematology and Oncology Doctors From Diverse Backgrounds

     Wed, 15 May 2024 15:00:00 -0000

     

     For AANHPI Heritage Month, meet three of our pediatric hematologists and oncologists, who reflect on their heritage and how it influenced their careers.

     <div><img width="450" height="450" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/jay-balagtas-md-stanford-childrens-1200x675-1-450x450.jpg" class="attachment-450x450 size-450x450 wp-post-image" alt="" style="margin-bottom: 15px;" decoding="async" loading="lazy" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/jay-balagtas-md-stanford-childrens-1200x675-1-450x450.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/jay-balagtas-md-stanford-childrens-1200x675-1-300x300.jpg 300w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/jay-balagtas-md-stanford-childrens-1200x675-1-600x600.jpg 600w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/jay-balagtas-md-stanford-childrens-1200x675-1-125x125.jpg 125w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/jay-balagtas-md-stanford-childrens-1200x675-1-24x24.jpg 24w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/jay-balagtas-md-stanford-childrens-1200x675-1-48x48.jpg 48w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/jay-balagtas-md-stanford-childrens-1200x675-1-96x96.jpg 96w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/jay-balagtas-md-stanford-childrens-1200x675-1-150x150.jpg 150w" sizes="(max-width: 450px) 100vw, 450px" /></div> <p>Each May, we celebrate our Asian American, Native Hawaiian, and Pacific Island (AANHPI) providers and staff who help make Stanford Medicine Children’s Health exceptional with their diversity and extraordinary talents. This year for AANHPI Heritage Month, we introduce you to three of our <a href="https://www.stanfordchildrens.org/en/services/hematology.html">Pediatric Hematology</a> and <a href="https://www.stanfordchildrens.org/en/services/oncology.html">Oncology</a> doctors, who reflect on their heritage and share how it influenced their careers. We also asked them to reflect on the 2024 AANHPI month theme: Advancing Leaders Through Innovation, which celebrates trailblazers who have made lasting contributions.</p> <p><strong>Overcoming obstacles with grit and persistence</strong></p> <div class="wp-block-image"> <figure class="alignleft size-full"><img loading="lazy" decoding="async" width="300" height="400" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/clara-lo-md-stanford-childrens-300x400-1.jpg" alt="Clara Lo, MD" class="wp-image-25031"/></figure></div> <p><a href="https://www.stanfordchildrens.org/en/doctor/clara-y-lo.html">Clara Lo, MD</a>, a pediatric hematologist/oncologist, knows what it’s like to feel different. As a first-generation Chinese-Taiwanese American, she only spoke Mandarin Chinese until she learned English in kindergarten. In Long Beach, California, she was one of very few Asian students in her elementary and middle schools. “It was challenging sometimes, because I felt ‘othered.’ I felt different than other kids,” she says. Yet she didn’t let those barriers stop her. When she was 10 years old, her grandparents moved in. Her grandfather was a very accomplished surgeon in Taiwan and had been an officer in the Taiwanese Army. “At the time he said, ‘You should be a doctor,’ I remember thinking, ‘Just because you said it, I am not going to do it.’ I felt really defiant.”</p> <p>Yet, her natural interest in science won out. She majored in biochemistry at the University of California, Los Angeles, and earned her medical degree from New York Medical College. From there, she completed her internship and residency at Children’s Hospital of Orange County. “I shadowed a pediatric hematologist and fell in love with it.” She came to Stanford for her hematology fellowship training 16 years ago and has stayed ever since.</p> <p>Dr. Lo’s mother passed away when she was young, so her father raised her and her two sisters on his own. Both of her parents were college educated, but because of language barriers when first coming to America, they were forced to work in blue-collar jobs to provide a living for their family. Her father, a trained journalist, opened a local restaurant. Dr. Lo and her siblings worked in the restaurant growing up. “The restaurant is where I learned to do mental math quickly, how to be efficient, and how to stay up on my feet for 14 hours a day. It boded well for medical school.”</p> <p>Dr. Lo has dedicated her career to hematology, focusing on caring for children and young adults with <a href="https://www.stanfordchildrens.org/en/services/hematology/hemophilia.html">hemophilia</a>—a bleeding disorder whereby the blood doesn’t clot properly. She is the medical director of the Stanford Hemophilia and Thrombosis Treatment Center, which treats both children and adults, allowing her to really get to know her patients over their lifetimes. She is also the section chief of Pediatric Hematology. “I love caring for my patients and watching kids grow from toddlers to young adults,” she says. “I have even had the chance to meet their own children.” She’s proud to be a part of improved care for hemophilia over the years. “Twenty years ago, the life span for people with hemophilia was not nearly as long as it is today, but thanks to new treatments, which we have played a part in creating via drug trials and gene therapy, the landscape of hemophilia care has changed. Some of my older patients comment on how much better their lives are today than in the past.”</p> <p>Dr. Lo is grateful to be at an institution that values diversity. She believes that having a diverse care team benefits patients. “From a psychosocial perspective, when patients and families from a variety of racial, ethnic backgrounds come in and see a provider who looks like them or speaks their language, they feel more connected and more at ease during scary times, and that’s really important.” She also believes that medicine is an art, not just a science, and that having different perspectives represented leads to better care.&nbsp;</p> <p>Another passion of hers is teaching fellows, residents, and medical students. “I find enjoyment in passing the torch by helping to train future doctors,” she says. Through her research and her teaching, Dr. Lo is making a lasting contribution. Her advice to people who want to get into medicine is to first be certain about it, and then to know that it takes time and perseverance. “Don’t be afraid to ask others for help, and don’t be afraid to give yourself grace. But keep at it. It’s a long road, but it is very worthwhile.”</p> <p><strong>Rising to great research heights through hard work and passion</strong></p> <figure class="wp-block-image alignleft size-full"><img loading="lazy" decoding="async" width="286" height="400" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kathleen-sakamoto-stanford-childrens-286x400-1.jpg" alt="Kathleen Sakamoto, MD, as a child" class="wp-image-25034"/><center><figcaption class="wp-element-caption">Kathleen Sakamoto, MD, as a child</figcaption></figure></center> <p>“I had a humble upbringing, but I never lacked for anything,” says <a href="https://www.stanfordchildrens.org/en/doctor/kathleen-m-sakamoto.html">Kathleen Sakamoto, MD, PhD</a>, a pediatric hematologist/oncologist at Stanford Children’s. Dr. Sakamoto was the first in her family to graduate from college. Her mother grew up in Japan during World War II, and her father was in a Japanese internment camp in the United States.</p> <p>Dr. Sakamoto was born and raised in Los Angeles, where her father worked as a gardener and her mother cleaned homes. They lived a middle-class lifestyle, and she attended high school in Highland Park—an inner-city school with plenty of diversity. She recalls always wanting to be a doctor. “My father and I would watch medical shows together. If my father had the opportunity, I believe he would have gone into medicine too,” she says. While her parents never pressured her about grades, there was an expectation that she would attend college. “My mom, being an immigrant, taught me that school was critical. I would offer to help make meals, and she would say, ‘No. Go back and study.’ Education always came first.”</p> <p>Her interest in science and her good grades earned her a chance to attend college across the country at Williams College in Massachusetts, where she earned a BA in biology and conducted research with a plant biologist. It was there that she first experienced the sense of being different. Most students were affluent, and she was one of three Asian American women in her class. It was also challenging to be so far from home, so after graduation she returned to Los Angeles.</p> <p>Her mother’s cousin was a hematologist in Japan, and he helped her get a job in a hematology lab in Los Angeles. She discovered her passion for the field and her interest in hematology research by studying blood mutations in certain types of anemias. From there, she attended medical school at the University of Cincinnati and upon graduating became a pediatric resident and hematology/oncology fellow at Children’s Hospital Los Angeles. “All of my experiences, starting in the lab and through my clinical fellowship and research training, got me excited to do research in pediatric oncology. Developing new therapies for pediatric leukemia has been my passion since my fellowship, and it continues today.”</p> <p>Dr. Sakamoto became a faculty member at UCLA, where she was division chief of Pediatric Hematology/Oncology and fellowship program director. While at the University of California, Los Angeles, she also received her PhD in biology from the California Institute of Technology. In 2011, she accepted the position of division chief of Pediatric Hematology, Oncology, and Stem Cell Transplantation at Stanford Medicine. Today, she focuses on her research and caring for her patients.&nbsp;</p> <p>“It was a big move from Los Angeles to Stanford, so it was reassuring to see doors open for me and have the chance to collaborate with unbelievably talented colleagues who encouraged me to think outside of the box.” She has been able to take her innovative research even further at Stanford Children’s, having earned several prestigious national grants and published several dozen studies. It has led to her biggest accomplishment in her career so far: leading a phase I clinical trial on her own discovery of a novel use of a drug for acute myelogenous leukemia (AML). The <a href="https://sakamotolab.com/" target="_blank" rel="noreferrer noopener">Sakamoto Lab</a> focuses on developing new approaches to treat blood diseases, including bone marrow failure and cancer, which includes AML. “Like all physician-scientists, my dream is to take what I learn in the lab and translate it to better patient care. It took 20 years to get here, but staying focused is paying off. What excites me is the chance to offer children with leukemia a new treatment, and I can’t think of a better place to do that than Stanford.”</p> <p>She also finds immense joy in patient care and mentoring students and fellows. “I’m continually inspired by kids with cancer and how brave they are.” In 2022, she received a National Institutes of Health grant for her project titled, “Increasing Diversity in Hematology: Training for Underrepresented Students.” As the director of the Stanford Hematology Internship Program (together with Bonnie Halpern-Felsher, PhD), she helps underrepresented high school and college students learn about careers in hematology research. “Because of my own background of feeling disadvantaged and different in college, I’m motivated to mentor underrepresented or disadvantaged students and fellows in my lab. I want them to have the opportunities that my mentors gave me.” Her advice to her students is to “do what you are passionate about and keep pursuing your goals, no matter what your background or training.”</p> <p><strong>Applying philosophies from the U.S. Navy to his leadership role today</strong></p> <div class="wp-block-image"> <figure class="alignleft size-full"><img loading="lazy" decoding="async" width="320" height="400" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/jay-balagtas-md-stanford-childrens-320x400-1.jpg" alt="Jay Balagtas, MD, during his time in the Navy" class="wp-image-25036"/><center><figcaption class="wp-element-caption">Jay Balagtas, MD, during his time in the Navy</figcaption></figure></div> <p><a href="https://www.stanfordchildrens.org/en/doctor/jay-michael-s-balagtas.html">Jay Balagtas, MD</a>, a pediatric oncologist, still considers himself an island boy at heart. Born in the Philippines, Dr. Balagtas moved with his family to the island of Guam when he was 4 years old so that his father could find a good job. “My childhood was spent running around an island. It was a great place to grow up, with a lot of diversity. Yet by the time I finished high school, I couldn’t wait to get off the island.” He wanted to go somewhere warm, so he chose the University of California, San Diego. After graduating with a BS in chemistry/biochemistry, Dr. Balagtas saw two options when it came to medical school. “Either you paid with time, or you paid with money. I chose to pay with time by joining the U.S. Navy. It was a defining moment in my life, and it laid a path moving forward.” He attended New York Medical College on a U.S. Navy scholarship and completed his residency at the Naval Medical Center San Diego.</p> <p>Dr. Balagtas knew that he wanted to be a pediatrician from the start. “I always wanted to work with children because I knew that no matter how bad a day might go, one child would make me laugh or smile, and that would make the day worth it.” His focus on hematology/oncology came during medical school, where he shadowed a doctor who inspired him. “She developed incredibly deep relationships with her patients, and I realized I wanted that too. I wanted to help people through tough times.”</p> <p>After completing his residency, Dr. Balagtas returned home to serve as a general pediatrician at Naval Hospital Guam. Upon completion of his military service, he came to Lucile Packard Children’s Hospital Stanford for his fellowship training. His first faculty position was with the UC Davis Medical Center, where he was the acting section chief of Pediatric Hematology/Oncology, as well as the institutional principal investigator for the Children’s Oncology Group (COG PI). He returned to Stanford Children’s in 2015 to start a joint Pediatric Hematology/Oncology program at John Muir Health in Walnut Creek and is now the director of Clinical Operations for the Division of <a href="https://www.stanfordchildrens.org/en/services/oncology.html">Pediatric Hematology/Oncology</a> at Stanford Medicine Children’s Health. These positions have been a great match with Dr. Balagtas’s unique leadership skills, polished by the U.S. Navy. “Besides caring for my patients, I also enjoy taking care of my colleagues,” he says. “It goes back to the ethos of the Navy, which is that leaders take care of their people. If I can make my colleagues’ lives a little easier by improving a process and making things flow more smoothly, then I want to do that.”</p> <p>When asked how he fits the theme of being a trailblazer, Dr. Balagtas names two accomplishments. The first is in building out his current clinical director position from scratch. “It was a privilege to be asked to originate this position, so I feel lucky to step into this role and effect positive change. It’s been a year, and it is still a work in progress, but we are making progress.” Second, he sees his work as the COG PI for Packard Children’s Hospital as important. “Only the best ideas make it to phase III clinical trials, so I am hopeful we can positively impact the survival of children with cancer and reduce the toxicity of chemotherapy drugs.”</p> <p>Dr. Balagtas feels fortunate to have been raised and trained to work in diverse environments. He particularly credits his time in the U.S. Navy. “I feel fortunate to have served in the Navy. It exposed me to a lot of different beliefs and viewpoints from people from every walk of life. It really influenced who I am today, and I am proud of that. Diversity brings different viewpoints, which brings diverse and innovative solutions.”&nbsp; Each year, Dr. Balagtas and his family return to Guam to visit his family there. He remains grateful for what his parents taught him, tenets he applies to his everyday life: “They taught me that everybody deserves respect, and when you treat others with respect, they will more than likely treat you the same way.” His parents also taught him to work hard—something he especially learned from his father, who faced challenges when working his way through college as an engineer and emigrating to Guam to build a better life for his family. “He made it possible for us to be successful, and I’m grateful for that.”</p>

186. Stanford Heart Team Keeps Extremely Ill Baby Alive With Finesse and Teamwork

     Mon, 13 May 2024 15:00:00 -0000

     

     Girl faces quadruple threat—a viral illness, heart failure, pulmonary hypertension, and a rare heart defect—and prevails.

     <div><img width="450" height="450" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1-450x450.jpg" class="attachment-450x450 size-450x450 wp-post-image" alt="" style="margin-bottom: 15px;" decoding="async" loading="lazy" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1-450x450.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1-300x300.jpg 300w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1-600x600.jpg 600w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1-125x125.jpg 125w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1-24x24.jpg 24w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1-48x48.jpg 48w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1-96x96.jpg 96w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1-150x150.jpg 150w" sizes="(max-width: 450px) 100vw, 450px" /></div> <p><em>Girl faces quadruple threat—a viral illness, heart failure, pulmonary hypertension, and a rare heart defect—and prevails</em></p> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="900" height="506" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1-900x506.jpg" alt="Zoraya celebrating her second birthday" class="wp-image-24976" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1-768x432.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-birthday-1200x675-1.jpg 1200w" sizes="(max-width: 900px) 100vw, 900px" /></figure> <p>When Marbella and Jadiel Rodriguez brought their baby girl, Zoraya, home from the hospital, they didn’t know that a <a href="https://www.stanfordchildrens.org/en/topic/default?id=congenital-heart-defects-85-P00205">congenital heart defect</a> was lurking inside her chest. It hid by mimicking symptoms of a viral illness—a croupy cough, fast breathing, and a poor appetite.</p> <p>“For eight months, we thought everything was normal. She had little symptoms here and there that were easily explained away,” says Jadiel.</p> <p>Marbella knew something was wrong when Zoraya got to the point where she could hardly keep a little liquid down without throwing up. “It was a red flag, but everyone said she was fine,” she says.</p> <p>Then Zoraya got a cough that wouldn’t go away. Her parents took her to their local emergency department near Boise, Idaho. She was diagnosed with pneumonia, which her mom now suspects was <a href="https://www.stanfordchildrens.org/en/services/pulmonary-vascular-disease/treatments.html">pulmonary hypertension</a>—high blood pressure in the lungs—a condition that can accompany heart failure. &nbsp;</p> <p>“The doctor asked, ‘Has anyone ever said she had a <a href="https://www.stanfordchildrens.org/en/topic/default?id=heart-murmurs-in-children-90-P01806">heart murmur</a>?’ He said it was probably nothing, but they did an <a href="https://www.stanfordchildrens.org/en/topic/default?id=tests-to-diagnose-heart-problems-85-P00208">echocardiogram</a> to be safe. That’s when they pronounced she had a heart defect, and things blew up from there,” Marbella says.</p> <p>A pediatric cardiologist from St. Luke’s System in Idaho, a partner hospital for the <a href="https://www.stanfordchildrens.org/en/services/heart-center.html">Betty Irene Moore Children’s Heart Center</a> at Stanford Medicine Children’s Health, quickly referred them to <a href="https://www.stanfordchildrens.org/en.html">Stanford Children’s</a> for advanced care, and Zoraya was airlifted that day.</p> <p>“At Stanford, we found out just how severely sick she was and how dangerous her heart defect could be,” Jadiel says.</p> <p><strong>Receiving care from a large team of experts</strong></p> <p>Zoraya was on the verge of cardiac arrest the day she arrived. A team of specialists quickly assembled. Epinephrine and a defibrillator were on standby for fast action. Little did the family know that Zoraya was beginning a 70-day stay in the <a href="https://www.stanfordchildrens.org/content/sch/us/en/services/cardiovascular-intensive-care.html">Cardiovascular Intensive Care Unit</a> (CVICU) at Stanford Children’s.</p> <div class="wp-block-image"> <figure class="alignright size-full is-resized"><img loading="lazy" decoding="async" width="400" height="500" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-hospital.jpg" alt="Zoraya in the hospital" class="wp-image-24972" style="width:369px;height:auto" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-hospital.jpg 400w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-hospital-360x450.jpg 360w" sizes="(max-width: 400px) 100vw, 400px" /></figure></div> <p>Not only was Zoraya in advanced <a href="https://www.stanfordchildrens.org/en/services/heart-transplant.html">heart failure</a> with severe <a href="https://www.stanfordchildrens.org/en/services/pulmonary-vascular-disease/treatments.html">pulmonary hypertension</a>, but also she was fighting two viruses: the human parainfluenza virus, which causes a common respiratory infection in babies and young children, and rhinovirus, which causes the common cold. Her care required close collaboration among several experts who met daily to discuss next steps, including <a href="https://www.stanfordchildrens.org/en/services/cardiology/careteam.html">pediatric cardiologists</a>, pulmonary hypertension specialists on the <a href="https://www.stanfordchildrens.org/en/services/ceal.html">Center for Advanced Lung (CEAL) Therapies</a> team, and <a href="https://www.stanfordchildrens.org/en/services/cardiothoracic-surgery/careteam.html">heart surgeons</a>.</p> <p>“Her pulmonary arteries grew abnormally, in that her right pulmonary artery branch arose from the aorta in a condition known as discontinuous pulmonary arteries. It’s a rare birth defect, and it can be easily missed,” says <a href="https://www.stanfordchildrens.org/en/doctor/rachel-knight-hopper.html">Rachel Hopper, MD</a>, a pediatric <a href="https://www.stanfordchildrens.org/en/services/cardiology/careteam.html">cardiologist</a> and associate director of the nationally leading <a href="https://www.stanfordchildrens.org/en/services/pulmonary-vascular-disease.html">Pulmonary Vascular Disease Program</a> and co-director of CEAL. “The abnormal blood flow caused pulmonary hypertension, which had likely been gradually getting worse with time.”</p> <p>Zoraya was in a tricky spot of needing <a href="https://www.stanfordchildrens.org/en/services/cardiothoracic-surgery.html">heart surgery</a> and <a href="https://www.stanfordchildrens.org/en/services/cardiac-catheterization-angiography.html">cardiac catheterization</a> but being too sick upon arrival to receive it. Her congenital heart defect wasn’t causing the heart murmur; it was her severe pulmonary hypertension and her dilated heart that were making one of her heart valves leak.</p> <p>“Our teams are used to taking care of very sick kids, especially those with difficult abnormalities, and we have outstanding experience in <a href="https://www.stanfordchildrens.org/en/services/heart-center.html">heart</a> and <a href="https://www.stanfordchildrens.org/en/services/pulmonary-medicine-cystic-fibrosis.html">pulmonary</a> care,” Dr. Hopper says.&nbsp;&nbsp;</p> <p>“During rounds, we received input from everyone, and everyone’s opinion counted,” Jadiel says. “It was amazing to be a part of my daughter’s care.”</p> <p><strong>Receiving four heart surgeries in one month</strong></p> <p>Two weeks after she arrived, Zoraya received the first of four <a href="https://www.stanfordchildrens.org/en/services/cardiothoracic-surgery.html">heart surgeries</a>—placing a pulmonary artery band to control blood flow to her overtaxed left lung. The surgery was a stopgap measure to help her gain enough strength to endure the bigger open-heart surgery that she needed to correct her heart defect.</p> <p>“Our options were limited. She showed up extremely ill and with an acute viral infection, and that’s not a good time for surgery,” says <a href="https://www.stanfordchildrens.org/en/doctor/elisabeth-martin.html">Elisabeth Martin, MD</a>, an exceptionally skilled Stanford Children’s <a href="https://www.stanfordchildrens.org/en/services/cardiothoracic-surgery/careteam.html">cardiothoracic surgeon</a> and the surgical director of the <a href="https://www.stanfordchildrens.org/en/services/pulmonary-artery-reconstruction.html">Pulmonary Artery Reconstruction Program</a>, the <a href="https://www.stanfordchildrens.org/en/services/ceal.html">Center for Advanced Lung (CEAL) Therapies</a>, and the <a href="https://www.stanfordchildrens.org/en/services/lung-transplant.html">Pediatric Lung and Heart-Lung Transplant Program</a>.</p> <p>While the band surgery went well, Zoraya remained acutely ill. Medicines could not control her <a href="https://www.stanfordchildrens.org/en/services/heart-transplant/conditions.html">heart failure</a>, and she was cyanotic—turning blue from too little oxygen. The team needed to perform open-heart surgery right away to save her life.</p> <p>“It was a game-time decision. Her lungs were as good as they were going to get after the viral infection. It was time to move forward,” Dr. Martin says.</p> <p>Most babies with discontinuous pulmonary arteries have surgery soon after birth, so her doctors were surprised that Zoraya made it to eight months. Her left lung was damaged from months of receiving extra blood from the aorta, and the infection made everything worse. Even though her <a href="https://www.stanfordchildrens.org/en/services/cardiothoracic-surgery.html">open-heart surgery</a>—a hemitruncus repair—went as planned to reposition her right pulmonary artery branch in the right position, her lungs remained sick and unable to process enough oxygen.</p> <p>Zoraya was placed on <a href="https://www.stanfordchildrens.org/en/services/heart-transplant/treatment-options.html">extracorporeal membrane oxygenation</a> (ECMO)—an advanced heart-lung bypass machine that helps keep children alive when their heart and/or lungs are failing.</p> <p>“She had four surgeries in one month,” Dr. Martin says. “I’m grateful to be at Stanford Children’s, where we have the support, technology, and brainpower to find a path forward even when so much goes wrong at once.”</p> <p><strong>Receiving extra support along the way</strong></p> <p>Zoraya’s time in the <a href="https://www.stanfordchildrens.org/en/services/cardiovascular-intensive-care.html">CVICU</a> was a roller coaster of emotions for her family. Despite their constant worry, they believed in the team’s skills and appreciated the extra support they received from <a href="https://www.stanfordchildrens.org/en/for-health-professionals/nursing.html">nurses</a>, respiratory therapists, and <a href="https://www.stanfordchildrens.org/en/services/social-services.html">social workers</a> so they could simply focus on their daughter. Zoraya’s care was led by <a href="https://www.stanfordchildrens.org/en/doctor/rebecca-johnson-kameny.html">Rebecca Kameny, MD</a>, an exceptional pediatric critical care medicine doctor and the co-director of CEAL.</p> <p>&nbsp;“You could tell the team was locked in. They had their flow and organization, and they all kind of melded together to care for her,” Marbella says.</p> <p>Despite the added ECMO procedure, three more weeks on the ventilator, and two more weeks on a continuous positive airway pressure (CPAP) machine, her family felt hope. “Even though she was on so many machines, I was happy. I knew she was back,” Marbella adds.</p> <p>Zoraya was sent home on oxygen and a special medicine pump for her <a href="https://www.stanfordchildrens.org/en/services/pulmonary-vascular-disease/treatments.html">pulmonary hypertension</a>. She is not expected to need another heart surgery in the future.</p> <p><strong>Coping with the trauma&nbsp;</strong></p> <p>It has been over a year since her hospital stay, but Marbella and Jadiel are still a bit shell-shocked. If Zoraya gets a cold, they get nervous, but they are learning to trust that she’s OK. “We were worried she wouldn’t be able to recover, but she is recovering,” Jadiel says.</p> <div class="wp-block-image"> <figure class="alignright size-full"><img loading="lazy" decoding="async" width="350" height="500" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-art-350x500-1.jpg" alt="Zoraya smiling" class="wp-image-24974" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-art-350x500-1.jpg 350w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/zoraya-art-350x500-1-315x450.jpg 315w" sizes="(max-width: 350px) 100vw, 350px" /></figure></div> <p>Zoraya’s providers at Stanford Children’s collaborated closely with providers near home. Because Dr. Hopper is licensed in several Western states, she still leads Zoraya’s pulmonary hypertension care. <a href="https://www.stanfordchildrens.org/en/services/pulmonary-vascular-disease/careteam.html">Nurse practitioners</a> with the <a href="https://www.stanfordchildrens.org/en/services/pulmonary-vascular-disease.html">Pulmonary Vascular Disease Program</a> also coordinated her special pulmonary hypertension medications and supported her parents via <a href="https://www.stanfordchildrens.org/en/telehealth.html">telehealth</a> with home administration by always being available to answer questions.</p> <p>“Her family is wonderful and they are great partners,” says <a href="https://www.stanfordchildrens.org/en/provider/esther-y-liu.html">Esther Liu, FNP-C</a>, pulmonary hypertension nurse practitioner. “When families live out of state, it’s important to have open communication with local cardiologists and to meet with the family regularly to ensure children receive the best care.”</p> <p><strong>Meeting milestones and loving life</strong></p> <p>Zoraya recently turned 2 years old. While she’s still on one medication for pulmonary hypertension, she is off the medication via pump and off oxygen support.&nbsp;</p> <p>“She’s running everywhere and climbing on everything. She has caught up completely on all her milestones—faster than we thought,” Marbella says.</p> <p>When Zoraya started feeling better, her sassy, sweet personality really popped. She’s super-social and loves making people laugh. One of her favorite activities is snuggling with her big sister and hero, Xiomara.</p> <p>“Zoraya has made tremendous progress. She’s a thriving toddler now. We are optimistic that she will someday outgrow her pulmonary hypertension,” Dr. Hopper says.&nbsp;</p> <p><strong><a href="https://www.stanfordchildrens.org/en/services/heart-center.html">Learn more about our exceptional heart care &gt;</a></strong></p>

187. Helping Your Child Cope With Anxiety and Depression

     Fri, 10 May 2024 15:00:00 -0000

     

     Pediatrician Nivedita More, MD, of Bayside Medical Group – Fremont, offers ways to support your kids when they are dealing with mental health concerns.

     <div><img width="450" height="450" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1-450x450.jpg" class="attachment-450x450 size-450x450 wp-post-image" alt="" style="margin-bottom: 15px;" decoding="async" loading="lazy" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1-450x450.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1-300x300.jpg 300w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1-600x600.jpg 600w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1-125x125.jpg 125w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1-24x24.jpg 24w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1-48x48.jpg 48w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1-96x96.jpg 96w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1-150x150.jpg 150w" sizes="(max-width: 450px) 100vw, 450px" /></div> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="900" height="506" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1-900x506.jpg" alt="Teenage boy talking to " class="wp-image-25015" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1-768x432.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/teenager-mental-health-stanford-children-1200x675-1.jpg 1200w" sizes="(max-width: 900px) 100vw, 900px" /></figure> <p>Watching your child struggle with anxiety or depression is one of the hardest things a parent can experience. Fellow parent and Stanford Medicine Children’s Health pediatrician <a href="https://www.stanfordchildrens.org/en/doctor/nivedita-n-more.html">Nivedita More, MD</a>, of <a href="https://www.stanfordchildrens.org/en/location/bayside-medical-group-fremont">Bayside Medical Group – Fremont</a>, offers ways to support your kids when they are dealing with mental health concerns.</p> <p><strong>Mental health struggles are common in children</strong></p> <p>Mental health disorders in children are very common, and according to the National Institutes of Health, the number is increasing.</p> <p>“We approximate 13 to 20 percent of patients probably have some sort of mental health disorder at any given point in life,” Dr. More shared. “That’s a pretty high number. I mean, that’s like one in five or one in six kids.”</p> <p>While we often associate depression and anxiety with older adolescents or adults, they can strike at any age. Dr. More advises parents to be mindful of the signs even in children as young as age 2 or 3.</p> <p>“It really can appear at any age, honestly,” she said. “So, parents just need to keep an eye out for any changes in their child’s behavior or learning or how they play, how they talk, how they act, or even how they handle emotions at really any age.”</p> <p><strong>Signals your child may have a mental health concern</strong></p> <p>Pediatricians like Dr. More start screening for mental health concerns around age 12, but parents know their kids best. So, if you notice changes in your child’s behavior, it may be time to speak to your pediatrician.</p> <p>“If a child is socially isolating themselves; this is a kid who was wanting to go out with friends or being social, and now they choose to stay away from them. They’re sad, lasting more than two or more weeks for no random reason,” she said. “Hurting themselves—if there is cutting or any kind of scratch marks on the forearms, if they feel like they’re hurting themselves in any way, those are definitely red flags.”</p> <p>Any big changes in mood, behavior, or personality are all warning signs, Dr. More explained. Some things to watch out for:</p> <ul> <li>Moodiness</li> <li>Trouble sleeping</li> <li>Changing eating habits</li> <li>Stomachache</li> <li>Headache</li> <li>Trouble focusing</li> <li>Falling grades</li> </ul> <p>If your child starts talking about death or suicide, Dr. More urges parents to call the pediatrician right away.</p> <p><strong>How you can get help for your child</strong></p> <p>If you suspect that your child’s emotional well-being is at risk, the first thing on the list should be consulting with your family’s pediatrician.</p> <p>“It’s best to bring it up to the pediatrician right away,” Dr. More said. “Our role is to make the diagnosis early, to intervene and offer all these treatment options with appropriate community resources for that child and their families early.”</p> <p>Your pediatrician can refer your child to professional help. There are also school-based clinics and counselors available for children struggling with mental health disorders.</p> <p>“Parents can also call their insurance or their workplace to look for professional help,” she said. “Some of the tech companies contract with psychologists. Since COVID, a lot of this has moved online. So, you don’t even have to take a child somewhere to get the help that they need anymore.”</p> <p>Dr. More shared that many school districts in the area have access to Care Solace, which is free to the patients. Additionally, the state of California has recently launched CalHOPE, with two separate apps for digital mental health support via phone and chat line for residents of California. The suicide crisis line for emergent situations is 988 nationally.</p> <p><strong>Creating a safe environment for your child with anxiety or depression</strong></p> <p>Support at home is an important part of helping your child heal. Encourage open and honest conversations with your child about their feelings. Let them know that it’s OK to feel sad, anxious, or overwhelmed at times, and you’re there to support them no matter what.</p> <p>Just like asthma or diabetes, anxiety and depression in children need to be treated, Dr. More explained.</p> <p>“Sometimes I feel families delay care because of the taboo that is prevalent with mental health disorders,” she said. “I really like to normalize mental health care by labeling it as a medical condition, just like a urine infection or pink eye or pneumonia or a fracture, for example, which can only get better with treatment.”</p> <p>Dr. More also suggested that parents work with their kids to create a consistent routine at home. Having stability and knowing what to expect can go a long way toward helping a struggling child.</p> <p>“The routines help. So, having timely meals, having a structure, same bedtime every night, making sure they get a good night’s sleep. Taking care of the devices, charging those outside their bedroom, making sure teens get at least eight hours of sleep. All of these help with the mental health concerns,” she explained.</p> <p>Be patient and flexible in your approach, and above all, let your child know that they are loved and supported unconditionally.</p> <p>“It’s a lifelong condition, so it’s like asthma. It has its good days, it has its bad days, you know. But there are all these tools that we can use to get these kids at a very young age to handle their emotions, handle their behavior in a general setting with their friends, with their families, moving forward,” Dr. More said. “There’s always going to be ups and downs, and that’s when they need to know how to get the help that they need. That’s most important.”</p> <p>You can get more advice from Dr. More in these articles: <a href="https://healthier.stanfordchildrens.org/en/what-parents-need-to-know-about-managing-teen-acne/">What Parents Need to Know About Managing Teen Acne</a>, <a href="https://healthier.stanfordchildrens.org/en/healthy-skin-habits-for-your-family/">Healthy Skin Habits for Your Family</a>, and <a href="https://healthier.stanfordchildrens.org/en/traveling-with-kids-during-holidays/">What to Know When Traveling With Kids During the Holidays</a>.</p>

188. Kangaroo Care for Premature Babies in the NICU

     Fri, 10 May 2024 15:00:00 -0000

     

     Innovative i-Rainbow guide helps parents and caregivers know when the time is right for vital skin-to-skin care.

     <div><img width="450" height="450" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1-450x450.jpg" class="attachment-450x450 size-450x450 wp-post-image" alt="" style="margin-bottom: 15px;" decoding="async" loading="lazy" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1-450x450.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1-300x300.jpg 300w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1-600x600.jpg 600w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1-125x125.jpg 125w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1-24x24.jpg 24w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1-48x48.jpg 48w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1-96x96.jpg 96w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1-150x150.jpg 150w" sizes="(max-width: 450px) 100vw, 450px" /></div> <p><em>Innovative i-Rainbow guide helps parents and caregivers know when the time is right for vital skin-to-skin care</em></p> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="900" height="506" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1-900x506.jpg" alt="An adult hand holding a newborn's hand" class="wp-image-24952" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1-768x432.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/kangaroo-care-stanford-childrens-1200x675-1.jpg 1200w" sizes="(max-width: 900px) 100vw, 900px" /></figure> <p>Kangaroo Care Awareness Day is May 15, so it’s a great time to celebrate the positive health benefits that kangaroo care has for newborns. Several studies show that <a href="https://www.stanfordchildrens.org/en/services/pregnancy-newborn/kangaroo-care.html">kangaroo care</a>—skin-to-skin time between a baby and a parent—lowers the risk of newborn health problems, promotes breastfeeding, and helps establish a bond between parents and babies.</p> <p>That’s all great news, but when you have a premature baby who is staying in the <a href="https://www.stanfordchildrens.org/en/services/neonatology/neonatal-intensive-care-unit.html">Neonatal Intensive Care Unit (NICU)</a>, it can be hard to know when and how to provide kangaroo care. Your child may be hooked up to machines for feeding and oxygen and seem very small and fragile. As a new parent, you can find it intimidating to hold and nurture your child.</p> <p>We encourage you to find a way to interact with your premature baby and work up to kangaroo care, because your loving touch and support is an extremely important aspect of your baby’s neurodevelopment.</p> <p>“Certainly, you want to provide kangaroo care as early and as often as possible as soon as your baby is ready, but if your baby is very immature or ill, it can be hard to know when it’s the right time,” says <a href="https://www.stanfordchildrens.org/en/doctor/melissa-lewis-scala.html">Melissa Scala, MD</a>, neonatal-perinatal medicine specialist at Stanford Medicine Children’s Health.</p> <p><strong>A Rainbow of options for preemie interaction</strong></p> <p>To encourage parents to get involved in their premature baby’s care in the NICU, Dr. Scala and colleagues Eilish Byrne, PT, DSC, and <a href="https://www.stanfordchildrens.org/en/services/occupational-therapy/careteam.html">Allison Freccero, OTD, OTR/L</a>, developed the <a href="https://pubmed.ncbi.nlm.nih.gov/38568275/">i-Rainbow</a>, a novel evidence-based clinical guide that helps doctors and nurses determine the type of interaction that a critically ill premature baby is ready for, including kangaroo care. The i-Rainbow is based on a six-level color-coded acuity scale, like a rainbow. Each stage has detailed, clear medical criteria on what type of interaction a baby can receive. At each stage, a menu of activities is provided for parents to choose from.&nbsp;</p> <p>“In stage one, parents use the gentlest way to interact: sharing the maternal scent. Next, they put still hands on their baby to mimic the boundaries of the uterus. Stage three can be talking or singing to your baby,” Dr. Scala says. “The early stages prepare babies for kangaroo care, which includes all of these interactions at once.”</p> <p>Babies can move up and down the rainbow, depending on their current health. Some stay in one stage for weeks, while others move in a single day. The i-Rainbow is a one-of-a-kind protocol allowing real-time flexibility and meeting a baby where she or he is. Unlike other protocols in the nation, it enables the care team to practice precision medicine and develop a customized care plan specific to a baby’s condition and current state.</p> <p><strong>Empowering parents to provide kangaroo care</strong></p> <p>Having a baby in the NICU is overwhelming. Parents can feel a loss of control and constant worry for their premature baby.</p> <p>“Their dreams of what it would be like to be a new parent are shattered. Parents can feel adrift and unsure how to be a parent, or unsure of what their role is to help their baby grow and develop,” Dr. Scala says. “I-Rainbow helps them replace the activities they thought they would be doing with new ones.”</p> <p>When a baby tolerates scent, gentle touching, and talking and singing, they graduate to stage four, and it’s skin-to-skin time with baby lying on a parent’s bare chest. Kangaroo care is linked to lower rates of depression and anxiety in parents, measured by a drop in cortisol levels.</p> <p>“Being involved in their premature baby’s care reduces parental stress and improves their sense of self-efficacy. Parents are super-important in their baby’s neurodevelopmental growth,” Dr. Scala says.</p> <p>Not many places offer the i-Rainbow, but that’s changing, since Dr. Scala and her Stanford Children’s colleagues have made it freely available for other hospitals to adopt. It’s now in use at more than 20 hospitals across the country. Having set criteria also evens the playing field, helping to remove disparities and biases in care.</p> <p><strong>Ask to be involved in your baby’s care</strong></p> <p>If you, a friend, or a family member have a baby in the NICU, remember to be proactive.</p> <p>“The number one thing I wish parents of premature babies would do is ask their hospital team, ‘How can I be involved in my baby’s care, today?’ This reminds the NICU team to communicate the important ways parents can contribute to helping their babies grow and develop,” Dr. Scala says. “They will find a way for you to interact.”</p> <p><a href="https://www.stanfordchildrens.org/en/services/pregnancy-newborn/kangaroo-care.html"><strong>Learn more about kangaroo care ></strong></a></p>

189. Early Diagnosis Is Key for Children With Autism

     Wed, 08 May 2024 15:00:00 -0000

     

     Screening for autism, along with appropriate therapies and fully engaged parents helped Olivia get on track developmentally.

     <div><img width="450" height="450" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1-450x450.jpg" class="attachment-450x450 size-450x450 wp-post-image" alt="" style="margin-bottom: 15px;" decoding="async" loading="lazy" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1-450x450.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1-300x300.jpg 300w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1-600x600.jpg 600w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1-125x125.jpg 125w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1-24x24.jpg 24w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1-48x48.jpg 48w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1-96x96.jpg 96w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1-150x150.jpg 150w" sizes="(max-width: 450px) 100vw, 450px" /></div> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="900" height="506" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1-900x506.jpg" alt="" class="wp-image-25019" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1-768x432.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/olivia-stanford-childrens-1200x675-1.jpg 1200w" sizes="(max-width: 900px) 100vw, 900px" /></figure> <p>Olivia Tang was just 2 years old when she was diagnosed with autism. With the support of a Stanford Medicine Children’s Health pediatrician, she has blossomed into a thriving preschooler. Her mother, Helen Feng, shares their journey.</p> <p>The Tang family had noticed that Olivia was not talking much by the time she turned 2. Olivia’s diagnosis came during the peak of the COVID-19 pandemic, when it was challenging to find services. However, her parents, Helen and Zhenning, were able to connect with <a href="https://www.stanfordchildrens.org/en/doctor/sumit-sen.html">Sumit Sen, MD</a>, a pediatrician at <a href="https://www.stanfordchildrens.org/en/bayside-medical-group">Bayside Medical Group</a>.</p> <p>“She wasn’t talking when she was about 2 years old. She could only say ‘Mommy,’ ‘Daddy,’ and a few words like that,” Helen said. “So, we went to Dr. Sen, and that is when he gave us the diagnosis that she has autism.”</p> <p><a href="https://www.stanfordchildrens.org/en/topic/default?id=autism-spectrum-disorder-in-children-90-P02556">Autism spectrum disorder</a> (ASD) is a condition that occurs in the brain and affects how a person communicates and interacts with others, among other symptoms.</p> <p>Dr. Sen and Stanford Medicine Children’s Health follow the American Academy of Pediatrics’ recommendation to screen children for autism at their well visits before age 2. Dr. Sen also leads educational training seminars for parents of toddlers and preschool-aged children with autism.</p> <p>According to Dr. Sen, not speaking by 18 months is one of the hallmark signals that a child has autism. But with early diagnosis, children like Olivia can find the support they need to get on track developmentally.</p> <p>“If we diagnose very early, we are not that much off track. With therapy, we can get your child on track and move forward,” Dr. Sen said. “With all the appropriate therapies and the parents fully engaged, a lot of my patients start elementary school at the same level as their peers. And by their late elementary school years, they do not have the diagnosis anymore.”</p> <p>Once Olivia was diagnosed, the Tang family were able to receive additional services for her without much delay.</p> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="900" height="506" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/tang-family-1200x675-1-900x506.jpg" alt="" class="wp-image-24944" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/tang-family-1200x675-1-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/tang-family-1200x675-1-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/tang-family-1200x675-1-768x432.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/tang-family-1200x675-1.jpg 1200w" sizes="(max-width: 900px) 100vw, 900px" /></figure> <p>“We started right away with all the services that we were eligible for,” Helen said. “The therapists were great; she started to get a lot of help, and we noticed that she was really learning. She was making great progress, and she started talking.”</p> <p>With the help of her therapists and parental involvement, Olivia can now speak and communicate with no issues.</p> <p>“She’s communicating well now, but she still needs help with social situations,” Helen shared. “Dr. Sen gave us a lot of ideas about how to work with her, like before we go to the park, we will prepare her with little social stories, so she knows what to do if a friend doesn’t want to play.”</p> <p>Helen credits Dr. Sen’s attentive support with helping Olivia make so much progress. “We love Dr. Sen. He’s great,” Helen said. “He checks on us every two months, and he sends us questionnaires about her development to see if she’s on track. So, if there’s any milestone she’s missing, Dr. Sen helps us figure out how we can help her meet the goal. He gave a lot of great advice, and she’s getting better and better.”</p> <p>The Tangs were able to get additional support for Olivia from their school district. “When she turned 3 years old, we had an evaluation with the school district and were able to enroll Olivia into a preschool program with an inclusive classroom,” Helen said. The preschool includes paraeducators, and Olivia has therapy while she is at school, she added.</p> <p>While getting the diagnosis that Olivia has autism was difficult at first, Helen is glad now that they were proactive about getting help. She urges other parents to bring their concerns to their pediatrician.</p> <p>“At the beginning, it was hard for me to admit she has autism because I felt like it was really a bad thing. But now … Olivia is healthy, she’s happy, she’s having a normal life,” Helen said.</p> <p>“So, if there is any sign that your child may have autism, test right away and then get the help; it is very necessary,” Helen said. “I’m glad we got the diagnosis from Dr. Sen. She is getting all the help she needs. That’s why she can go to school and just be a normal kid.”</p> <p>To learn more about ASD in children and Dr. Sen, read <a href="https://healthier.stanfordchildrens.org/en/understanding-autism-spectrum-disorder-in-young-children/">Understanding Autism Spectrum Disorder in Young Children</a>.</p> <p><a href="https://www.stanfordchildrens.org/en/services/autism"><strong>Learn more about Autism services at Stanford Medicine Children’s Health &gt;</strong></a></p>

190. Distance Runner Charging Forward After Crawling Across Finish Line

     Tue, 07 May 2024 15:00:00 -0000

     

     Medha's Stanford care team has helped her bounce back stronger after multiple injuries and learn how to reduce her injury risk in the future.

     <div><img width="450" height="450" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-featured-1200x675-1-450x450.jpg" class="attachment-450x450 size-450x450 wp-post-image" alt="" style="margin-bottom: 15px;" decoding="async" loading="lazy" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-featured-1200x675-1-450x450.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-featured-1200x675-1-300x300.jpg 300w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-featured-1200x675-1-600x600.jpg 600w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-featured-1200x675-1-125x125.jpg 125w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-featured-1200x675-1-24x24.jpg 24w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-featured-1200x675-1-48x48.jpg 48w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-featured-1200x675-1-96x96.jpg 96w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-featured-1200x675-1-150x150.jpg 150w" sizes="(max-width: 450px) 100vw, 450px" /></div> <p><em>Medha&#8217;s Stanford care team has helped her bounce back stronger after multiple injuries</em></p> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="900" height="506" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-stanford-childrens-1200x675-1-900x506.jpg" alt="Medha standing with crutches" class="wp-image-24929" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-stanford-childrens-1200x675-1-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-stanford-childrens-1200x675-1-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-stanford-childrens-1200x675-1-768x432.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-crutches-stanford-childrens-1200x675-1.jpg 1200w" sizes="(max-width: 900px) 100vw, 900px" /></figure> <p>The gun goes off. Distance runner Medha Gowda is on the line, ready to win and considered the top contender for California’s North Coast Section Championship. She takes one step and falls.</p> <p>“I felt a pain from my Achilles to my calf, and I face-planted. Adrenaline got me back up, and I led the first two miles,” she says. “With 600 meters to go, I collapsed from unbearable pain.”</p> <p>Instead of tapping out as 99.9% of us would do, Medha crawled the approximately half mile to the finish line. Her coach and her mother ran beside her. She asked them to not touch her for fear of getting a “DQ,” or disqualification.</p> <p>“At the end, I tried to get up to jog. I didn’t want the memory of my final senior year race to be me crawling across the finish line,” she says.</p> <p><strong>Getting expert sports medicine care quickly at Stanford Medicine Children&#8217;s Health</strong></p> <p>The Monday after the weekend meet, Medha was at the Stanford Medicine Children’s Orthopedic and Sports Medicine Center location in <a href="https://www.stanfordchildrens.org/en/location/orthopedics-sports-medicine-pleasanton" target="_blank" rel="noreferrer noopener">Pleasanton</a>. There, she saw <a href="https://www.stanfordchildrens.org/en/doctor/arvind-balaji" target="_blank" rel="noreferrer noopener">Arvind Balaji, MD</a>, a pediatric <a href="https://www.stanfordchildrens.org/en/service/sports-medicine" target="_blank" rel="noreferrer noopener">sports medicine</a> specialist.</p> <p>Medha received medical care, psychological support, and physical therapy over the course of eight weeks to get her back to sport. This included Dr. Balaji getting down to the nitty-gritty of exactly which exercises she needed and at what intensity to help her heal safely.</p> <p>“It’s a bit unique, but I pull up videos of my patients’ physical therapy sessions, and I point out how it should look and feel and where they can push or not,” Dr. Balaji says. “We take care of the highest level of young athletes here at Stanford Children’s—those who compete at the national and world level—so we want to get them back to sport but also make sure their injury won’t affect them long-term.”</p> <p>Medha appreciated that Dr. Balaji understood how badly she wanted to get back out there, and he “set up an efficient way to get [her] back quickly and safely.” She has since seen Dr. Balaji for several other running-related injuries.</p> <p>Medha also visited Stanford’s <a href="https://www.stanfordchildrens.org/en/services/motion-sports-performance-laboratory.html">Motion Analysis and Sports Performance Laboratory</a>, where a running analysis helped pinpoint changes she can make to reduce her risk of getting injured again.</p> <div class="wp-block-image"> <figure class="alignright size-full"><img loading="lazy" decoding="async" width="350" height="525" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-running-stanford-childrens-350x525-1.jpg" alt="Medha running in a race" class="wp-image-24927" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-running-stanford-childrens-350x525-1.jpg 350w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-running-stanford-childrens-350x525-1-300x450.jpg 300w" sizes="(max-width: 350px) 100vw, 350px" /></figure></div> <p>At the lab, Medha ran on an instrumented treadmill that measures the force she inputs into the ground with each step, while special 3-D cameras recorded the motion of her joints.</p> <p>The <a href="https://www.stanfordchildrens.org/en/services/motion-sports-performance-laboratory/careteam.html">lab team</a> found that Medha may benefit from increasing her cadence (taking more steps per minute) to reduce the impact force when her feet hit the ground as well as improve her performance.</p> <p>“Gait retraining is difficult, so we like to look for the low-hanging fruit that is easy change but will make a real impact on a runner’s mechanics,” says Jeff Morgan, ATC, a biomechanist at the lab. “Getting an athlete like Medha to increase her cadence using a specially timed playlist should reduce her injury risk. We also recommended exercises to help her build her body up to handle the demands she is placing on it.”</p> <p>Deborah Callahan, ATC, an athletic trainer at the lab, said that athletes like Medha are well-suited for the lab’s data-driven approach.</p> <p>“Medha is very driven and had a lot of really great questions,” she says. “She trains smart, and now I think she can train even smarter.”</p> <p><strong>A shining high school track career</strong></p> <div class="wp-block-image"> <figure class="alignright size-full"><img loading="lazy" decoding="async" width="350" height="525" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-award-stanford-childrens-350x525-1.jpg" alt="Medha holding an athletic award" class="wp-image-24931" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-award-stanford-childrens-350x525-1.jpg 350w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/05/medha-award-stanford-childrens-350x525-1-300x450.jpg 300w" sizes="(max-width: 350px) 100vw, 350px" /></figure></div> <p>Medha ran varsity cross-country and track at Dublin High School all four years. But she wasn’t always a runner. Prior to that, she played soccer.</p> <p>“My soccer coaches called me ‘slow bug.’ They suggested I join cross-country the summer before my freshman year to become better conditioned. I found a passion for it,” she says.</p> <p>Medha quit soccer and went out for track and cross-country, making the varsity team as a freshman. She went on to make school history by becoming the first female at Dublin High to ever win a league title at the cross-country championships. She also set a high school record for the three mile at 18:01 minutes on the Hayward course.</p> <p>“Medha has a positive attitude, and she is very self-motivated. It’s that combination that makes her a successful student athlete,” says <a href="https://www.stanfordchildrens.org/en/services/sports-physical-therapy/careteam" target="_blank" rel="noreferrer noopener">Charlie Lee, PT, DPT, CSCS</a>, <a href="https://www.stanfordchildrens.org/en/services/sports-physical-therapy" target="_blank" rel="noreferrer noopener">sports physical therapist</a> at Stanford Children’s who helped Medha recover.</p> <p>Medha, now 18, is running track and cross-country at Chabot Community College as a freshman. She hopes to someday transfer to a four-year college and continue her running career. She plans to take her experience and apply it to her goal of becoming a pediatric sports medicine doctor like Dr. Balaji.</p> <p>“My success has not been from genetics and raw talent but from my own hard work. Every day I put in the work. That’s why each of my successes are so sweet for me,” she concludes.</p> <p><a href="https://www.stanfordchildrens.org/en/services/sports-medicine"><strong>Learn more about our Sports Medicine Program ></strong></a></p>